Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  de Figueiredo Pontes, Lorena L ^a   Assis, Patricia A ^a   Santana Lemos, Bárbara A A ^a   Jácomo, Rafael H ^b   Lima, Ana Sílvia G ^a   Garcia, Aglair B ^a   Thomé, Carolina H ^a   Araújo Amé, Amélia G ^a   Panepucci, Rodrigo A ^a   Zago, Marco A ^a   Nagler, Arnon ^c   Falcão, Roberto P ^a   Rego, Eduardo M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF BRASILIA   (Brazil)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

HALOFUGINONE; TRANSFORMING GROWTH FACTOR BETA; ONCOPROTEIN; PIPERIDINE DERIVATIVE; PROMYELOCYTIC LEUKEMIA RETINOIC ACID RECEPTOR ALPHA FUSION ONCOPROTEIN; PROMYELOCYTIC LEUKEMIA-RETINOIC ACID RECEPTOR ALPHA FUSION ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; QUINAZOLINONE DERIVATIVE; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW; CANCER INHIBITION; CANCER TRANSPLANTATION; CELL CYCLE; CELL PROLIFERATION; CIRCULATION; CONTROLLED STUDY; DOWN REGULATION; IN VIVO STUDY; LEUKEMIA CELL; LEUKEMIA REMISSION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE MYC; P15 GENE; P21 GENE; PROMYELOCYTIC LEUKEMIA; SMAD3 GENE; SPLEEN; TGFB GENE; TGFBRI GENE; UPREGULATION; ANIMAL; BLOOD; BLOOD CELL COUNT; DISEASE MODEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALIA; MUS; MUS MUSCULUS;

ANIMALS; BLOOD CELL COUNT; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MICE; MICE, SCID; ONCOGENE PROTEINS, FUSION; PIPERIDINES; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINONES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 80055043382     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026713     Document Type: Article

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