Phosphorylation of Thr-516 and Ser-520 in the kinase activation loop of MEKK3 is required for lysophosphatidic acid-mediated optimal IκB kinase β (IKKβ)/nuclear factor-κB (NF-κB) activation

Journal of Biological Chemistry

Volumn 285, Issue 11, 2010, Pages 7911-7918

  Sun, Wenjing ^a,b   Ge, Ningling ^a,c   Yu, Yang ^a,b   Burlingame, Susan ^a   Li, Xiaonan ^a   Zhang, Ming ^a   Ye, Shenglong ^c   Fu, Songbin ^b   Yang, Jianhua ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC RESIDUES; CONSTITUTIVELY ACTIVES; KINASE ACTIVATION; LYSOPHOSPHATIDIC ACID; MOLECULAR LEVELS; NUCLEAR FACTORS; PHOSPHORYLATION SITES; SIGNALING MOLECULES;

ACIDS; CHEMICAL ACTIVATION; LAWS AND LEGISLATION; PHOSPHORYLATION;

PHOSPHOLIPIDS;

ALANINE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 3; SERINE; THREONINE; ANTIBODY; I KAPPA B KINASE; IL6 PROTEIN, HUMAN; LUCIFERASE; LYSOPHOSPHOLIPID; MAP3K3 PROTEIN, HUMAN; PROTEIN KINASE C;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; CELL CULTURE; CELL DIVISION; CYTOLOGY; GENETICS; IMMUNOLOGY; KIDNEY; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PHYSIOLOGY; RABBIT; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; CELL DIVISION; CELLS, CULTURED; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-6; KIDNEY; LUCIFERASES; LYSOPHOSPHOLIPIDS; MAP KINASE KINASE KINASE 3; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NF-KAPPA B; PHOSPHORYLATION; PROTEIN KINASE C; RABBITS; SERINE; SIGNAL TRANSDUCTION; THREONINE;

EID: 77950891312     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.051219     Document Type: Article

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