Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells

Development

Volumn 133, Issue 23, 2006, Pages 4731-4735

  Vereshchagina, Natalia ^a   Wilson, Clive ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Drosophila; Insulin; Obesity; Oogenesis; PTEN

Indexed keywords

FAT DROPLET; INSULIN; PERILIPIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SOMATOMEDIN; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CELL GROWTH; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; DEVELOPMENT; DISEASE ASSOCIATION; DROSOPHILA; DROSOPHILA MELANOGASTER; ENZYME ACTIVATION; FEMALE; GENETIC CONSERVATION; GROWTH REGULATION; INSULIN RESISTANCE; LIFESPAN; LIPID METABOLISM; LIPID STORAGE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRIENT; OVARY CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; GENES, INSECT; INSULIN; LIPID METABOLISM; MODELS, BIOLOGICAL; MUTATION; OVARY; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; SOMATOMEDINS;

VERTEBRATA;

EID: 33846108659     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.02659     Document Type: Article

References (38)

1. Akimoto, N., Sato, T., Iwata, C., Koshizuka, M., Shibata, F., Nagai, A., Sumida, M. and Ito, A. (2005). Expression of perilipin A on the surface of lipid droplets increases along with the differentiation of hamster sebocytes in vivo and in vitro. J. Invest. Dermatol. 124, 1127-1133.
2. Ayala, G., Thompson, T, Yang, G., Frolov, A., Li, R., Scardino, P., Ohori, M., Wheeler, T. and Harper, W. (2004). High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clin. Cancer Res. 10, 6572-6578.
3. Böhni, R., Riesgo-Escovar, J., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B. F, Beckingham, K. and Hafen, E. (1999). Autonomous control of cell, and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell 97, 865-875.
4. Britton, J. S., Lockwood, W. K., Li, L., Cohen, S. M. and Edgar, B. A. (2002). Drosophila's insulin/P13-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev. Cell 2, 239-249.
5. Brogiolo, W., Stocker, H., Ikeya, T, Rintelen, F, Fernandez, R. and Hafen, E. (2001). An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr. Biol. 11, 213-221.
6. Burks, D. J., Font de Mora, J., Schubert, M., Withers, D. J., Myers, M. G., Towery, H. H., Altamuro, S. L., Flint, C. L. and White, M. F. (2000). IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 407, 377-382.
7. Déléris, P., Gayral, S. and Breton-Douillon, M. (2006). Nuclear Ptdlns(3,4,5)P(3) signaling: an ongoing story. J. Cell. Biochem. 98, 469-485.
8. Downward, J. (1998). Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell Biol. 10, 262-267.
9. Drummond-Barbosa, D. and Spradling, A. C. (2001). Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis. Dev. Biol. 231, 265-278.
10. Dugani, C. B. and Klip, A. (2005). Glucose transporter 4, cycling, compartments and controversies. EMBO Rep. 6, 1137-1142.
11. Eberle, D., Hegarty, B., Bossard, P., Ferre, P. and Foufelle, E (2004). SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 86, 839-848.
12. Gao, X., Neufeld, T. P. and Pan, D. (2000). Drosophila PTEN regulates cell growth and proliferation through P13K-dependent and -independent pathways. Dev. Biol. 221, 404-418.
13. Goberdhan, D. C. I. and Wilson, C. (2003a). The functions of insulin signalling: size isn't everything, even in Drosophila. Differentiation 71, 375-397.
14. Goberdhan, D. C. I. and Wilson, C. (2003b). PTEN: multifunctional growth regulator and more. Hum. Mol. Genet 12, R239-R248.
15. Goberdhan, D. C., Paricio, N., Goodman, E. C., Mlodzik, M. and Wilson, C. (1999). Drosophila tumour suppressor PTEN controls cell size and number by antagonising the P13-kinase/Chico signaling pathway. Genes Dev. 13, 3244-3258.
16. Goberdhan, D. C. I., Meredith, D., Boyd, C. A. R. and Wilson, C. (2005). PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Development 132, 2365-2375.
17. Hafen, E. (2004). Cancer, type 2 diabetes, and ageing: news from flies and worms. Swiss Med. Wkly 134, 711-719.
18. Harrington, L. S., Findlay, G. M. and Lamb, R. F. (2005). Restraining P13K: mTOR signalling goes back to the membrane. Trends Biochem. Sci. 30, 35-42.
19. Haslam, D. W. and James, W. P. (2005). Obesity. Lancet 366, 1197-1209.
20. Holm, C. (2003). Molecular mechanisms regulating hormone-sensitive lipase and lipolysis, Biochem. Soc. Trans. 31, 1120-1124.
21. Horie, Y., Suzuki, A., Kataoka, E., Sasaki, T., Hamada, K., Sasaki, J., Mizuno, K., Hasegawa, G., Kishimoto, H., Iizuka, M. et al. (2004). Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J. Clin. Invest 113, 1774-1783.
22. Huang, H., Potter, C. J., Tao, W., Li, D. M., Brogiolo, W., Hafen, E., Sun, H. and Xu, T. (1999). PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development 126, 5365-5372.
23. Kovacs, P. and Stumvoll, M. (2005). Fatty acids and insulin resistance in muscle and liver. Best Pract. Res. Clin. Endocrinol. Metab. 19, 625-635.
24. Kumar, R. and Hung, M. C. (2005). Signaling intricacies take center stage in cancer cells. Cancer Res. 65, 2511-2515.
25. Leevers, S. J., Weinkove, D., MacDougall, L. K., Hafen, E. and Waterfield, M. D. (1996). The Drosophila phosphoinositice 3-kinase Dp110 promotes cell growth. EMBO J. 15, 6584-6594.
26. Magun, R., Burgering, B. M., Coffer, P. J., Pardasani, D., Lin, Y., Chabot, J. and Sorisky, A. (1996). Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation. Endocrinology 137, 3590-3593.
27. Neufeld, T. P, de la Cruz, A. D. A., Johnston, L. A. and Edgar, B. A. (1998). Coordination of growth and cell division in the Drosophila wing. Cell 93, 1183-1193.
28. Oldham, S., Stocker, H., Laffargue, M., Wittwer, F., Wymann, M. and Hafen, E. (2002). The Drosophila insulin/IGF receptor controls growth and size by modulating PtdlnsP(3) levels. Development 129, 4103-4109.
29. Pinal, N., Goberdhan, D. C., Collinson, L., Fujita, Y., Cox, I. M., Wilson, C. and Pichaud, F. (2006). Regulated and polarized accumulation of Ptdlns(3,4,5)P3 is essential for morphogenesis of the apical membrane in photoreceptor epithelial cells. Curr. Biol. 16, 140-149.
30. Prusty, D., Park, B. H., Davis, K. E. and Farmer, S. R. (2002). Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARgamma) and C/ EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes. J. Biol. Chem. 277, 46226-46232.
31. Puig, O. and Tjian, R. (2005). Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. Genes Dev. 19, 2435-2446.
32. Rulifson, E. J., Kim, S. K. and Nusse, R. (2002). Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296, 1118-1120.
33. Schwertfeger, K. L., McManaman, J. L., Palmer, C. A., Neville, M. C. and Anderson, S. M. (2003). Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation. J. Lipid Res. 44, 1100-1112.
34. Stocker, H., Andjelkovic, M., Oldham, S., Laffargue, M., Wymann, M. P., Hemmings, B. A. and Hafen, E. (2002). Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/ PKB. Science 295, 2088-2091.
35. Sulis, M. L. and Parsons, R. (2003). PTEN: from pathology to biology. Trends Cell Biol 13, 478-483.
36. Teixeira, L., Rabouille, C., Rorth, P., Ephrussi, A. and Vanzo, N. F. (2003). Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism. Mech. Dev. 120, 1071-1081.
37. Teleman, A. A., Chen, Y. W. and Cohen, S. M. (2005). Drosophila Melted modulates FOXO and TOR activity. Dev. Cell 9, 271-281.
38. Welte, M. A., Cermelli, S., Griner, J., Viera, A., Guo, Y., Kim, D. H., Gindhart, J. G. and Gross, S. P. (2005). Regulation of lipid-droplet transport by the perilipin homolog LSD2. Curr. Biol. 15, 1266-1275.