Smad2 functions as a co-activator of canonical Wnt/β-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300

Cellular Signalling

Volumn 20, Issue 9, 2008, Pages 1632-1641

  Hirota, Morihisa ^a,b   Watanabe, Kazuhide ^a,b   Hamada, Shin ^a,b   Sun, Youping ^a,e   Strizzi, Luigi ^a,c   Mancino, Mario ^a,f   Nagaoka, Tadahiro ^a   Gonzales, Monica ^a   Seno, Masaharu ^d   Bianco, Caterina ^a   Salomon, David S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b TOHOKU UNIVERSITY   (Japan)

^c NORTHWESTERN UNIVERSITY   (United States)

^d OKAYAMA UNIVERSITY   (Japan)

^e HARVARD MEDICAL SCHOOL   (United States)

^f Oncology Research Center of Mercogliano (AV)   (Italy)

Author keywords

Activin; Beta catenin; Smads; Tcf Lef; TGF beta; Wnt

Indexed keywords

ACTIVIN LIKE KINASE 4; BETA CATENIN; HISTONE ACETYLTRANSFERASE; PHOSPHOTRANSFERASE; PROTEIN P300; SMAD2 PROTEIN; SMAD4 PROTEIN; T CELL FACTOR 4; T CELL FACTOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

ARTICLE; CANCER INHIBITION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MISSENSE MUTATION; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TUMOR GROWTH;

ACTIVIN RECEPTORS, TYPE I; BETA CATENIN; CELL LINE; HISTONE ACETYLTRANSFERASES; HUMANS; MODELS, GENETIC; P300-CBP TRANSCRIPTION FACTORS; PROTEIN BINDING; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD4 PROTEIN; TCF TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; WNT PROTEINS;

EID: 47049131867     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2008.05.003     Document Type: Article

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