Nitric oxide synthase inhibition: A new principle in the treatment of migraine attacks

Cephalalgia

Volumn 18, Issue 1, 1998, Pages 27-32

  Lassen, L H ^a,c   Ashina, M ^a   Christiansen, I ^a   Ulrich, V ^a   Grover, R ^b   Donaldson, J ^b   Olesen, J ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b GLAXOSMITHKLINE   (United Kingdom)

^c NONE   (Denmark)

Author keywords

Migraine; Migraine therapy; Nitric oxide; NOS inhibition

Indexed keywords

ERGOTAMINE; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; SUMATRIPTAN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERABILITY; ENZYME INHIBITION; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MIGRAINE; PHOTOPHOBIA; SYMPTOMATOLOGY;

ADOLESCENT; ADULT; DOUBLE-BLIND METHOD; ENZYME INHIBITORS; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; MIGRAINE DISORDERS; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; TREATMENT OUTCOME;

EID: 0031907881     PISSN: 03331024     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-2982.1998.1801027.x     Document Type: Article

References (31)

1. Olesen J, Iversen HK, Thomsen LL. Nitric oxide supersensitivity: a possible molecular mechanism of migraine pain. Neuroreport 1993;4:1027-30
2. Thomsen LL, Kruuse C, Iversen HK, Olesen J. A nitric oxide donor (nitroglycerin) triggers genuine migraine attacks. Eur J Neurol 1994;1:73-80
3. Lassen LH, Thomsen LL, Kruuse C, Iversen HK, Olesen J. Histamine-1 receptor blockade does not prevent nitroglycerin-induced migraine. Support for the NO-hypothesis of migraine. Eur J Clin Pharmacol 1996;49:335-9
4. Lassen LH, Thomsen LL, Olesen J. Histamine induces migraine via the H1-receptor. Support for the NO hypothesis of migraine. Neuro Report 1995;6:1475-9
5. Feelisch M, Noack EA. Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase. Eur J Pharmacol 1987;139:19-30
6. Romanin C, Kukovetz WR. Guanylate cyclase activation by organic nitrates is not mediated via nitrite. J Mol Cell Cardiol 1988;20:389-96
7. Toda N. Mechanism underlying responses to histamine of isolated monkey and human cerebral arteries. Am J Physiol 1990;258:311-7
8. Fujiwara M, Usui H, Kurahashi K, Jino H, Shirahase H, Mekata F. Endothelium-dependent contraction produced by acetylcholine and relaxation produced by histamine in monkey basilar arteries. J Cardiovasc Pharmacol 1992;20:114-6
9. Olesen J, Thomsen LL, Lassen LH, Olesen IJ. The nitric oxide hypothesis of migraine and other vascular headaches. Cephalalgia 1995;15:94-100
10. Lassen LH, Ashina M, Christiansen I, Ulrich V, Olesen J. Nitric oxide synthase inhibition in migraine. Lancet 1997;349:401-2
11. Altman DG. Table B13. Random digits. In: Altman DG, ed. Practical statistics for medical research. London: Chapman and Hall, 1991:540-4
12. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 1988;8:19-28
13. Mathew NT, Dexter J, Couch J, Flamenbaum W, Goldstein J, Rapoport A, et al. Dose-ranging efficacy and safety of subcutaneous sumatriptan in the acute treatment of migraine. Arch Neurol 1992;49:1271-6
14. 2 reactivity in migraine with aura - transcranial Doppler study during hyperventilation. Cephalalgia 1995;15:211-5
15. Krabbe AÆ, Olesen J. Headache provocation by continuous intravenous infusion of histamine. Clinical results and receptor mechanisms. Pain 1980;8:253-9
16. Iversen HK, Olesen J, Tfelt-Hansen P. Intravenous nitroglycerin as an experimental model of vascular headache. Basic characteristics. Pain 1989;38:17-24
17. Iversen HK, Nielsen TH, Garre K, Tfelt-Hansen P, Olesen J. Dose-dependent headache response and dilatation of limb and extracranial arteries after three doses of 5-isosorbide mononitrate. Eur J Clin Pharmacol 1992;42:31-5
18. Iversen HK. N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses. Clin Pharmacol Ther 1992;52:125-33
19. Thomsen LL, Iversen HK, Brinck TA, Olesen J. Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers. Cephalalgia 1993;13:395-9
20. Lassen LH, Thomsen LL, Olesen J. Histamine induces both immediate and delayed headache in migraineurs due to H1 receptor activation. Support for the NO-hypothesis of migraine. J Cereb Blood Flow Metab 1995;15:168
21. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991;43: 109-42
22. Garthwaite J. Nitric oxide signalling in the nervous system. Neurosciences 1993;5:171-80
23. Radomski MW, Palmer RMJ, Moncada S. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 1990;87:10043-7
24. Nichols FT, Mawad M, Mohr JP, Stein B, Hilal S, Michelsen WJ. Focal headache during balloon inflation in the internal carotid and middle cerebral arteries. Stroke 1990;21:555-9
25. Friberg L, Olesen J, Iversen HK, Sperling B. Migraine pain associated with middle cerebral artery dilatation: reversal by sumatriptan. Lancet 1991;338:13-17
26. Zwetloot CP, Caekebeke JFV, Ferrari MD. Lack of asymmetry of middle cerebral artery blood velocity in unilateral migraine. Stroke 1993;24:1335-8
27. Nosaki K, Moskowitz MA, Maynard KI, Koketsu N, Dawson TM, Bredt DS, et al. Possible origins and distribution of immunoreactive nitric oxide synthase containing nerve fibers in cerebral arteries. J Cereb Blood Flow Metab 1993;13:70-9
28. Moskowitz MA. Neurogenic inflammation in the pathophysiology and treatment of migraine. Neurology 1993;43:16-20
29. Meller ST, Gebhart GF. Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain 1993;52:127-36
30. Lücher TF, Vanhoutte PM. The endothelium: modulator of cardiovascular functions. Ann Arbor: CRC Press, 1990
31. Southan GJ, Szabo C. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem Pharmacol 1996;4:383-94