Vanadium induces dopaminergic neurotoxicity via protein kinase Cdelta dependent oxidative signaling mechanisms: Relevance to etiopathogenesis of Parkinson's disease

Toxicology and Applied Pharmacology

Volumn 240, Issue 2, 2009, Pages 273-285

  Afeseh Ngwa, Hilary ^a   Kanthasamy, Arthi ^a   Anantharam, Vellareddy ^a   Song, Chunjuan ^a   Witte, Travis ^a,b   Houk, Robert ^a,b   Kanthasamy, Anumantha G ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b U S DEPARTMENT OF ENERGY   (United States)

Author keywords

Manganese; Metal mixtures; Neurotoxicity; Oxidative stress; Parkinson's disease; Vanadium

Indexed keywords

CARRIER PROTEIN; CASPASE 3; CASPASE 9; CYTOCHROME C; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PHOSPHOLIPASE C DELTA; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; VANADIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CATALYSIS; CELL PROTECTION; CELL STRESS; CONTROLLED STUDY; CYTOPLASM; DISEASE COURSE; DNA FRAGMENTATION; DOPAMINERGIC NERVE CELL; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; FETUS; MOUSE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PROTEIN CLEAVAGE; RAT; SIGNAL TRANSDUCTION; TOXICOKINETICS; UPREGULATION;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CATION TRANSPORT PROTEINS; CELL LINE; CELL SURVIVAL; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROMES C; DNA FRAGMENTATION; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; INHIBITORY CONCENTRATION 50; MESENCEPHALON; MITOCHONDRIA; NEURONS; NEUROTOXICITY SYNDROMES; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN KINASE C-DELTA; RATS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFERRIN; VANADIUM COMPOUNDS;

EID: 70349240229     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.07.025     Document Type: Article

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