Nonmyeloablative Stem Cell Therapy Enhances Microcirculation and Tissue Regeneration in Murine Inflammatory Bowel Disease

Gastroenterology

Volumn 132, Issue 3, 2007, Pages 944-954

  Khalil, Philipe N ^a   Weiler, Véronique ^b   Nelson, Peter J ^b   Khalil, Maurice N ^a   Moosmann, Sabine ^b   Mutschler, Wolf E ^a   Siebeck, Matthias ^a   Huss, Ralf ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN RECEPTOR; CD34 ANTIGEN; DEXTRAN SULFATE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD34 SELECTION; CELL IMMORTALIZATION; CELL REGENERATION; COLITIS; COLON MUCOSA; CONTROLLED STUDY; DIGESTIVE SYSTEM; DISEASE SEVERITY; ENTERITIS; EPITHELIUM; FEMALE; GENETIC MARKER; LARGE INTESTINE; MICROCIRCULATION; MOUSE; NONHUMAN; NONMYELOABLATIVE STEM CELL TRANSPLANTATION; PRIORITY JOURNAL; SURVIVAL; TISSUE INJURY; TISSUE REGENERATION;

EID: 33947307177     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2006.12.029     Document Type: Article

References (49)

1. Bouma G., and Strober W. The immunological and genetic basis of inflammatory bowel disease. Nature 3 (2003) 521-533
2. Podolsky D.K. Inflammatory bowel disease. N Engl J Med 347 (2002) 417-429
3. Boismenu R., and Chen Y. Insights from mouse models of colitis. J Leukocyte Biol 67 (2000) 267-278
4. Elson C.O., Sator R.B., Tennyson G.S., and Riddell R.H. Experimental models of inflammatory bowel disease. Gastroenterology 109 (1995) 1344-1367
5. Strober W., Fuss I.J., and Blumberg R.S. The immunology of mucosal models of inflammation. Annu Rev Immunol 20 (2002) 495-549
6. Neurath M.F., Finotto S., and Glimcher L.H. The role of TH1/TH2 polarization in mucosal immunity. Nat Med 8 (2002) 567-573
7. Hanauer S.B. Inflammatory bowel disease. N Engl J Med 334 (1996) 841-848
8. Farrell R.J., and Peppercorn M.A. Ulcerative colitis. Lancet 359 (2002) 331-340
9. Shanahan F. Crohn's disease. Lancet 359 (2002) 62-69
10. Rafii S., and Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 9 (2003) 702-712
11. Takahashi T., Kalka C., Masuda H., Chen D., Silver M., Kearney M., Magner M., Isner J.M., and Asahara T. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 5 (1999) 434-438
12. MacDermott R.P., Sanderson I.R., and Reinecker H.C. The central role of chemokines (chemotactic cytokines) in the immunopathogenesis of ulcerative colitis and Crohn's disease. Inflamm Bowel Dis 4 (1998) 54-67
13. Mangi A.A., Noiseux N., Kong H., He H., Rezvani M., Ingwall J.S., and Dzau V.J. Mesenchymal stem cells modified with AKT prevent remodeling and restore performance of infarcted hearts. Nat Med 9 (2003) 1195-1201
14. Orlic D., Kajstura J., Chimenti S., Jakoniuk I., Anderson S.M., Li B., Pickel J., McKay R., Nadal-Ginard B., Bodine D.M., Leri A., and Anversa P. Bone marrow cells regenerate infarcted myocaedium. Nature 410 (2001) 701-705
15. Carmeliet P. Angiogenesis in health and disease. Nat Med 9 (2003) 653-660
16. Laroux F.S., and Grisham M.B. Immunological basis of inflammatory bowel disease: role of the microcirculation. Microcirculation 8 (2001) 283-301
17. Hatoum O.A., Binion D.G., Otterson M.F., and Gutterman D.D. Acquired microvascular dysfunction in infammatory bowel disease: loss of nitric oxide-mediated vasodilatation. Gastroenterology 125 (2003) 58-69
18. Kanazawa S., Tsunoda T., Onuma E., Majima T., Kagiyama M., and Kikuchi K. VEGF, basic-FGF, and TGF-β in Crohn's disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation. Am J Gastroenterol 96 (2001) 822-828
19. Okayasu I., Hatakeyama S., Yamada M., Ohkusa T., Inahgaki Y., and Nakaya R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98 (1990) 694-702
20. Lange C., Kaltz C., Thalmeier K., Kolb H.J., and Huss R. Long-term hematopoietic reconstitution of syngeneic mice with a peripheral blood-derived, monoclonal CD34-, Sca-1+, Thy-1 low, c-kit+ stem cell line. J Hematother Stem Cell Res 8 (1999) 335-342
21. Huss R., Heil M., Moosmann S., Ziegelhoeffer T., Sagebiel S., Seliger C., Kinston S., and Gottgens B. Improved arteriogenesis with simultaneous skeletal muscle repair in ischemic tissue by SCL(+) multipotent adult progenitor cell clones from peripheral blood. J Vasc Res 41 (2004) 422-431
22. Cuzzocrea S., McDonald M.C., Mazzon E., Mota-Filipe H., Centorrino T., Terranova M.L., Ciccolo A., Britti D., Caputi A.P., and Thiemermann C. Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat. Gut 48 (2001) 478-488
23. Wallace J.L., Keenan C.M., Gale D., and Shoupe T.S. Exacerbation of experimental colitis by non-steroidal anti-inflammatory drugs is not related to elevated leukotriene B4 synthesis. Gastroenterology 102 (1992) 18-27
24. Cooper H.S., Murthy S.N., Shah R.S., and Sedergran D.J. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69 (1993) 238-249
25. Onderdonk A.B., Hermos J.A., and Bartlett J.G. The role of the intestinal microflora in experimental colitis. Am J Clin Nutr 30 (1977) 1819-1825
26. Huss R., Renner-Muller I., and Buchstaller A. Adult scl+/+ murine hemangioblasts persist in allogenic mutant blastocysts but fail to rescue the scl-/- phenotype. Stem Cells Dev 14 (2005) 402-407
27. -negative stem cells. J Hematother Stem Cell Res 9 (2000) 783-793
28. - progenitor cells functionally express the chemokine receptors CCR1, CCR4, CCR7, CXCR5, and CCR10 but not CXCR4. Stem Cells Dev 14 (2005) 329-336
29. - hematopoietic and mesenchymal stem cells from various sources. Stem Cells 18 (2000) 1-9
30. Conrad C., and Huss R. Adult stem cell lines in regenerative medicine and reconstructive surgery. J Surg Res 124 (2005) 201-208
31. Huss R., Hong D.S., McSweeney P.A., Hoy C.A., and Deeg H.J. Diffentiation of canine bone marrow cells with hematopoietic characteristics from adherent stromal cell precursor. Proc Natl Acad Sci U S A 92 (1995) 748-752
32. Bamba S., Lee C.Y., Brittan M., Preston S.L., Direkze N.C., Alison M.R., Wright N.A., and Otto W.R. Bone marrow transplantation ameliorates pathology in interleukin-10 knockout colitic mice. J Pathol 209 (2006) 265-273
33. Brittan M., Chance V., Elia G., Poulsom R., Alison M.R., MacDonald T.T., and Wright N.A. A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesisan myofibroblasts. Gastroenterology 128 (2005) 1984-1995
34. Komori M., Tsuji S., Tsujii M., Murata H., Iijima H., Yasumaru M., Nishida T., Irie T., Kawano S., and Hori M. Involvement of bone marrow-derived cells in healing of experimental colitis in rats. Wound Rep Reg 13 (2005) 109-118
35. Barkholt L., and Löfberg R. Resetting the immune system in refractory Crohn's disease: is autologous hematopoietic stem cell transplantation the way forward?. Gastroenterology 128 (2005) 786-789
36. Folwaczny C., Glas J., Folwaczny M., and Török H.P. Autologous hematopoietic stem cell transplantation in refractory Crohn's disease: a feasible therapeutic approach?. Gastroenterology 128 (2005) 2180
37. Oyama Y., Craig R.M., Traynor A.E., Quigley K., Statkute L., Halverson A., Brush M., Verda L., Kowalska B., Krosnjar N., Kletzel M., Whitington P.F., and Burt R.K. Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease. Gastroenterology 128 (2005) 552-563
38. Dielman L.A., Pena A.S., Meuwissen S.G.M., and Van Rees E.P. Role of animal models for the pathogenesis and treatment of inflammatory bowel disease. Scand J Gastroenterol 32 (1997) 99-104
39. Pizarro T.T., Arseneau K.O., Bamias G., and Cominelli F. Mouse models for the study of Crohn's disease. Trends Mol Med 9 (2003) 218-222
40. Conrad C., Gottgens B., Kinston S., Ellwart J., and Huss R. GATA-trancription in a small rhodamine 123(low)CD34(+) subpopulation of a peripheral blood-derived CD34(-)CD105(+) mesenchymal cell line. Exp Hematol 30 (2002) 887-895
41. Scholz D., Cai W.J., and Schaper W. Arteriogenesis, a new concept of vascular adaptation in occlusive disease. Angiogenesis 4 (2001) 247-257
42. Ziegelhoeffer T., Fernandez B., Kostin S., Heil M., Voswinckel R., Helisch A., and Schaper W. Bone marrow-derived cells do not incorporate into the adult growing vasculature. Circ Res 94 (2004) 230-238
43. Scholz D., Ziegelhoeffer T., Helisch A., Wagner S., Friedrich C., Podzuweit T., and Schaper W. Contribution of arteriogenesis and angiogenesis to postocclusive hindlimb perfusion in mice. J Mol Cell Cardiol 34 (2002) 775-787
44. Hattori K., Heissig B., Wu Y., Dias S., Tejada R., Ferris B., Hicklin D.J., Zhu Z., Bohlen P., Witte L., Hendrikx J., Hackett N.R., Crystal R.G., Moore M.A., Werb Z., Lyden D., and Rafii S. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med 8 (2002) 841-849
45. Pipp F., Heil M., Issbrucker K., Ziegelhoeffer T., Martin S., van den Heuvel J., Weich H., Fernandez B., Golomb G., Carmeliet P., Schaper W., and Clauss M. VEGF-1-selective VEGF homologue PlGF is arteriogenic. Evidence for a monocyte-mediated mechanism. Circ Res 92 (2003) 378-385
46. Luttun A., Tjwa M., Moons L., Wu Y., Angelillo-Scherrer A., Liao F., Nagy J.A., Hooper A., Priller J., De Klerck B., Compernolle V., Daci E., Bohlen P., Dewerchin M., Herbert J.M., Fava R., Matthys P., Carmeliet G., Collen D., Dvorak H.F., Hicklin D.J., and Carmeliet P. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 8 (2002) 831-840
47. Gering M., Rodaway A.R., Gottgens B., Patient R.K., and Green A.R. The SCL gene specifies haemangioblast development from early mesoderm. EMBO J 17 (1998) 4029-4045
48. Kamihata H., Matsubara H., Nishiue T., Fujiyama S., Amano K., Iba O., Imada T., and Iwasaka T. Improvement of collateral perfusion and regional function by implantation of peripheral blood mononuclear cells into ischemic hibernating myocardium. Arterioscler Thromb Vasc Biol 22 (2002) 1804-1810
49. Potten C.S., Booth C., Tudor G.L., Booth D., Brady G., Hurley P., Ashton G., Clarke R., Sakakibara S., and Okano H. Identification of a putative intestinal stem cell and early lineage marker; musashi-1. Differentiation 71 (2003) 28-41