메뉴 건너뛰기




Volumn 175, Issue 8, 2005, Pages 4847-4857

Inefficient cell spreading and cytoskeletal polarization by CD4 +CD8+ thymocytes: Regulation by the thymic environment

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ANTIBODY; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

EID: 26844436431     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.8.4847     Document Type: Article
Times cited : (5)

References (55)
  • 1
    • 0028201339 scopus 로고
    • Selective events in T cell development
    • Robey, E., and B. J. Fowlkes. 1994. Selective events in T cell development. Annu. Rev. Immunol. 12: 675-705.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 675-705
    • Robey, E.1    Fowlkes, B.J.2
  • 4
  • 6
    • 0028409106 scopus 로고
    • Intracellular signals that mediate thymic negative selection
    • Vasquez, N. J., L. P. Kane, and S. M. Hedrick. 1994. Intracellular signals that mediate thymic negative selection. Immunity 1: 45-56.
    • (1994) Immunity , vol.1 , pp. 45-56
    • Vasquez, N.J.1    Kane, L.P.2    Hedrick, S.M.3
  • 7
    • 0033559135 scopus 로고    scopus 로고
    • Negative selection of immature thymocytes by a few peptide-MHC complexes: Differential sensitivity of immature and mature T cells
    • Peterson, D. A., R. J. DiPaolo, O. Kanagawa, and E. R. Unanue. 1999. Negative selection of immature thymocytes by a few peptide-MHC complexes: differential sensitivity of immature and mature T cells. J. Immunol. 162: 3117-3120.
    • (1999) J. Immunol. , vol.162 , pp. 3117-3120
    • Peterson, D.A.1    DiPaolo, R.J.2    Kanagawa, O.3    Unanue, E.R.4
  • 9
    • 0027162398 scopus 로고
    • Actin polymerization and pseudopod reorganization accompany anti-CD3-induced growth arrest in jurkat T cells
    • Parsey, M. V., and G. K. Lewis. 1993. Actin polymerization and pseudopod reorganization accompany anti-CD3-induced growth arrest in jurkat T cells. J. Immunol. 151: 1881-1893.
    • (1993) J. Immunol. , vol.151 , pp. 1881-1893
    • Parsey, M.V.1    Lewis, G.K.2
  • 11
    • 0035075507 scopus 로고    scopus 로고
    • Dynamic actin polymerization drives T cell receptor-induced spreading: A role for the signal transduction adaptor LAT
    • Bunnell, S. C., V. Kapoor, R. P. Trible, W. Zhang, and L. E. Samelson. 2001. Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity 14: 315-329.
    • (2001) Immunity , vol.14 , pp. 315-329
    • Bunnell, S.C.1    Kapoor, V.2    Trible, R.P.3    Zhang, W.4    Samelson, L.E.5
  • 12
    • 0024327897 scopus 로고
    • Cell biology of cytotoxic and helper T cell functions: Immunofluorescence microscopic studies of single cells and cell couples
    • Kupfer, A., and S. J. Singer. 1989. Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples. Annu. Rev. Immunol. 7: 309-337.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 309-337
    • Kupfer, A.1    Singer, S.J.2
  • 14
    • 0020365635 scopus 로고
    • Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells
    • Geiger, B., D. Rosen, and G. Berke. 1982. Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells. J. Cell Biol. 95: 137-143.
    • (1982) J. Cell Biol. , vol.95 , pp. 137-143
    • Geiger, B.1    Rosen, D.2    Berke, G.3
  • 15
    • 3042793578 scopus 로고    scopus 로고
    • Linking albinism and immunity: The secrets of secretory lysosomes
    • Stinchcombe, J., G. Bossi, and G. M. Griffiths. 2004. Linking albinism and immunity: the secrets of secretory lysosomes. Science 305: 55-59.
    • (2004) Science , vol.305 , pp. 55-59
    • Stinchcombe, J.1    Bossi, G.2    Griffiths, G.M.3
  • 16
    • 0025978984 scopus 로고
    • Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells
    • Kupfer, A., T. R. Mosmann, and H. Kupfer. 1991. Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells. Proc. Natl. Acad. Sci. USA 88: 775-779.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 775-779
    • Kupfer, A.1    Mosmann, T.R.2    Kupfer, H.3
  • 17
    • 0034714184 scopus 로고    scopus 로고
    • Differential clustering of CD4 and CD3ζ during T cell recognition
    • Krummel, M. F., M. D. Sjaastad, C. Wülfing, and M. M. Davis. 2000. Differential clustering of CD4 and CD3ζ during T cell recognition. Science 289: 1349-1352.
    • (2000) Science , vol.289 , pp. 1349-1352
    • Krummel, M.F.1    Sjaastad, M.D.2    Wülfing, C.3    Davis, M.M.4
  • 18
    • 0036172220 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
    • Egen, J. G., and J. P. Allison. 2002. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 16: 23-35.
    • (2002) Immunity , vol.16 , pp. 23-35
    • Egen, J.G.1    Allison, J.P.2
  • 19
    • 0042931251 scopus 로고    scopus 로고
    • Regulation of sustained actin dynamics by the TCR and costimulation as a mechanism of receptor localization
    • Tskvitaria-Fuller, I., A. L. Rozelle, H. L. Yin, and C. Wülfing. 2003. Regulation of sustained actin dynamics by the TCR and costimulation as a mechanism of receptor localization. J. Immunol. 171: 2287-2295.
    • (2003) J. Immunol. , vol.171 , pp. 2287-2295
    • Tskvitaria-Fuller, I.1    Rozelle, A.L.2    Yin, H.L.3    Wülfing, C.4
  • 20
    • 0345257150 scopus 로고    scopus 로고
    • Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: Manifestation of a dual activation threshold
    • Faroudi, M., C. Utzny, M. Salio, V. Cerundolo, M. Guiraud, S. Müller, and S. Valitutti. 2003. Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold. Proc. Natl. Acad. Sci. USA 100: 14145-14150.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 14145-14150
    • Faroudi, M.1    Utzny, C.2    Salio, M.3    Cerundolo, V.4    Guiraud, M.5    Müller, S.6    Valitutti, S.7
  • 21
    • 0038445896 scopus 로고    scopus 로고
    • Linker for activation of T cells, ζ-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization
    • Kuhné, M. R., J. Lin, D. Yablonski, M. N. Mollenauer, L. I. Ehrlich, J. Huppa, M. M. Davis, and A. Weiss. 2003. Linker for activation of T cells, ζ-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization. J. Immunol. 171: 860-866.
    • (2003) J. Immunol. , vol.171 , pp. 860-866
    • Kuhné, M.R.1    Lin, J.2    Yablonski, D.3    Mollenauer, M.N.4    Ehrlich, L.I.5    Huppa, J.6    Davis, M.M.7    Weiss, A.8
  • 22
    • 0031884839 scopus 로고    scopus 로고
    • The duration of antigenic stimulation determines the fate of naive and effector T cells
    • Iezzi, G., K. Karjalainen, and A. Lanzavecchia. 1998. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8: 89-95.
    • (1998) Immunity , vol.8 , pp. 89-95
    • Iezzi, G.1    Karjalainen, K.2    Lanzavecchia, A.3
  • 25
  • 28
    • 0025231503 scopus 로고
    • Developmental biology of T cells in T cell-receptor transgenic mice
    • von Boehmer, H. 1990. Developmental biology of T cells in T cell-receptor transgenic mice. Annu. Rev. Immunol. 8: 531-556.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 531-556
    • Von Boehmer, H.1
  • 31
    • 0025095655 scopus 로고
    • Ligand thresholds at different stages of T cell development
    • Yagi, J., and C. A. Janeway, Jr. 1990. Ligand thresholds at different stages of T cell development. Int. Immunol. 2: 83-89.
    • (1990) Int. Immunol. , vol.2 , pp. 83-89
    • Yagi, J.1    Janeway Jr., C.A.2
  • 32
    • 0025761241 scopus 로고
    • Lower receptor avidity required for thymic clonal deletion than for effector T-cell function
    • Pircher, H., U. H. Rohrer, D. Moskophidis, R. M. Zinkernagel, and H. Hengartner. 1991. Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature 351: 482-485.
    • (1991) Nature , vol.351 , pp. 482-485
    • Pircher, H.1    Rohrer, U.H.2    Moskophidis, D.3    Zinkernagel, R.M.4    Hengartner, H.5
  • 33
    • 0032538986 scopus 로고    scopus 로고
    • Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells
    • Davey, G. M., S. L. Schober, B. T. Endrizzi, A. K. Dutcher, S. C. Jameson, and K. A. Hogquist. 1998. Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells. J. Exp. Med. 188: 1867-1874.
    • (1998) J. Exp. Med. , vol.188 , pp. 1867-1874
    • Davey, G.M.1    Schober, S.L.2    Endrizzi, B.T.3    Dutcher, A.K.4    Jameson, S.C.5    Hogquist, K.A.6
  • 34
    • 0033577859 scopus 로고    scopus 로고
    • A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex
    • Williams, C. B., D. L. Engle, G. J. Kersh, M. J. White, and P. M. Allen. 1999. A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex. J. Exp. Med. 189: 1531-1544.
    • (1999) J. Exp. Med. , vol.189 , pp. 1531-1544
    • Williams, C.B.1    Engle, D.L.2    Kersh, G.J.3    White, M.J.4    Allen, P.M.5
  • 35
    • 0033103008 scopus 로고    scopus 로고
    • Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire
    • Lucas, B., I. Stefanová, K. Yasutomo, N. Dautigny, and R. N. Germain. 1999. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. Immunity 10: 367-376.
    • (1999) Immunity , vol.10 , pp. 367-376
    • Lucas, B.1    Stefanová, I.2    Yasutomo, K.3    Dautigny, N.4    Germain, R.N.5
  • 36
    • 0142149044 scopus 로고    scopus 로고
    • Thymocyte sensitivity and supramolecular activation cluster formation are developmentally regulated: A partial role for sialylation
    • Starr, T. K., M. A. Daniels, M. M. Lucido, S. C. Jameson, and K. A. Hogquist. 2003. Thymocyte sensitivity and supramolecular activation cluster formation are developmentally regulated: a partial role for sialylation. J. Immunol. 171: 4512-4520.
    • (2003) J. Immunol. , vol.171 , pp. 4512-4520
    • Starr, T.K.1    Daniels, M.A.2    Lucido, M.M.3    Jameson, S.C.4    Hogquist, K.A.5
  • 37
    • 0025809282 scopus 로고
    • Signaling via the inositol phospholipid pathway by T cell antigen receptor is limited by receptor number
    • Graber, M., L. K. Bockenstedt, and A. Weiss. 1991. Signaling via the inositol phospholipid pathway by T cell antigen receptor is limited by receptor number. J. Immunol. 146: 2935-2943.
    • (1991) J. Immunol. , vol.146 , pp. 2935-2943
    • Graber, M.1    Bockenstedt, L.K.2    Weiss, A.3
  • 38
    • 0029840935 scopus 로고    scopus 로고
    • Dual T cell receptor T cells have a decreased sensitivity to physiological ligands due to reduced density of each T cell receptor
    • Blichfeldt, E., L. A. Munthe, J. S. Rotnes, and B. Bogen. 1996. Dual T cell receptor T cells have a decreased sensitivity to physiological ligands due to reduced density of each T cell receptor. Eur. J. Immunol. 26: 2876-2884.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2876-2884
    • Blichfeldt, E.1    Munthe, L.A.2    Rotnes, J.S.3    Bogen, B.4
  • 40
    • 0032438114 scopus 로고    scopus 로고
    • Altered thymic positive selection and intracellular signals in Cbl-deficient mice
    • Naramura, M., H. K. Kole, R.-J. Hu, and H. Gu. 1998. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc. Natl. Acad. Sci. USA 95: 15547-15552.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15547-15552
    • Naramura, M.1    Kole, H.K.2    Hu, R.-J.3    Gu, H.4
  • 41
    • 0022993986 scopus 로고
    • Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor
    • Samelson, L. E., M. D. Patel, A. M. Weissman, J. B. Harford, and R. D. Klausner. 1986. Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell 46: 1083-1090.
    • (1986) Cell , vol.46 , pp. 1083-1090
    • Samelson, L.E.1    Patel, M.D.2    Weissman, A.M.3    Harford, J.B.4    Klausner, R.D.5
  • 43
    • 0028535120 scopus 로고
    • Zap-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells
    • van Oers, N. S. C., N. Killeen, and A. Weiss. 1994. Zap-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells. Immunity 1: 675-685.
    • (1994) Immunity , vol.1 , pp. 675-685
    • Van Oers, N.S.C.1    Killeen, N.2    Weiss, A.3
  • 45
    • 0037191792 scopus 로고    scopus 로고
    • Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes
    • Stefanová, I., J. R. Dorfman, and R. N. Germain. 2002. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature 420: 429-434.
    • (2002) Nature , vol.420 , pp. 429-434
    • Stefanová, I.1    Dorfman, J.R.2    Germain, R.N.3
  • 46
    • 0027957577 scopus 로고
    • + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28
    • + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 179: 709-713.
    • (1994) J. Exp. Med. , vol.179 , pp. 709-713
    • Punt, J.A.1    Osborne, B.A.2    Takahama, Y.3    Sharrow, S.O.4    Singer, A.5
  • 47
    • 0034663892 scopus 로고    scopus 로고
    • Opening a window on thymic positive selection: Developmental changes in the influence of cosignaling by integrins and CD28 on selection events induced by TCR engagement
    • Lucas, B., and R. N. Germain. 2000. Opening a window on thymic positive selection: developmental changes in the influence of cosignaling by integrins and CD28 on selection events induced by TCR engagement. J. Immunol. 165: 1889-1895.
    • (2000) J. Immunol. , vol.165 , pp. 1889-1895
    • Lucas, B.1    Germain, R.N.2
  • 48
    • 0037351084 scopus 로고    scopus 로고
    • Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse
    • Ardouin, L., M. Bracke, A. Mathiot, S. N. Pagakis, T. Norton, N. Hogg, and V. L. Tybulewicz. 2003. Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse. Eur. J. Immunol. 33: 790-797.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 790-797
    • Ardouin, L.1    Bracke, M.2    Mathiot, A.3    Pagakis, S.N.4    Norton, T.5    Hogg, N.6    Tybulewicz, V.L.7
  • 49
    • 0028851581 scopus 로고
    • Tyrosine-phosphorylated T cell receptor ζ chain associates with the actin cytoskeleton upon activation of mature T lymphocytes
    • Rozdzial, M. M., B. Malissen, and T. H. Finkel. 1995. Tyrosine-phosphorylated T cell receptor ζ chain associates with the actin cytoskeleton upon activation of mature T lymphocytes. Immunity 3: 623-633.
    • (1995) Immunity , vol.3 , pp. 623-633
    • Rozdzial, M.M.1    Malissen, B.2    Finkel, T.H.3
  • 50
    • 0029008280 scopus 로고
    • Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42
    • Stowers, L., D. Yelon, L. J. Berg, and J. Chant. 1995. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc. Natl. Acad. Sci. USA 92: 5027-5031.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5027-5031
    • Stowers, L.1    Yelon, D.2    Berg, L.J.3    Chant, J.4
  • 51
    • 0036798653 scopus 로고    scopus 로고
    • In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern
    • Blanchard, N., V. Di Bartolo, and C. Hivroz. 2002. In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern. Immunity 17: 389-399.
    • (2002) Immunity , vol.17 , pp. 389-399
    • Blanchard, N.1    Di Bartolo, V.2    Hivroz, C.3
  • 52
    • 0033953888 scopus 로고    scopus 로고
    • Functional cooperation between the microtubule and actin cytoskeletons
    • Goode, B. L., D. G. Drubin, and G. Barnes. 2000. Functional cooperation between the microtubule and actin cytoskeletons. Curr. Opin. Cell Biol. 12: 63-71.
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 63-71
    • Goode, B.L.1    Drubin, D.G.2    Barnes, G.3
  • 53
    • 0036166541 scopus 로고    scopus 로고
    • Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing
    • Kuhn, J. R., and M. Poenie. 2002. Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing. Immunity 16: 111-121.
    • (2002) Immunity , vol.16 , pp. 111-121
    • Kuhn, J.R.1    Poenie, M.2
  • 55
    • 0031936042 scopus 로고    scopus 로고
    • + T cells: Compulsory cytoskeletal alterations for the triggering of an intracellular calcium response
    • + T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response. Eur. J. Immunol. 28: 716-729.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 716-729
    • Delon, J.1    Bercovici, N.2    Liblau, R.3    Trautmann, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.