High throughput short interfering RNA (siRNA) screening of the human kinome identifies novel kinases controlling the canonical nuclear factor-κB (NF-κB) activation pathway

Journal of Biological Chemistry

Volumn 286, Issue 43, 2011, Pages 37187-37195

  Choudhary, Sanjeev ^a,b   Rosenblatt, Kevin P ^d,e   Fang, Ling ^b   Tian, Bing ^b   Wu, Zhao Hui ^c   Brasier, Allan R ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d UNIVERSITY OF TEXAS   (United States)

^e UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION PATHWAY; CANDIDATE GENES; CYTOKINES; EPITHELIAL CELLS; HIGH THROUGHPUT; HUMAN KINASE; MASTER REGULATORS; MOUSE EMBRYO FIBROBLASTS; NUCLEAR FACTORS; NUCLEAR TRANSLOCATIONS; REPORTER GENE; SCREENING ASSAYS; SHORT INTERFERING RNA (SIRNA); TYPE II; Z-SCORES;

AUTOMATIC TELLER MACHINES; CELL CULTURE; GENES; INTERNET PROTOCOLS; MAMMALS; PHOSPHORYLATION; RNA; SIGNALING; THROUGHPUT; TRANSCRIPTION; TRANSCRIPTION FACTORS;

ENZYMES;

ATM PROTEIN; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE 7; ELONGATION FACTOR 2 KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 5; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 3; PROTEIN KINASE; SERINE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EPITHELIUM CELL; FIBROBLAST; GENE SILENCING; GENETIC TRANSCRIPTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; CELL LINE; EMBRYO, MAMMALIAN; FIBROBLASTS; HUMANS; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN KINASES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80054811234     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.224923     Document Type: Article

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