Gene expression time-series analysis of Camptothecin effects in U87-MG and DBTRG-05 glioblastoma cell lines

Molecular Cancer

Volumn 7, Issue , 2008, Pages

  Morandi, Elena ^a   Severini, Cinzia ^a   Quercioli, Daniele ^a   D'Ario, Giovanni ^b   Perdichizzi, Stefania ^c   Capri, Miriam ^c   Farruggia, Giovanna ^c   Mascolo, Maria Grazia ^a   Horn, Wolfango ^a   Vaccari, Monica ^a   Serra, Roberto ^d   Colacci, Annamaria ^a   Silingardi, Paola ^a  

^a Excellence Environmental Carcinogenesis   (Italy)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BUB1 RELATED PROTEIN; BUB3 RELATED PROTEIN; CAMPTOTHECIN; CARRIER PROTEIN; DNA TOPOISOMERASE; INTERLEUKIN 1BETA; MYC PROTEIN; PROTEIN MAD2; PROTEIN P53; TRANSCRIPTION FACTOR DP1; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG MECHANISM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE SILENCING; GLIOBLASTOMA; GROWTH INHIBITION; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MITOSIS; SENESCENCE; TIME SERIES ANALYSIS; UPREGULATION; WILD TYPE; CELL AGING; CENTRAL NERVOUS SYSTEM TUMOR; DNA MICROARRAY; DRUG ANTAGONISM; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION; GENETICS; METABOLISM; PATHOLOGY; PHENOTYPE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CAMPTOTHECIN; CELL AGING; CELL LINE, TUMOR; CENTRAL NERVOUS SYSTEM NEOPLASMS; DNA TOPOISOMERASES, TYPE I; FLOW CYTOMETRY; GENE EXPRESSION; GLIOBLASTOMA; HUMANS; INTERLEUKIN-1BETA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 53249127050     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-7-66     Document Type: Article

References (48)

1. Hsiang YH Lihou MG Liu LF Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin Cancer Res 1989, 49:5077-5082 2548710
2. Liu LF Desai SD LI T Mao Y Sun M Sim S Mechanism of action of camptothecin Ann N Y Acad Sci 2000, 922:1-26 11193884
3. Carson JP Zhang N Frampton GM Gerry NP Lenburg ME Christman MF Pharmacogenomic identification of targets for adjuvant therapy with the topoisomerase poison camptothecin Cancer Res 2004, 64:2096-2104 15026349
4. Han Z Wei W Dunaway S Darnowski JW Calabresi P Sedivy J Hendrickson EA Balan KV Pantazis P Wyche JH Role of p21 in Apoptosis and senescence of human colon cancer cells treated with camptothecin J Biol Chem 2002, 277:17154-17160 11877436
5. Wang Y Zhu S Cloughesy TF Liau LM Mischel PS p53 disruption profoundly alters the response of human glioblastoma cells to DNA topoisomerase I inhibition Oncogene 2004, 23:1283-1290 14961077
6. Eom YW Kim MA Park SS Goo MJ Kwon HJ Sohn S Kim WH Yoon G Choi KS Two distinctive modes of cell death induced by doxorubicin: Apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype Oncogene 2005, 24:4765-4777 15870702
7. Zhou BB Elledge SJ The DNA damage response: Putting checkpoints in perspective Nature 2000, 408:433-439 11100718
8. Ljungman M Activation of DNA damage signaling Mutat Res 2005, 577:203-216 15922368
9. Flatten K Dai NT Vroman BT Loegering D Erlichman C Karnitz LM Kaufmann SH The role of Checkpoint kinase 1 in sensitivity to topoisomerase I poisons J Biol Chem 2005, 280(14):14349-14355 15699047
10. Huang TT Wuezberger-Davis SM Seuzer BJ Shumway SD Kurama T Boothman DA Miyamoto S NF-kB activation by camptothecin: A linkage between nuclear DNA damage and cytoplasmic signaling events J Biol Chem 2000, 275:9501-9509 10734098
11. Janssens S Tschopp J Signals from within: The DNA-damage-induced NF-kappaB response Cell Death Differ 2006, 13:773-784 16410802
12. Amundson SA Do KT Vinikor L Koch-Paiz CA Bittner ML Trent JM Meltzer P Fornace AJ Jr Stress specific signatures: Expression profiling of p53 wild-type and -null human cells Oncogene 2005, 24:4572-4579 15824734
13. Zhou Y Gwadry FG Reinhold WC Miller LD Smith LH Scherf U Liu ET Kohn KW Pommier Y Weinstein JN Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: Microarray analysis of dose- and time-dependent effects Cancer Res 2002, 62:1688-1695 11912141
14. Ullmannova V Haskovec C Gene expression during camptothecin-induced apoptosis in human myeloid leukemia cell line ML-2 Neoplasma 2004, 51:175-180 15254669
15. Minderman H Conroy JM O'Loughlin KL McQuaid D Quinn P Li S Pendyala L Nowak NJ Baer MR In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells Mol Cancer Ther 2005, 4:885-900 15956246
16. Reinhold WC Kouros-Mehr H Kohn KW Maunakea AK Lababidi S Roschke A Stover K Alexander J Pantazis P Miller L Liu E Kirsch IR Urasaki Y Pommier Y Weinstein JN Apoptotic susceptibility of cancer cells selected for camptothecin resistance: Gene expression profiling, functional analysis, and molecular interaction mapping Cancer Res 2003, 63:1000-1011 12615715
17. Friedman HS Keir ST Houghton PJ The emerging role of Irinotecan (CPT11) in the treatment of malignant glioma in brain tumours Cancer 2003, 97:2359-2362 12712457
18. Bent Van den MJ Hegi ME Stupp R Recent developments in the use of chemotherapy in brain tumours Eur J Cancer 2006, 42:582-588 16427778
19. Morandi E Zingaretti C Chiozzotto D Severini C Semeria A Horn W Vaccari M Serra R Silingardi P Colacci A A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines Cancer Lett 2006, 231:74-86 16356833
20. Kahlem P Dorken B Schmitt CA Cellular senescence in cancer treatment: friend or foe J Clin Invest 2004, 113:169-174 311442 14722606
21. Campisi J Senescent cells, tumor suppression, and organism aging: Good citizens, bad neighbors Cell 2005, 120:513-522 15734683
22. Roberson RS Kussick SJ Vallieres E Chen SJ Wu DY Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers Cancer Res 2005, 65:2795-2803 15805280
23. Wu H Kerr K Cui X Churchill GA MAANOVA: A software package for the analysis of spotted cDNA microarray experiments The analysis of gene expression data: Methods and software Heidelberg: Springer Parmigiani G, Garett ES, Irizarry RA, et al 2003:313-341
24. Zeeberg BR Qin H Narasimhan S Sunshine M Cao H Kane DW Reimers M Stephens RM Bryant D Burt SK Elnekave E Hari DM Wynn TA Cunningham-Rundles C Stewart DM Nelson D Weinstein JN High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID) BMC Bioinformatics 2005, 6:1-18 545949 15631638
25. Hosack DA Glynn D Jr Sherman BT Lane HC Lempicki RA Identifying Biological Themes within Lists of Genes with EASE Genome Biology 2003, 4:R70 328459 14519205
26. Li Y Dowbenko D Lasky LA AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival J Biol Chem 2002, 277:11352-11361 11756412
27. Kho PS Wang Z Zhuang L Li Y Chew JL Ng HH Liu ET Yu Q p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis J Biol Chem 2004, 279:21183-21192 15016801
28. Fukuda S Pelus LM Survivin, a cancer target with an emerging role in normal adult tissues Mol Cancer Ther 2006, 5:1087-1098 16731740
29. Xie D Zeng YX Wang HJ Wen JM Tao Y Sham JS Guan XY Expression of cytoplasmic and nuclear Survivin in primary and secondary human glioblastoma Br J Cancer 2006, 94:108-114 16404364
30. Crawfords DF Piwnica-Worms H The G2 DNA damage checkpoint delays expression of genes encoding mitotic regulators J Biol Chem 2001, 276(40):37166-37177 11483598
31. Gjoerup OV Wu J Chandler-Militello D Williams GL Zhao J Schaffhausen B Jat PS Roberts TM Surveillance mechanism linking Bub1 loss to the p53 pathway Proc Natl Acad Sci USA 2007, 104:8334-8339 1895950 17488820
32. Vogel C Kienitz A Muller R Bastians H The mitotic spindle checkpoint is a critical determinant for topoisomerase-based chemotherapy J Biol Chem 2005, 280:4025-4028 15611124
33. Du Y Yin F Hu S Wang J Xie H Hong L Fan D Depression of Mad2 inhibits apoptosis of gastric cancer cells by upregulating Bcl-2 and interfering mitochondrion pathway Biochem Biophys Res Commun 2006, 345:1092-1098 16714000
34. Dyson N The regulation of E2F by pRB-family proteins Genes Dev 1998, 12:2245-2262 9694791
35. Maehara K Yamakoshi K Ohtani N Kubo Y Takahashi A Arase S Jones N Hara E Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53 J Cell Biol 2005, 168:553-560 2171766 15716376
36. Ishida S Huang E Zuzan H Spang R Leone G West M Nevins JR Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis Mol Cell Biol 2001, 21:4684-4699 87143 11416145
37. Arango D Mariadason JM Wilson AJ Yang W Corner GA Nicholas C Aranes MJ Augenlicht LH c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis Brit J Cancer 2003, 89:1757-1765 14583781
38. Adachi S Obaya AJ Han Z Ramos-Desimone N Wyche JH Sedivy J c-myc is necessary for DNA damage-induced apoptosis in the G2 phase of the cell cycle Mol Cell Biol 2001, 21:4929-4937 87219 11438650
39. Guney I Wu. S Sedivy JM Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16INK4a Proc Natl Acad Sci USA 2006, 103:3645-3650 1450136 16537449
40. Wu CH van Riggelen J Yetil A Fan AC Bachereddy P Felsher DW Cellular senescence is an important mechanism of tumor regression upon c-myc inactivation Proc Natl Acad Sci USA 2007, 104:13028-13033 1941831 17664422
41. Gee JR Ding Q Keller JN Age-related alterations of Apolipoprotein E and Interleukin-1beta in the aging brain Biogerontology 2006, 7:69-79 16802110
42. Hardy K Mansfield L Mackay A Benvenuti S Ismail S Arora P O'Hare MJ Jat PS Transcriptional networks and cellular senescence in human mammary fibroblast Mol Biol Cell 2005, 16:943-953 545924 15574883
43. Coussens LM Werb Z Inflammation and cancer Nature 2002, 420:860-867 12490959
44. Krelin Y Voronov E Dotan S Elkabets M Reich E Fogel M Huszar M Iwakura Y Segal S Dinarello CA Apte RN Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors Cancer Res 2007, 67:1062-1071 17283139
45. Apte RN Krelin Y Song X Dotan S Recih E Elkabets M Carmi Y Dvorkin T White RM Gayvoronsky L Segal S Voronov E Effects of micro-environment- and malignant cell-deriverd inteleukin-1 in carcinogenesis, tumors invasiveness and tumors-host interactions Eur J Cancer 2006, 42:751-759 16530403
46. Cui X Hwang JT Qiu J Blades NJ Churchill GA Improved statistical tests for differential gene expression by shrinking variance components estimates Biostatistics 2005, 6:59-75 15618528
47. Benjamini Y Hochberg Y Controlling the false discovery rate: A practical and powerful approach to multiple testing J R Statist Soc B 1995, 57:289-300
48. Livak KJ Schmittgen TD Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 2001, 25:402-408 11846609