Requirement for a complex array of costimulators in the negative selection of autoreactive thymocytes in vivo

Journal of Immunology

Volumn 166, Issue 10, 2001, Pages 6050-6056

  Li, Ruixia ^a   Page, Dawne M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANTIGEN ANTIBODY REACTION; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL MATURATION; FLOW CYTOMETRY; GENE DELETION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR AFFINITY; THYMOCYTE;

EID: 0035873688     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.10.6050     Document Type: Article

References (55)

1. Garboczi, D. N., U. Utz, P. Ghosh, A. Seth, J. Kim, E. A. VanTienhoven, W. E. Biddison, and D. C. Wiley. 1996. Assembly, specific binding, and crystallization of a human TCR-αβ with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2. J. Immunol. 157:5403.
2. Garcia, K. C., M. Degano, R. L. Stanfield, A. Brunmark, M. R. Jackson, P. A. Peterson, L. Teyton, and I. A. Wilson. 1996. An αβ T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science 274:209.
3. Sim, B. C., L. Zerva, M. I. Greene, and N. R. J. Gascoigne. 1996. Control of MHC restriction by TCR Vα CDR1 and CDR2. Science 273:963.
4. Zerrahn, J., W. Held, and D. H. Raulet. 1997. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 88:627.
5. Alam, S. M., P. J. Travers, J. L. Wung, W. Nasholds, S. Redpath, S. C. Jameson, and N. R. Gascoigne. 1996. T-cell-receptor affinity and thymocyte positive selection. Nature 381:616.
6. Hogquist, K. A., and M. J. Bevan. 1996. The nature of the peptide/MHC ligand involved in positive selection. Semin. Immunol. 8:63.
7. Liu, C. P., F. Crawford, P. Marrack, and J. Kappler. 1998. T cell positive selection by a high density, low affinity ligand. Proc. Natl. Acad. Sci. USA 95:4522.
8. Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84:521.
9. Merkenschlager, M., D. Graf, M. Lovatt, U. Bommhardt, R. Zamoyska, and A. G. Fisher. 1997. How many thymocytes audition for selection? J. Exp. Med. 186:1149.
10. van Meerwijk, J. P., S. Marguerat, R. K. Lees, R. N. Germain, B. J. Fowlkes, and H. R. MacDonald. 1997. Quantitative impact of thymic clonal deletion on the T cell repertoire. J. Exp. Med. 185:377.
11. Egwuagu, C. E., P. Charukamnoetkanok, and I. Gery. 1997. Thymic expression of autoantigens correlates with resistance to autoimmune disease. J. Immunol. 159:3109.
12. Pugliese, A., M. Zeller, A. J. Fernandez, L. J. Zalcberg, R. J. Bartlett, C. Ricordi, M. Pietropaolo, G. S. Eisenbarth, S. T. Bennett, and D. D. Patel. 1997. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type I diabetes. Nat. Genet. 15:293.
13. Vafiadis, P., S. T. Bennett, J. A. Todd, J. Nadeau, R. Grabs, C. G. Goodyer, S. Wickramasinghe, E. Colle, and C. Polychronakos. 1997. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat. Genet. 15:289.
14. + thymocytes. J. Immunol. 151: 1868.
15. Aiba, Y., O. Mazda, M. M. Davis, S. Muramatsu, and Y. Katsura. 1994. Requirement of a second signal from antigen presenting cells in the clonal deletion of immature T cells. Int. Immunol. 6:1475.
16. + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 179:709.
17. Kishimoto, H., and J. Sprent. 1997. Negative selection in the thymus includes semimature T cells. J. Exp. Med. 185:263.
18. Page, D. M., E. M. Roberts, J. J. Peschon, and S. M. Hedrick. 1998. TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection. J. Immunol. 160:120.
19. Singer, G. G., and A. K. Abbas. 1994. The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1:365.
20. Walunas, T. L., A. I. Sperling, R. Khattri, C. B. Thompson, and J. A. Bluestone. 1996. CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance. J. Immunol. 156:1006.
21. Foy, T. M., D. M. Page, T. J. Waldschmidt, A. Schoneveld, J. D. Laman, S. R. Masters, L. Tygrett, J. A. Ledbetter, A. Aruffo, E. Claassen, et al. 1995. An essential role for gp39, the ligand for CD40, in thymic selection. J. Exp. Med. 182:1377.
22. Dautigny, N., A. Le Campion, and B. Lucas. 1999. Timing and casting for actors of thymic negative selection. J. Immunol. 162:1294.
23. + T cell responses to CD40-deficient APCs: defects in proliferation and negative selection apply only with B cells as APCs. J. Immunol. 163:5250.
24. Ferrero, I., F. Anjuere, P. Martin, G. Martinez del Hoyo, M. L. Fraga, N. Wright, R. Varona, G. Marquez, and C. Ardavin. 1999. Functional and phenotypic analysis of thymic B cells: role in the induction of T cell negative selection. Eur. J. Immunol. 29:1598.
25. Page, D. M., L. P. Kane, T. M. Onami, and S. M. Hedrick. 1996. Cellular and biochemical requirements for thymocyte negative selection. Semin. Immunol. 8:69.
26. Grewal, I. S., and R. A. Flavell. 1998. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16:111.
27. Page, D. M. 1999. Cutting edge: thymic selection and autoreactivity are regulated by multiple coreceptors involved in T cell activation. J. Immunol. 163:3577.
28. Kishimoto, H., and J. Sprent. 1999. Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190:65.
29. Van de Velde, H., I. von Hoegen, W. Luo, J. R. Parnes, and K. Thielemans. 1991. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. Nature 351:662.
30. Biancone, L., M. A. Bowen, A. Lim, A. Aruffo, G. Andres, and I. Stamenkovic. 1996. Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes. J. Exp. Med. 184:811.
31. Bikah, G., F. M. Lynd, A. A. Aruffo, J. A. Ledbetter, and S. Bondada. 1998. A role for CD5 in cognate interactions between T cells and B cells, and identification of a novel ligand for CD5. Int. Immunol. 10:1185.
32. Marrack, P., G. M. Winslow, Y. Choi, M. Scherer, A. Pullen, J. White, and J. W. Kappler. 1993. The bacterial and mouse mammary tumor virus superantigens; two different families of proteins with the same functions. Immunol. Rev. 131:79.
33. Scherer, M. T., L. Ignatowicz, G. M. Winslow, J, W. Kappler, and P. Marrack. 1993. Superantigens: bacterial and viral proteins that manipulate the immune system. Annu. Rev. Cell Biol. 9:101.
34. Kappler, J. W., U. Staerz, J. White, and P. C. Marrack. 1988. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332:35.
35. Held, W., G. A. Waanders, A. N. Shakhov, L. Scarpellino, H. Acha-Orbea, and H. R. MacDonald. 1993. Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission. Cell 74:529.
36. Winer, B. J. 1971. Statistical Principles in Experimental Design. McGraw-Hill, New York.
37. + T cells. Blood 89:1308.
38. Pena-Rossi, C., L. A. Zuckerman, J. Strong, J. Kwan, W. Ferris, S. Chan, A. Tarakhovsky, A. D. Beyers, and N. Killeen. 1999. Negative regulation of CD4 lineage development and responses by CD5. J. Immunol. 163:6494.
39. Tarakhovsky, A., S. B. Kanner, J. Hombach, J. A. Ledbetter, W. Muller, N. Killeen, and K. Rajewsky. 1995. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269:535.
40. Chan, S., C. Waltzinger, A. Tarakhovsky, C. Benoist, and D. Mathis. 1999. An influence of CD5 on the selection of CD4-lineage T cells. Eur. J. Immunol. 29:2916.
41. Shahinian, A., K. Pfeffer, K. P. Lee, T. M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P. S. Ohashi, C. B. Thompson, and T. W. Mak. 1994. Differential T cell costimulatory requirements in CD28-deficient mice. J. Immunol. 152:3254.
42. Green, J. M., P. J. Noel, A. I. Sperling, T. L. Walunas, G. S. Gray, J. A. Bluestone, and C. B. Thompson. 1994. Absence of B7-dependent responses in CD28-deficient mice. Immunity 1:501.
43. Scherer, M. T., L. Ignatowicz, A. Pullen, J. Kappler, and P. Marrack. 1995. The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire. J. Exp. Med. 182:1493.
44. Matsuzaki, G., Y. Yoshikai, M. Ogimoto, K. Kishihara, and K. Nomoto. 1990. Clonal deletion of self-reactive T cells at the early stage of T cell development in thymus of radiation bone marrow chimeras. J. Immunol. 145:46.
45. Yoshikai, Y., M. Ogimoto, G. Matsuzaki, and K. Nomoto. 1990. Bone marrow-derived cells are essential for intrathymic deletion of sell-reactive T cells in both the host- and donor-derived thymocytes of fully allogeneic bone marrow chimeras. J. Immunol. 145:505.
46. Mazda, O., Y. Watanabe, J. Gyotoku, and Y. Katsura. 1991. Requirement of dendritic cells and B cells in the clonal deletion of Mls-reactive T cells in the thymus. J. Exp. Med. 173:539.
47. Surh, C. D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372:100.
48. + T cells by transgenic I-E restricted to thymic medullary epithelium. J. Immunol. 151:3954.
49. Woodland, D., M. P. Happ, J. Bill, and E. Palmer. 1990. Requirement for cotolerogenic gene products in the clonal deletion of I-E reactive T cells. Science 247:964.
50. Bill, J., O. Kanagawa, J. Linten, Y. Utsunomiya, and E. Palmer. 1990. Class I and class II MHC gene products differentially affect the fate of Vβ5 bearing thymocytes. J. Mol. Cell. Immunol. 4:269.
51. Webb, S. R., J. Hutchinson, K. Hayden, and J. Sprent. 1994. Expansion/deletion of mature T cells exposed to endogenous superantigens in vivo. J. Immunol. 152:586.
52. + T cells. J. Exp. Med. 175:1067.
53. Beutner, U., E. Kraus, D. Kitamura, K. Rajewsky, and B. T. Huber. 1994. B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens. J. Exp. Med. 179:1457.
54. Ardavin, C., G. Waanders, I. Ferrero, F. Anjuere, H. Acha-Orbea, and H. R. MacDonald. 1996. Expression and presentation of endogenous mouse mammary tumor virus superantigens by thymic and splenic dendritic cells and B cells. J. Immunol. 157:2789.
55. + T cells. Science 248:1643.