메뉴 건너뛰기




Volumn 3, Issue , 2009, Pages 22-24

The nature of increased circulating CD4+CD25 -Foxp3+ T cells in patients with systemic lupus erythematosus: A novel hypothesis

Author keywords

Foxp3; Regulatory T cells; Systemic lupus erythematosus

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

EID: 77953422283     PISSN: None     EISSN: 18743129     Source Type: Journal    
DOI: 10.2174/1874312900903010022     Document Type: Article
Times cited : (19)

References (30)
  • 1
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008; 133(5): 775-87.
    • (2008) Cell , vol.133 , Issue.5 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 2
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow ME, Jeffery EW, Hjerrild KA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001; 27(1): 68-73.
    • (2001) Nat Genet , vol.27 , Issue.1 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3
  • 3
    • 0035167967 scopus 로고    scopus 로고
    • Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001; 27(1): 20-1.
    • Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001; 27(1): 20-1.
  • 4
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299(5609): 1057-61.
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 5
    • 33846923124 scopus 로고    scopus 로고
    • IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells
    • Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol 2007; 178(4): 2018-27.
    • (2007) J Immunol , vol.178 , Issue.4 , pp. 2018-2027
    • Zheng, S.G.1    Wang, J.2    Wang, P.3    Gray, J.D.4    Horwitz, D.A.5
  • 6
    • 33947644716 scopus 로고    scopus 로고
    • Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells
    • Davidson TS, DiPaolo RJ, Andersson J, Shevach EM. Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J Immunol 2007; 178(7): 4022-6.
    • (2007) J Immunol , vol.178 , Issue.7 , pp. 4022-4026
    • Davidson, T.S.1    DiPaolo, R.J.2    Andersson, J.3    Shevach, E.M.4
  • 7
    • 0346969978 scopus 로고    scopus 로고
    • Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells
    • Walker MR, Kasprowicz DJ, Gersuk VH, et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J Clin Invest 2003; 112(9): 1437-43.
    • (2003) J Clin Invest , vol.112 , Issue.9 , pp. 1437-1443
    • Walker, M.R.1    Kasprowicz, D.J.2    Gersuk, V.H.3
  • 8
    • 33947121146 scopus 로고    scopus 로고
    • Transient regulatory T-cells: A state attained by all activated human T-cells
    • Pillai V, Ortega SB, Wang CK, Karandikar NJ. Transient regulatory T-cells: a state attained by all activated human T-cells. Clin Immunol 2007; 123(1): 18-29.
    • (2007) Clin Immunol , vol.123 , Issue.1 , pp. 18-29
    • Pillai, V.1    Ortega, S.B.2    Wang, C.K.3    Karandikar, N.J.4
  • 11
    • 20844432429 scopus 로고    scopus 로고
    • Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level
    • Roncador G, Brown PJ, Maestre L, et al. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol 2005; 35(6): 1681-91.
    • (2005) Eur J Immunol , vol.35 , Issue.6 , pp. 1681-1691
    • Roncador, G.1    Brown, P.J.2    Maestre, L.3
  • 12
    • 36349010693 scopus 로고    scopus 로고
    • The quantitative analysis of peripheral blood FOXP3-expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients
    • Lin SC, Chen KH, Lin CH, Kuo CC, Ling QD, Chan CH. The quantitative analysis of peripheral blood FOXP3-expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients. Eur J Clin Invest 2007; 37(12): 987-96.
    • (2007) Eur J Clin Invest , vol.37 , Issue.12 , pp. 987-996
    • Lin, S.C.1    Chen, K.H.2    Lin, C.H.3    Kuo, C.C.4    Ling, Q.D.5    Chan, C.H.6
  • 13
    • 46849087978 scopus 로고    scopus 로고
    • Clinical significance of increased CD4+CD25-Foxp3+ T cells in patients with new-onset systemic lupus erythematosus
    • Zhang B, Zhang X, Tang FL, Zhu LP, Liu Y, Lipsky PE. Clinical significance of increased CD4+CD25-Foxp3+ T cells in patients with new-onset systemic lupus erythematosus. Ann Rheum Dis 2008; 67(7): 1037-40.
    • (2008) Ann Rheum Dis , vol.67 , Issue.7 , pp. 1037-1040
    • Zhang, B.1    Zhang, X.2    Tang, F.L.3    Zhu, L.P.4    Liu, Y.5    Lipsky, P.E.6
  • 14
    • 42449123048 scopus 로고    scopus 로고
    • Foxp3 expression in CD4+ T cells of patients with systemic lupus erythematosus: A comparative phenotypic analysis
    • Bonelli M, von Dalwigk K, Savitskaya A, Smolen JS, Scheinecker C. Foxp3 expression in CD4+ T cells of patients with systemic lupus erythematosus: a comparative phenotypic analysis. Ann Rheum Dis 2008; 67(5): 664-71.
    • (2008) Ann Rheum Dis , vol.67 , Issue.5 , pp. 664-671
    • Bonelli, M.1    von Dalwigk, K.2    Savitskaya, A.3    Smolen, J.S.4    Scheinecker, C.5
  • 15
    • 65449149735 scopus 로고    scopus 로고
    • Altered homeostasis of CD4 (+)FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus
    • Suen JL, Li HT, Jong YJ, Chiang BL, Yen JH. Altered homeostasis of CD4 (+)FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus. Immunology 2008; 127(2): 196-205.
    • (2008) Immunology , vol.127 , Issue.2 , pp. 196-205
    • Suen, J.L.1    Li, H.T.2    Jong, Y.J.3    Chiang, B.L.4    Yen, J.H.5
  • 16
    • 63149094153 scopus 로고    scopus 로고
    • Phenotypic and functional analysis of CD4+ CD25-Foxp3+ T cells in patients with systemic lupus erythematosus
    • Bonelli M, Savitskaya A, Steiner CW, Rath E, Smolen JS, Scheinecker C. Phenotypic and functional analysis of CD4+ CD25-Foxp3+ T cells in patients with systemic lupus erythematosus. J Immunol 2009; 182(3): 1689-95.
    • (2009) J Immunol , vol.182 , Issue.3 , pp. 1689-1695
    • Bonelli, M.1    Savitskaya, A.2    Steiner, C.W.3    Rath, E.4    Smolen, J.S.5    Scheinecker, C.6
  • 17
    • 34249337428 scopus 로고    scopus 로고
    • Immunopathogenesis of systemic lupus ertyhematosus
    • Mittal G, Mason L, Isenberg D. Immunopathogenesis of systemic lupus ertyhematosus. Future Rheumatol 2007; 2(1): 93-103.
    • (2007) Future Rheumatol , vol.2 , Issue.1 , pp. 93-103
    • Mittal, G.1    Mason, L.2    Isenberg, D.3
  • 18
    • 62349128189 scopus 로고    scopus 로고
    • Horwitz DA. Regulatory T cells in systemic lupus erythematosus: past, present and future. Arthritis Res Ther 2008; 10(6): 227-235.
    • Horwitz DA. Regulatory T cells in systemic lupus erythematosus: past, present and future. Arthritis Res Ther 2008; 10(6): 227-235.
  • 19
    • 15244354491 scopus 로고    scopus 로고
    • De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells
    • Walker MR, Carson BD, Nepom GT, Ziegler SF, Buckner JH. De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells. Proc Natl Acad Sci USA 2005; 102(11): 4103-8.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.11 , pp. 4103-4108
    • Walker, M.R.1    Carson, B.D.2    Nepom, G.T.3    Ziegler, S.F.4    Buckner, J.H.5
  • 20
    • 33748296240 scopus 로고    scopus 로고
    • Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo
    • Vukmanovic-Stejic M, Zhang Y, Cook JE, et al. Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J Clin Invest 2006; 116(9): 2423-33.
    • (2006) J Clin Invest , vol.116 , Issue.9 , pp. 2423-2433
    • Vukmanovic-Stejic, M.1    Zhang, Y.2    Cook, J.E.3
  • 21
    • 40549128298 scopus 로고    scopus 로고
    • Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells
    • Yan B, Ye S, Chen G, Kuang M, Shen N, Chen S. Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells. Arthritis Rheum 2008; 58(3): 801-12.
    • (2008) Arthritis Rheum , vol.58 , Issue.3 , pp. 801-812
    • Yan, B.1    Ye, S.2    Chen, G.3    Kuang, M.4    Shen, N.5    Chen, S.6
  • 22
    • 47249145164 scopus 로고    scopus 로고
    • Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127 -/low regulatory T cells in patients with active systemic lupus erythematosus
    • Venigalla RK, Tretter T, Krienke S, et al. Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127 -/low regulatory T cells in patients with active systemic lupus erythematosus. Arthritis Rheum 2008; 58(7): 2120-30.
    • (2008) Arthritis Rheum , vol.58 , Issue.7 , pp. 2120-2130
    • Venigalla, R.K.1    Tretter, T.2    Krienke, S.3
  • 23
    • 61449187505 scopus 로고    scopus 로고
    • Walker LS. Regulatory T cells overturned: the effectors fight back. Immunology 2009; 126(4): 466-74.
    • Walker LS. Regulatory T cells overturned: the effectors fight back. Immunology 2009; 126(4): 466-74.
  • 24
    • 29144516273 scopus 로고    scopus 로고
    • Global natural regulatory T cell depletion in active systemic lupus erythematosus
    • Miyara M, Amoura Z, Parizot C, et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005; 175(12): 8392-400.
    • (2005) J Immunol , vol.175 , Issue.12 , pp. 8392-8400
    • Miyara, M.1    Amoura, Z.2    Parizot, C.3
  • 25
    • 34548223736 scopus 로고    scopus 로고
    • Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus
    • Chun HY, Chung JW, Kim HA, et al. Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus. J Clin Immunol 2007; 27(5): 461-6.
    • (2007) J Clin Immunol , vol.27 , Issue.5 , pp. 461-466
    • Chun, H.Y.1    Chung, J.W.2    Kim, H.A.3
  • 26
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003; 299(5609): 1033-6.
    • (2003) Science , vol.299 , Issue.5609 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 27
    • 34249799285 scopus 로고    scopus 로고
    • Cutting edge: Regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta
    • Xu L, Kitani A, Fuss I, Strober W. Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J Immunol 2007; 178(11): 6725-9.
    • (2007) J Immunol , vol.178 , Issue.11 , pp. 6725-6729
    • Xu, L.1    Kitani, A.2    Fuss, I.3    Strober, W.4
  • 28
    • 16844376445 scopus 로고    scopus 로고
    • Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
    • Juang YT, Wang Y, Solomou EE, et al. Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. J Clin Invest 2005; 115(4): 996-1005.
    • (2005) J Clin Invest , vol.115 , Issue.4 , pp. 996-1005
    • Juang, Y.T.1    Wang, Y.2    Solomou, E.E.3
  • 29
    • 0032911002 scopus 로고    scopus 로고
    • Cytokine-mediated down-regulation of B cell activity in SLE: Effects of interleukin-2 and transforming growth factor-beta
    • Ohtsuka K, Gray JD, Quismorio FP Jr., Lee W, Horwitz DA. Cytokine-mediated down-regulation of B cell activity in SLE: effects of interleukin-2 and transforming growth factor-beta. Lupus 1999; 8(2): 95-102.
    • (1999) Lupus , vol.8 , Issue.2 , pp. 95-102
    • Ohtsuka, K.1    Gray, J.D.2    Quismorio Jr., F.P.3    Lee, W.4    Horwitz, D.A.5
  • 30
    • 15244340167 scopus 로고    scopus 로고
    • Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion
    • Zelenay S, Lopes-Carvalho T, Caramalho I, Moraes-Fontes MF, Rebelo M, Demengeot J. Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc Natl Acad Sci USA 2005; 102(11): 4091-6.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.11 , pp. 4091-4096
    • Zelenay, S.1    Lopes-Carvalho, T.2    Caramalho, I.3    Moraes-Fontes, M.F.4    Rebelo, M.5    Demengeot, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.