Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 9, 2007, Pages 2540-2544

  Patman, Joanne ^a   Bhardwaj, Namrta ^a   Ramnauth, Jailall ^a   Annedi, Subhash C ^a   Renton, Paul ^a   Maddaford, Shawn P ^a   Rakhit, Suman ^a   Andrews, John S ^a  

^a NeurAxon Inc   (Canada)

Author keywords

2 Aminobenzothiazole; Inhibitor; Nitric oxide; Nitric oxide synthase

Indexed keywords

2 AMINOBENZOTHIAZOLE DERIVATIVE; N BENZYLPIPERIDINE DERIVATIVE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IC 50; NONHUMAN; RAT;

ANIMALS; BENZOTHIAZOLES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; MODELS, CHEMICAL; MOLECULAR CONFORMATION; NITRIC OXIDE SYNTHASE TYPE I; RATS; THIAZOLES;

RATTUS;

EID: 34047147091     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.011     Document Type: Article

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