Discovery of N -(3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1 H -indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain

Journal of Medicinal Chemistry

Volumn 54, Issue 20, 2011, Pages 7408-7416

  Annedi, Subhash C ^a   Maddaford, Shawn P ^a   Mladenova, Gabriela ^a   Ramnauth, Jailall ^a   Rakhit, Suman ^a   Andrews, John S ^a   Lee, David K H ^b   Zhang, Dongqin ^c   Porreca, Frank ^c   Bunton, David ^d   Christie, Lee ^d  

^a NeurAxon Inc   (Canada)

^b NoAb BioDiscoveries Inc   (Canada)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d ReproCELL Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (1 METHYL 1,2,3,6 TETRAHYDROPYRIDIN 4 YL) 6 NITRO 1H INDOLE; 3 (6 NITRO 1H INDOL 3 YL) 1 AZABICYCLO[2.2.2]OCT 2 ENE; CYTOCHROME P450; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDOLE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; N [3 (1 AZABICYCLO[2.2.2]OCT 2 EN 3 YL) 1H INDOL 6 YL]THIOPHENE 2 CARBOXIMIDAMIDE; N [3 (1 METHYL 1,2,3,6 TETRAHYDROPYRIDIN 4 YL) 1H INDOL 6 YL]THIOPHENE 2 CARBOXAMIDINE; N [3 (1 METHYL 1,2,3,6 TETRAHYDROPYRIDIN 4 YL) 1H INDOL 6 YL]THIOPHENE 2 CARBOXIMIDAMIDE; N [3 (1 METHYLPIPERIDIN 4 YL) 1H INDOL 6 YL]THIOPHENE 2 CARBOXAMIDINE; N [3 (1 METHYLPYRROLIDIN 3 YL) 1H INDOL 6 YL]THIOPHENE 2 CARBOXIMIDAMIDE; N [3 (QUINUCLIDIN 3 YL) 1H INDOL 6 YL]THIOPHENE 2 CARBOXIMIDAMIDE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY CONSTRICTION; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; HYPERALGESIA; IN VIVO STUDY; NEUROPATHIC PAIN; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANALGESICS; CORONARY VESSELS; CYTOCHROME P-450 ENZYME SYSTEM; HOT TEMPERATURE; HUMANS; HYPERALGESIA; INDOLES; LIGATION; NEURALGIA; NITRIC OXIDE SYNTHASE TYPE I; PAIN; PYRIDINES; SPINAL NERVES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 80054932325     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201063u     Document Type: Article

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