메뉴 건너뛰기




Volumn 9, Issue 7, 2009, Pages 841-847

Overview of stem cell therapy for Crohn's disease

Author keywords

Crohn's disease; Mesenchymal stem cell therapy; Regional enteritis; Stem cell therapy

Indexed keywords

ADALIMUMAB; ANTIINFECTIVE AGENT; CERTOLIZUMAB PEGOL; FIBRIN GLUE; INFLIXIMAB; NATALIZUMAB;

EID: 67650379009     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712590902956615     Document Type: Review
Times cited : (44)

References (49)
  • 1
    • 33847381116 scopus 로고    scopus 로고
    • The fundamental basis of inflammatory bowel disease
    • Strober W, Fuss I, Mannon P. The fundamental basis of inflammatory bowel disease. J Clin Invest 2007;117(3):514-521
    • (2007) J Clin Invest , vol.117 , Issue.3 , pp. 514-521
    • Strober, W.1    Fuss, I.2    Mannon, P.3
  • 2
    • 20444464523 scopus 로고    scopus 로고
    • Mucosal integrity and barrier function in the pathogenesis of early lesions in Crohn's disease
    • Sanders DSA. Mucosal integrity and barrier function in the pathogenesis of early lesions in Crohn's disease. J Clin Pathol 2005;58:568-572
    • (2005) J Clin Pathol , vol.58 , pp. 568-572
    • Sanders, D.S.A.1
  • 3
    • 84934437928 scopus 로고    scopus 로고
    • Mesenchymal stem cells increase self-renewal of small intestinal epithelium and accelerate structural recovery after radiation injury
    • Sémont A, François S, Mouiseddine M, et al. Mesenchymal stem cells increase self-renewal of small intestinal epithelium and accelerate structural recovery after radiation injury. Adv Exp Med Biol 2006;585:19-30
    • (2006) Adv Exp Med Biol , vol.585 , pp. 19-30
    • Sémont, A.1    François, S.2    Mouiseddine, M.3
  • 4
    • 0026228558 scopus 로고
    • Mesenchymal stem cells
    • Caplan AI. Mesenchymal stem cells. J Orthotop Res 1991;9(5):641-650
    • (1991) J Orthotop Res , vol.9 , Issue.5 , pp. 641-650
    • Caplan, A.I.1
  • 5
    • 0017119380 scopus 로고
    • Fibroblast precursors in normal and irradiated mouse hematopoietic organs
    • Friedenstein AJ, Gorskaja UF, Kulagina NN. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol 1976;4(5):267-274
    • (1976) Exp Hematol , vol.4 , Issue.5 , pp. 267-274
    • Friedenstein, A.J.1    Gorskaja, U.F.2    Kulagina, N.N.3
  • 6
    • 84990622726 scopus 로고
    • Bone marrow osteogenic stem cells: In vitro cultivation and transplantation in diffusion chambers
    • Friedenstein AJ, Chailikhyan RK, Gerasimov UV. Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet 1987;20(3):263-272
    • (1987) Cell Tissue Kinet , vol.20 , Issue.3 , pp. 263-272
    • Friedenstein, A.J.1    Chailikhyan, R.K.2    Gerasimov, U.V.3
  • 8
    • 0028788268 scopus 로고
    • Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine
    • Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 1995;18(12):1417-1426
    • (1995) Muscle Nerve , vol.18 , Issue.12 , pp. 1417-1426
    • Wakitani, S.1    Saito, T.2    Caplan, A.I.3
  • 9
    • 0033106384 scopus 로고    scopus 로고
    • Cardiomyocytes can be generated from marrow stromal cells in vitro
    • Makino S, Fukuda K, Miyoshi S, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J. Clin. Invest 1999;103:697-705
    • (1999) J. Clin. Invest , vol.103 , pp. 697-705
    • Makino, S.1    Fukuda, K.2    Miyoshi, S.3
  • 10
    • 2942523981 scopus 로고    scopus 로고
    • Mesenchymal stem cells can be differentiated into endothelial cells in vitro
    • Oswald J, Boxberger S, Jørgensen B, et al. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 2004;22:377-384
    • (2004) Stem Cells , vol.22 , pp. 377-384
    • Oswald, J.1    Boxberger, S.2    Jørgensen, B.3
  • 11
    • 0034663515 scopus 로고    scopus 로고
    • Adult rat and human bone marrow stromal cells differentiate into neurons
    • Woodbury D, Schwarz EJ, Prockop DJ, Black IB. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 2000;61:364-370
    • (2000) J Neurosci Res , vol.61 , pp. 364-370
    • Woodbury, D.1    Schwarz, E.J.2    Prockop, D.J.3    Black, I.B.4
  • 12
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005;105(4):1815-1822
    • (2005) Blood , vol.105 , Issue.4 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 13
    • 18544371666 scopus 로고    scopus 로고
    • Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells
    • Jiang XX, Zhang Y, Liu B, et al. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 2005;105(10): 4120-4126
    • (2005) Blood , vol.105 , Issue.10 , pp. 4120-4126
    • Jiang, X.X.1    Zhang, Y.2    Liu, B.3
  • 14
    • 36749001082 scopus 로고    scopus 로고
    • Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells
    • Abe K, Nguyen KP, Fine SD, et al. Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. PNAS 2007;104(43):17022-17027
    • (2007) PNAS , vol.104 , Issue.43 , pp. 17022-17027
    • Abe, K.1    Nguyen, K.P.2    Fine, S.D.3
  • 15
    • 0036142769 scopus 로고    scopus 로고
    • Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    • Bartholomew A, Sturgeon C, Siatskas M, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002;30:42-48
    • (2002) Exp Hematol , vol.30 , pp. 42-48
    • Bartholomew, A.1    Sturgeon, C.2    Siatskas, M.3
  • 16
    • 0038204193 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide
    • Krampera M, Glennie S, Dyson J, et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003;101:3722-3729
    • (2003) Blood , vol.101 , pp. 3722-3729
    • Krampera, M.1    Glennie, S.2    Dyson, J.3
  • 17
    • 34848851890 scopus 로고    scopus 로고
    • Mesenchymal stem cells fail to trigger effector functions of cytotoxic T lymphocytes
    • Rasmusson I, Uhlin M, Le Blanc K, Levitsky V. Mesenchymal stem cells fail to trigger effector functions of cytotoxic T lymphocytes. J Leukoc Biol 2007;82(4):887-893
    • (2007) J Leukoc Biol , vol.82 , Issue.4 , pp. 887-893
    • Rasmusson, I.1    Uhlin, M.2    Le Blanc, K.3    Levitsky, V.4
  • 18
    • 0042740515 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatability complex
    • Le Blanc K, Tammik L, Sundberg B, et al. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatability complex. Scand J Immunol 2003;57:11-20
    • (2003) Scand J Immunol , vol.57 , pp. 11-20
    • Le Blanc, K.1    Tammik, L.2    Sundberg, B.3
  • 19
    • 34547907464 scopus 로고    scopus 로고
    • Immunomodulatory properties of mesenchymal stem cells: A review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
    • [published online 29 January 2007, doi:10.1186/ar2103]
    • Tyndall A, Walker UA, Cope A, et al. Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005. Arthritis Res Ther 2007;9:301 [published online 29 January 2007, doi:10.1186/ar2103]
    • (2007) Arthritis Res Ther , vol.9 , pp. 301
    • Tyndall, A.1    Walker, U.A.2    Cope, A.3
  • 20
    • 2942595706 scopus 로고    scopus 로고
    • Human bone marrow stromal cells inhibit allogeneic T-cell responses by indolamine 2,3-dioxygenase-mediated tryptophan degredation
    • Meisel R, Zibert A, Laryea M, et al. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indolamine 2,3-dioxygenase-mediated tryptophan degredation. Blood 2004;103:4619-4621
    • (2004) Blood , vol.103 , pp. 4619-4621
    • Meisel, R.1    Zibert, A.2    Laryea, M.3
  • 21
    • 38349053355 scopus 로고    scopus 로고
    • Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells
    • Selmani Z, Naji A, Zidi I, et al. Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells. Stem Cells 2008;26:212-222
    • (2008) Stem Cells , vol.26 , pp. 212-222
    • Selmani, Z.1    Naji, A.2    Zidi, I.3
  • 22
    • 0141484485 scopus 로고    scopus 로고
    • HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells
    • Le Blanc K, Tammik C, Rosendahl K, et al. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 2003;31(10):890-896
    • (2003) Exp Hematol , vol.31 , Issue.10 , pp. 890-896
    • Le Blanc, K.1    Tammik, C.2    Rosendahl, K.3
  • 23
    • 0038281370 scopus 로고    scopus 로고
    • Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates
    • Devine SM, Cobbs C, Jennings M, et al. Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. Blood 2003;101:2999-3001
    • (2003) Blood , vol.101 , pp. 2999-3001
    • Devine, S.M.1    Cobbs, C.2    Jennings, M.3
  • 24
    • 1942528355 scopus 로고    scopus 로고
    • Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome
    • Chapel A, Bertho JM, Bensidhoum M, et al. Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome. J Gene Med 2003;5:1028-1038
    • (2003) J Gene Med , vol.5 , pp. 1028-1038
    • Chapel, A.1    Bertho, J.M.2    Bensidhoum, M.3
  • 25
    • 35449007194 scopus 로고    scopus 로고
    • Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon
    • Ringdén O, Uzunel M, Sundberg B, et al. Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon. Leukemia 2007;21:2271-2276
    • (2007) Leukemia , vol.21 , pp. 2271-2276
    • Ringdén, O.1    Uzunel, M.2    Sundberg, B.3
  • 26
    • 67650391562 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell therapy in patients with refractory Crohn's disease
    • Duijvestein M, Verwey MH, Fidder HH, et al. Autologous mesenchymal stem cell therapy in patients with refractory Crohn's disease. J Crohns Colitis 2009;3(1):S46-7
    • (2009) J Crohns Colitis , vol.3 , Issue.1
    • Duijvestein, M.1    Verwey, M.H.2    Fidder, H.H.3
  • 27
    • 15744405106 scopus 로고    scopus 로고
    • Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease
    • Oyama Y, Craig RM, Traynor AE, et al. Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease. Gastroenterology 2005;128(3):552-563
    • (2005) Gastroenterology , vol.128 , Issue.3 , pp. 552-563
    • Oyama, Y.1    Craig, R.M.2    Traynor, A.E.3
  • 28
    • 38549137308 scopus 로고    scopus 로고
    • Autologous haematopoietic stem cell transplantation without CD34+ cell selection in refractory Crohn's disease
    • Cassinotti A, Annaloro C, Ardizzone S, et al. Autologous haematopoietic stem cell transplantation without CD34+ cell selection in refractory Crohn's disease. Gut 2008;57(2):211-217
    • (2008) Gut , vol.57 , Issue.2 , pp. 211-217
    • Cassinotti, A.1    Annaloro, C.2    Ardizzone, S.3
  • 29
    • 21644462655 scopus 로고    scopus 로고
    • A PhaseI clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation
    • García-Olmo D, García-Arranz M, Herreros D, et al. A PhaseI clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 2005;48(7):1416-1423
    • (2005) Dis Colon Rectum , vol.48 , Issue.7 , pp. 1416-1423
    • García-Olmo, D.1    García-Arranz, M.2    Herreros, D.3
  • 30
    • 67650391557 scopus 로고    scopus 로고
    • Successful outpatient treatment of refractory Crohn's disease using adult mesenchymal stem cells
    • Onken J, Gallup D, Hanson J et al. Successful outpatient treatment of refractory Crohn's disease using adult mesenchymal stem cells. ACG 2006 Final Program Book 2006;121
    • (2006) ACG 2006 Final Program Book , pp. 121
    • Onken, J.1    Gallup, D.2    Hanson, J.3
  • 31
    • 32044451548 scopus 로고    scopus 로고
    • Human anti-tumor necrosis factor monoclonal antibody (Adalimumab) in Crohn's disease: The CLASSIC-I trial
    • Hanauer SB, Sandborn WJ, Rutgeerts P, et al. Human anti-tumor necrosis factor monoclonal antibody (Adalimumab) in Crohn's disease: the CLASSIC-I trial. Gastroenterology 2006;130(2):323-333
    • (2006) Gastroenterology , vol.130 , Issue.2 , pp. 323-333
    • Hanauer, S.B.1    Sandborn, W.J.2    Rutgeerts, P.3
  • 32
    • 34249281002 scopus 로고    scopus 로고
    • Adalimumab for maintenance treatment of Crohn's disease: Results of the CLASSIC II trial
    • Sandborn WJ, Hanauer SB, Rutgeerts P, et al. Adalimumab for maintenance treatment of Crohn's disease: results of the CLASSIC II trial. Gut 2007;56(9):1232-1239
    • (2007) Gut , vol.56 , Issue.9 , pp. 1232-1239
    • Sandborn, W.J.1    Hanauer, S.B.2    Rutgeerts, P.3
  • 33
    • 33846242958 scopus 로고    scopus 로고
    • Adalimumab for maintenance of clinical response and remission in patients with Crohn's Disease: The CHARM trial
    • Colombel J-F, Sandborn WJ, Rutgeerts P, et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn's Disease: The CHARM trial. Gastroenterology 2007;132(1):52-65
    • (2007) Gastroenterology , vol.132 , Issue.1 , pp. 52-65
    • Colombel, J.-F.1    Sandborn, W.J.2    Rutgeerts, P.3
  • 34
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn's disease: The ACCENT I randomised trial
    • Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet 2002;359(9317):1541-1549
    • (2002) Lancet , vol.359 , Issue.9317 , pp. 1541-1549
    • Hanauer, S.B.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 35
    • 34347402306 scopus 로고    scopus 로고
    • Adalimumab induction therapy for Crohn's disease previously treated with infliximab
    • Sandborn WJ, Rutgeerts P, Enns R, et al. Adalimumab induction therapy for Crohn's disease previously treated with infliximab. Ann Intern Med 2007;146(12):829-838
    • (2007) Ann Intern Med , vol.146 , Issue.12 , pp. 829-838
    • Sandborn, W.J.1    Rutgeerts, P.2    Enns, R.3
  • 36
    • 34447523749 scopus 로고    scopus 로고
    • Certolizumab pegol for the treatment of Crohn's disease
    • Sandborn WJ, Feagan BG, Stoinov S, et al. Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med 2007;357(3):228-238
    • (2007) N Engl J Med , vol.357 , Issue.3 , pp. 228-238
    • Sandborn, W.J.1    Feagan, B.G.2    Stoinov, S.3
  • 37
    • 34447515607 scopus 로고    scopus 로고
    • Maintenance therapy with certolizumab pegol for Crohn's disease
    • Schreiber S, Khaliq-Kareemi M, Lawrance IC, et al. Maintenance therapy with certolizumab pegol for Crohn's disease. N Engl J Med 2007;357(3):239-250
    • (2007) N Engl J Med , vol.357 , Issue.3 , pp. 239-250
    • Schreiber, S.1    Khaliq-Kareemi, M.2    Lawrance, I.C.3
  • 38
    • 27644441529 scopus 로고    scopus 로고
    • Natalizumab induction and maintenance therapy for Crohn's disease
    • Sandborn WJ, Colombel JF, Enns R, et al. Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med 2005;353(18):1912-1925
    • (2005) N Engl J Med , vol.353 , Issue.18 , pp. 1912-1925
    • Sandborn, W.J.1    Colombel, J.F.2    Enns, R.3
  • 39
    • 34247884424 scopus 로고    scopus 로고
    • Natalizumab for the treatment of active Crohn's disease: Results of the ENCORE Trial
    • Targan SR, Feagan BG, Fedorak RN, et al. Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial. Gastroenterology 2007;132(5):1672-1683
    • (2007) Gastroenterology , vol.132 , Issue.5 , pp. 1672-1683
    • Targan, S.R.1    Feagan, B.G.2    Fedorak, R.N.3
  • 40
    • 0038350648 scopus 로고    scopus 로고
    • Improvement of inflammatory bowel disease after allogeneic stem-cell transplantation
    • Ditschkowski M, Einsele H, Schwerdtfeger R, et al. Improvement of inflammatory bowel disease after allogeneic stem-cell transplantation. Transplantation 2003;75(10):1745-1747
    • (2003) Transplantation , vol.75 , Issue.10 , pp. 1745-1747
    • Ditschkowski, M.1    Einsele, H.2    Schwerdtfeger, R.3
  • 41
    • 2342482526 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    • Le Blanc K, Rasmusson I, Sundberg B, et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004;363(9419):1439-1441
    • (2004) Lancet , vol.363 , Issue.9419 , pp. 1439-1441
    • Le Blanc, K.1    Rasmusson, I.2    Sundberg, B.3
  • 42
    • 64049104052 scopus 로고    scopus 로고
    • Expanded adipose-derived stem cells for the treatment of complex perianal fistula: A PhaseII clinical trial
    • Garcia-Olmo D, Herreros D, Pascual I, et al. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a PhaseII clinical trial. Dis Colon Rectum 2009;52(1):79-86
    • (2009) Dis Colon Rectum , vol.52 , Issue.1 , pp. 79-86
    • Garcia-Olmo, D.1    Herreros, D.2    Pascual, I.3
  • 43
    • 67650351449 scopus 로고    scopus 로고
    • Long-term safety of Prochymal adult mesenchymal stem cells in Crohn's disease
    • Onken J, Jaffe T, Custer L. Long-term safety of Prochymal adult mesenchymal stem cells in Crohn's disease. Gastroenterology 2008;134(4):A-661
    • (2008) Gastroenterology , vol.134 , Issue.4
    • Onken, J.1    Jaffe, T.2    Custer, L.3
  • 44
    • 61449171881 scopus 로고    scopus 로고
    • Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangectasia patient
    • [published online 17 February 2009, doi:10.1371/journal.pmed.1000029]
    • Amariglio N, Hirshberg A, Scheithauer BW, et al. Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangectasia patient. PLos Med 2009;6(2) [published online 17 February 2009, doi:10.1371/journal.pmed.1000029]
    • (2009) PLos Med , vol.6 , Issue.2
    • Amariglio, N.1    Hirshberg, A.2    Scheithauer, B.W.3
  • 45
    • 35448996504 scopus 로고    scopus 로고
    • Immunomodulation by mesenchymal stem cells and clinical experience
    • Le Blanc K, Ringden O. Immunomodulation by mesenchymal stem cells and clinical experience. J Intern Med 2007;262(5):509-525
    • (2007) J Intern Med , vol.262 , Issue.5 , pp. 509-525
    • Le Blanc, K.1    Ringden, O.2
  • 46
    • 33744913533 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease
    • Ringden O, Uzunel M, Rasmusson I, et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006;81(10):1390-1397
    • (2006) Transplantation , vol.81 , Issue.10 , pp. 1390-1397
    • Ringden, O.1    Uzunel, M.2    Rasmusson, I.3
  • 47
    • 50149114968 scopus 로고    scopus 로고
    • Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responses
    • Karlsson H, Samarasinghe S, Ball LM, et al. Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responses. Blood 2008;112(3):532-541
    • (2008) Blood , vol.112 , Issue.3 , pp. 532-541
    • Karlsson, H.1    Samarasinghe, S.2    Ball, L.M.3
  • 48
    • 39449085441 scopus 로고    scopus 로고
    • Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: An open randomised trial
    • D'Haens G, Baert F, van Assche G, et al. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial. Lancet 2008;371(9613):660-667
    • (2008) Lancet , vol.371 , Issue.9613 , pp. 660-667
    • D'Haens, G.1    Baert, F.2    Van Assche, G.3
  • 49
    • 55249088369 scopus 로고    scopus 로고
    • SONIC: A randomized, double-blind, controlled trial comparing infliximab and inflximab and azathioprine in patients with Crohn's disease naïve to immunomodulators and biologic therapy
    • Sandborn WJ, Rutgeerts P, Reinisch W et al. SONIC: a randomized, double-blind, controlled trial comparing infliximab and inflximab and azathioprine in patients with Crohn's disease naïve to immunomodulators and biologic therapy. Am J Gastroenterol 2008;103(S1):S436
    • (2008) Am J Gastroenterol , vol.103 , Issue.S1
    • Sandborn, W.J.1    Rutgeerts, P.2    Reinisch, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.