QuantiWcation of regulatory T cells in peripheral blood of patients with systemic lupus erythematosus

Rheumatology International

Volumn 31, Issue 9, 2011, Pages 1219-1225

  Habibagahi, Mojtaba ^a   Habibagahi, Zahra ^a   Jaberipour, Mansooreh ^b   Aghdashi, Amir ^a  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Autoimmune disease; SLE; Treg

Indexed keywords

APRIL PROTEIN; AZATHIOPRINE; CYCLOPHOSPHAMIDE; HYDROXYCHLOROQUINE; PREDNISOLONE; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL2RA PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR ALPHA;

ADOLESCENT; ADULT; ANTIGEN EXPRESSION; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE ACTIVITY; FEMALE; FLOW CYTOMETRY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEPHRITIS; PRIORITY JOURNAL; RATING SCALE; REGULATORY T LYMPHOCYTE; SCORING SYSTEM; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; BLOOD; CD4 LYMPHOCYTE COUNT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; HOSPITALIZATION; IMMUNOLOGY; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; CD4 LYMPHOCYTE COUNT; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 80054963956     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-010-1427-0     Document Type: Article

References (44)

1. Tan EM (1997) Autoantibodies and autoimmunity: a three-decade perspective. A tribute to Henry G. Kunkel. Ann NY Acad Sci 815:1-14 (Pubitemid 27309484)
2. Bohm M, Luger TA, Schneider M, Schwarz T, Kuhn A (2006) New insight into immunosuppression and treatment of autoimmune diseases. Clin Exp Rheumatol 24:S67-S71
3. Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G (2001) Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med 193:1303-1310 (Pubitemid 32524780)
4. Baecher-Allan C, Brown JA, Freeman GJ, HaXer DA (2001) CD4+CD25high regulatory cells in human peripheral blood. J Immunol 167:1245-1253 (Pubitemid 32703119)
5. Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057-1061 (Pubitemid 36222930)
6. Hsu WT, Suen JL, Chiang BL (2006) The role of CD4CD25 T cells in autoantibody production in murine lupus. Clin Exp Immunol 145:513-519
7. Crispin JC, Martinez A, Alcocer-Varela J (2003) QuantiWcation of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 21:273-276 (Pubitemid 37410115)
8. Lee JH, Wang LC, Lin YT, Yang YH, Lin DT, Chiang BL (2006) Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus. Immunology 117:280-286
9. Liu MF, Wang CR, Fung LL, Wu CR (2004) Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus. Scand J Immunol 59:198-202
10. Miyara M, Amoura Z, Parizot C, Badoual C, Dorgham K, Trad S, Nochy D, Debre P, Piette JC, Gorochov G (2005) Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 175:8392-8400 (Pubitemid 41798406)
11. Cao D, Malmstrom V, Baecher-Allan C, HaXer D, Klareskog L, Trollmo C (2003) Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol 33:215-223 (Pubitemid 36157659)
12. Cepika AM, Marinic I, Morovic-Vergles J, Soldo-Juresa D, Gagro A (2007) EVect of steroids on the frequency of regulatory T cells and expression of FOXP3 in a patient with systemic lupus erythe-matosus: a two-year follow-up. Lupus 16:374-377 (Pubitemid 47074842)
13. Cools N, Ponsaerts P, Van Tendeloo VF, Berneman ZN (2007) Regulatory T cells and human disease. Clin Dev Immunol 2007:89195
14. Hochberg MC (1997) Updating the American College of rheumatology revised criteria for the classiWcation of systemic lupus ery-thematosus. Arthritis Rheum 40:1725
15. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH (1992) Derivation of the SLEDAI. A disease activity index for lupus patients. The committee on prognosis studies in SLE. Arthritis Rheum 35:630-640
16. Yan B, Liu Y (2009) The nature of increased circulating CD4CD25Foxp3 T cells in patients with systemic lupus erythema-tosus: a novel hypothesis. Open Rheumatol J 3:22-24
17. Levings MK, Sangregorio R, Roncarolo MG (2001) Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 193:1295-1302
18. Esensten JH, Wofsy D, Bluestone JA (2009) Regulatory T cells as therapeutic targets in rheumatoid arthritis. Nat Rev Rheumatol 5:560-565
19. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St GB, Clayberger C, Soper DM, Ziegler SF, Bluestone JA (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 203:1701-1711 (Pubitemid 44036276)
20. Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, Ghosh T, Atkinson MA, Bluestone JA (2009) Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes 58:652-662
21. Torchia D, Caproni M, Volpi W, Fabbri P (2009) Naturally occurring regulatory T cells in mucous membrane pemphigoid lesions. Acta Dermatovenerol Alp Panonica Adriat 18:3-6
22. Valencia X, Yarboro C, Illei G, Lipsky PE (2007) DeWcient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 178:2579-2588 (Pubitemid 46233461)
23. Su MA, Stenerson M, Liu W, Putnam A, Conte F, Bluestone JA, Anderson MS (2009) The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients. Clin Immunol 131:139-144
24. Kuhn A, Beissert S, Krammer PH (2009) CD4(+)CD25 (+) regulatory T cells in human lupus erythematosus. Arch Dermatol Res 301:71-81
25. Barath S, Aleksza M, Tarr T, Sipka S, Szegedi G, Kiss E (2007) Measurement of natural (CD4+CD25high) and inducible (CD4+IL-10+) regulatory T cells in patients with systemic lupus erythematosus. Lupus 16:489-496 (Pubitemid 47242522)
26. Fathy A, Mohamed RW, TawWk GA, Omar AS (2005) Diminished CD4+CD25+ T-lymphocytes in peripheral blood of patients with systemic lupus erythematosus. Egypt J Immunol 12:25-31
27. Lyssuk EY, Torgashina AV, Soloviev SK, Nassonov EL, Bykovskaia SN (2007) Reduced number and function of CD4+ CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus. Adv Exp Med Biol 601:113-119
28. Vargas-Rojas MI, Crispin JC, Richaud-Patin Y, cocer-Varela J (2008) Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance. Lupus 17:289-294 (Pubitemid 351655795)
29. Bonelli M, Savitskaya A, von Dalwigk K, Steiner CW, Aletaha D, Smolen JS, Scheinecker C (2008) Quantitative and qualitative deWciencies of regulatory T cells in patients with systemic lupus erythematosus (SLE). Int Immunol 20:861-868 (Pubitemid 351876312)
30. Azab NA, Bassyouni IH, Emad Y, El-Wahab GA, Hamdy G, Mashahit MA (2008) CD4+CD25+ regulatory T cells (TREG) in systemic lupus erythematosus (SLE) patients: the possible inXu-ence of treatment with corticosteroids. Clin Immunol 127:151-157
31. Suarez A, Lopez P, Gomez J, Gutierrez C (2006) Enrichment of CD4+ CD25high T cell population in patients with systemic lupus erythematosus treated with glucocorticoids. Ann Rheum Dis 65:1512-1517 (Pubitemid 44629132)
32. SWkakis PP, Souliotis VL, Fragiadaki KG, Moutsopoulos HM, Boletis JN, TheoWlopoulos AN (2007) Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis. Clin Immunol 123:66-73 (Pubitemid 46401511)
33. Barreto M, Ferreira RC, Lourenco L, Moraes-Fontes MF, Santos E, Alves M, Carvalho C, Martins B, Andreia R, Viana JF, Vasconcelos C, Mota-Vieira L, Ferreira C, Demengeot J, Vicente AM (2009) Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGFbeta gene variants. BMC Immunol 10:5
34. Lin SC, Chen KH, Lin CH, Kuo CC, Ling QD, Chan CH (2007) The quantitative analysis of peripheral blood FOXP3-expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients. Eur J Clin Invest 37:987-996
35. Lee HY, Hong YK, Yun HJ, Kim YM, Kim JR, Yoo WH (2008) Altered frequency and migration capacity of CD4+CD25+ regulatory T cells in systemic lupus erythematosus. Rheumatology (Oxford) 47:789-794
36. Barath S, Soltesz P, Kiss E, Aleksza M, Zeher M, Szegedi G, Sipka S (2007) The severity of systemic lupus erythematosus negatively correlates with the increasing number of CD4+CD25(high) FoxP3+ regulatory T cells during repeated plasmapheresis treatments of patients. Autoimmunity 40:521-528 (Pubitemid 351233173)
37. Wu HY, Center EM, Tsokos GC, Weiner HL (2009) Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells. Lupus 18:586-596
38. Zhang B, Zhang X, Tang F, Zhu L, Liu Y (2008) Reduction of forkhead box P3 levels in CD4+CD25high T cells in patients with new-onset systemic lupus erythematosus. Clin Exp Immunol 153:182-187 (Pubitemid 351989160)
39. Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY (2005) Regulatory T cell lineage speciWcation by the forkhead transcription factor foxp3. Immunity 22:329-341 (Pubitemid 40387475)
40. Roncador G, Brown PJ, Maestre L, Hue S, Martinez-Torrecuadra-da JL, Ling KL, Pratap S, Toms C, Fox BC, Cerundolo V, Powrie F, Banham AH (2005) Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol 35:1681-1691 (Pubitemid 40862316)
41. Bonelli M, Savitskaya A, Steiner CW, Rath E, Smolen JS, Scheinecker C (2009) Phenotypic and functional analysis of CD4+. J Immunol 182:1689-1695
42. Zhang B, Zhang X, Tang FL, Zhu LP, Liu Y, Lipsky PE (2008) Clinical signiWcance of increased CD4+CD25-Foxp3+ T cells in patients with new-onset systemic lupus erythematosus. Ann Rheum Dis 67:1037-1040 (Pubitemid 351956671)
43. Bonelli M, von Dalwigk K, Savitskaya A, Smolen JS, Scheinecker C (2007) Foxp3 expression in CD4+ T cells of patients with systemic lupus erythematosus (SLE): a comparative phenotypic analysis. Ann Rheum Dis 67:664-671
44. Zelenay S, Lopes-Carvalho T, Caramalho I, Moraes-Fontes MF, Rebelo M, Demengeot J (2005) Foxp3+ CD25-CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc Natl Acad Sci USA 102:4091-4096 (Pubitemid 40388560)