Structural investigation and intracellular trafficking of a novel multicomposite cationic solid lipid nanoparticle platform as a pDNA carrier

Therapeutic Delivery

Volumn 2, Issue 11, 2011, Pages 1419-1435

  Vighi, Eleonora ^a   Leo, Eliana ^a   Montanari, Monica ^a   Mucci, Adele ^a   Hanuskova, Miriam ^a   Iannuccelli, Valentina ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; ENHANCED GREEN FLUORESCENT PROTEIN; NANOCOMPOSITE; OCTADECYLAMINE; PHOSPHATIDYLCHOLINE; PLASMID DNA; POLOXAMER; PROTAMINE; SOLID LIPID NANOPARTICLE; STEARIC ACID;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG FORMULATION; DRUG SAFETY; GENE DELIVERY SYSTEM; GENETIC TRANSFECTION; IN VITRO STUDY; INTRACELLULAR TRANSPORT; LIPID COMPOSITION; NANOPHARMACEUTICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PARTICLE SIZE; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

EID: 80054917301     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.11.118     Document Type: Article

References (51)

1. Lim ST, Airavaara M, Harvey BK. Viral vectors for neurotrophic factor delivery: a gene therapy approach for neurodegenerative diseases of the CNS. Pharmacol. Res. 61(1), 14-26 (2010).
2. Bachtarzi H, Stevenson M, Seymour LW, Fisher KD. Targeting adenovirus gene delivery to activated tumor-associated vasculature via endothelial selectines. J. Control. Release 150(2), 196-203 (2011).
3. Santhosh CV, Tamhane MC, Kamat RH, Patel VV, Mukhopadhyaya R. A lentiviral vector with novel multiple cloning sites: stable transgene expression in vitro and in vivo. Biochem. Biophysic. Res. Comm. 371 (13), 546-550 (2008).
4. Canine BF, Hatefi A. Development of recombinant cationic polymers for gene therapy research. Adv. Drug. Deliv. Rev. 62(15), 1524-1529 (2010).
5. Raper SE, Chirmule N, Lee FS et al. Fatal systemic inflammatory response syndrome in an ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol. Genet. Metab. 80(1-2), 148-158 (2003).
6. Kang JH, Toita M, Katayama Y. Bio and nanotechnological strategies for tumor targeted gene therapy. Biotech. Adv. 28(6), 757-763 (2010).
7. Joshi MD, Muller RH. Lipid nanoparticles for parenteral delivery of actives. Eur. J. Pharm. Biopharm. 71(2), 161-172 (2009). Points up the potentialities of solid lipid nanoparticle in drug delivery and gene therapy, highlighting their advantages in comparison to liposomes and polymeric nanoparticles.
8. Pedersen N, Hansen S, Heydenreich AV, Kristensen HG, Poulsen HS. Solid lipid nanoparticles can effectively bind DNA, streptavidin and biotinylated ligands. Eur. J. Pharm. Biopharm. 62(2), 155-162 (2006).
9. Montana G, Bondi ML, Cerrotta R et al. Employment of cationic solid lipid nanoparticles as RNA carriers. Bioconjugate Chem. 18(21), 302-308 (2007).
10. del Pozo-Rodriguez A, Delgado D, Solinis MA et al. Solid lipid nanoparticles as potential tools for gene therapy: in vivo protein expression after intravenous administration. Int. J. Pharm. 385(1-2), 157-162 (2010).
11. Tabatt K, Sameti M, Olbrich C, Muller RH, Lehr C-M. Effect of cationic lipid and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer. Eur. J. Pharm. Biopharm. 57(2), 155-162 (2004).
12. del Pozo-Rodriguez A, Delgado D, Solinis MA, Gascon AR, Pedrez JL. Solid lipid nanoparticles: formulation factors affecting cell transfection capacity. Int. J. Pharm. 339(1-2), 261-268 (2007).
13. Bondi ml, Azzolina A, Craparo EF et al. Novel cationic-solid lipid nanoparticles as non-viral vectors for gene delivery. J. Drug. Target. 15(4), 295-301 (2007).
14. Torchilin V. TAT peptide-mediated intracellular delivery of pharmaceutical nanocarriers. Adv. Drug. Deliv. Rev. 60(4-5), 548-558 (2008). Role of protamine in the transfection enhancement of nonviral vector is well underlined.
15. Yuan H, Zhang W, Du YZ, Hu FQ. Ternary nanoparticles of anionic lipid nanoparticles/protamine/DNA for gene delivery. Int. J. Pharm. 392(1-2), 224-231 (2010).
16. del Pozo-Rodriguez A, Pujals S, Delgado D et al. A proline-rich peptide improves cell transfection of solid lipid nanoparticle-based non viral-vectors. J. Control. Release 133(1), 52-59 (2009).
17. Vighi E, Ruozi B, Montanari M, Battini R, Leo E. Re-dispersible cationic solid lipid nanoparticles (SLNs) freeze-dried without cryoprotectors: characterization and ability to bind the pEGFP plasmid. Eur. J. Pharm. Biopharm. 67, 320-328 (2007).
18. Vighi E, Ruozi B, Montanari M, Battini R, Leo E. pDNA condensation capacity and in vitro gene delivery properties of cationic solid lipid nanoparticles. Int. J. Pharm. 389(1-2), 254-261 (2010).
19. Vighi E, Montanari M, Ruozi B, Tosi G, Magli A, Leo E. Nuclear localization of cationic solid lipid nanoparticles containing Protamine as transfection promoter. Eur. J. Pharm. Biopharm. 76(3), 384-393 (2010).
20. Lombardi-Borgia S, Regehly M, Sivaramakrishnan R et al. Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and paraelectric spectroscopy. J. Control. Release 110, 151-163 (2005).
21. Stewart JC. Colorimetric determination of phospholipids with ammonium ferrothiocyanate. Anal. Biochem. 104(1), 10-14 (1980).
22. Sorgi FL, Huang L. Large scale production of DC-Chol cationic liposomes by microfluidization. Int. J. Pharm. 144(2), 131-139 (1996).
23. Childs CE. The determination of polyethylene glicole in γ globulin solution. Microchem. J. 20(2), 190-192 (1975).
24. Pintel DJ, Tullis GE. Transfection of mammalian cells using linear polyethylenimine is a simple and effective means of producing recombinant adeno-associated virus vectors. J. Virol. Methods 138(1-2), 85-98 (2006).
25. Huh S-H, Do HJ, Lim HY et al. Optimazation of 25 KDa linear polyethylenimine for efficient gene delivery. Biologicals 35(3), 165-171 (2007).
26. Xu Z, Pilch DS, Srinivasan AR, Olson WK, Geacintov NE, Breslauer KJ. Modulation of nucleic acid structure by ligand binding: induction of DNA-RNA-DNA hybrid triplex by DAPI intercalation. Bioorg. Med. Chem. 5(6), 1137-1147 (1997).
27. Sherwood SA. Data ana lysis in x-ray photonelectron spectroscopy. In: Practical Surface Ana lysis (2nd Edition). Wiley, NY, USA 555-594 (1990).
28. Tsuchiya Y, Ishii T, Okahata Y, Sato T. Characterization of protamine as transfection accelerator for gene delivery. J. Bioact. Comp. Pol. 21(6), 519-537 (2006).
29. Shubert MA, Harms M, Muller-Goymann CC. Structural incvestigation on lipid nanoparticles containing high amounts of lecithin. Eur. J. Pharm. Sci. 27(2-3), 223-236 (2006).
30. Jores K, Mehenert W, Mader K. Physicochemical investigations on solid lipid nanoparticles and oil-loaded solid lipid nanoparticles: a nuclear magnetic resonance and electron spin resonance study. Pharm. Res. 20(8), 1274-1283 (2003).
31. Fan TWM. Metabolite profiling by one- and two- dimensional NMR ana lysis of complex mixtures. Prog. Nucl. Magn. Reson. Spectrosc. 28(2), 161-219 (1996).
32. Ma B, Zhang S, Jiang H, Zhao B, Lv H. Lipoplex morphologies and their influence on transfection efficiency in gene delivery. J. Control. Release 123(3), 184-191 (2007).
33. Elouahabi A, Ruysschaert JM. Formation and intracellular trafficking of lipoplexes and polyplexes. Mol. Ther. 11(3), 336-347 (2005). The polyplex/lipoplex physicochemical properties crucial for efficient gene delivery are clearly discussed.
34. del Pozo-Rodriguez A, Delgado D, Solinis MA, Gascon AR, Pedraz JL. Solid lipid nanoparticles for retinal gene therapy: transfection and intracellular trafficking in RPE cells. Int. J. Pharm. 360, 177-183 (2008).
35. Mukerjee A, Vishwanatha JK. Formulation, characterization and evaluation of curamin-loaded PLGA nanospheres for cancer therapy. Anticancer Res. 29, 3867-3876 (2009).
36. Boulon S, Westman BJ, Hutten S, Boisvert F-M, Lamond AI. The nucleolus under stress. Mol. Cell. 40(2), 216-227 (2010). Elucidates nucleolus structure and suggests nucleoli targeting as an alternative and efficient strategy for the treatment of cancer.
37. Louvet E, Junera HR, Le Panse S, Hernandez-Verdun D. Dynamics and compartmentation of the nucleolar processing machinery. Exp. Cell Res. 304, 457-470 (2005).
38. Carlotti F, Bazuine M, Kekarainen T et al. Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes. Mol. Ther. 9, 209-217(2004).
39. Vereshchagina N, Wilson C. Cytoplasmatic activated protein kinase AKT regulates lipid-droplet accumulation in Drosophila nurse cells. Development 133, 4731-4735 (2006).
40. Valdearcos M, Esquinas E, Guijas C et al. Subcellular localization and role of Lipin-1 in human macrophages. J. Imm. 186(10), 6004-6013 (2011).
41. Dean DA, Strong DD, Zimmer WE. Nucelar entry of non-viral vectors. Gene Ther. 12(11), 881-890 (2005).
42. Storni T, Kundig TM, Senti G, Johansen P. Immunity in response to particulate antigen-delivery systems. Adv. Drug Deliv. Rev. 57, 335-355 (2005).
43. Fisher S, Vetz-von Allen E, Waeckerle-Men Y, Groettrip M, Merkle HP, Gander B. The preservation of phenotype and functionality of dendritic cells upon phagocytosis of polyelectrolyte-coated PLGA microparticles. Biomaterials 28, 994-1004 (2007).
44. Varkouhi AK, Scholte M, Storm G, Haisma HJ. Endosomal escape pathways for delivery of biological. J. Control. Release 151, 220-228 (2011).
45. Budai L, Hajdù M, Budai M et al. Gels and liposomes in optimized ocular delivery: studies on ciprofloxacin formulations. Int. J. Pharm. 343(1-2), 34-40 (2007).
46. Lam YW, Trinkle-Mulcahy L, Lamond AI. The nucleolus. J. Cell Sci. 118(7), 1335-1337 (2005). Explains the role of the nucleoli in cell physiology.
47. Grummt I. Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus. Genes Dev. 17(14), 1691-1702 (2003).
48. Rubbi CP, Milner J. Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses. EMBO J. 22(22), 6068-6077 (2003).
49. Yu B, Mitchell GA, Richter A. Nucleolar localization of cirhin, the protein mutated in North American Indian childhood cirrhosis. Exp. Cell Res. 311(2), 218-228 (2005). Nucleoli are highlighted as an important target for gene therapy of genetic disease.
50. Timani KA, Liao Q, Ye L et al. Nuclear/ nucleolar localization properties of C-terminal nucleocapsid protein of SARS coronavirus. Virus Res. 114(1-2), 23-34 (2005).
51. Biological magnetic resonance data bank. www. bmrb.wisc.edu