Cerebral cortical dysplasia: Giant neurons show potential for increased excitation and axonal plasticity

Developmental Neuroscience

Volumn 21, Issue 3-5, 1999, Pages 260-270

  Kerfoot, Christopher ^a,c   Vinters, Harry V ^b   Mathern, Gary W ^a  

^a UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cortical dysplasia; Immunohistochemistry; Neurotransmitter receptor; Pediatric epilepsy; PSA NCAM; Rasmussen encephalitis

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; AMPA RECEPTOR; GLUTAMATE DECARBOXYLASE; GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERVE CELL ADHESION MOLECULE; PHOSPHOPROTEIN; RECEPTOR SUBUNIT;

ARTICLE; BENIGN CHILDHOOD EPILEPSY; BRAIN CORTEX; BRAIN MATURATION; CHILD; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOPLASM; DYSPLASIA; FEMALE; GIANT NERVE CELL; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; INTRACTABLE EPILEPSY; MALE; NERVE CELL PLASTICITY; PRIORITY JOURNAL; WHITE MATTER;

EID: 0032733905     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017405     Document Type: Article

References (43)

1. Babb TL, Mathern GW, Leite JP, Pretorius JK, Yeoman KM, Kuhlman PA (1996): Glutamate AMPA receptors in the fascia dentata of human and kainate rat hippocampal epilepsy. Epilepsy Res 26:193-205.
2. Babb TL, Pretorius JK, Kupfer WR, Crandall PH (1989): Glutamate decarboxylase-immunoreactive neurons are preserved in human epileptic hippocampus. J Neurosci 9:2562-2574.
3. Ben-Ari Y, Cherubini E, Corradetti R, Gaiarsa JL (1989): Giant synaptic potentials in immature rat CA3 hippocampal neurones. J Physiol 416: 303-325.
4. Bignami A, Palladini G, Zapella M (1968): Unilateral megalencephaly with nerve cell hypertrophy: An anatomical and quantitative histochemical study. Brain Res 9:103-114.
5. Byk T, Ozon S, Sobel A (1998): The Ulip family phosphoproteins: Common and specific properties. Eur J Biochem 254:14-24.
6. Chagnac-Amitai Y, Connors BW (1989): Synchronized excitation and inhibition driven by intrinsically bursting neurons in neocortex. J Neurophysiol 62:1149-1162.
7. Crino PB, Eberwine J (1997): Cellular and molecular basis of cerebral dysgenesis. J Neurosci Res 50:907-916.
8. De Rosa MJ, Secor DL, Barsom M, Fisher RS, Vinters HV (1992): Neuropathologic findings in surgically treated hemimegalencephaly: Immunohistochemical, morphometric, and ultrastructural study. Acta Neuropathol 84:250-260.
9. Dudek FE, Obenaus A, Schweitzer JS, Wuarin J-P (1994): Functional significance of hippocampal plasticity in epileptic brain: Electrophysiological changes of the dentate granule cells associated with mossy fiber sprouting. Hippocampus 4: 259-265.
10. Duong T, Dc Rosa MJ, Poukens V, Vinters HV, Fisher RS (1994): Neuronal cytoskeletal abnormalities in human cerebral cortical dysplasia. Acta Neuropathol 87:493-503.
11. Engel J Jr, Levesque M, Crandall PH, Shewman A, Rausch R, Sutherling W (1991): The epilepsies; in Grossman RG (ed): Principles of Neurosurgery. New York, Raven Press, pp 319-358.
12. Farrell MA, De Rosa MJ, Curran JG, Secor DL, Cornford ME, Comair YG, Peacock WJ, Shields WD, Vinters HV (1992): Neuropathologic findings in cortical resections (including hemispherectomies) performed for the treatment of intractable childhood epilepsy. Acta Neuropathol 83:246-259.
13. Flint AC, Kriegstein AR (1997): Mechanisms underlying neuronal migration disorders and epilepsy. Curr Opin Neurol 10:92-97.
14. Gaetano C, Matsuo T, Thiele CJ (1997): Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene hUlip from neuroblastoma cells. J Biol Chem 272:12195-12201.
15. Hoffman S, Edelman GM (1983): Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule. Proc Natl Acad Sci USA 80:5762-5766.
16. Hoffman S, Sorking BC, White PC, Brachenbury R, Mailhammer R, Rutishauser U, Cunningham BA, Edelman GM (1982): Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes. J Biol Chem 257:7720-7729.
17. 2+ oscillations mediated by the synergistic excitatory actions of GABA(A) and NMDA receptors in the neonatal hippocampus. Neuron 18:243-255.
18. Lynd-Balta E, Pilcher WH, Joseph SA (1996): Distribution of AMPA receptor subunits in the hippocampal formation of temporal lobe epilepsy. Neuroscience 72:15-29.
19. Manz HJ, Phillips TM, Rowden G, McCullough DC (1979): Unilateral megalencephaly, cerebral cortical dysplasia, neuronal hypertrophy and heterotopia: Cytomorphometric, fluorometric, cytochemical and biochemical analyses. Acta Ncuropathol 45:97-103.
20. Mathern GW, Babb TL, Pretorius JK, Leite JP (1995): Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata. J Neurosci 15:3990-4004.
21. A receptors. Neuroscience 77:1003-1019.
22. Mathern GW, Leite JP, Babb TL, Pretorius JK, Kuhlman PA, Mendoza D, Fried I, Sakamoto AC, Assirati JA, Adelson PD, Peacock WJ (1996): Aberrant hippocampal mossy fiber sprouting correlates with greater NMDAR2 receptor staining. Neuro Report 7:1029-1035.
23. Mathern GW, Leite JP, Pretorius JK, Quinn B, Peacock WJ, Babb TL (1994): Children with severe epilepsy: Evidence of hippocampal neuron losses and aberrant mossy fiber sprouting during postnatal granule cell migration and differentiation. Dev Brain Res 78:70-80.
24. Mathern GW, Pretorius JK, Mendoza D, Lozada A, Leite JP, Chimelli L, Fried I, Sakamoto AC, Assirati JA, Adelson PD (1998): Increased hippocampal AMPA and NMDA receptor subunit immunoreactivity in temporal lobe epilepsy patients. J Neuropathol Exp Neurol 57:615-634.
25. Minturn JM, Fryer HJL, Geschwind DH, Hockfield S (1995): TOAD-64, a mammalian UNC-33 homologue essential for axonal outgrowth. J Neurosci 15:6757-6766.
26. Minturn JE, Geschwind DH, Fryer HJ, Hockfield S (1990): Early postmitotic neurons transiently express TOAD-64, a neural specific protein. J Comp Neurol 355:369-379.
27. Mischel PS, Nguyen LP, Vinters HV (1995): Cerebral cortical dysplasia associated with pediatric epilepsy: Review of neuropathologic features and proposal for a grading system. J Neuropathol Exp Neurol 54:137-15 3.
28. A receptor in the rat brain. J Comp Neurol 350:260-271.
29. Müller M, Gähwiler BH, Rietschin L, Thompson SM (1993): Reversible loss of dendritic spines and altered excitability after chronic epilepsy in hippocampal slice cultures. Proc Natl Acad Sci USA 90:257-261.
30. Oertal WH, Schmechel DE, Tappaz ML, Kopin IJ (1981): Production of specific antiserum to rat brain glutamic acid decarboxylase by injection of an antigen-antibody complex. Neuroscience 6:2689-2700.
31. Peacock WJ, Comair Y, Hoffman HJ, Montes JL, Morrison G (1993): Special considerations for epilepsy surgery in childhood; in Engel J Jr (ed): Surgical Treatment of the Epilepsies, ed 2. New York, Raven Press, pp 541-547.
32. Peacock WJ, Wehby-Grant MC, Shields WD, Shewmon DA, Chugani HT, Sankar R, Vinters HV (1996): Hemispherectomy for intractable seizures in children: A report of 58 cases. Child Nerv Syst 12:376-384.
33. Robain O, Chiron C, Dulac O (1989): Electron microscopic and Golgi study in a case of hemimegalencephaly. Acta Neuropathol 77:664-666.
34. Salin P, Tseng G-F, Hoffman S, Parada I, Prince DA (1995): Axonal sprouting in layer V pyramidal neurons of chronically injured cerebral cortex. J Neurosci 15:8234-8245.
35. Schwartzkioin PA (1997): Progress in epilepsy research: Origins of the epileptic state. Epilepsia 38:853-858.
36. Seki T, Arai Y (1991): Expression of highly polysialylated NCAM in the neocortex and piriform cortex of the developing and the adult rat. Anat Embryol 184:395-401.
37. Seki T, Arai Y (1993): Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system. Neurosci Res 17:265-290.
38. Shewmon DA, Shields WD, Chugani HT, Peacock WJ (1990): Contrasts between pediatric and adult epilepsy surgery: Rationale and strategy for focal resection. J Epilepsy 3(suppl 1):141-155.
39. Shields WD, Peacock WJ, Roper SN (1993): Surgery for epilepsy: Special pediatric considerations. Neurosurg Clin North Am 4:301-310.
40. Spreafico R, Battaglia G, Arcelli P, Andermann F, Dubeau F, Palmini A, Olivier A, Villemure J-G, Tampieri D, Avanzini G, Avoli M (1998): Cortical dysplasia: An immunocytochemical study. Neurology 50:27-36.
41. Stasheff SF, Anderson WW, Clark S, Wilson WA (1989): NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. Science 259:97-100.
42. Vinters HV, Fisher RS, Cornford ME, Mah V, Secor DL, DeRosa MJ, Comair YG, Peacock WJ, Shields WD (1992): Morphological substrates of infantile spasms: Studies based on surgically resected cerebral tissue. Child Nerv Syst 8:8-17.
43. Ying Z, Babb TL, Comair YG, Bingaman W, Bushey M, Touhalisky K (1998): Induced expression of NMDAR2 proteins and differential expression of NMDAR1 splice variants in dysplastic neurons of human epileptic neocortex. J Neuropathol Exp Neurol 57:47-62.