Neural cell 3d microtissue formation is marked by cytokines' up-regulation

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Lai, Yinzhi ^a   Asthana, Amish ^a   Cheng, Ke ^a,b   Kisaalita, William S ^a  

^a University of Georgia   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN LIKE 7; ARIGININE RICH MUTATED IN EARLY STAGE TUMOR PROTEIN; BIOLOGICAL MARKER; BONE MORPHOGENETIC PROTEIN 8B; CELL PROTEIN; CORNEA DERIVED TRANSCRIPT 6; CXCL13 CHEMOKINE; CYTOKINE; ENDOTHELIN 3; FIBROBLAST GROWTH FACTOR 5; GHRELIN; GREMLIN 2 CYSTEINE KNOT SUPERFAMILY HOMOLOG; GROWTH DIFFERENTIATION FACTOR 3; INSULIN LIKE 5; INTERFERON ALPHA 4; INTERLEUKIN 11; INTERLEUKIN 1BETA; LEUKEMIA INHIBITORY FACTOR; MESENCEPHALIC ASTROCYTE DERIVED NEUROTROPHIC FACTOR; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; NEU DIFFERENTIATION FACTOR; OSTEOGENIC PROTEIN 2; PLATELET DERIVED GROWTH FACTOR B; POLYSTYRENE; PRO PLATELET BASIC PROTEIN LIKE 2; STANNIOCALCIN 1; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG; UROCORTIN III; VASCULOTROPIN A;

ANGPTL7 GENE; ARMET GENE; ARTICLE; BIOSENSOR; BMP8B GENE; CCL13 GENE; CCL28 GENE; CDT6 GENE; CELL ASSAY; CELL CULTURE; CELL STRUCTURE; CONTROLLED STUDY; CXCL2 GENE; EDN3 GENE; FASLG GENE; FGF22 GENE; FGF5 GENE; GDF3 GENE; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GHRL GENE; GREM2 GENE; HUMAN; HUMAN CELL; IFNA4 GENE; IFNA7 GENE; IL11 GENE; IL1B GENE; IN VIVO STUDY; INSL5 GENE; LIF GENE; MANF GENE; MICROENVIRONMENT; NERVE CELL CULTURE; NERVOUS TISSUE; NEURAL STEM CELL; NEUROSPHERE; NOV GENE; NRG1 GENE; PDGFB GENE; PPBPL2 GENE; STC1 GENE; TGFA GENE; THREE DIMENSIONAL CELL CULTURE; TRANSCRIPTOMICS; TWO DIMENSIONAL CELL CULTURE; UCN3 GENE; UPREGULATION; VALIDATION STUDY; VEGFA GENE; BIOSYNTHESIS; COMPARATIVE STUDY; CYTOLOGY; METHODOLOGY; PRIMARY CELL CULTURE; TISSUE ENGINEERING;

BIOLOGICAL MARKERS; CYTOKINES; HUMANS; NEURAL STEM CELLS; PRIMARY CELL CULTURE; TISSUE ENGINEERING; UP-REGULATION;

EID: 80055052200     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026821     Document Type: Article

References (61)

1. Kisaalita WS, (2010) 3D cell-based biosensors in drug discovery programs: Microtissue engineering for high throughput screening Boca Raton CRC Press.
2. Green JA, Yamada KM, (2007) Three-dimensional microenvironments moderate fibroblast signaling responses. Adv Drug Deliv Rev 59: 1293-1298.
3. Griffith LG, Swartz MA, (2006) Capturing complex 2D tissue physiology in vitro. Nat Rev Mol Biol 7: 211-224.
4. Lai Y, Asthana A, Kisaalita WS, (2011) Biomarkers for simplifying HTS 3D cell culture platforms for drug discovery: the case for cytokines. Drug Discov Today 16 (7/8): 293-297.
5. Cukierman E, Pankov R, Stevens DR, Yamada KM, (2001) Taking cell-matrix adhesions to the third dimension. Science 294 (5547): 1708-1712.
6. Simon CG Jr, Stephens JS, Dorsey SM, Becker ML, (2007) Fabrication of combinatorial polymer scaffold libraries. Rev Sci Instrum 78 (7): 2755-2761.
7. Yang Y, Bolikal D, Becker ML, Kohn J, Zeiger DN, et al. (2008) Combinatorial polymer scaffold libraries for screening cell-biomaterial interactions in 3D. Advanced Materials 20 (11): 2037-2043.
8. Yang Y, Dorsey SM, Becker ML, Lin-Gibson S, Schumacher GE, et al. (2008) X-ray imaging optimization of 3D tissue engineering scaffolds via combinatorial fabrication methods. Biomaterials 29 (12): 1901-1911.
9. Yamada KM, Cukierman E, (2007) Modeling tissue morphogenesis and cancer in 3D. Cell 130 (4): 601-610.
10. Kato-Negishi M, Tsuda Y, Onoe H, Takeuchi S, (2010) A neurospheroid network-stamping method for neural transplantation to the brain. Biometarials 31: 8939-8945.
11. Oppenheim JJ, (2001) Cytokines: past, present, and future. Int J Hematol 74 (1): 3-8.
12. Coussens LM, Werb Z, (2002) Inflammation and cancer. Nature 420 (6917): 860-867.
13. Cheng K, Lai Y, Kisaalita WS, (2008) Three-dimensional polymer scaffolds for high throughput cell-based assay systems. Biomaterials 29 (18): 2802-2812.
14. Good PI, (2005) Permutation, parametric and bootstrap tests of hypotheses, 3rd ed New York Springer.
15. Wu ZZ, Kisaalita WS, Wang L, Zachman AL, Zhao Y, et al. (2010) Effects of topography on the functional development of human neural progenitor cells. Biotechnol Bioeng 106 (4): 649-659.
16. Enzerink A, Salmenpera P, Kankuri E, Vaheri A, (2009) Clustering of fibroblasts induces proinflammatory chemokine secretion promoting leukocyte migration. Mol Immunol 46 (8-9): 1787-1795.
17. Fischbach C, Kong HJ, Hsiong SX, Evangelista MB, Yuen W, et al. (2009) Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement. Proc Natl Acad Sci U S A 106 (2): 399-404.
18. Ghosh S, Spagnoli GC, Martin I, Ploegert S, Demougin P, et al. (2005) Three-dimensional culture of melanoma cells profoundly affects gene expression profile: a high density oligonucleotide array study. J Cell Physiol 204 (2): 522-531.
19. Klapperich CM, Bertozzi CR, (2004) Global gene expression of cells attached to a tissue engineering scaffold. Biomaterials 25 (25): 5631-5641.
20. Cheok MH, Yang W, Pui CH, Downing JR, Cheng C, et al. (2003) Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. Nat Genet 34 (1): 85-90.
21. Zampetaki A, Mitsialis SA, Pfeilschifter J, Kourembanas S, (2004) Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-kappaB: the prominent role of p42/p44 and PI3 kinase pathways. FASEB J 18 (10): 1090-1092.
22. Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, et al. (1997) Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 137 (1): 231-245.
23. Pries AR, Reglin B, Secomb TW, (2001) Structural adaptation of microvascular networks: functional roles of adaptive responses. Am J Physiol Heart Circ Physiol 281 (3): H1015-H1025.
24. Kelm JM, Ehler E, Nielsen LK, Schlatter S, Perriard JC, et al. (2004) Design of artificial myocardial microtissues. Tissue Eng 10 (1-2): 201-214.
25. Birgersdotter A, Sandberg R, Ernberg I, (2005) Gene expression perturbation in vitro-a growing case for three-dimensional (3D) culture systems. Semin Cancer Biol 15 (5): 405-412.
26. Frisch SM, Ruoslahti E, (1997) Integrins and anoikis. Curr Opin Cell Biol 9 (5): 701-706.
27. Watanabe K, Nakamura M, Okano H, Toyama Y, (2007) Establishment of three-dimensional culture of neural stem/progenitor cells in collagen Type-1 Gel. Restor Neurol Neurosci 25 (2): 109-117.
28. Kuhn HG, Winkler J, Kempermann G, Thal LJ, Gage FH, (1997) Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neurosci 17 (15): 5820-5829.
29. Peek R, Kammerer RA, Frank S, Otte-Holler I, Westphal JR, (2002) The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea. J Biol Chem 277 (1): 686-693.
30. Apostolou A, Shen Y, Liang Y, Luo J, Fang S, (2008) Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death. Exp Cell Res 314 (13): 2454-2467.
31. Yu YQ, Liu LC, Wang FC, Liang Y, Cha DQ, et al. (2010) Induction profile of MANF/ARMET by cerebral ischemia and its implication for neuron protection. J Cereb Blood Flow Metab 30 (1): 79-91.
32. Lindholm P, Peranen J, Andressoo JO, Kalkkinen N, Kokaia Z, et al. (2008) MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain. Mol Cell Neurosci 39 (3): 356-371.
33. Allerstorfer S, Sonvilla G, Fischer H, Spiegl-Kreinecker S, Gauglhofer C, et al. (2008) FGF5 as an oncogenic factor in human glioblastoma multiforme: autocrine and paracrine activities. Oncogene 27 (30): 4180-4190.
34. Lindholm D, Harikka J, da Penha Berzaghi M, Castren E, Tzimagiorgis G, et al. (1994) Fibroblast growth factor-5 promotes differentiation of cultured rat septal cholinergic and raphe serotonergic neurons: comparison with the effects of neurotrophins. Eur J Neurosci 6: 244-252.
35. Reuss B, Hertel M, Werner S, Unsicker K, (2000) Fibroblast growth factors-5 and-9 distinctly regulate expression and function of the gap junction protein connexin43 in cultured astroglial cells from different brain regions. Glia 30 (3): 231-241.
36. Volante M, Rosas R, Ceppi P, Rapa I, Cassoni P, et al. (2009) Obestatin in human neuroendocrine tissues and tumours: expression and effect on tumour growth. J Pathol 218 (4): 58-466.
37. Ito Y, Yamamoto M, Li M, Mitsuma N, Tanaka F, et al. (2000) Temporal expression of mRNAs for neuropoietic cytokines, interleukin-11 (IL-11), oncostatin M (OSM), cardiotrophin-1 (CT-1) and their receptors (IL-11Ralpha and OSMRbeta) in peripheral nerve injury. Neurochem Res 25 (8): 1113-1118.
38. Yanagisawa M, Nakashima K, Arakawa H, Ikenaka K, Yoshida K, et al. (2000) Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3. J Neurochem 74 (4): 1498-1504.
39. Mehler MF, Rozental R, Dougherty M, Spray DC, Kessler JA, (1993) Cytokine regulation of neuronal differentiation of hippocampal progenitor cells. Nature 362 (6415): 62-65.
40. Nagashima G, Suzuki R, Asai J, Fujimoto T, (2002) Immunohistochemical analysis of reactive astrocytes around glioblastoma: an immunohistochemical study of postmortem glioblastoma cases. Clin Neurol Neurosurg 104 (2): 125-131.
41. Sharief MK, (1998) Cytokines in multiple sclerosis: pro-inflammation or pro-remyelination? Mult Scler 4 (3): 169-173.
42. Merrill JE, Benveniste EN, (1996) Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci 19 (8): 331-338.
43. Planque N, Perbal B, (2003) A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis. Cancer Cell Int 3 (1): 15.
44. Kubota S, Takigawa M, (2007) CCN family proteins and angiogenesis: from embryo to adulthood. Angiogenesis 10 (1): 1-11.
45. Lin CG, Chen CC, Leu SJ, Grzeszkiewicz TM, Lau LF, (2005) Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing. J Biol Chem 280 (9): 8229-8237.
46. Perbal B, (2001) NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues. Mol Pathol 54 (2): 57-79.
47. Chevalier G, Yeger H, Martinerie C, Laurent M, Alami J, et al. (1998) novH: differential expression in developing kidney and Wilm's tumors. Am J Pathol 152 (6): 1563-1575.
48. Calzolari F, Appolloni I, Tutucci E, Caviglia S, Terrile M, et al. (2008) Tumor progression and oncogene addiction in a PDGF-B-induced model of gliomagenesis. Neoplasia 10 (12): 1373-1382.
49. Sjoborg M, Pietz K, Ahgren A, Yamada N, Lindvall O, et al. (1998) Expression of platelet-derived growth factor after intrastriatal ibotenic acid injury. Exp Brain Res 119 (2): 245-250.
50. Williams BP, Park JK, Alberta JA, Muhlebach SG, Hwang GY, et al. (1997) A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells. Neuron 18 (4): 553-562.
51. Nakao N, Brundin P, Funa K, Lindvall O, Odin P, (1994) Platelet-derived growth factor exerts trophic effects on rat striatal DARPP-32-containing neurons in culture. Exp Brain Res 101 (2): 291-296.
52. Koide Y, Sasaki T, (2006) Stanniocalcin-1 (STC-1) as a molecular marker for human cancer. Rinsho Byori 54 (3): 213-220.
53. Zhang K, Lindsberg PJ, Tatlisumak T, Kaste M, Olsen HS, et al. (2000) Stanniocalcin: A molecular guard of neurons during cerebral ischemia. Proc Natl Acad Sci U S A 97 (7): 3637-3642.
54. Serlachius M, Zhang KZ, Andersson LC, (2004) Stanniocalcin in terminally differentiated mammalian cells. Peptides 25 (10): 1657-1662.
55. Dunn IF, Heese O, Black PM, (2000) Growth factors in glioma angiogenesis: FGFs, PDGF, EGF, and TGFs. J Neurooncol 50 (1-2): 121-137.
56. Junier MP, (2000) What role(s) for TGFalpha in the central nervous system? Prog Neurobiol 62 (5): 443-473.
57. Plate KH, Breier G, Weich HA, Mennel HD, Risau W, (1994) Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer 59 (4): 520-529.
58. Zagzag D, Lukyanov Y, Lan L, Ali MA, Esencay M, et al. (2006) Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion. Lab Invest 86 (12): 1221-1232.
59. Nag S, Takahashi JL, Kilty DW, (1997) Role of vascular endothelial growth factor in blood-brain barrier breakdown and angiogenesis in brain trauma. J Neuropath Exp Neurol 56 (8): 912-921.
60. Krum JM, Rosenstein JM, (1998) VEGF mRNA and its receptor flt-1 are expressed in reactive astrocytes following neural grafting and tumor cell implantation in the adult CNS. Exp Neurol 154 (1): 57-65.
61. Rosenstein JM, Krum JM, (2004) New roles for VEGF in nervous tissue-beyond blood vessels. Exp Neurol 187 (2): 246-253.