High confidence predictions of drug-drug interactions: Predicting affinities for cytochrome P450 2C9 with multiple computational methods

Journal of Medicinal Chemistry

Volumn 51, Issue 3, 2008, Pages 648-654

  Hudelson, Matthew G ^a   Ketkar, Nikhil S ^b   Holder, Lawrence B ^b   Carlson, Timothy J ^c   Peng, Chi Chi ^a   Waldher, Benjamin J ^a,b   Jones, Jeffrey P ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b Washington State University   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZBROMARONE; BROMINE DERIVATIVE; CHROMENONE DERIVATIVE; CYTOCHROME P450 2C9; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPUTER ANALYSIS; DRUG DETERMINATION; ENZYME BINDING; ENZYME SUBSTRATE COMPLEX; MOLECULAR MODEL; PREDICTION;

CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; DRUG INTERACTIONS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 39149140400     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701130z     Document Type: Article

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