Insulin signaling proteins in pancreatic islets of insulin-resistant rats induced by glucocorticoid

Biological Research

Volumn 44, Issue 3, 2011, Pages 251-257

  de Paula, Flávia M M ^a   Boschero, Antonio C ^a   Carneiro, Everardo M ^a   Bosqueiro, José R ^b   Rafacho, Alex ^a,b,c  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Dexamethasone; Glucocorticoid; Insulin resistance; Insulin signaling; Pancreatic islets

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; INSULIN; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, RAT; IRS2 PROTEIN, RAT; PROTEIN SHC;

ANIMAL; ARTICLE; DRUG EFFECT; INSULIN RESISTANCE; MALE; METABOLISM; PANCREAS ISLET; RAT; SECRETION (PROCESS); SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; DEXAMETHASONE; GLUCOCORTICOIDS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; RATS; RATS, WISTAR; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION;

RATTUS;

EID: 80855127475     PISSN: 07169760     EISSN: 07176287     Source Type: Journal    
DOI: 10.4067/S0716-97602011000300006     Document Type: Article

References (37)

1. ASPINWALL CA, LAKEY JR, KENNEDY RT (1999) Insulin-stimulated insulin secretion in single pancreatic beta cells. J Biol Chem 274:6360-6365.
2. BEARD JC, HALTER JB, BEST JD, PFEIFER MA, PORTE D Jr (1984) Dexamethasone-induced insulin resistance enhances B cell responsiveness to glucose level in normal men. Am J Physiol 247:E592-E596.
3. BERNAL-MIZRACHI E, WEN W, STAHLHUT S, WELLING CM, PERMUTT MA (2001) Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest 108:1631-1638.
4. BINNERT C, RUCHAT S, NICOD N, TAPPY L (2004) Dexamethasoneinduced insulin resistance shows no gender difference in healthy humans. Diabetes Metab 30:321-326.
5. BURÉN J, LAI YC, LUNDGREN M, ERIKSSON JW, JENSEN J (2008) Insulin action and signaling in fat and muscle from dexamethasone-treated rats. Arch Biochem Biophys 474:91-101.
6. CANTLEY J, CHOUDHURY AI, ASARE-ANANE H, SELMAN C, LINGARD S, HEFFRON H, HERRERA P, PERSAUD SJ, WITHERS DJ (2007) Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice. Diabetologia 50:1248-1256.
7. CZOCK D, KELLER F, RASCHE FM, HÄUSSLER U (2005) Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet 44:61-98.
8. GIOZZET VAG, RAFACHO A, BOSCHERO AC, CARNEIRO EM, BOSQUEIRO JR (2008) Dexamethasone treatment in vivo counteracts the functional pancreatic islet alterations caused by malnourishment in rats. Metabolism 57:617-624.
9. KARLSSON S, OSTLUND B, MYRSÉN-AXCRONA U, SUNDLER F, AHRÉN B (2001) Beta cell adaptation to dexamethasone-induced insulin resistance in rats involves increased glucose responsiveness but not glucose effectiveness. Pancreas 22:148-156.
10. KORACH-ANDRÉ M, GAO J, GOUNARIDES JS, DEACON R, ISLAM A, LAURENT D (2005) Relationship between visceral adiposity and intramyocellular lipid content in two rat models of insulin resistance. Am J Physiol Endocrinol Metab 288:E106-E116.
11. KUBOTA N, TOBE K, TERAUCHI Y, ETO K, YAMAMUCHI T, SUZUKI R, TSUBAMOTO Y, KOMEDA K, NAKANO R, MIKI H, SATOH S, SEKIHARA H, SCIACCHITANO S, LESNIAK M, AIZAWA S, NAGAI R, KIMURA S, AKANUMA Y, TAYLOR SI, KADOWAKI T (2000) Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 49:1880-1889.
12. KULKARNI RN, HOLZENBERGER M, SHIH DQ, OZCAN U, STOFFEL M, MAGNUSON MA, KAHN CR (2002) Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet 31:111-115.
13. KULKARNI RN, BRÜNING JC, WINNAY JN, POSTIC C, MAGNUSON MA, KAHN CR (1999a) Tissue specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96:329-339.
14. KULKARNI RN, WINNAY JN, DANIELS M, BRÜNING JC, FLIER SN, HANAHAN D, KAHN CR (1999b) Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest 104:R69-R75.
15. LEIBIGER IB, BRISMAR K, BERGGREN PO (2010) Novel aspects of pancreatic beta-cell signal-transduction. Biochem Biophys Res Commun 396:111-115.
16. LEIBIGER IB, LEIBIGER B, BERGGREN PO (2008) Insulin signaling in the pancreatic beta-cell. Annu Rev Nutr 28:233-251.
17. MARANZANO E, FEYER PCh, MOLASSIOTIS A, ROSSI R, CLARK-SNOW RA, OLVER I, WARR D, SCHIAVONE C, ROILA F (2005) Evidencebased recommendations for the use of antiemetics in radiotherapy. Radiother Oncol 76:227-233.
18. MOHANTY S, SPINAS GA, MAEDLER K, ZUELLIG RA, LEHMANN R, DONATH MY, TRÜB T, NIESSENS M (2005) Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human betacells from hyperglycemia-induced apoptosis. Exp Cell Res 303:68-78.
19. NICOD N, GIUSTI V, BESSE C, TAPPY L (2003) Metabolic adaptations to dexamethasone-induced insulin resistance in healthy volunteers. Obes Res 11:625-631.
20. OTANI K, KULKARNI RN, BALDWIN AC, KRUTZFELDT J, UEKI K, STOFFEL M, KAHN CR, POLONSKY KS (2004) Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 286:E41-E49.
21. PENDE M, KOZMA SC, JAQUET M, OORSCHOT V, BURCELIN R, LE MARCHAND-BRUSTEL Y, KLUMPERMAN J, THORENS B, THOMAS G (2000) Hypoinsulinaemia, glucose intolerance and diminished betacell size in S6K1-deficient mice. Nature 408:994-997.
22. POLLAK M (2008) Insulin and insulin-like growth factor signaling in neoplasia. Nat Rev Cancer 8:915-928
23. RAFACHO A, ABRANTES JLF, RIBEIRO DL, PINTO ME, BOSCHERO AC, BOSQUEIRO JR (2011) Morphofunctional alterations in endocrine pâncreas of short- and long-term dexamethasone-treated rats. Horm Metab Res 43:275-281.
24. RAFACHO A, MARROQUÍ L, TABOGA SR, ABRANTES JL, SILVEIRA LR, BOSCHERO AC, CARNEIRO EM, BOSQUEIRO JR, NADAL A, QUESADA I (2010a) Glucocorticoids in vivo induce both insulin hypersecretion and enhanced glucose sensitivity of stimulus-secretion coupling in isolated rat islets. Endocrinology 151:85-95.
25. RAFACHO A, QUALLIO S, RIBEIRO DL, TABOGA SR, PAULA FM, BOSCHERO AC, BOSQUEIRO JR (2010b) The adaptive compensations in endocrine pancreas from glucocorticoid-treated rats are reversible after interruption of treatment. Acta Physiol 200:3543-3554.
26. RAFACHO A, CESTARI TM, TABOGA SR, BOSCHERO AC, BOSQUEIRO JR (2009) High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets. Am J Physiol Endocrinol Metab 296:E681-E689.
27. RAFACHO A, GIOZZET VA, BOSCHERO AC, BOSQUEIRO JR (2008a) Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance. Pancreas 36:284-293.
28. RAFACHO A, RIBEIRO DL, BOSCHERO AC, TABOGA SR, BOSQUEIRO JR (2008b) Increased pancreatic islet mass is accompanied by activation of the insulin receptor substrate-2/serine-threonine kinase pathway and augmented cyclin D2 protein levels in insulin-resistant rats. Int J Exp Pathol 89:264-275.
29. RUZZIN J, WAGMAN AS, JENSEN J (2005). Glucocorticoid-induced insulin resistance in skeletal muscles: defects in insulin signaling and the effects of a selective glycogen synthase kinase-3 inhibitor. Diabetologia 48:2119-2130.
30. SAAD MJ, FOLLI F, KAHN JA, KAHN CR (1993) Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. J Clin Invest 92:2065-2072.
31. SALTIEL AR, KAHN CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799-806.
32. SCHÄCKE H, DÖCKE WD, ASADULLAH K (2002) Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 96:23-43.
33. STOJANOVSKA L, ROSELLA G, PROIETTO J (1990) Evolution of dexamethasone-induced insulin resistance in rats. Am J Physiol 258:E748-E756.
34. VASAVADA RC, GONZALEZ-PERTUSA JA, FUJINAKA Y, FIASCHI-TAESCH N, COZAR-CASTELLANO I, GARCIA-OCAÑA A (2006) Growth factors and beta cell replication. Int J Biochem Cell Biol 38:931-950.
35. VIRKAMÄKI A, UEKI K, KAHN CR (1999) Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103:931-943.
36. WEIR GC, LAYBUTT DR, KANETO H, BONNER-WEIR S, SHARMA A (2001) Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes 50 Suppl:S154-S159.
37. WITHERS DJ, GUTIERREZ JS, TOWERY H, BURKS DJ, REN JM, PREVIS S, ZHANG Y, BERNAL D, PONS S, SHULMAN GI, BONNER-WEIR S, WHITE MF (1998) Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391:900-904.