-
1
-
-
0034604110
-
Role of transforming growth factor beta in human disease
-
10.1056/NEJM200005043421807, 10793168
-
Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 2000, 342(18):1350-8. 10.1056/NEJM200005043421807, 10793168.
-
(2000)
N Engl J Med
, vol.342
, Issue.18
, pp. 1350-1358
-
-
Blobe, G.C.1
Schiemann, W.P.2
Lodish, H.F.3
-
2
-
-
0038682002
-
Mechanisms of TGF-beta signaling from cell membrane to the nucleus
-
10.1016/S0092-8674(03)00432-X, 12809600
-
Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003, 113(6):685-700. 10.1016/S0092-8674(03)00432-X, 12809600.
-
(2003)
Cell
, vol.113
, Issue.6
, pp. 685-700
-
-
Shi, Y.1
Massague, J.2
-
3
-
-
44349125602
-
Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system
-
10.1073/pnas.0710134105, 2373357, 18443295
-
Schmierer B, Tournier AL, Bates PA, Hill CS. Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system. Proc Natl Acad Sci USA 2008, 105(18):6608-13. 10.1073/pnas.0710134105, 2373357, 18443295.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.18
, pp. 6608-6613
-
-
Schmierer, B.1
Tournier, A.L.2
Bates, P.A.3
Hill, C.S.4
-
4
-
-
0034460336
-
Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus
-
10.1128/MCB.20.23.9041-9054.2000, 86557, 11074002
-
Pierreux CE, Nicolas FJ, Hill CS. Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus. Mol Cell Biol 2000, 20(23):9041-54. 10.1128/MCB.20.23.9041-9054.2000, 86557, 11074002.
-
(2000)
Mol Cell Biol
, vol.20
, Issue.23
, pp. 9041-9054
-
-
Pierreux, C.E.1
Nicolas, F.J.2
Hill, C.S.3
-
5
-
-
0038369998
-
A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
-
10.1016/S1097-2765(03)00109-6, 12718878
-
Kang Y, Chen CR, Massague J. A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 2003, 11(4):915-26. 10.1016/S1097-2765(03)00109-6, 12718878.
-
(2003)
Mol Cell
, vol.11
, Issue.4
, pp. 915-926
-
-
Kang, Y.1
Chen, C.R.2
Massague, J.3
-
6
-
-
0034517389
-
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation
-
10.1016/S1097-2765(00)00134-9, 11163210
-
Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell 2000, 6(6):1365-75. 10.1016/S1097-2765(00)00134-9, 11163210.
-
(2000)
Mol Cell
, vol.6
, Issue.6
, pp. 1365-1375
-
-
Kavsak, P.1
Rasmussen, R.K.2
Causing, C.G.3
Bonni, S.4
Zhu, H.5
Thomsen, G.H.6
Wrana, J.L.7
-
7
-
-
0035918274
-
Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
-
10.1074/jbc.C100008200, 11278251
-
Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, Miyazono K. Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem 2001, 276(16):12477-80. 10.1074/jbc.C100008200, 11278251.
-
(2001)
J Biol Chem
, vol.276
, Issue.16
, pp. 12477-12480
-
-
Ebisawa, T.1
Fukuchi, M.2
Murakami, G.3
Chiba, T.4
Tanaka, K.5
Imamura, T.6
Miyazono, K.7
-
8
-
-
0037080983
-
Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif
-
125817, 11782434
-
Randall RA, Germain S, Inman GJ, Bates PA, Hill CS. Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif. EMBO J 2002, 21(1-2):145-56. 125817, 11782434.
-
(2002)
EMBO J
, vol.21
, Issue.1-2
, pp. 145-156
-
-
Randall, R.A.1
Germain, S.2
Inman, G.J.3
Bates, P.A.4
Hill, C.S.5
-
9
-
-
0031587828
-
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
-
10.1016/S0092-8674(00)80303-7, 9215638
-
Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone JMA, Wrana JL, Falb D. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell 1997, 89(7):1165-73. 10.1016/S0092-8674(00)80303-7, 9215638.
-
(1997)
Cell
, vol.89
, Issue.7
, pp. 1165-1173
-
-
Hayashi, H.1
Abdollah, S.2
Qiu, Y.3
Cai, J.4
Xu, Y.Y.5
Grinnell, B.W.6
Richardson, M.A.7
Topper, J.N.8
Gimbrone, J.M.A.9
Wrana, J.L.10
Falb, D.11
-
10
-
-
0034654497
-
Controlling TGF-beta signaling
-
Massague J, Chen YG. Controlling TGF-beta signaling. Genes Dev 2000, 14(6):627-44.
-
(2000)
Genes Dev
, vol.14
, Issue.6
, pp. 627-644
-
-
Massague, J.1
Chen, Y.G.2
-
11
-
-
0035805505
-
Ligand binding and functional properties of betaglycan, a co-receptor of the transforming growth factor-beta superfamily. Specialized binding regions for transforming growth factor-beta and inhibin A
-
10.1074/jbc.M008866200, 11278442
-
Esparza-Lopez J, Montiel JL, Vilchis-Landeros MM, Okadome T, Miyazono K, Lopez-Casillas F. Ligand binding and functional properties of betaglycan, a co-receptor of the transforming growth factor-beta superfamily. Specialized binding regions for transforming growth factor-beta and inhibin A. J Biol Chem 2001, 276(18):14588-96. 10.1074/jbc.M008866200, 11278442.
-
(2001)
J Biol Chem
, vol.276
, Issue.18
, pp. 14588-14596
-
-
Esparza-Lopez, J.1
Montiel, J.L.2
Vilchis-Landeros, M.M.3
Okadome, T.4
Miyazono, K.5
Lopez-Casillas, F.6
-
12
-
-
0037598870
-
Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover
-
10.1038/ncb975, 12717440
-
Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL. Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol 2003, 5(5):410-21. 10.1038/ncb975, 12717440.
-
(2003)
Nat Cell Biol
, vol.5
, Issue.5
, pp. 410-421
-
-
Di Guglielmo, G.M.1
Le Roy, C.2
Goodfellow, A.F.3
Wrana, J.L.4
-
13
-
-
4344608791
-
A simple molecular complex mediates widespread BMP-induced repression during Drosophila development
-
10.1016/j.devcel.2004.07.008, 15296719
-
Pyrowolakis G, Hartmann B, Muller B, Basler K, Affolter M. A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Dev Cell 2004, 7(2):229-40. 10.1016/j.devcel.2004.07.008, 15296719.
-
(2004)
Dev Cell
, vol.7
, Issue.2
, pp. 229-240
-
-
Pyrowolakis, G.1
Hartmann, B.2
Muller, B.3
Basler, K.4
Affolter, M.5
-
14
-
-
0035694910
-
Smad regulation in TGF-beta signal transduction
-
Moustakas A, Souchelnytskyi S, Heldin CH. Smad regulation in TGF-beta signal transduction. J Cell Sci 2001, 114(Pt 24):4359-69.
-
(2001)
J Cell Sci
, vol.114
, Issue.PART 24
, pp. 4359-4369
-
-
Moustakas, A.1
Souchelnytskyi, S.2
Heldin, C.H.3
-
15
-
-
0033106484
-
A mechanism of repression of TGFbeta/Smad signaling by oncogenic Ras
-
10.1101/gad.13.7.804, 316599, 10197981
-
Kretzschmar M, Doody J, Timokhina I, Massague J. A mechanism of repression of TGFbeta/Smad signaling by oncogenic Ras. Genes Dev 1999, 13(7):804-16. 10.1101/gad.13.7.804, 316599, 10197981.
-
(1999)
Genes Dev
, vol.13
, Issue.7
, pp. 804-816
-
-
Kretzschmar, M.1
Doody, J.2
Timokhina, I.3
Massague, J.4
-
16
-
-
0033780420
-
Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II
-
10.1128/MCB.20.21.8103-8111.2000, 86420, 11027280
-
Wicks SJ, Lui S, Abdel-Wahab N, Mason RM, Chantry A. Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II. Mol Cell Biol 2000, 20(21):8103-11. 10.1128/MCB.20.21.8103-8111.2000, 86420, 11027280.
-
(2000)
Mol Cell Biol
, vol.20
, Issue.21
, pp. 8103-8111
-
-
Wicks, S.J.1
Lui, S.2
Abdel-Wahab, N.3
Mason, R.M.4
Chantry, A.5
-
17
-
-
3142546336
-
Cyclin-dependent kinases regulate the antiproliferative function of Smads
-
10.1038/nature02650, 15241418
-
Matsuura I, Denissova NG, Wang G, He D, Long J, Liu F. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 2004, 430(6996):226-31. 10.1038/nature02650, 15241418.
-
(2004)
Nature
, vol.430
, Issue.6996
, pp. 226-231
-
-
Matsuura, I.1
Denissova, N.G.2
Wang, G.3
He, D.4
Long, J.5
Liu, F.6
-
18
-
-
0036301992
-
Nuclear exclusion of Smad2 is a mechanism leading to loss of competence
-
10.1038/ncb812, 12068307
-
Grimm OH, Gurdon JB. Nuclear exclusion of Smad2 is a mechanism leading to loss of competence. Nat Cell Biol 2002, 4(7):519-22. 10.1038/ncb812, 12068307.
-
(2002)
Nat Cell Biol
, vol.4
, Issue.7
, pp. 519-522
-
-
Grimm, O.H.1
Gurdon, J.B.2
-
19
-
-
49849103199
-
Decoding the quantitative nature of TGF-beta/Smad signaling
-
10.1016/j.tcb.2008.06.006, 2774497, 18706811
-
Clarke DC, Liu X. Decoding the quantitative nature of TGF-beta/Smad signaling. Trends Cell Biol 2008, 18(9):430-42. 10.1016/j.tcb.2008.06.006, 2774497, 18706811.
-
(2008)
Trends Cell Biol
, vol.18
, Issue.9
, pp. 430-442
-
-
Clarke, D.C.1
Liu, X.2
-
21
-
-
0038548187
-
Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest
-
10.1038/sj.onc.1206420, 12802277
-
Nicolas FJ, Hill CS. Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest. Oncogene 2003, 22(24):3698-711. 10.1038/sj.onc.1206420, 12802277.
-
(2003)
Oncogene
, vol.22
, Issue.24
, pp. 3698-3711
-
-
Nicolas, F.J.1
Hill, C.S.2
-
22
-
-
33845424529
-
A rate equation approach to elucidate the kinetics and robustness of the TGF-beta pathway
-
10.1529/biophysj.105.080408, 1779910, 17012329
-
Melke P, Jonsson H, Pardali E, ten Dijke P, Peterson C. A rate equation approach to elucidate the kinetics and robustness of the TGF-beta pathway. Biophys J 2006, 91(12):4368-80. 10.1529/biophysj.105.080408, 1779910, 17012329.
-
(2006)
Biophys J
, vol.91
, Issue.12
, pp. 4368-4380
-
-
Melke, P.1
Jonsson, H.2
Pardali, E.3
ten Dijke, P.4
Peterson, C.5
-
23
-
-
41549094989
-
Constraint-based modeling and kinetic analysis of the Smad dependent TGF-beta signaling pathway
-
10.1371/journal.pone.0000936, 1978528, 17895977
-
Zi Z, Klipp E. Constraint-based modeling and kinetic analysis of the Smad dependent TGF-beta signaling pathway. PLoS One 2007, 2(9):e936. 10.1371/journal.pone.0000936, 1978528, 17895977.
-
(2007)
PLoS One
, vol.2
, Issue.9
-
-
Zi, Z.1
Klipp, E.2
-
24
-
-
65549170041
-
Quantitative modeling and analysis of the transforming growth factor beta signaling pathway
-
10.1016/j.bpj.2008.11.050, 2717289, 19254534
-
Chung SW, Miles FL, Sikes RA, Cooper CR, Farach-Carson MC, Ogunnaike BA. Quantitative modeling and analysis of the transforming growth factor beta signaling pathway. Biophys J 2009, 96(5):1733-50. 10.1016/j.bpj.2008.11.050, 2717289, 19254534.
-
(2009)
Biophys J
, vol.96
, Issue.5
, pp. 1733-1750
-
-
Chung, S.W.1
Miles, F.L.2
Sikes, R.A.3
Cooper, C.R.4
Farach-Carson, M.C.5
Ogunnaike, B.A.6
-
25
-
-
79957536131
-
Quantitative analysis of transient and sustained transforming growth factor-beta signaling dynamics
-
3130555, 21613981
-
Zi Z, Feng Z, Chapnick DA, Dahl M, Deng D, Klipp E, Moustakas A, Liu X. Quantitative analysis of transient and sustained transforming growth factor-beta signaling dynamics. Mol Syst Biol 2011, 7:492. 3130555, 21613981.
-
(2011)
Mol Syst Biol
, vol.7
, pp. 492
-
-
Zi, Z.1
Feng, Z.2
Chapnick, D.A.3
Dahl, M.4
Deng, D.5
Klipp, E.6
Moustakas, A.7
Liu, X.8
-
26
-
-
56749160113
-
Design principles of biochemical oscillators
-
10.1038/nrm2530, 2796343, 18971947
-
Novák B, Tyson JJ. Design principles of biochemical oscillators. Nat Rev Mol Cell Biol 2008, 9(12):981-991. 10.1038/nrm2530, 2796343, 18971947.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, Issue.12
, pp. 981-991
-
-
Novák, B.1
Tyson, J.J.2
-
27
-
-
71449121678
-
Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor
-
2824491, 19953086
-
Shankaran H, Ippolito DL, Chrisler WB, Resat H, Bollinger N, Opresko LK, Wiley HS. Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor. Molecular systems biology 2009, 5:332. 2824491, 19953086.
-
(2009)
Molecular systems biology
, vol.5
, pp. 332
-
-
Shankaran, H.1
Ippolito, D.L.2
Chrisler, W.B.3
Resat, H.4
Bollinger, N.5
Opresko, L.K.6
Wiley, H.S.7
-
28
-
-
79960003271
-
Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development
-
Paulsen M, Legewie S, Eils R, Karaulanov E, Niehrs C. Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development. PNAS 2011,
-
(2011)
PNAS
-
-
Paulsen, M.1
Legewie, S.2
Eils, R.3
Karaulanov, E.4
Niehrs, C.5
-
29
-
-
33645754505
-
Signal processing in the TGF-beta superfamily ligand-receptor network
-
10.1371/journal.pcbi.0020003, 1356091, 16446785
-
Vilar JM, Jansen R, Sander C. Signal processing in the TGF-beta superfamily ligand-receptor network. PLoS Comput Biol 2006, 2:e3. 10.1371/journal.pcbi.0020003, 1356091, 16446785.
-
(2006)
PLoS Comput Biol
, vol.2
-
-
Vilar, J.M.1
Jansen, R.2
Sander, C.3
-
30
-
-
84858237475
-
A computational analysis of the dynamic roles of talin, Dok1, and PIPKI for integrin activation
-
Geier F, Fengos G, Iber D. A computational analysis of the dynamic roles of talin, Dok1, and PIPKI for integrin activation. PloS One 2011,
-
(2011)
PloS One
-
-
Geier, F.1
Fengos, G.2
Iber, D.3
-
31
-
-
68749118345
-
Defining network topologies that can achieve biochemical adaptation
-
10.1016/j.cell.2009.06.013, 3068210, 19703401
-
Ma W, Trusina A, El-Samad H, Lim W, Tang C. Defining network topologies that can achieve biochemical adaptation. Cell 2009, 138(4):760-73. 10.1016/j.cell.2009.06.013, 3068210, 19703401.
-
(2009)
Cell
, vol.138
, Issue.4
, pp. 760-773
-
-
Ma, W.1
Trusina, A.2
El-Samad, H.3
Lim, W.4
Tang, C.5
-
32
-
-
71449121678
-
Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor
-
2824491, 19953086
-
Shankaran H, Ippolito DL, Chrisler WB, Resat H, Bollinger N, Opresko LK, Wiley HS. Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor. Mol Syst Biol 2009, 5:332. 2824491, 19953086.
-
(2009)
Mol Syst Biol
, vol.5
, pp. 332
-
-
Shankaran, H.1
Ippolito, D.L.2
Chrisler, W.B.3
Resat, H.4
Bollinger, N.5
Opresko, L.K.6
Wiley, H.S.7
-
33
-
-
0031964859
-
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
-
10.1101/gad.12.2.186, 316444, 9436979
-
Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev 1998, 12(2):186-197. 10.1101/gad.12.2.186, 316444, 9436979.
-
(1998)
Genes Dev
, vol.12
, Issue.2
, pp. 186-197
-
-
Hata, A.1
Lagna, G.2
Massagué, J.3
Hemmati-Brivanlou, A.4
-
34
-
-
61749097816
-
Tgf-beta superfamily signaling in embryonic development and homeostasis
-
10.1016/j.devcel.2009.02.012, 19289080
-
Wu MY, Hill CS. Tgf-beta superfamily signaling in embryonic development and homeostasis. Dev Cell 2009, 16(3):329-343. 10.1016/j.devcel.2009.02.012, 19289080.
-
(2009)
Dev Cell
, vol.16
, Issue.3
, pp. 329-343
-
-
Wu, M.Y.1
Hill, C.S.2
-
35
-
-
65449144474
-
Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics
-
10.1128/MCB.01443-08, 2668365, 19223462
-
Clarke DC, Brown ML, Erickson R, Shi Y, Liu X. Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics. Molecular and cellular biology 2009, 29(9):2443-55. 10.1128/MCB.01443-08, 2668365, 19223462.
-
(2009)
Molecular and cellular biology
, vol.29
, Issue.9
, pp. 2443-2455
-
-
Clarke, D.C.1
Brown, M.L.2
Erickson, R.3
Shi, Y.4
Liu, X.5
-
36
-
-
36448936383
-
TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility
-
10.1038/nrm2297, 18000526
-
Schmierer B, Hill CS. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 2007, 8(12):970-82. 10.1038/nrm2297, 18000526.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.12
, pp. 970-982
-
-
Schmierer, B.1
Hill, C.S.2
-
37
-
-
33244485265
-
The interpretation of morphogen gradients
-
10.1242/dev.02238, 16410409
-
Ashe HL, Briscoe J. The interpretation of morphogen gradients. Development 2006, 133(3):385-94. 10.1242/dev.02238, 16410409.
-
(2006)
Development
, vol.133
, Issue.3
, pp. 385-394
-
-
Ashe, H.L.1
Briscoe, J.2
-
38
-
-
46749139806
-
Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila
-
[Kamiya, Yuto Miyazono, Kohei Miyazawa, Keiji Research Support, Non-U.S. Gov't Netherlands FEBS letters FEBS Lett. 2008 Jul 23;582(17):2496-500. Epub 2008 Jun 25.], 10.1016/j.febslet.2008.05.052, 18588885
-
Kamiya Y, Miyazono K, Miyazawa K. Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila. FEBS letters 2008, 582(17):2496-2500. [Kamiya, Yuto Miyazono, Kohei Miyazawa, Keiji Research Support, Non-U.S. Gov't Netherlands FEBS letters FEBS Lett. 2008 Jul 23;582(17):2496-500. Epub 2008 Jun 25.], 10.1016/j.febslet.2008.05.052, 18588885.
-
(2008)
FEBS letters
, vol.582
, Issue.17
, pp. 2496-2500
-
-
Kamiya, Y.1
Miyazono, K.2
Miyazawa, K.3
|