Biochemical, structural, and biomarker evidence for calpain-mediated cytoskeletal change after diffuse brain injury uncomplicated by contusion

Journal of Neuropathology and Experimental Neurology

Volumn 68, Issue 3, 2009, Pages 241-249

  McGinn, Melissa J ^a   Kelley, Brian J ^a   Akinyi, Linnet ^b   Oli, Monika W ^b   Liu, Ming Cheng ^c   Hayes, Ronald L ^c   Wang, Kevin K W ^c,d   Povlishock, John T ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b Diagnostic Research and Development Department

^c BANYAN BIOMARKERS INC   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Biomarker; Calpain; Cytoskeleton; Diffuse axonal injury; Spectrin; Traumatic brain injury

Indexed keywords

BIOLOGICAL MARKER; CALPAIN; FODRIN; SPECTRIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BRAIN CONTUSION; CELLULAR DISTRIBUTION; CEREBROSPINAL FLUID; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NEOCORTEX; NERVE ENDING; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STRUCTURE; RAT; THALAMUS; TRAUMATIC BRAIN INJURY; WESTERN BLOTTING; WHITE MATTER; ANIMAL; BRAIN INJURY; CYTOSKELETON; ENZYMOLOGY; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BRAIN INJURIES; CALPAIN; CYTOSKELETON; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; RATS; RATS, SPRAGUE-DAWLEY; SPECTRIN;

EID: 65349147745     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181996bfe     Document Type: Article

References (43)

1. Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: A brief overview. J Head Trauma Rehabil 2006;21:375-378
2. Bramlett HM, Dietrich WD. Progressive damage after brain and spinal cord injury: Pathomechanisms and treatment strategies. Prog Brain Res 2007;161:125-141
3. Buki A, Povlishock JT. All roads lead to disconnection?VTraumatic axonal injury revisited. Acta Neurochir (Wien) 2006;148:181-193
4. Farkas O, Povlishock JT. Cellular and subcellular change evoked by diffuse traumatic brain injury: A complex web of change extending far beyond focal damage. Prog Brain Res 2007;161:43-59
5. Povlishock JT, Katz DI. Update of neuropathology and neurological recovery after traumatic brain injury. J Head Trauma Rehabil 2005;20: 76-94
6. Vanderklish PW, Bahr BA. The pathogenic activation of calpain: A marker and mediator of cellular toxicity and disease states. Int J Exp Pathol 2000;81:323-339 .
7. Czogalla A, Sikorski AF. Spectrin and calpain: A Ftarget- and a Fsniper- in the pathology of neuronal cells. Cell Mol Life Sci 2005;62:1913-1924
8. Liu J, Liu MC, Wang KK. Calpain in the CNS: From synaptic function to neurotoxicity. Sci Signal 2008;1:tr3
9. Saatman KE, Bozyczko-Coyne D, Marcy V, et al. Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat. J Neuropathol Exp Neurol 1996;55:850-860
10. Siman R, Baudry M, Lynch G. Brain fodrin: Substrate for calpain I, an endogenous calcium-activated protease. Proc Natl Acad Sci U S A 1984; 81:3572-3576
11. Siman R, Noszek JC. Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo. Neuron 1988;1:279-287
12. Roberts-Lewis JM, Siman R. Spectrin proteolysis in the hippocampus: A biochemical marker for neuronal injury and neuroprotection. Ann N Y Acad Sci 1993;679:78-86
13. Buki A, Siman R, Trojanowski JQ, et al. The role of calpain-mediated spectrin proteolysis in traumatically induced axonal injury. J Neuro-pathol Exp Neurol 1999;58:365-375
14. Newcomb JK, Kampfl A, Posmantur RM, et al. Immunohistochemical study of calpain-mediated breakdown products to alpha-spectrin following controlled cortical impact injury in the rat. J Neurotrauma 1997;14: 369-383
15. Pike BR, Zhao X, Newcomb JK, et al. Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injury. Neuroreport 1998;9:2437-2442
16. McCracken E, Hunter AJ, Patel S, et al. Calpain activation and cytoskeletal protein breakdown in the corpus callosum of head-injured patients. J Neurotrauma 1999;16:749-761
17. Pineda JA, Wang KK, Hayes RL. Biomarkers of proteolytic damage following traumatic brain injury. Brain Pathol 2004;14:202-209
18. Siman R, McIntosh TK, Soltesz KM, et al. Proteins released from degenerating neurons are surrogate markers for acute brain damage. Neurobiol Dis 2004;16:311-20
19. Farkas O, Polgar B, Szekeres-Bartho J, et al. Spectrin breakdown products in the cerebrospinal fluid in severe head injuryVPreliminary observations. Acta Neurochir (Wien) 2005;147:855-861
20. Pineda JA, Lewis SB, Valadka AB, et al. Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury. J Neurotrauma 2007;24:354-366
21. Cardali S, Maugeri R. Detection of alphaII-spectrin and breakdown products in humans after severe traumatic brain injury. J Neurosurg Sci 2006;50:25-31
22. Deng Y, Thompson BM, Gao X, et al. Temporal relationship of peroxynitrite-induced oxidative damage, calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury. Exp Neurol 2007;205:154-165
23. Hall ED, Sullivan PG, Gibson TR, et al. Spatial and temporal characteristics of neurodegeneration after controlled cortical impact in mice: More than a focal brain injury. J Neurotrauma 2005;22: 252-265
24. Kelley BJ, Lifshitz J, Povlishock JT. Neuroinflammatory responses after experimental diffuse traumatic brain injury. J Neuropathol Exp Neurol 2007;66:989-1001
25. Sullivan HG, Martinez J, Becker DP, et al. Fluid-percussion model of mechanical brain injury in the cat. J Neurosurg 1976;45:521-534
26. Dixon CE, Lyeth BG, Povlishock JT, et al. A fluid percussion model of experimental brain injury in the rat. J Neurosurg 1987;67:110-119
27. Nath R, Huggins M, Glantz SB, et al. Development and characterization of antibodies specific to caspase-3-produced alpha IIYspectrin 120 kDa breakdown product: Marker for neuronal apoptosis. Neurochem Int 2000;37:351-361
28. Wang KK. Calpain and caspase: Can you tell the difference? Trends Neurosci 2000;23:20-26
29. Stone JR, Walker SA, Povlishock JT. The visualization of a new class of traumatically injured axons through the use of a modified method of microwave antigen retrieval. Acta Neuropathol 1999;97:335-345
30. Huh JW, Widing AG, Raghupathi R. Basic science; repetitive mild non-contusive brain trauma in immature rats exacerbates traumatic axonal injury and axonal calpain activation: A preliminary report. J Neurotrauma 2007;24:15-27
31. Kupina NC, Nath R, Bernath EE, et al. The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury. J Neurotrauma 2001;18:1229-1240
32. Kupina NC, Detloff MR, Bobrowski WF, et al. Cytoskeletal protein degradation and neurodegeneration evolves differently in males and females following experimental head injury. Exp Neurol 2003;180: 55-73
33. Aikman J, O'Steen B, Silver X, et al. Alpha-IIYspectrin after controlled cortical impact in the immature rat brain. Dev Neurosci 2006;28:457-465
34. Thompson SN, Gibson TR, Thompson BM, et al. Relationship of calpain-mediated proteolysis to the expression of axonal and synaptic plasticity markers following traumatic brain injury in mice. Exp Neurol 2006;201:253-265
35. Huh JW, Franklin MA, Widing AG, et al. Regionally distinct patterns of calpain activation and traumatic axonal injury following contusive brain injury in immature rats. Dev Neurosci 2006;28:466-476
36. Serbest G, Burkhardt MF, Siman R, et al. Temporal profiles of cytoskeletal protein loss following traumatic axonal injury in mice. Neurochem Res 2007;32:2006-2014
37. Saatman KE, Abai B, Grosvenor A, et al. Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in mice. J Cereb Blood Flow Metab 2003;23:34-42
38. Ai J, Liu E, Wang J, et al. Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J Neurotrauma 2007;24:960-978
39. Farkas O, Lifshitz J, Povlishock JT. Mechanoporation induced by diffuse traumatic brain injury: An irreversible or reversible response to injury? J Neurosci 2006;26:3130-3140
40. Buki A, Farkas O, Doczi T, et al. Preinjury administration of the calpain inhibitor MDL-28170 attenuates traumatically induced axonal injury. J Neurotrauma 2003;20:261-268
41. Pike BR, Flint J, Dutta S, et al. Accumulation of non-erythroid alpha IIYspectrin and calpain-cleaved alpha IIYspectrin breakdown products in cerebrospinal fluid after traumatic brain injury in rats. J Neurochem 2001;78:1297-1306
42. Ringger NC, O'Steen BE, Brabham JG, et al. A novel marker for traumatic brain injury: CSF alphaII-spectrin breakdown product levels. J Neurotrauma 2004;21:1443-1456
43. Belanger HG, Vanderploeg RD, Curtiss G, et al. Recent neuroimaging techniques in mild traumatic brain injury. J Neuropsychiatry Clin Neurosci 2007;19:5-20 (Pubitemid 46294440)