메뉴 건너뛰기




Volumn 36, Issue 4, 2011, Pages 725-729

Nucleic acid therapy for lifespan prolongation: Present and future

Author keywords

Aging; genes; lifespan; longevity; nucleic acid therapy

Indexed keywords

GENE THERAPY AGENT; HUR PROTEIN; NUCLEIC ACID;

EID: 80054971400     PISSN: 02505991     EISSN: 09737138     Source Type: Journal    
DOI: 10.1007/s12038-011-9096-z     Document Type: Review
Times cited : (15)

References (55)
  • 1
    • 79955946232 scopus 로고    scopus 로고
    • Network reconstruction reveals new links between aging and calorie restriction in yeast
    • Balazsi G. 2010 Network reconstruction reveals new links between aging and calorie restriction in yeast. HFSP J. 4 94-99
    • (2010) HFSP J. , vol.4 , pp. 94-99
    • Balazsi, G.1
  • 2
    • 29744458522 scopus 로고    scopus 로고
    • A phase I/II clinical trial of β-globin gene therapy for β-thalassemia
    • DOI 10.1196/annals.1345.007
    • A Bank R Dorazio P Leboulch 2005 A phase I/II clinical trial of beta-globin gene therapy for beta-thalassemia Ann. N. Y. Acad. Sci. 1054 308 316 16339679 10.1196/annals.1345.007 1:CAS:528:DC%2BD28XotlKgsw%3D%3D (Pubitemid 43031038)
    • (2005) Annals of the New York Academy of Sciences , vol.1054 , pp. 308-316
    • Bank, A.1    Dorazio, R.2    Leboulch, P.3
  • 3
    • 38949161899 scopus 로고    scopus 로고
    • Anti-aging properties of resveratrol: Review and report of a potent new antioxidant skin care formulation
    • DOI 10.1111/j.1473-2165.2008.00354.x
    • RA Baxter 2008 Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation J. Cosmet. Dermatol. 7 2 7 18254804 10.1111/j.1473-2165.2008.00354.x (Pubitemid 351228159)
    • (2008) Journal of Cosmetic Dermatology , vol.7 , Issue.1 , pp. 2-7
    • Baxter, R.A.1
  • 4
    • 78650448343 scopus 로고    scopus 로고
    • 3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1
    • Berdichevsky A, Nedelcu S, Boulias K, Bishop NA, Guarente L and Horvitz HR 2010 3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1. Proc. Natl. Acad. Sci. USA 107 18927-18932
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 18927-18932
    • Berdichevsky, A.1    Nedelcu, S.2    Boulias, K.3    Bishop, N.A.4    Guarente, L.5    Horvitz, H.R.6
  • 5
    • 34547770365 scopus 로고    scopus 로고
    • Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin
    • DOI 10.1016/j.neurobiolaging.2006.08.010, PII S0197458006003058
    • Boghossian S, Ueno N, Dube MG, Kalra P and Kalra S 2007 Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin. Neurobiol. Aging 28 1594-1604 (Pubitemid 47238536)
    • (2007) Neurobiology of Aging , vol.28 , Issue.10 , pp. 1594-1604
    • Boghossian, S.1    Ueno, N.2    Dube, M.G.3    Kalra, P.4    Kalra, S.5
  • 6
    • 70849127580 scopus 로고    scopus 로고
    • Phenotypic plasticity and longevity in plants and animals: Cause and effect?
    • 19920345 10.1007/s12038-009-0078-3
    • RM Borges 2009 Phenotypic plasticity and longevity in plants and animals: Cause and effect? J. Biosci. 34 605 611 19920345 10.1007/s12038-009-0078-3
    • (2009) J. Biosci. , vol.34 , pp. 605-611
    • Borges, R.M.1
  • 8
    • 70449427834 scopus 로고    scopus 로고
    • Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
    • 19892975 10.1126/science.1171242 1:CAS:528:DC%2BD1MXhtlGhs7zO
    • N Cartier S Hacein-Bey-Abina CC Bartholomae G Veres M Schmidt I Kutschera M Vidaud U Abel, et al. 2009 Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy Science 326 818 823 19892975 10.1126/science.1171242 1:CAS:528:DC%2BD1MXhtlGhs7zO
    • (2009) Science , vol.326 , pp. 818-823
    • Cartier, N.1    Hacein-Bey-Abina, S.2    Bartholomae, C.C.3    Veres, G.4    Schmidt, M.5    Kutschera, I.6    Vidaud, M.7    Abel, U.8
  • 9
    • 77957889331 scopus 로고    scopus 로고
    • A functional single nucleotide polymorphism in promoter of ATM is associated with longevity
    • Chen T, Dong B, Lu Z, Tian B, Zhang J, Zhou J, Wu H, Zhang Y, et al. 2010 A functional single nucleotide polymorphism in promoter of ATM is associated with longevity. Mech. Ageing Dev. 131 636-640
    • (2010) Mech. Ageing Dev. , vol.131 , pp. 636-640
    • Chen, T.1    Dong, B.2    Lu, Z.3    Tian, B.4    Zhang, J.5    Zhou, J.6    Wu, H.7    Zhang, Y.8
  • 10
    • 34248326042 scopus 로고    scopus 로고
    • Nucleus pulposus cellular longevity by telomerase gene therapy
    • DOI 10.1097/BRS.0b013e31805471a3, PII 0000763220070515000007
    • Chung SA, Wei AQ, Connor DE, Webb GC, Molloy T, Pajic M and Diwan AD 2007 Nucleus pulposus cellular longevity by telomerase gene therapy. Spine (Phila Pa 1976) 32 1188-1196 (Pubitemid 46743019)
    • (2007) Spine , vol.32 , Issue.11 , pp. 1188-1196
    • Chung, S.A.1    Wei, A.Q.2    Connor, D.E.3    Webb, G.C.4    Molloy, T.5    Pajic, M.6    Diwan, A.D.7
  • 11
    • 67650439330 scopus 로고    scopus 로고
    • Caloric restriction delays disease onset and mortality in rhesus monkeys
    • 19590001 10.1126/science.1173635 1:CAS:528:DC%2BD1MXos1SrtL0%3D
    • RJ Colman RM Anderson SC Johnson EK Kastman KJ Kosmatka TM Beasley DB Allison C Cruzen, et al. 2009 Caloric restriction delays disease onset and mortality in rhesus monkeys Science 325 201 204 19590001 10.1126/science.1173635 1:CAS:528:DC%2BD1MXos1SrtL0%3D
    • (2009) Science , vol.325 , pp. 201-204
    • Colman, R.J.1    Anderson, R.M.2    Johnson, S.C.3    Kastman, E.K.4    Kosmatka, K.J.5    Beasley, T.M.6    Allison, D.B.7    Cruzen, C.8
  • 12
    • 70349782312 scopus 로고    scopus 로고
    • Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain
    • 19747824 10.1016/j.cub.2009.08.016 1:CAS:528:DC%2BD1MXht1GksrbP
    • JM Copeland J Cho T Lo JH Hur S Bahadorani T Arabyan J Rabie J Soh, et al. 2009 Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain Curr. Biol. 19 1591 1598 19747824 10.1016/j.cub.2009.08.016 1:CAS:528:DC%2BD1MXht1GksrbP
    • (2009) Curr. Biol. , vol.19 , pp. 1591-1598
    • Copeland, J.M.1    Cho, J.2    Lo, T.3    Hur, J.H.4    Bahadorani, S.5    Arabyan, T.6    Rabie, J.7    Soh, J.8
  • 13
    • 29144446185 scopus 로고    scopus 로고
    • The SENS challenge: $20,000 says the foreseeable defeat of aging is not laughable
    • DOI 10.1089/rej.2005.8.207
    • de Grey AD 2005 The SENS challenge: 20,000 US dollars says the foreseeable defeat of aging is not laughable. Rejuvenation Res. 8 207-210 (Pubitemid 41814341)
    • (2005) Rejuvenation Research , vol.8 , Issue.4 , pp. 207-210
    • De Grey, A.D.N.J.1
  • 14
    • 70450212881 scopus 로고    scopus 로고
    • Hormone replacement therapy and successful pregnancy in a patient with premature ovarian failure
    • 19905994 10.3109/09513590903004126
    • S Dragojević-Dikić S Rakić B Nikolić S Popovac 2009 Hormone replacement therapy and successful pregnancy in a patient with premature ovarian failure Gynecol. Endocrinol. 25 769 72 19905994 10.3109/09513590903004126
    • (2009) Gynecol. Endocrinol. , vol.25 , pp. 769-72
    • Dragojević-Dikić, S.1    Rakić, S.2    Nikolić, B.3    Popovac, S.4
  • 15
    • 0347365764 scopus 로고    scopus 로고
    • An overview of current delivery systems in cancer gene therapy
    • DOI 10.1016/j.jconrel.2003.09.013
    • El-Aneed A 2004 An overview of current delivery systems in cancer gene therapy. J. Control. Release 94 1-14 (Pubitemid 37542373)
    • (2004) Journal of Controlled Release , vol.94 , Issue.1 , pp. 1-14
    • El-Aneed, A.1
  • 17
    • 0033540649 scopus 로고    scopus 로고
    • Sugar-mediated uptake of glycosylated polylysines and gene transfer into normal and cystic fibrosis airway epithelial cells
    • DOI 10.1089/10430349950018841
    • Fajac I, Briand P, Monsigny M and Midoux P 1999 Sugar-mediated uptake of glycosylated polylysines and gene transfer into normal and cystic fibrosis airway epithelial cells. Hum. Gene Ther. 10 395-406 (Pubitemid 29097318)
    • (1999) Human Gene Therapy , vol.10 , Issue.3 , pp. 395-406
    • Fajac, I.1    Briand, P.2    Monsigny, M.3    Midoux, P.4
  • 19
    • 77952578025 scopus 로고    scopus 로고
    • 20 years of gene therapy for SCID
    • 20485269 10.1038/ni0610-457 1:CAS:528:DC%2BC3cXmtFClsL0%3D
    • A Fischer S Hacein-Bey-Abina M Cavazzana-Calvo 2010 20 years of gene therapy for SCID Nat. Immunol. 11 457 460 20485269 10.1038/ni0610-457 1:CAS:528:DC%2BC3cXmtFClsL0%3D
    • (2010) Nat. Immunol. , vol.11 , pp. 457-460
    • Fischer, A.1    Hacein-Bey-Abina, S.2    Cavazzana-Calvo, M.3
  • 20
    • 34447625911 scopus 로고    scopus 로고
    • Epigenetics and aging: The targets and the marks
    • DOI 10.1016/j.tig.2007.05.008, PII S0168952507001862
    • Fraga MF and Esteller M 2007 Epigenetics and aging: The targets and the marks. Trends Genet. 23 413-418 (Pubitemid 47088010)
    • (2007) Trends in Genetics , vol.23 , Issue.8 , pp. 413-418
    • Fraga, M.F.1    Esteller, M.2
  • 22
    • 78650644717 scopus 로고    scopus 로고
    • Mutation in a mitochondrial ribosomal protein causes increased sensitivity to oxygen with decreased longevity in the nematode Caenorhabditis elegans
    • 21156009 10.1111/j.1365-2443.2010.01469.x 1:CAS:528:DC%2BC3MXhtV2rtrk%3D
    • M Fujii K Shikatani K Ogura Y Goshima D Ayusawa 2011 Mutation in a mitochondrial ribosomal protein causes increased sensitivity to oxygen with decreased longevity in the nematode Caenorhabditis elegans Genes Cells 16 69 79 21156009 10.1111/j.1365-2443.2010.01469.x 1:CAS:528:DC%2BC3MXhtV2rtrk%3D
    • (2011) Genes Cells , vol.16 , pp. 69-79
    • Fujii, M.1    Shikatani, K.2    Ogura, K.3    Goshima, Y.4    Ayusawa, D.5
  • 23
    • 70849124305 scopus 로고    scopus 로고
    • Ageing and cancer as diseases of epigenesist
    • 19920344 10.1007/s12038-009-0077-4 1:CAS:528:DC%2BD1MXhs1Wit7bE
    • SF Gilbert 2009 Ageing and cancer as diseases of epigenesist J. Biosci. 34 601 604 19920344 10.1007/s12038-009-0077-4 1:CAS:528:DC%2BD1MXhs1Wit7bE
    • (2009) J. Biosci. , vol.34 , pp. 601-604
    • Gilbert, S.F.1
  • 24
    • 62349089251 scopus 로고    scopus 로고
    • Oxidative damage and cognitive dysfunction: Antioxidant treatments to promote healthy brain aging
    • 18683046 10.1007/s11064-008-9808-4 1:CAS:528:DC%2BD1MXivVajsLo%3D
    • E Head 2009 Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging Neurochem. Res. 34 670 678 18683046 10.1007/s11064-008-9808-4 1:CAS:528:DC%2BD1MXivVajsLo%3D
    • (2009) Neurochem. Res. , vol.34 , pp. 670-678
    • Head, E.1
  • 25
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • DOI 10.1038/nature01298
    • M Holzenberger J Dupont B Ducos P Leneuve A Geloen PC Even P Cervera Y Le Bouc 2003 IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice Nature 421 182 187 12483226 10.1038/nature01298 1:CAS:528: DC%2BD3sXhs1KhtA%3D%3D (Pubitemid 36090987)
    • (2003) Nature , vol.421 , Issue.6919 , pp. 182-187
    • Holzenberger, M.1    Dupont, J.2    Ducos, B.3    Leneuve, P.4    Geloen, A.5    Even, P.C.6    Cervera, P.7    Le Bouc, Y.8
  • 26
    • 0036111173 scopus 로고    scopus 로고
    • Effects of the Pit1 mutation on the insulin signaling pathway: Implications on the longevity of the long-lived Snell dwarf mouse
    • DOI 10.1016/S0047-6374(02)00037-4, PII S0047637402000374
    • Hsieh CC, DeFord JH, Flurkey K, Harrison DE and Papaconstantinou J 2002 Effects of the Pit1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse. Mech. Ageing Dev. 123 1245-1255 (Pubitemid 34518556)
    • (2002) Mechanisms of Ageing and Development , vol.123 , Issue.9 , pp. 1245-1255
    • Hsieh, C.-C.1    DeFord, J.H.2    Flurkey, K.3    Harrison, D.E.4    Papaconstantinou, J.5
  • 27
    • 17144361835 scopus 로고    scopus 로고
    • Regaining lost youth: The controversial and colorful beginnings of hormone replacement therapy in aging
    • Kahn A 2005 Regaining lost youth: the controversial and colorful beginnings of hormone replacement therapy in aging. J. Gerontol. A Biol. Sci. Med. Sci. 60 142-147 (Pubitemid 40524852)
    • (2005) Journals of Gerontology - Series A Biological Sciences and Medical Sciences , vol.60 , Issue.2 , pp. 142-147
    • Kahn, A.1
  • 28
    • 38349109305 scopus 로고    scopus 로고
    • The genetics of ageing: Insight from genome-wide approaches in invertebrate model organisms
    • 18226092 10.1111/j.1365-2796.2007.01903.x 1:CAS:528:DC%2BD1cXjtFKktbo%3D
    • BK Kennedy 2008 The genetics of ageing: Insight from genome-wide approaches in invertebrate model organisms J. Intern. Med. 263 142 152 18226092 10.1111/j.1365-2796.2007.01903.x 1:CAS:528:DC%2BD1cXjtFKktbo%3D
    • (2008) J. Intern. Med. , vol.263 , pp. 142-152
    • Kennedy, B.K.1
  • 29
    • 77955124676 scopus 로고    scopus 로고
    • Calcium based non-viral gene delivery: An overview of methodology and applications
    • Khosravi-Darani K, Mozafari MR, Rashidi L and Mohammadi M 2010 Calcium based non-viral gene delivery: an overview of methodology and applications. Acta Med. Iran. 48 133-141
    • (2010) Acta Med. Iran. , vol.48 , pp. 133-141
    • Khosravi-Darani, K.1    Mozafari, M.R.2    Rashidi, L.3    Mohammadi, M.4
  • 30
    • 79952614101 scopus 로고    scopus 로고
    • In vivo nucleic acid delivery with PEI and its derivatives: Current status and perspectives
    • Lai WF 2011 In vivo nucleic acid delivery with PEI and its derivatives: current status and perspectives. Expert Rev. Med. Devices 8 173-185
    • (2011) Expert Rev. Med. Devices , vol.8 , pp. 173-185
    • Lai, W.F.1
  • 31
    • 79951833024 scopus 로고    scopus 로고
    • Beyond sole longevity: A social perspective on healthspan extension
    • Lai WF and Chan ZCY 2011 Beyond sole longevity: a social perspective on healthspan extension. Rejuvenation Res. 14 83-88
    • (2011) Rejuvenation Res. , vol.14 , pp. 83-88
    • Lai, W.F.1    Zcy, C.2
  • 32
    • 61349123258 scopus 로고    scopus 로고
    • Nucleic acid delivery with chitosan and its derivatives
    • Lai WF and Lin MCM 2009 Nucleic acid delivery with chitosan and its derivatives. J. Control. Release 134 158-168
    • (2009) J. Control. Release , vol.134 , pp. 158-168
    • Lai, W.F.1    McM, L.2
  • 34
    • 33751404334 scopus 로고    scopus 로고
    • Whole genome RNAi screens for increased longevity: Important new insights but not the whole story
    • DOI 10.1016/j.exger.2006.06.048, PII S0531556506002300
    • SS Lee 2006 Whole genome RNAi screens for increased longevity: important new insights but not the whole story Exp. Gerontol. 41 968 973 16891077 10.1016/j.exger.2006.06.048 1:CAS:528:DC%2BD28Xht1KrsLjI (Pubitemid 44821694)
    • (2006) Experimental Gerontology , vol.41 , Issue.10 , pp. 968-973
    • Lee, S.S.1
  • 35
    • 35448970692 scopus 로고    scopus 로고
    • Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: In vivo interaction with early-onset Alzheimer disease genes
    • DOI 10.1093/hmg/ddm219
    • A Li Z Xie Y Dong KM McKay ML McKee RE Tanzi 2007 Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes Hum. Mol. Genet. 16 2626 2639 17704509 10.1093/hmg/ddm219 1:CAS:528:DC%2BD2sXhtF2mtLbO (Pubitemid 47617729)
    • (2007) Human Molecular Genetics , vol.16 , Issue.21 , pp. 2626-2639
    • Li, A.1    Xie, Z.2    Dong, Y.3    Mckay, K.M.4    Mckee, M.L.5    Tanzi, R.E.6
  • 37
    • 38349018367 scopus 로고    scopus 로고
    • Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system
    • Madia F, Gattazzo C, Wei M, Fabrizio P, Burhans WC, Weinberger M, Galbani A, Smith JR, et al. 2008 Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J. Cell Biol. 180 67-81
    • (2008) J. Cell Biol. , vol.180 , pp. 67-81
    • Madia, F.1    Gattazzo, C.2    Wei, M.3    Fabrizio, P.4    Burhans, W.C.5    Weinberger, M.6    Galbani, A.7    Smith, J.R.8
  • 38
    • 78649823068 scopus 로고    scopus 로고
    • Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle
    • 20883771 10.1016/j.exger.2010.09.011 1:CAS:528:DC%2BC3cXhsFanu7fE
    • SH McKiernan RJ Colman M Lopez TM Beasley JM Aiken RM Anderson R Weindruch 2011 Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle Exp. Gerontol. 46 23 29 20883771 10.1016/j.exger.2010.09.011 1:CAS:528:DC%2BC3cXhsFanu7fE
    • (2011) Exp. Gerontol. , vol.46 , pp. 23-29
    • McKiernan, S.H.1    Colman, R.J.2    Lopez, M.3    Beasley, T.M.4    Aiken, J.M.5    Anderson, R.M.6    Weindruch, R.7
  • 39
    • 39449121888 scopus 로고    scopus 로고
    • Gene transfer with a vector expressing Maxi-K from a smooth muscle-specific promoter restores erectile function in the aging rat
    • DOI 10.1038/sj.gt.3303093, PII 3303093
    • Melman A, Biggs G, Davies K, Zhao W, Tar MT and Christ GJ 2008 Gene transfer with a vector expressing Maxi-K from a smooth muscle-specific promoter restores erectile function in the aging rat. Gene Ther. 15 364-370 (Pubitemid 351267378)
    • (2008) Gene Therapy , vol.15 , Issue.5 , pp. 364-370
    • Melman, A.1    Biggs, G.2    Davies, K.3    Zhao, W.4    Tar, M.T.5    Christ, G.J.6
  • 40
    • 78049312236 scopus 로고    scopus 로고
    • RNA interference in ageing research - A mini-review
    • 20090308 10.1159/000277626 1:CAS:528:DC%2BC3cXhtVyhurfP
    • N Minois P Sykacek B Godsey DP Kreil 2010 RNA interference in ageing research - a mini-review Gerontology 56 496 506 20090308 10.1159/000277626 1:CAS:528:DC%2BC3cXhtVyhurfP
    • (2010) Gerontology , vol.56 , pp. 496-506
    • Minois, N.1    Sykacek, P.2    Godsey, B.3    Kreil, D.P.4
  • 41
    • 33645226449 scopus 로고    scopus 로고
    • Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats
    • Mouravlev A, Dunning J, Young D and During MJ 2006 Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats. Proc. Natl. Acad. Sci. USA 103 4705-4710
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 4705-4710
    • Mouravlev, A.1    Dunning, J.2    Young, D.3    During, M.J.4
  • 42
    • 0034707074 scopus 로고    scopus 로고
    • Diabetes - Gene therapy for rats and mice
    • 11100710 10.1038/35044177 1:CAS:528:DC%2BD3cXos1SrsLg%3D
    • JM Olefsky 2000 Diabetes - gene therapy for rats and mice Nature 408 420 421 11100710 10.1038/35044177 1:CAS:528:DC%2BD3cXos1SrsLg%3D
    • (2000) Nature , vol.408 , pp. 420-421
    • Olefsky, J.M.1
  • 44
    • 33746269894 scopus 로고    scopus 로고
    • Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2
    • DOI 10.1111/j.1474-9726.2006.00225.x
    • AE Roux A Quissac P Chartrand G Ferbeyre LA Rokeach 2006 Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2 Aging Cell 5 345 357 16822282 10.1111/j.1474-9726.2006.00225.x 1:CAS:528:DC%2BD28Xoslait70%3D (Pubitemid 44103249)
    • (2006) Aging Cell , vol.5 , Issue.4 , pp. 345-357
    • Roux, A.E.1    Quissac, A.2    Chartrand, P.3    Ferbeyre, G.4    Rokeach, L.A.5
  • 45
    • 84887212354 scopus 로고    scopus 로고
    • Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production
    • Tang S, Le PK, Tse S, Wallace DC and Huang T 2009 Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production. PLoS One 4 e4492
    • (2009) PLoS One , vol.4
    • Tang, S.1    Le, P.K.2    Tse, S.3    Wallace, D.C.4    Huang, T.5
  • 46
    • 77953019511 scopus 로고    scopus 로고
    • Gene delivery by lipoplexes and polyplexes
    • 20359532 10.1016/j.ejps.2010.03.019 1:CAS:528:DC%2BC3cXmsVCrur4%3D
    • C Tros de Ilarduya Y Sun N Düzgüneş 2010 Gene delivery by lipoplexes and polyplexes Eur. J. Pharm. Sci. 40 159 170 20359532 10.1016/j.ejps.2010.03.019 1:CAS:528:DC%2BC3cXmsVCrur4%3D
    • (2010) Eur. J. Pharm. Sci. , vol.40 , pp. 159-170
    • Tros De Ilarduya, C.1    Sun, Y.2    Düzgüneş, N.3
  • 47
    • 0015885681 scopus 로고
    • The 5-methylcytosine in DNA of rats. Tissue and age specificity and the changes induced by hydrocortisone and other agents
    • 4763637 10.1159/000211967 1:CAS:528:DyaE2cXhsl2j
    • BF Vanyushin LE Nemirovsky VV Klimenko VK Vasiliev AN Belozersky 1973 The 5-methylcytosine in DNA of rats. Tissue and age specificity and the changes induced by hydrocortisone and other agents Gerontologia 19 138 152 4763637 10.1159/000211967 1:CAS:528:DyaE2cXhsl2j
    • (1973) Gerontologia , vol.19 , pp. 138-152
    • Vanyushin, B.F.1    Nemirovsky, L.E.2    Klimenko, V.V.3    Vasiliev, V.K.4    Belozersky, A.N.5
  • 48
    • 0034908634 scopus 로고    scopus 로고
    • Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence
    • DOI 10.1128/MCB.21.17.5889-5898.2001
    • Wang W, Yang X, Cristofalo VJ, Holbrook NJ and Gorospe M 2001 Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence. Mol. Cell Biol. 21 5889-5898 (Pubitemid 32737806)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.17 , pp. 5889-5898
    • Wang, W.1    Yang, X.2    Cristofalo, V.J.3    Holbrook, N.J.4    Gorospe, M.5
  • 49
    • 2542450965 scopus 로고    scopus 로고
    • Delayed angiogenesis in aging rats and therapeutic effect of adenoviral gene transfer of VEGF
    • 15010860 1:CAS:528:DC%2BD2cXjtFarurs%3D
    • H Wang JA Keiser B Olszewski W Rosebury A Robertson I Kovesdi D Gordon 2004 Delayed angiogenesis in aging rats and therapeutic effect of adenoviral gene transfer of VEGF Int. J. Mol. Med. 13 581 587 15010860 1:CAS:528: DC%2BD2cXjtFarurs%3D
    • (2004) Int. J. Mol. Med. , vol.13 , pp. 581-587
    • Wang, H.1    Keiser, J.A.2    Olszewski, B.3    Rosebury, W.4    Robertson, A.5    Kovesdi, I.6    Gordon, D.7
  • 50
    • 79953938360 scopus 로고
    • The Makropulos case: Reflections on the tedium of immortality
    • (ed) J Rachels (New York: Harper & Row)
    • Williams B 1975 The Makropulos case: reflections on the tedium of immortality; in Moral problems: a collection of philosophical essays (ed) J Rachels (New York: Harper & Row) pp 410-428
    • (1975) Moral Problems: A Collection of Philosophical Essays , pp. 410-428
    • Williams, B.1
  • 51
    • 0020638422 scopus 로고
    • DNA methylation decreases in aging but not in immortal cells
    • VL Wilson PA Jones 1983 DNA methylation decreases in aging but not in immortal cells Science 220 1055 1057 6844925 10.1126/science.6844925 1:CAS:528:DyaL3sXktVenurk%3D (Pubitemid 13090144)
    • (1983) Science , vol.220 , Issue.4601 , pp. 1055-1057
    • Wilson, V.L.1    Jones, P.A.2
  • 52
    • 34848827481 scopus 로고    scopus 로고
    • Hormone replacement up-to-date. Hormone replacement therapy in anti-aging medicine
    • Yonei Y, Takahashi Y and Hibino S 2007 Hormone replacement up-to-date. Hormone replacement therapy in anti-aging medicine. Clin. Calcium 17 1400-1406
    • (2007) Clin. Calcium , vol.17 , pp. 1400-1406
    • Yonei, Y.1    Takahashi, Y.2    Hibino, S.3
  • 54
    • 42249095447 scopus 로고    scopus 로고
    • A novel mutation of the WRN gene in a Chinese patient with Werner syndrome
    • DOI 10.1111/j.1365-2230.2007.02641.x
    • N Zhao F Hao T Qu YG Zuo BX Wang 2008 A novel mutation of the WRN gene in a Chinese patient with Werner syndrome Clin. Exp. Dermatol. 33 278 281 18205852 10.1111/j.1365-2230.2007.02641.x 1:STN:280:DC%2BD1c3lslyntw%3D%3D (Pubitemid 351550634)
    • (2008) Clinical and Experimental Dermatology , vol.33 , Issue.3 , pp. 278-281
    • Zhao, N.1    Hao, F.2    Qu, T.3    Zuo, Y.-G.4    Wang, B.-X.5
  • 55
    • 40049092674 scopus 로고    scopus 로고
    • A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: Both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms
    • 18056343 1:CAS:528:DC%2BD2sXhtlyitrnP
    • L Zheng R Sharma F Gaskin SM Fu ST Ju 2007 A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms J. Immunol. 179 8035 8041 18056343 1:CAS:528:DC%2BD2sXhtlyitrnP
    • (2007) J. Immunol. , vol.179 , pp. 8035-8041
    • Zheng, L.1    Sharma, R.2    Gaskin, F.3    Fu, S.M.4    Ju, S.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.