Dexamethasone treatment in vivo counteracts the functional pancreatic islet alterations caused by malnourishment in rats

Metabolism: Clinical and Experimental

Volumn 57, Issue 5, 2008, Pages 617-624

  Giozzet, Vanessa A G ^a   Rafacho, Alex ^a   Boschero, Antonio C ^a   Carneiro, Everardo M ^a   Bosqueiro, José R ^b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; FATTY ACID; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GLUCOSE BLOOD LEVEL; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; MALE; MALNUTRITION; METABOLIC PARAMETERS; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DIET; RAT;

ANIMALS; BLOOD GLUCOSE; DEXAMETHASONE; FATTY ACIDS, NONESTERIFIED; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; PROTEIN DEFICIENCY; RATS; RATS, WISTAR;

EID: 42949098384     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2007.12.004     Document Type: Article

References (40)

1. Cerf M.E. High fat diet modulation of glucose sensing in the beta-cell. Med Sci Monit 13 (2007) RA12-RA17
2. Nieuwenhuizen A.G., Schuiling G.A., Moes H., and Koiter T.R. Role of increased insulin demand in the adaptation of the endocrine pancreas to pregnancy. Acta Physiol Scand 159 (1997) 303-312
3. Matschinsky F.M., Rujanavech C., Pagliara A., and Norfleet W.T. Adaptations of alpha2- and beta-cells of rat and mouse pancreatic islets to starvation, to refeeding after starvation, and to obesity. J Clin Invest 65 (1980) 207-218
4. Novelli M., De Tata V., Bombara M., et al. Insufficient adaptative capability of pancreatic endocrine function in dexamethasone-treated ageing rats. J Endocrinol 162 (1999) 425-432
5. 45Ca uptake by pancreatic rat islets. J Nutr Biochem 6 (1995) 314-318
6. Latorraca M.Q., Reis M.A.B., Carneiro E.M., et al. Protein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats. J Nutr 128 (1998) 1643-1649
7. Ferreira F., Filiputti E., Stoppiglia F., et al. Decreased colinergic stimulation of insulin secretion by islet from rats fed a low protein diet is associated with reduced PKCa expression. J Nutr 133 (2003) 695-699
8. Koko V., Pavlovic M., Laban A., et al. A stereological investigation of rat endocrine pancreas after a long-term low-protein diet. Pancreas 7 (1992) 672-679
9. Reis M.A., Carneiro E.M., Mello M.A., et al. Glucose-induced insulin secretion is impaired and insulin-induced phosphorylation of the insulin receptor and insulin receptor substrate-1 are increased in protein-deficient rats. J Nutr 127 (1997) 403-410
10. Rafacho A., Roma L.P., Taboga S.R., Boschero A.C., and Bosqueiro J.R. Dexamethasone-induced insulin resistance is associated with increased connexins 36 mRNA and protein expression in pancreatic rat islets. Can J Physiol Pharmacol 85 (2007) 536-545
11. Ogawa A., Jonson J.H., Ohneda M., et al. Roles of insulin resistance and b-cell dysfunction in dexamethasone-induced diabetes. J Clin Invest 90 (1992) 497-504
12. Lo S., Russel J.C., and Taylor A.W. Determination of glycogen in small tissue samples. J Appl Physiol 28 (1970) 234-236
13. Boschero A.C., Szpak-Glasman M., Carneiro E.M., et al. Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors. Am J Physiol 268 (1995) 336-342
14. Mokuda O., and Sakamoto Y. Peripheral insulin sensitivity is decreased by elevated nonesterified fatty acid level in dexamethasone-treated rats. Diabetes Nutr Metab 12 (1999) 252-255
15. De Vries W.B., Van Der Leij F.R., Bakker J.M., et al. Alterations in adult rat heart after neonatal dexamethasone therapy. Pediatr Res 52 (2002) 900-906
16. Ruzzin J., Wagman A.S., and Jensen J. Glucocorticoid-induced insulin resistance in skeletal muscles: defects in insulin signaling and the effects of a selective glycogen synthase kinase-3 inhibitor. Diabetologia 48 (2005) 2119-2130
17. Komamura K., Shirotani-Ikejima H., Tatsumi R., et al. Differential gene expression in the rat skeletal and heart muscle in glucocorticoid-induced myopathy: analysis by microarray. Cardiovasc Drugs Ther 17 (2003) 303-310
18. Rhee M.S., Perianayagam A., Chen P., et al. Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat. Am J Physiol 287 (2004) C1229-C1237
19. Ahtikoski A.M., Riso E.M., Koskinen S.O.A., et al. Regulation of type IV collagen gene expression and degradation in fast and slow muscles during dexamethasone treatment and exercise. Eur J Physiol 448 (2004) 123-130
20. Dimidriadis G., Leighton B., Parry-Billings M., et al. Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle. Biochem J 321 (1997) 707-712
21. Guillaume-Gentil C., Assimacopoulos-Jeannet F., and Jeanrenaud B. Involvement of non-esterified fatty acid oxidation in glucocorticoid-induced peripheral insulin resistance in vivo in rats. Diabetologia 36 (1993) 899-906
22. Mokuda O., Sakamoto Y., Ikeda T., et al. Sensitivity and responsiveness of glucose output to insulin in isolated perfused liver from dexamethasone treated rats. Horm Metab Res 23 (1991) 53-55
23. Kayali A.C., Young V.R., and Goodman M.N. Sensitivity of myofibrillar proteins to glucocorticoid-induced muscle proteolysis. Am J physiol 252 (1987) E621-E626
24. Tappy L. Metabolic effects of glucocorticoids: the unfinished story. Eur J Clin Invest 29 (1999) 814-815
25. Proietto J., Filippis A., Nakhla C., and Clark S. Nutrient-induced insulin resistance. Mol Cell Endocrinol 151 (1999) 143-149
26. Visser P.A., Pierce G.E., Tomita T., et al. Stimulation of pancreatic islet hypertrophy and beta-cell hyperplasia in Syrian hamsters. Surg Forum 30 (1979) 310-311
27. Bonner-Weir S., Trent D.F., Zamachinski C.J., Clore E.T., and Weir G.C. Limited beta cell regeneration in a beta cell deficient rat model: studies with dexamethasone. Metabolism 9 (1981) 914-918
28. Pick A., Clark J., Kubstrup C., et al. Role of apoptosis in failure of b-cell mass compensation for insulin resistance and b-cell defects in the male Zucker diabetic fatty rat. Diabetes 47 (1998) 358-364
29. Crace C.J., Swenne I., Kohn P.G., et al. Protein-energy malnutrition induces changes in insulin sensitivity. Diabete Metab 16 (1990) 484-491
30. Larsson H., and Ahrén B. Insulin resistant subjects lack islet adaptation to short-term dexamethasone-induced reduction in insulin sensitivity. Diabetologia 42 (1999) 936-943
31. McMahon M., Gerich J., and Rizza R. Effects of glucocorticoids on carbohydrate metabolism. Diabetes Metab Rev 4 (1988) 17-30
32. Saad M.J.A. Molecular mechanisms of insulin resistance. Braz J Med Biol Res 27 (1994) 941-957
33. Slavin B.G., Ong J.M., and Kern P.A. Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes. J Lip Res 35 (1994) 1535-1541
34. Barbera M., Fierabracci V., Novelli M., et al. Dexamethasone-induced insulin resistance and pancreatic adaptive response in aging rats are not modified by oral vanadyl sulfate treatment. Eur J Endocrinol 145 (2001) 799-806
35. Lee Y., Hirose H., Ohneda M., et al. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A 91 (1994) 10878-10882
36. Milburn Jr. J.L., Hirose H., Lee Y.H., et al. Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic and metabolic abnormalities by increased long chain fatty acids. J Biol Chem 270 (1995) 1295-1299
37. McGarry J.D., and Dobbins R.L. Fatty acids, lipotoxicity and insulin secretion. Diabetologia 42 (1999) 128-138
38. Kawai A., and Kuzuya N. On the role of glucocorticoid in glucose-induced insulin secretion. Horm Metab Res 9 (1977) 361-365
39. Wang Z.L., Bennet W.M., Wang R.M., et al. Evidence of a paracrine role of neuropeptide Y in the regulation of insulin release from pancreatic islets of normal and dexamethasone-treated rats. Endocrinology 135 (1994) 200-206
40. O'Brien T.D., Westermark P., and Johnson K.H. Islet amyloid polypeptide and insulin secretion from isolated perfused pancreas of fed, fasted, glucose-treated, and dexamethasone-treated rats. Diabetes 40 (1991) 1701-1706