Nitrogen oxide-releasing aspirin induces histone H2AX phosphorylation, ATM activation and apoptosis preferentially in S-phase cells: Involvement of reactive oxygen species

Cell Cycle

Volumn 5, Issue 15, 2006, Pages 1669-1674

  Tanaka, Toshiki ^a,b   Kurose, Akira ^a,c   Halicka, H Dorota ^a   Huang, Xuan ^a   Traganos, Frank ^a   Darzynkiewicz, Zbigniew ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Anti oxidants; Cell cycle; Chromatin; DNA damage; DNA double strand breaks; DNA repair; DNA replication; Free radicals; Mitosis; Oxidative stress; ROIs; S phase

Indexed keywords

ACETYLCYSTEINE; ACETYLSALICYLIC ACID; ATM PROTEIN; CASPASE 3; HISTONE H2AX; NITRIC OXIDE DONOR; NITRIC OXIDE RELEASING ACETYLSALICYLIC ACID; NITROGEN OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE S PHASE; CHROMATIN; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NICK END LABELING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

EID: 33747814469     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.15.3100     Document Type: Article

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