Toward handheld diagnostics of cancer biomarkers in breath: Micro preconcentration of trace levels of volatiles in human breath

IEEE Sensors Journal

Volumn 11, Issue 11, 2011, Pages 2756-2762

  Alfeeli, Bassam ^a,b   Agah, Masoud ^a  

^a State University   (United States)

^b KUWAIT INSTITUTE FOR SCIENTIFIC RESEARCH   (Kuwait)

Author keywords

Complex gas mixtures; microanalytical systems; microelectromechanical systems; point of care diagnostics

Indexed keywords

BREATH ANALYZERS; CANCER BIOMARKERS; COMPLEX GAS MIXTURES; DEVICE PERFORMANCE; GEOMETRIC SHAPE; HANDHELDS; HIGH ADSORPTION CAPACITY; HIGH-ASPECT RATIO; HUMAN BREATH; MICRO ANALYTICAL SYSTEMS; MICRO ELECTRO MECHANICAL SYSTEM; MICROFABRICATED; PILLAR DESIGN; POINT-OF-CARE DIAGNOSTICS; PRE-CONCENTRATION; PRECONCENTRATORS; SURFACE AREA; TRACE LEVEL; VOLATILE COMPOUNDS;

ADSORPTION; ASPECT RATIO; MEMS; MICROELECTROMECHANICAL DEVICES; VOLATILE ORGANIC COMPOUNDS;

DISEASES;

EID: 80054941460     PISSN: 1530437X     EISSN: None     Source Type: Journal    
DOI: 10.1109/JSEN.2011.2160390     Document Type: Conference Paper

References (62)

1. D. M. Parkin, "International variation," Oncogene, vol. 23, no. 38, pp.6329-6340, 2004. (Pubitemid 39272833)
2. D. Chu and J. Lu, "Novel therapies in breast cancer: What is new fromASCO 2008," J. Hematology Oncology, vol. 1, no. 1, p. 16, 2008.
3. M. Phillips, R. N. Cataneo, C. Saunders, P. Hope, P. Schmitt, and J.Wai, "Volatile biomarkers in the breath of women with breast cancer,"J. Breath Res., vol. 4, no. 2, p. 026003, 2010.
4. A. Hengstenberg, M. Grossherr, T. Meier, and H. Gehring, "Breathanalysis and artificial ventilation: Chemical identification and classificationof volatile substances in exhaled breath during I.V. anesthesia,"Anesthesiology, vol. 103, p. A808, 2005.
5. M. Libardoni, P. T. Stevens, J. H. Waite, and R. Sacks, "Analysisof human breath samples with a multi-bed sorption trap and comprehensivetwo- dimensional gas chromatography (GC × GC)," J.Chromatography B, vol. 842, no. 1, pp. 13-21, 2006. (Pubitemid 44311087)
6. M. Agah and K. D. Wise, "Low-mass PECVD oxynitride gas chromatographiccolumns," J. Microelectromech. Syst., vol. 16, no. 4, pp.853-860, 2007. (Pubitemid 47278829)
7. S. C. Terry, J. H. Jerman, and J. B. Angell, "A gas chromatographic airanalyzer fabricated on a silicon wafer," IEEE Trans. Electron Devices,vol. 26, no. 12, pp. 1880-1886, Dec. 1979. (Pubitemid 10128644)
8. M. Kim and S. Mitra, "A microfabricated microconcentrator for sensorsand gas chromatography," J. Chromatography A, vol. 996, no. 1-2,pp. 1-11, 2003. (Pubitemid 36627788)
9. C. E. Davis, C. K. Ho, R. C. Hughes, and M. L. Thomas, "Enhanceddetection of m-xylene using a preconcentrator with a chemiresistorsensor," Sens. Actuators B: Chem., vol. 104, no. 2, pp. 207-216, 2005.
10. R. R. Lima, R. A. M. Carvalho, A. P. N. Filho, M. L. P. Silva, and N. R.Demarquette, "Production and deposition of adsorbent films by plasmapolymerization on low cost micromachined non-planar microchannelsfor preconcentration of organic compound in air," Sens. Actuators B:Chem., vol. 108, no. 1-2, pp. 435-444, 2005.
11. W.-C. Tian, H. K. L. Chan, L. Chia-Jung, S. W. Pang, and E. T. Zellers,"Multiple-stage microfabricated preconcentrator-focuser for micro gaschromatography system," J. Microelectromech. Syst., vol. 14, no. 3, pp.498-507, 2005. (Pubitemid 41005069)
12. E. W. Simoes, S. G. de Souza, M. L. P. da Silva, R. Furlan, and H.E. M. Peres, "Study of preconcentration of non-polar compounds inmicrochannels with constrictions," Sens. Actuators B: Chem., vol. 115,no. 1, pp. 232-239, 2006.
13. C. Pijolat, M. Camara, J. Courbat, J. P. Viricelle, D. Briand, and N. F.de Rooij, "Application of carbon nano-powders for a gas micro-preconcentrator,"Sens. Actuators B: Chem., vol. 127, no. 1, pp. 179-185,2007. (Pubitemid 47503721)
14. M. Martin, M. Crain, K.Walsh, R. A. McGill, E. Houser, J. Stepnowski,S. Stepnowski, H.-D.Wu, and S. Ross, "Microfabricated vapor preconcentratorfor portable ion mobility spectroscopy," Sens. Actuators B:Chem., vol. 126, no. 2, pp. 447-454, 2007. (Pubitemid 47405170)
15. A. M. Ruiz, I. Gracia, N. Sabate, P. Ivanov, A. Sanchez, M. Duch, M.Gerboles, A. Moreno, and C. Cane, "Membrane-suspended microgridas a gas preconcentrator for chromatographic applications," Sens. ActuatorsA: Phys., vol. 135, no. 1, pp. 192-196, 2007. (Pubitemid 46428098)
16. S. Li, J. C. Day, J. J. Park, C. P. Cadou, and R. Ghodssi, "A fast-responsemicrofluidic gas concentrating device for environmentalsensing, " Sens. Actuators A: Phys., vol. 136, no. 1, pp. 69-79, 2007. (Pubitemid 46590681)
17. Y. Junghoon, C. R. Field, B. Byunghoon, R. I. Masel, and M. A.Shannon, "The design, fabrication and characterization of a siliconmicroheater for an integrated MEMS gas preconcentrator," J. Micromech.Microeng., vol. 18, no. 12, p. 125001 (12pp.), 2008.
18. I. Gràcia, P. Ivanov, F. Blanco, N. Sabaté, X. Vilanova, X. Correig, L.Fonseca, E. Figueras, J. Santander, and C. Cané, "Sub-ppm gas sensordetection via spiral m-preconcentrator," Sens. Actuators B: Chem., vol.132, no. 1, pp. 149-154, 2008. (Pubitemid 351694414)
19. R. P. Manginell, D. R. Adkins, M. W. Moorman, R. Hadizadeh, D.Copic, D. A. Porter, J. M. Anderson, V. M. Hietala, J. R. Bryan, D. R.Wheeler,K. B. Pfeifer, and A. Rumpf, "Mass-sensitive microfabricatedchemical preconcentrator," J. Microelectromech. Syst., vol. 17, no. 6,pp. 1396-1407, 2008.
20. I. Voiculescu, M. Zaghloul, and N. Narasimhan, " Microfabricatedchemical preconcentrators for gas-phase microanalytical detectionsystems," TrAC Trends Anal. Chem., vol. 27, no. 4, pp. 327-343,2008.
21. B. Alfeeli, D. Cho, M. Ashraf-Khorassani, L. T. Taylor, and M. Agah,"MEMS-based multi-inlet/outlet preconcentrator coated by inkjetprinting of polymer adsorbents," Sens. Actuators B: Chem., vol. 133,no. 1, pp. 24-32, 2008.
22. S. Zampolli, I. Elmi, J. Stürmann, S. Nicoletti, L. Dori, and G. C. Cardinali,"Selectivity enhancement of metal oxide gas sensors using a micromachinedgas chromatographic column," Sens. Actuators B: Chem.,vol. 105, no. 2, pp. 400-406, 2005. (Pubitemid 40330114)
23. M. Agah, G. R. Lambertus, R. Sacks, and K. Wise, "High-speedMEMS- based gas chromatography," J. Microelectromech. Syst., vol.15, no. 5, pp. 1371-8, 2006.
24. M. Agah and K. D. Wise, "Low-mass PECVD oxynitride gas chromatographiccolumns," J. Microelectromech. Syst., vol. 16, no. 4, pp.853-860, 2007. (Pubitemid 47278829)
25. J. A. Potkay, G. R. Lambertus, R. D. Sacks, and K. D. Wise, "Alow-power pressure- and temperature-programmable micro gas chromatographycolumn," J. Microelectromech. Syst., vol. 16, no. 5, pp.1071-1079, 2007. (Pubitemid 47528005)
26. A. Bhushan, D.Yemane, D. Trudell, E. Overton, and J. Goettert, "Fabricationof micro-gas chromatograph columns for fast chromatography,"Microsystem Technologies, vol. 13, no. 3, pp. 361-368, Feb. 2007. (Pubitemid 46012833)
27. S.-I. Ohira and K. Toda, "Micro gas analyzers for environmental andmedical applications," Analytica Chimica Acta., vol. 619, no. 2, pp.143-156, 2008.
28. M. A. Zareian-Jahromi, M. Ashraf-Khorassani, L. T. Taylor, and M.Agah, "Design, modeling, and fabrication of MEMS-based multicapillarygas chromatographic columns," J. Microelectromech. Syst., vol.18, no. 1, pp. 28-37, 2009.
29. S. Ali, M. Ashraf-Khorassani, L. T. Taylor, and M. Agah, "MEMSbasedsemi-packed gas chromatography columns," Sens. Actuators B:Chem., vol. 141, no. 1, pp. 309-315, 2009.
30. G. Serrano, H. Chang, and E. T. Zellers, "A micro gas chromatographfor high-speed determinations of explosive vapors," in Proc. Int. Conf.Solid-State Sensors, Actuators and Microsyst.,TRANSDUCERS'09,2009, pp. 1654-1657.
31. A. D. Radadia, A. Salehi-Khojin, R. I. Masel, and M. A. Shannon,"The fabrication of all-silicon micro gas chromatography columnsusing gold diffusion eutectic bonding," J. Micromech. Microeng., no.1, p. 015002, 2010.
32. M. A. Zareian-Jahromi and M. Agah, "Microfabricated gas chromatographycolumns with mono-layer protected gold stationary phases," J.Microelectromech. Syst., vol. 19, no. 2, pp. 294-304, 2010.
33. I. Simon and M. Arndt, "Thermal and gas-sensing properties of a micromachinedthermal conductivity sensor for the detection of hydrogenin automotive applications," Sens. Actuators A: Phys., vol. 97-98, pp.104-108, 2002. (Pubitemid 34758715)
34. G. R. Lambertus, C. S. Fix, S. M. Reidy, R. A. Miller, D. Wheeler,E. Nazarov, and R. Sacks, "Silicon microfabricated column withmicrofabricated differential mobility spectrometer for GC Analysisof volatile organic compounds," Analy. Chem., vol. 77, no. 23, pp.7563-7571, 2005. (Pubitemid 41746223)
35. D. Cruz, J. P. Chang, S. K. Showalter, F. Gelbard, R. P. Manginell,and M. G. Blain, "Microfabricated thermal conductivity detector forthe micro-chemlab," Sens. Actuators B: Chem., vol. 121, no. 2, pp.414-422, 2007. (Pubitemid 46186887)
36. W. J. Kuipers and J. Muller, "A planar micro-flame ionization detectorwith an integrated guard electrode," J. Micromech. Microeng., no. 6, p.064015, 2008.
37. B. C. Kaanta, H. Chen, G. Lambertus, W. H. Steinecker, O. Zhdaneev,and X. Zhang, "High sensitivity micro-thermal conductivity detectorfor gas chromatography," in Proc. Int. Conf. Micro Electro Mech. Syst.,MEMS'09, 2009, pp. 264-267.
38. F. I. Bohrer, E. Covington, C. Kurdak, and E. T. Zellers,"Nanoscale chemiresistor arrays with patterned nanoparticle interfacelayers for micro gas chromatography," in Proc. Int. Solid-StateSensors, Actuators and Microsyst. Conf., TRANSDUCERS'09, 2009,pp. 148-151.
39. S. Narayanan, B. Alfeeli, and M. Agah, "A micro gas chromatographychip with an embedded non-cascaded thermal conductivity detector,"Procedia Eng., vol. 5, pp. 29-32, 2010.
40. G. C. Frye-Mason, R. P. Manginell, E. J. Heller, C. M. Matzke, S.A. Casalnuovo, V. M. Hietala, R. J. Kottenstette, P. R. Lewis, and C.C. Wong, "Microfabricated gas phase chemical analysis systems," inDigest of Papers. Microprocesses and Nanotechnology Conf., 1999, pp.60-1.
41. G. Vas and K. Vékey, "Solid-phase microextraction: A powerfulsample preparation tool prior to mass spectrometric analysis," J. MassSpectrometry, vol. 39, no. 3, pp. 233-254, 2004. (Pubitemid 38379528)
42. J. W. Russell, "Analysis of air pollutants using sampling tubes and gaschromatography," Environ. Sci. Technol., vol. 9, no. 13, pp. 1175-1178,1975.
43. R. H. Brown and C. J. Purnell, "Collection and analysis of trace organicvapor pollutants in ambient atmospheres: The performance of aTenax-GC adsorbent tube," J. Chromatography A, vol. 178, no. 1, pp.79-90, 1979.
44. E. D. Pellizzari, J. E. Bunch, R. E. Berkley, and J. McRae, "Collectionand analysis of trace organic vapor pollutants in ambient atmospheres.The performance of a Tenax GC cartridge sampler for hazardous vapors,"Anal. Lett., vol. 9, no. 1, pp. 45-63, 1976.
45. M. W. Losey, R. J. Jackman, S. L. Firebaugh, M. A. Schmidt, and K. F.Jensen, "Design and fabrication of microfluidic devices for multiphasemixing and reaction," J. Microelectromech. Syst., vol. 11, no. 6, pp.709-717, 2002.
46. B. Alfeeli, M. A. Zareian-Jahromi, and M. Agah, "Micro preconcentratorwith seedless electroplated gold as self-heating adsorbent," inProc. 8th IEEE Conf. Sensors, Christchurch, New Zealand, 2009, pp.1947-1950.
47. S. Reidy, G. Lambertus, J. Reece, and R. Sacks, "High-performance, static-coated silicon microfabricated columns for gas chromatography,"Anal. Chem., vol. 78, no. 8, pp. 2623-2630, 2006.
48. I. Voiculescu, R. A. McGill, M. E. Zaghloul, D. Mott, J. Stepnowski,S. Stepnowski, H. Summers, V. Nguyen, S. Ross, K. Walsh, andM. Martin, "Micropreconcentrator for enhanced trace detection ofexplosives and chemical agents," IEEE Sensors J., vol. 6, no. 5, pp.1094-1104, Oct 2006.
49. P. Ivanov, F. Blanco, I. Gracia, N. Sabate, A. Ruiz, X.Vilanova,X. Correig,L. Fonseca, E. Figueras, J. Santander, and C. Cane, "Improvementof the gas sensor response via silicon m-preconcentrator," Sens. ActuatorsB: Chem., vol. 127, no. 1, pp. 288-294, 2007. (Pubitemid 47503737)
50. W.-C. Tian, S. W. Pang, L. Chia-Jung, and E. T. Zellers, "Microfabricatedpreconcentrator-focuser for a microscale gas chromatograph," J.Microelectromech. Syst., vol. 12, no. 3, pp. 264-272, 2003.
51. H. K. L. Chan, S. W. Pang, R. A.Veeneman, E. T. Zellers, and M. Takei,"Microfabricated preconcentrator for quantitative analysis of low concentrationvolatile organic compounds," in Proc. Int. Conf. Solid-StateSensors, Actuators and Microsyst., TRANSDUCERS'07, Korea, 2005,pp. 2091-2094. (Pubitemid 41538914)
52. B. Alfeeli and M. Agah, "MEMS-based selective preconcentrationof trace level breath analytes," IEEE Sensors J., vol. 9, no. 9, pp.1068-1075, Sep. 2009.
53. J. Yeom, D. D. Agonafer, J.-H. Han, and M. A. Shannon, "LowReynolds number flow across an array of cylindrical micropostsin a microchannel and figure-of-merit analysis of micropost-filledmicroreactors," J. Micromech. Microeng., vol. 19, no. 6, p. 065025,2009.
54. B. Alfeeli and M. Agah, "Micro preconcentrator for handheld diagnosticsof cancer biomarkers in breath," in Proc. 9th IEEE Conf. Sensors,Waikoloa, HI, 2010, pp. 2490-2493.
55. B. Alfeeli, L. T. Taylor, and M. Agah, "Evaluation of Tenax TA thinfilms as adsorbent material for micro preconcentration applications, "Microchem. J., vol. 95, no. 2, pp. 259-267, 2010.
56. I. Maier and M. Fieber, "Retention characteristics of volatile compoundson Tenax TA," J. High Resolut. Chromatogr., vol. 11, no. 8,pp. 566-576, 1988.
57. S. M. Cho, Y. J. Kim, G. S. Heo, and S.-M. Shin, "Two-step preconcentrationfor analysis of exhaled gas of human breath with electronicnose," Sens. Actuators B: Chem., vol. 117, no. 1, pp. 50-57, 2006.
58. K. Sakodynskii, L. Panina, and N. Klinskaya, "A study of some propertiesof Tenax, A porous polymer sorbent," Chromatographia, vol. 7,no. 7, pp. 339-344, 1974.
59. D. Poli, P. Carbognani, M. Corradi, M. Goldoni, O. Acampa, B. Balbi,L. Bianchi, M. Rusca, and A. Mutti, "Exhaled volatile organic compoundsin patients with non-small cell lung cancer: Cross sectional andnested short-term follow-up study," Respiratory Res., vol. 6, Jul. 2005.
60. J. E. Szulejko, M. McCulloch, J. Jackson, D. L. McKee, J. C. Walker,and T. Solouki, "Evidence for cancer biomarkers in exhaled breath,"IEEE Sensors J., vol. 10, no. 1, pp. 185-210, Jan. 2010.
61. A. Ulanowska, T. Ligor, M. Michel, and B. Buszewski, "Hyphenatedand unconventional methods for searching volatile cancer biomarkers,"Ecological Chem. Eng., vol. 17, no. 1, pp. 9-23, 2010.
62. S. K. Kim, H. Chang, and E. T. Zellers, "Prototype micro gas chromatographfor breath biomarkers of respiratory disease," in Proc.Int. Conf. Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS'09, 2009, pp. 128-131.