Post-injury administration of the mitochondrial permeability transition pore inhibitor, NIM811, is neuroprotective and improves cognition after traumatic brain injury in rats

Journal of Neurotrauma

Volumn 28, Issue 9, 2011, Pages 1845-1853

  Readnower, Ryan D ^a   Pandya, Jignesh D ^a   McEwen, Melanie L ^a   Pauly, James R ^a,b   Springer, Joseph E ^a   Sullivan, Patrick G ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

cognitive function; mitochondria; neurodegeneration; neuroprotection; TBI

Indexed keywords

BIOLOGICAL MARKER; CYCLOSPORIN A [4 N METHYLISOLEUCINE];

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; BRAIN CORTEX; BRAIN MITOCHONDRION; BRAIN REGION; COGNITION; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORPUS CALLOSUM; DOSE RESPONSE; DRUG EFFICACY; HIPPOCAMPUS; INJURY SEVERITY; MALE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; NEUROPROTECTION; NEUROPSYCHOLOGICAL TEST; NONHUMAN; OXIDATIVE STRESS; RAT; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN INJURIES; COGNITION; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; MALE; MAZE LEARNING; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 80054825353     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2011.1755     Document Type: Article

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