메뉴 건너뛰기




Volumn 224, Issue 7, 2007, Pages 580-584

N-Acetylcysteine improves lysosomal function and enhances the degradation of photoreceptor outer segments in cultured RPE cells;N-acetylcystein verbessert die lysosomale funktion und beschleunigt den abbau von photorezeptor-außensegmenten in der RPE-zellkultur

Author keywords

ARMD; Lipofuscin; Lysosomes; N acetylcysteine; RPE

Indexed keywords

ACETYLCYSTEINE; METHYLAMINE;

EID: 34547794713     PISSN: 00232165     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-963339     Document Type: Article
Times cited : (7)

References (30)
  • 1
    • 0035036258 scopus 로고    scopus 로고
    • Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases
    • Banaclocha MM. Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases. Med Hypotheses 2001; 56: 472-477
    • (2001) Med Hypotheses , vol.56 , pp. 472-477
    • MM, B.1
  • 2
    • 2342420427 scopus 로고    scopus 로고
    • Oxygen, reactive oxygen species and tissue damage
    • Bergamini CM, Gambetti S, Dondi A et al. Oxygen, reactive oxygen species and tissue damage. Curr Pharm Des 2004; 10: 1611-1626
    • (2004) Curr Pharm Des , vol.10 , pp. 1611-1626
    • Bergamini, C.M.1    Gambetti, S.2    Dondi, A.3
  • 3
    • 13144274594 scopus 로고    scopus 로고
    • Randomised, controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease
    • Black PN, Morgan-Day A, McMillan TE et al. Randomised, controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease. BMC Pulm Med 2004; 6: 4-13
    • (2004) BMC Pulm Med , vol.6 , pp. 4-13
    • Black, P.N.1    Morgan-Day, A.2    McMillan, T.E.3
  • 4
    • 0024497335 scopus 로고
    • The formation of autofluorescent granules in cultured human RPE
    • Boulton M, McKechnie NM, Breda J et al. The formation of autofluorescent granules in cultured human RPE. Invest Ophthalmol Vis Sci 1989; 30: 82-89
    • (1989) Invest Ophthalmol Vis Sci , vol.30 , pp. 82-89
    • Boulton, M.1    McKechnie, N.M.2    Breda, J.3
  • 5
    • 0033991466 scopus 로고    scopus 로고
    • Oxidative damage and protection of the RPE
    • Cai J, Nelson KC, Wu M et al. Oxidative damage and protection of the RPE. Prog Retin Eye Res 2000; 19: 205-221
    • (2000) Prog Retin Eye Res , vol.19 , pp. 205-221
    • Cai, J.1    Nelson, K.C.2    Wu, M.3
  • 6
    • 0024468660 scopus 로고
    • The action of 4-hydroxynonenal on heat shock gene expression in cultured hepatoma cells
    • Cajone F, Bernelli-Zazzera A. The action of 4-hydroxynonenal on heat shock gene expression in cultured hepatoma cells. Free Radic Res Commun 1989; 7: 189-194
    • (1989) Free Radic Res Commun , vol.7 , pp. 189-194
    • Cajone, F.1    Bernelli-Zazzera, A.2
  • 7
    • 0037426556 scopus 로고    scopus 로고
    • Flow cytometric detection of spontaneous apoptosis in human breast cancer using the TUNEL-technique
    • Ehemann V, Sykora J, Vera-Delgado J et al. Flow cytometric detection of spontaneous apoptosis in human breast cancer using the TUNEL-technique. Cancer Lett 2003; 194: 125-131
    • (2003) Cancer Lett , vol.194 , pp. 125-131
    • Ehemann, V.1    Sykora, J.2    Vera-Delgado, J.3
  • 8
    • 0025814980 scopus 로고
    • Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
    • Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991; 11: 81-128
    • (1991) Free Radic Biol Med , vol.11 , pp. 81-128
    • Esterbauer, H.1    Schaur, R.J.2    Zollner, H.3
  • 9
    • 0033017053 scopus 로고    scopus 로고
    • Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin
    • Holz FG, Schutt F, Kopitz J et al. Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin. Invest Ophthalmol Vis Sci 1999; 40: 737-743
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 737-743
    • Holz, F.G.1    Schutt, F.2    Kopitz, J.3
  • 10
    • 1542297332 scopus 로고    scopus 로고
    • Pathogenesis of lesions in late age-related macular disease
    • Holz FG, Pauleikhoff D, Klein R et al. Pathogenesis of lesions in late age-related macular disease. Am J Ophthalmol 2004; 137: 504-510
    • (2004) Am J Ophthalmol , vol.137 , pp. 504-510
    • Holz, F.G.1    Pauleikhoff, D.2    Klein, R.3
  • 11
    • 1542297335 scopus 로고    scopus 로고
    • The epidemiology of age-related macular degeneration
    • Klein R, Peto T, Bird A et al. The epidemiology of age-related macular degeneration. Am J Ophthalmol 2004; 137: 486-495
    • (2004) Am J Ophthalmol , vol.137 , pp. 486-495
    • Klein, R.1    Peto, T.2    Bird, A.3
  • 12
    • 0029868973 scopus 로고    scopus 로고
    • Methylamine accumulation in cultured cells as a measure of the aqueous storage compartment in the laboratory diagnosis of genetic lysosomal diseases
    • Kopitz J, Harzer K, Kohlschutter A et al. Methylamine accumulation in cultured cells as a measure of the aqueous storage compartment in the laboratory diagnosis of genetic lysosomal diseases. Am J Med Genet 1996; 63: 198-202
    • (1996) Am J Med Genet , vol.63 , pp. 198-202
    • Kopitz, J.1    Harzer, K.2    Kohlschutter, A.3
  • 13
    • 0037239512 scopus 로고    scopus 로고
    • Reactive oxygen species, antioxidant mechanisms, and serum cytokine levels in cancer patients: Impact of an antioxidant treatment
    • Mantovani G, Maccio A, Madeddu C et al. Reactive oxygen species, antioxidant mechanisms, and serum cytokine levels in cancer patients: impact of an antioxidant treatment. J Environ Pathol Toxicol Oncol 2003; 22: 17-28
    • (2003) J Environ Pathol Toxicol Oncol , vol.22 , pp. 17-28
    • Mantovani, G.1    Maccio, A.2    Madeddu, C.3
  • 14
    • 0041731614 scopus 로고    scopus 로고
    • Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells
    • Niedernhofer LJ, Daniels JS, Rouzer CA et al. Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. J Biol Chem 2003; 278: 31426-1433
    • (2003) J Biol Chem , vol.278 , pp. 31426-31433
    • Niedernhofer, L.J.1    Daniels, J.S.2    Rouzer, C.A.3
  • 15
    • 0031762824 scopus 로고    scopus 로고
    • Lipid peroxidation products and antioxidants in human disease
    • Romero FJ, Bosch-Morell F, Romero MJ et al. Lipid peroxidation products and antioxidants in human disease. Environ Health Perspect 1998; 106: 1229-1234
    • (1998) Environ Health Perspect , vol.106 , pp. 1229-1234
    • Romero, F.J.1    Bosch-Morell, F.2    Romero, M.J.3
  • 16
    • 0036254707 scopus 로고    scopus 로고
    • Comparing beta-carotene, vitamin E and nitric oxide as membrane antioxidants
    • Schafer FQ, Wang HP, Kelley EE et al. Comparing beta-carotene, vitamin E and nitric oxide as membrane antioxidants. Biol Chem 2002; 383: 671-681
    • (2002) Biol Chem , vol.383 , pp. 671-681
    • Schafer, F.Q.1    Wang, H.P.2    Kelley, E.E.3
  • 17
    • 0030876652 scopus 로고    scopus 로고
    • Porcine iris pigment epithelial cells can take up retinal outer segments
    • Schraermeyer U, Enzmann V, Kohen L et al. Porcine iris pigment epithelial cells can take up retinal outer segments. Exp Eye Res 1997; 65: 277-287
    • (1997) Exp Eye Res , vol.65 , pp. 277-287
    • Schraermeyer, U.1    Enzmann, V.2    Kohen, L.3
  • 18
    • 0033174543 scopus 로고    scopus 로고
    • Current understanding on the role of retinal pigment epithelium and its pigmentation
    • Schraermeyer U, Heimann K. Current understanding on the role of retinal pigment epithelium and its pigmentation. Pigment Cell Res 1999; 12: 219-236
    • (1999) Pigment Cell Res , vol.12 , pp. 219-236
    • Schraermeyer, U.1    Heimann, K.2
  • 19
    • 0000117096 scopus 로고    scopus 로고
    • Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin
    • Schutt F, Davies S, Kopitz J et al. Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin. Invest Ophthalmol Vis Sci 2000; 41: 2303-2308
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 2303-2308
    • Schutt, F.1    Davies, S.2    Kopitz, J.3
  • 20
    • 20244373585 scopus 로고    scopus 로고
    • Isolation of intact lysosomes from human RPE cells and effects of A2-E on the integrity of the lysosomal and other cellular membranes
    • Schutt F, Bergmann M, Holz FG et al. Isolation of intact lysosomes from human RPE cells and effects of A2-E on the integrity of the lysosomal and other cellular membranes. Graefes Arch Clin Exp Ophthalmol 2002; 240: 983-988
    • (2002) Graefes Arch Clin Exp Ophthalmol , vol.240 , pp. 983-988
    • Schutt, F.1    Bergmann, M.2    Holz, F.G.3
  • 21
    • 0041342065 scopus 로고    scopus 로고
    • Proteins modified by malondialdehyde, 4-hydroxynonenal, or advanced glycation end products in lipofuscin of human retinal pigment epithelium
    • Schutt F, Bergmann M, Holz FG et al. Proteins modified by malondialdehyde, 4-hydroxynonenal, or advanced glycation end products in lipofuscin of human retinal pigment epithelium. Invest Ophthalmol Vis Sci 2003; 44: 3663-3668
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 3663-3668
    • Schutt, F.1    Bergmann, M.2    Holz, F.G.3
  • 22
    • 0034766880 scopus 로고    scopus 로고
    • Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin
    • Shamsi FA, Boulton M. Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin. Invest Ophthalmol Vis Sci 2001; 42: 3041-3046
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 3041-3046
    • Shamsi, F.A.1    Boulton, M.2
  • 23
    • 0032858054 scopus 로고    scopus 로고
    • Induction of glutathione S-transferase hGST 5.8 is an early response to oxidative stress in RPE cells
    • Singhal SS, Godley BF, Chandra A et al. Induction of glutathione S-transferase hGST 5.8 is an early response to oxidative stress in RPE cells. Invest Ophthalmol Vis Sci 1999; 40: 2652-2659
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 2652-2659
    • Singhal, S.S.1    Godley, B.F.2    Chandra, A.3
  • 24
    • 18444396890 scopus 로고    scopus 로고
    • The effect of N-acetylcysteine supplementation upon viral load, CD4, CD8, total lymphocyte count and hematocrit in individuals undergoing antiretroviral treatment
    • Spada C, Treitinger A, Reis M et al. The effect of N-acetylcysteine supplementation upon viral load, CD4, CD8, total lymphocyte count and hematocrit in individuals undergoing antiretroviral treatment. Clin Chem Lab Med 2002; 40: 452-455
    • (2002) Clin Chem Lab Med , vol.40 , pp. 452-455
    • Spada, C.1    Treitinger, A.2    Reis, M.3
  • 25
    • 0027769391 scopus 로고
    • Protection of retinal pigment epithelium from oxidative injury by glutathione and precursors
    • Sternberg Jr P, Davidson PC, Jones DP et al. Protection of retinal pigment epithelium from oxidative injury by glutathione and precursors. Invest Ophthalmol Vis Sci 1993; 34: 3661-3668
    • (1993) Invest Ophthalmol Vis Sci , vol.34 , pp. 3661-3668
    • Sternberg Jr, P.1    Davidson, P.C.2    Jones, D.P.3
  • 26
    • 0037465546 scopus 로고    scopus 로고
    • The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure: A randomized, controlled trial
    • Tepel M, van der Giet M, Statz M et al. The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure: a randomized, controlled trial. Circulation 2003; 107: 992-995
    • (2003) Circulation , vol.107 , pp. 992-995
    • Tepel, M.1    van der Giet, M.2    Statz, M.3
  • 28
    • 0027946778 scopus 로고
    • Michael addition-type 4-hydroxy-2-nonenal adducts in modified low-density lipoproteins: Markers for atherosclerosis
    • Uchida K, Toyokuni S, Nishikawa K et al. Michael addition-type 4-hydroxy-2-nonenal adducts in modified low-density lipoproteins: markers for atherosclerosis. Biochemistry 1994; 33: 12487-12494
    • (1994) Biochemistry , vol.33 , pp. 12487-12494
    • Uchida, K.1    Toyokuni, S.2    Nishikawa, K.3
  • 29
    • 18544371009 scopus 로고    scopus 로고
    • Metals, toxicity and oxidative stress
    • Valko M, Morris H, Cronon MT. Metals, toxicity and oxidative stress. Curr Med Chem 2005; 12: 1161-1208
    • (2005) Curr Med Chem , vol.12 , pp. 1161-1208
    • Valko, M.1    Morris, H.2    Cronon, M.T.3
  • 30
    • 0035044121 scopus 로고    scopus 로고
    • Lysosomal ceroid depletion by drugs: Therapeutic implications for a hereditary neurodegenerative disease of childhood
    • Zhang Z, Butler JD, Levin SW et al. Lysosomal ceroid depletion by drugs: therapeutic implications for a hereditary neurodegenerative disease of childhood. Nat Med 2001; 7: 478-484
    • (2001) Nat Med , vol.7 , pp. 478-484
    • Zhang, Z.1    Butler, J.D.2    Levin, S.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.