GSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+ thymocytes to polarize their MTOC in response to TCR stimulation

International Immunology

Volumn 23, Issue 11, 2011, Pages 693-700

  Cunningham, Nicole R ^a   Hinchcliff, Emily M ^b   Kutyavin, Vassily I ^a   Beck, Thomas ^c   Reid, Whitney A ^a   Punt, Jenni A ^a  

^a HAVERFORD COLLEGE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

GSK3; MTOC; TCR; Thymocyte

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; T LYMPHOCYTE RECEPTOR; TUBULIN;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CELL POLARITY; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; IMMUNOSTIMULATION; INTRACELLULAR SIGNALING; MICROTUBULE ASSEMBLY; MICROTUBULE ORGANIZING CENTER; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; THYMOCYTE;

AMINOPHENOLS; ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; BLOTTING, WESTERN; CELL DIFFERENTIATION; ENZYME INHIBITORS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLYCOGEN SYNTHASE KINASE 3; LYMPHOCYTE ACTIVATION; MALEIMIDES; MICE; MICE, INBRED C57BL; MICROTUBULE-ORGANIZING CENTER; MICROTUBULES; POLYMERIZATION; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMOCYTES; TUBULIN;

EID: 80055108523     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxr076     Document Type: Article

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