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Volumn 15, Issue 5, 2008, Pages 364-370

Gene transfer with a vector expressing Maxi-K from a smooth muscle-specific promoter restores erectile function in the aging rat

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

EID: 39449121888     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3303093     Document Type: Article
Times cited : (42)

References (31)
  • 1
    • 4444339494 scopus 로고    scopus 로고
    • Changes in sexual function in middle-aged and older men: Longitudinal data from the Massachusetts Male Aging Study
    • Araujo A, Mohr B, McKinlay J. Changes in sexual function in middle-aged and older men: Longitudinal data from the Massachusetts Male Aging Study. J Am Geriatr Soc 2004; 52: 1502-1509.
    • (2004) J Am Geriatr Soc , vol.52 , pp. 1502-1509
    • Araujo, A.1    Mohr, B.2    McKinlay, J.3
  • 2
    • 0035084495 scopus 로고    scopus 로고
    • Age-related prevalence of erectile dysfunction in Japan: Assessment by the international index of erectile function
    • Marumo K, Nakashima J, Muria M. Age-related prevalence of erectile dysfunction in Japan: Assessment by the international index of erectile function. Int J Urol 2001; 8: 53-59.
    • (2001) Int J Urol , vol.8 , pp. 53-59
    • Marumo, K.1    Nakashima, J.2    Muria, M.3
  • 3
    • 0344761974 scopus 로고    scopus 로고
    • The epidemiology and pathophysiology of erectile dysfunction
    • Melman A, Gingell JC. The epidemiology and pathophysiology of erectile dysfunction. J Urol 1999; 161: 5-11.
    • (1999) J Urol , vol.161 , pp. 5-11
    • Melman, A.1    Gingell, J.C.2
  • 4
    • 0028860594 scopus 로고
    • The epidemiology of erectile dysfunction
    • Benet AE, Melman A. The epidemiology of erectile dysfunction. Urol Clin North Am 1995; 22: 699-709.
    • (1995) Urol Clin North Am , vol.22 , pp. 699-709
    • Benet, A.E.1    Melman, A.2
  • 5
    • 0028880076 scopus 로고
    • Restoration of normal adult penile erectile response in aged rats by long term treatment with androgens
    • Garban H, Marquez D, Liping C, Rajfer J, Gonzalez-Cadavid N. Restoration of normal adult penile erectile response in aged rats by long term treatment with androgens. Bio Reprod 1995; 53: 1365-1372.
    • (1995) Bio Reprod , vol.53 , pp. 1365-1372
    • Garban, H.1    Marquez, D.2    Liping, C.3    Rajfer, J.4    Gonzalez-Cadavid, N.5
  • 6
    • 0027167570 scopus 로고
    • A review of erectile dysfunction: New insights and more questions
    • Lerner SE, Melman A, Christ GJ. A review of erectile dysfunction: New insights and more questions. J Urol 1993; 149: 1246-1255.
    • (1993) J Urol , vol.149 , pp. 1246-1255
    • Lerner, S.E.1    Melman, A.2    Christ, G.J.3
  • 7
    • 0036637599 scopus 로고    scopus 로고
    • The hemodynamics of erection and the pharmacotherapies of erectile dysfunction
    • Melman A, Christ GJ. The hemodynamics of erection and the pharmacotherapies of erectile dysfunction. Heart Dis 2002; 4 252-264.
    • (2002) Heart Dis , vol.4 , pp. 252-264
    • Melman, A.1    Christ, G.J.2
  • 8
    • 0034981758 scopus 로고    scopus 로고
    • Integrative erectile biology. The effects of age and disease on gap junctions and ion channels and their potential value to the treatment of erectile dysfunction
    • vii
    • Melman A, Christ GJ. Integrative erectile biology. The effects of age and disease on gap junctions and ion channels and their potential value to the treatment of erectile dysfunction. Urol Clin North Am 2001; 28: 217-231, vii.
    • (2001) Urol Clin North Am , vol.28 , pp. 217-231
    • Melman, A.1    Christ, G.J.2
  • 9
    • 0008627240 scopus 로고    scopus 로고
    • Smooth muscle pathology and erectile dysfunction
    • Wespes E. Smooth muscle pathology and erectile dysfunction. Int J Impot Res 2002; 14: S17-S21.
    • (2002) Int J Impot Res , vol.14
    • Wespes, E.1
  • 10
    • 0035110585 scopus 로고    scopus 로고
    • Aging-related expression of inducible nitric oxide synthase and marker of tissue damage in the rat penis
    • Ferrini M, Magee T, Vernet D, Rajfer J, Gonzalez-Cadavid N. Aging-related expression of inducible nitric oxide synthase and marker of tissue damage in the rat penis. Bio Reprod 2001; 64: 974-982.
    • (2001) Bio Reprod , vol.64 , pp. 974-982
    • Ferrini, M.1    Magee, T.2    Vernet, D.3    Rajfer, J.4    Gonzalez-Cadavid, N.5
  • 11
    • 0037301102 scopus 로고    scopus 로고
    • Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via Rho-kinase-beta
    • Chang S, Hypolite JA, Changolkar A, Wein AJ, Chacko S, DiSanto ME. Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via Rho-kinase-beta. Int J Impot Res 2003; 15: 53-62.
    • (2003) Int J Impot Res , vol.15 , pp. 53-62
    • Chang, S.1    Hypolite, J.A.2    Changolkar, A.3    Wein, A.J.4    Chacko, S.5    DiSanto, M.E.6
  • 12
    • 34548043524 scopus 로고    scopus 로고
    • Effect of aging on the endothelial function of the penile corpus cavernosum in rats
    • Li J, Wang G, Qin W, Yang Y. Effect of aging on the endothelial function of the penile corpus cavernosum in rats. Zonghua Nan Ke Xue 2004; 10: 824-826.
    • (2004) Zonghua Nan Ke Xue , vol.10 , pp. 824-826
    • Li, J.1    Wang, G.2    Qin, W.3    Yang, Y.4
  • 13
    • 0036461641 scopus 로고    scopus 로고
    • Detection and implications of potassium channel alterations
    • Korovkina VP, England SK. Detection and implications of potassium channel alterations. Vascul Pharmacol 2002; 38: 3-12.
    • (2002) Vascul Pharmacol , vol.38 , pp. 3-12
    • Korovkina, V.P.1    England, S.K.2
  • 14
    • 0031827271 scopus 로고    scopus 로고
    • Intracorporal injection of hSlo cDNA in rats produces physiologically relevant alterations in penile function
    • Christ GJ, Rehman J, Day N, Salkoff L, Valcic M, Melman A et al. Intracorporal injection of hSlo cDNA in rats produces physiologically relevant alterations in penile function. Am J Physiol 1998; 275 H600-H608.
    • (1998) Am J Physiol , vol.275
    • Christ, G.J.1    Rehman, J.2    Day, N.3    Salkoff, L.4    Valcic, M.5    Melman, A.6
  • 15
    • 0038340638 scopus 로고    scopus 로고
    • The successful long-term treatment of age related erectile dysfunction with hSlo cDNA in rats in vivo
    • Melman A, Zhao W, Davies KP, Bakal R, Christ GJ. The successful long-term treatment of age related erectile dysfunction with hSlo cDNA in rats in vivo. J Urol 2003; 170: 285-290.
    • (2003) J Urol , vol.170 , pp. 285-290
    • Melman, A.1    Zhao, W.2    Davies, K.P.3    Bakal, R.4    Christ, G.J.5
  • 16
  • 17
    • 21844432423 scopus 로고    scopus 로고
    • The first human trial for gene transfer therapy for the treatment of enrectile dysfunction preliminary results
    • Melman A, Bar-Chama N, McCullough A, Davies K, Christ G. The first human trial for gene transfer therapy for the treatment of enrectile dysfunction preliminary results. Eur Urol 2005; 48: 314-318.
    • (2005) Eur Urol , vol.48 , pp. 314-318
    • Melman, A.1    Bar-Chama, N.2    McCullough, A.3    Davies, K.4    Christ, G.5
  • 18
    • 33845774784 scopus 로고    scopus 로고
    • hMaxi-K gene transfer in males with erectile dysfunction: Results of the first hupian trial
    • Melman A, Bar-Chama N, McCullough A, Davies K, Christ G. hMaxi-K gene transfer in males with erectile dysfunction: Results of the first hupian trial. Hum Gene Ther 2006; 18: 1165-1176.
    • (2006) Hum Gene Ther , vol.18 , pp. 1165-1176
    • Melman, A.1    Bar-Chama, N.2    McCullough, A.3    Davies, K.4    Christ, G.5
  • 21
    • 0142213213 scopus 로고    scopus 로고
    • Overexpression of semicarbazide-sensitive amine oxidase in smooth muscle cells leads to an abnormal structure of the aortic elastic laminas
    • Gokturk C, Nilsson J, Nordquist J, Kristensson M, Svensson K, Soderberg C et al. Overexpression of semicarbazide-sensitive amine oxidase in smooth muscle cells leads to an abnormal structure of the aortic elastic laminas. Am J Pathol 2003; 163: 1921-1928.
    • (2003) Am J Pathol , vol.163 , pp. 1921-1928
    • Gokturk, C.1    Nilsson, J.2    Nordquist, J.3    Kristensson, M.4    Svensson, K.5    Soderberg, C.6
  • 22
    • 0242468494 scopus 로고    scopus 로고
    • Altered renal hemodynamics in mice overexpressing the parathyroid hormone (PTH)/ PTH-related peptide type 1 receptor in smooth muscle
    • Noonan WT, Qian J, Stuart WD, Clemens TL, Lorenz JN. Altered renal hemodynamics in mice overexpressing the parathyroid hormone (PTH)/ PTH-related peptide type 1 receptor in smooth muscle. Endocrinology 2003; 144: 4931-4938.
    • (2003) Endocrinology , vol.144 , pp. 4931-4938
    • Noonan, W.T.1    Qian, J.2    Stuart, W.D.3    Clemens, T.L.4    Lorenz, J.N.5
  • 23
    • 0037077257 scopus 로고    scopus 로고
    • Targeted expression of a protease-resistant IGFBP-4 mutant in smooth muscle of transgenic mice results in IGFBP-4 stabilization and smooth muscle hypotrophy
    • Zhang M, Smith EP, Kuroda H, Banach W, Chernausek SD, Fagin JA. Targeted expression of a protease-resistant IGFBP-4 mutant in smooth muscle of transgenic mice results in IGFBP-4 stabilization and smooth muscle hypotrophy. J Biol Chem 2002; 277: 21285-21290.
    • (2002) J Biol Chem , vol.277 , pp. 21285-21290
    • Zhang, M.1    Smith, E.P.2    Kuroda, H.3    Banach, W.4    Chernausek, S.D.5    Fagin, J.A.6
  • 24
    • 0035106356 scopus 로고    scopus 로고
    • Smooth muscle-targeted overexpression of insulin-like growth factor I results in enhanced vascular contractility
    • Zhao G, Sutliff RL, Weber CS, Wang J, Lorenz J, Paul RJ et al. Smooth muscle-targeted overexpression of insulin-like growth factor I results in enhanced vascular contractility. Endocrinology 2001; 142: 623-632.
    • (2001) Endocrinology , vol.142 , pp. 623-632
    • Zhao, G.1    Sutliff, R.L.2    Weber, C.S.3    Wang, J.4    Lorenz, J.5    Paul, R.J.6
  • 25
    • 0033019212 scopus 로고    scopus 로고
    • Reduced blood pressure and increased sensitivity of the vasculature to parathyroid hormone-related protein (PTHrP) in transgenic mice overexpressing the PTH/PTHrP receptor in vascular smooth muscle
    • Qian J, Lorenz JN, Maeda S, Sutliff RL, Weber C, Nakayama T et al. Reduced blood pressure and increased sensitivity of the vasculature to parathyroid hormone-related protein (PTHrP) in transgenic mice overexpressing the PTH/PTHrP receptor in vascular smooth muscle. Endocrinology 1999; 140: 1826-1833.
    • (1999) Endocrinology , vol.140 , pp. 1826-1833
    • Qian, J.1    Lorenz, J.N.2    Maeda, S.3    Sutliff, R.L.4    Weber, C.5    Nakayama, T.6
  • 26
    • 0031790160 scopus 로고    scopus 로고
    • Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia
    • Wang J, Niu W, Witte DP, Chernausek SD, Nikiforov YE, Clemens TL et al. Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinology 1998; 139: 2605-2614.
    • (1998) Endocrinology , vol.139 , pp. 2605-2614
    • Wang, J.1    Niu, W.2    Witte, D.P.3    Chernausek, S.D.4    Nikiforov, Y.E.5    Clemens, T.L.6
  • 27
    • 0025733352 scopus 로고
    • Transcriptional regulatory elements in the 5′ upstream and first regions of the humans smooth muscle (aortic type) alpha-actin-encoding gene
    • Nakano Y, Nishihara T, Sasayama S, Miwa T, Kamada S, Kakunaga T. Transcriptional regulatory elements in the 5′ upstream and first regions of the humans smooth muscle (aortic type) alpha-actin-encoding gene. Gene 1991; 99: 285-289.
    • (1991) Gene , vol.99 , pp. 285-289
    • Nakano, Y.1    Nishihara, T.2    Sasayama, S.3    Miwa, T.4    Kamada, S.5    Kakunaga, T.6
  • 28
    • 0035860832 scopus 로고    scopus 로고
    • Targeted overexpression CCAAT/enhanced-binding protein-d evokes enhanced gene transcription of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells
    • Yang Z-H, Kitami Y, Takata Y, Okura T, Hiwada K. Targeted overexpression CCAAT/enhanced-binding protein-d evokes enhanced gene transcription of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells. Circ Res 2001; 89: 503-508.
    • (2001) Circ Res , vol.89 , pp. 503-508
    • Yang, Z.-H.1    Kitami, Y.2    Takata, Y.3    Okura, T.4    Hiwada, K.5
  • 29
    • 14744282879 scopus 로고    scopus 로고
    • Gene medicines: The end of the beginning?
    • Rolland A. Gene medicines: The end of the beginning? Adv Drug Deliv Rev 2005; 57: 669-673.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 669-673
    • Rolland, A.1
  • 30
    • 0345867239 scopus 로고    scopus 로고
    • Urogenital tract expression of enhanced green fluorescent in transgenic mice driven by a smooth muscle [gamma]-actin promoter
    • Szucik JC, Lewis AG, Marmer DJ, Lessard JL. Urogenital tract expression of enhanced green fluorescent in transgenic mice driven by a smooth muscle [gamma]-actin promoter. J Urol 2004; 171: 944-949.
    • (2004) J Urol , vol.171 , pp. 944-949
    • Szucik, J.C.1    Lewis, A.G.2    Marmer, D.J.3    Lessard, J.L.4
  • 31
    • 15044366000 scopus 로고    scopus 로고
    • Proceedings of the Baltimore smooth muscle meeting: Identifying research frontiers and priorities for the lower urinary tract
    • Christ GJ, Liebert M. Proceedings of the Baltimore smooth muscle meeting: Identifying research frontiers and priorities for the lower urinary tract. J Urol 2005; 173: 1406-1409.
    • (2005) J Urol , vol.173 , pp. 1406-1409
    • Christ, G.J.1    Liebert, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.