MEK/ERK pathway mediates UVB-induced AQP1 downregulation and water permeability impairment in human retinal pigment epithelial cells

International Journal of Molecular Medicine

Volumn 23, Issue 6, 2009, Pages 771-777

  Jiang, Qin ^a   Cao, Cong ^b   Lu, Shan ^c   Kivlin, Rebecca ^c   Wallin, Brittany ^c   Chu, Wenming ^b   Bi, Zhigang ^a   Wang, Xinru ^a   Wan, Yinsheng ^c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b BROWN UNIVERSITY   (United States)

^c PROVIDENCE COLLEGE   (United States)

Author keywords

Aquaporin 1; Retinal pigment epithelial cells; UV radiation; Water permeability

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTIOXIDANT; AQUAPORIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; RETINOIC ACID; SB 202580; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; WATER;

ARTICLE; CELL DAMAGE; CELL FUNCTION; CELL JUNCTION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FLUID TRANSPORT; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; ULTRAVIOLET B RADIATION; WATER PERMEABILITY;

AQUAPORIN 1; BLOTTING, WESTERN; CELL LINE; CELL MEMBRANE PERMEABILITY; DOWN-REGULATION; HUMANS; HYDROGEN PEROXIDE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PIGMENT EPITHELIUM OF EYE; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TRETINOIN; ULTRAVIOLET RAYS; WATER;

EID: 67649562160     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000191     Document Type: Article

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