-
1
-
-
0038052805
-
The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer
-
Vermeulen K, Van Bockstaele DR, Berneman ZN (2003a) The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif. 36, 131 149.
-
(2003)
Cell Prolif.
, vol.36
, pp. 131-149
-
-
Vermeulen, K.1
Van Bockstaele, D.R.2
Berneman, Z.N.3
-
2
-
-
0037155839
-
E2F-1 is essential for normal epidermal wound repair
-
D'Souza SJ, Vespa A, Murkherjee S, Maher A, Pajak A, Dagnino L (2002) E2F-1 is essential for normal epidermal wound repair. J. Biol. Chem. 277, 10626 10632.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 10626-10632
-
-
D'Souza, S.J.1
Vespa, A.2
Murkherjee, S.3
Maher, A.4
Pajak, A.5
Dagnino, L.6
-
3
-
-
0035252592
-
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
-
Muller H, Bracken AP, Vernell R, Moroni MC, Christians F, Grassilli E, Prosperini E, Vigo E, Oliner JD, Helin K (2001) E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev. 15, 267 285.
-
(2001)
Genes Dev.
, vol.15
, pp. 267-285
-
-
Muller, H.1
Bracken, A.P.2
Vernell, R.3
Moroni, M.C.4
Christians, F.5
Grassilli, E.6
Prosperini, E.7
Vigo, E.8
Oliner, J.D.9
Helin, K.10
-
4
-
-
0036897835
-
A revised picture of the E2F transcriptional network and RB function
-
Stevaux O, Dyson NJ (2002) A revised picture of the E2F transcriptional network and RB function. Curr. Opin. Cell Biol. 14, 684 691.
-
(2002)
Curr. Opin. Cell Biol.
, vol.14
, pp. 684-691
-
-
Stevaux, O.1
Dyson, N.J.2
-
5
-
-
0037445901
-
E2F and cell cycle control: A double-edged sword
-
Stevens C, La Thangue NB (2003) E2F and cell cycle control: a double-edged sword. Arch. Biochem. Biophys. 412, 157 169.
-
(2003)
Arch. Biochem. Biophys.
, vol.412
, pp. 157-169
-
-
Stevens, C.1
La Thangue, N.B.2
-
7
-
-
0042303844
-
Cyclin-dependent kinase inhibitors
-
Dai Y, Grant S (2003) Cyclin-dependent kinase inhibitors. Curr. Opin. Pharmacol. 3, 362 370.
-
(2003)
Curr. Opin. Pharmacol.
, vol.3
, pp. 362-370
-
-
Dai, Y.1
Grant, S.2
-
8
-
-
0036716567
-
Recent advances in cyclin-dependent kinase inhibition. Purine-based derivatives as anti-cancer agents. Roles and perspectives for the future
-
Haesslein JL, Jullian N (2002) Recent advances in cyclin-dependent kinase inhibition. Purine-based derivatives as anti-cancer agents. Roles and perspectives for the future. Curr. Top. Med. Chem. 2, 1037 1050.
-
(2002)
Curr. Top. Med. Chem.
, vol.2
, pp. 1037-1050
-
-
Haesslein, J.L.1
Jullian, N.2
-
9
-
-
0031742097
-
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity
-
Alessi F, Quarta S, Savio M, Riva F, Rossi L, Stivala LA, Scovassi AI, Meijer L, Prosperi E (1998) The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp. Cell Res. 245, 8 18.
-
(1998)
Exp. Cell Res.
, vol.245
, pp. 8-18
-
-
Alessi, F.1
Quarta, S.2
Savio, M.3
Riva, F.4
Rossi, L.5
Stivala, L.A.6
Scovassi, A.I.7
Meijer, L.8
Prosperi, E.9
-
11
-
-
0037392942
-
The specificities of protein kinase inhibitors: An update
-
Bain J, McLauchlan H, Elliott M, Cohen P (2003) The specificities of protein kinase inhibitors: an update. Biochem. J. 371, 199 204.
-
(2003)
Biochem. J.
, vol.371
, pp. 199-204
-
-
Bain, J.1
McLauchlan, H.2
Elliott, M.3
Cohen, P.4
-
12
-
-
33750714000
-
Cyclin-dependent kinase (CDK) inhibitor olomoucine enhances gamma-irradiation-induced apoptosis and cell cycle arrest in Raji cells
-
Boutis A, Papazisis K, Pistevou-Gompaki K, Lambropoulos A, Sofroniadis I, Papageorgiou A, Destouni E, Kortsaris A (2006) Cyclin-dependent kinase (CDK) inhibitor olomoucine enhances gamma-irradiation-induced apoptosis and cell cycle arrest in Raji cells. Anticancer Res. 26, 3493 3498.
-
(2006)
Anticancer Res.
, vol.26
, pp. 3493-3498
-
-
Boutis, A.1
Papazisis, K.2
Pistevou-Gompaki, K.3
Lambropoulos, A.4
Sofroniadis, I.5
Papageorgiou, A.6
Destouni, E.7
Kortsaris, A.8
-
13
-
-
38149082690
-
R-Roscovitine simultaneously targets both the p53 and NF-κB pathways and causes potentiation of apoptosis: Implications in cancer therapy
-
Dey A, Wong ET, Cheok CF, Tergaonkar V, Lane DP (2008) R-Roscovitine simultaneously targets both the p53 and NF-κB pathways and causes potentiation of apoptosis: implications in cancer therapy. Cell Death Differ. 15, 263 273.
-
(2008)
Cell Death Differ.
, vol.15
, pp. 263-273
-
-
Dey, A.1
Wong, E.T.2
Cheok, C.F.3
Tergaonkar, V.4
Lane, D.P.5
-
14
-
-
33748462267
-
Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis
-
Rossi AG, Sawatzky DA, Walker A, Ward C, Sheldrake TA, Riley NA, Caldicott A, Martinez-Losa M, Walker TR, Duffin R, Gray M, Crescenzi E, Martin MC, Brady HJ, Savill JS, Dransfield I, Haslett C (2006) Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis. Nat. Med. 12, 1056 1064.
-
(2006)
Nat. Med.
, vol.12
, pp. 1056-1064
-
-
Rossi, A.G.1
Sawatzky, D.A.2
Walker, A.3
Ward, C.4
Sheldrake, T.A.5
Riley, N.A.6
Caldicott, A.7
Martinez-Losa, M.8
Walker, T.R.9
Duffin, R.10
Gray, M.11
Crescenzi, E.12
Martin, M.C.13
Brady, H.J.14
Savill, J.S.15
Dransfield, I.16
Haslett, C.17
-
15
-
-
0348143168
-
An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis
-
Calegari F, Huttner WB (2003) An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis. J. Cell Sci. 116, 4947 4955.
-
(2003)
J. Cell Sci.
, vol.116
, pp. 4947-4955
-
-
Calegari, F.1
Huttner, W.B.2
-
16
-
-
20444427615
-
Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury
-
Di Giovanni S, Movsesyan V, Ahmed F, Cernak I, Schinelli S, Stoica B, Faden AI (2005) Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc. Natl. Acad. Sci. USA 102, 8333 8338.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 8333-8338
-
-
Di Giovanni, S.1
Movsesyan, V.2
Ahmed, F.3
Cernak, I.4
Schinelli, S.5
Stoica, B.6
Faden, A.I.7
-
17
-
-
0030845233
-
Survival-promoting activity of inhibitors of cyclin-dependent kinases on primary neurons correlates with inhibition of c-Jun kinase-1
-
Markus MA, Kahle PJ, Winkler A, Horstmann S, Anneser JM, Borasio GD (1997) Survival-promoting activity of inhibitors of cyclin-dependent kinases on primary neurons correlates with inhibition of c-Jun kinase-1. Neurobiol. Dis. 4, 122 133.
-
(1997)
Neurobiol. Dis.
, vol.4
, pp. 122-133
-
-
Markus, M.A.1
Kahle, P.J.2
Winkler, A.3
Horstmann, S.4
Anneser, J.M.5
Borasio, G.D.6
-
18
-
-
2342587462
-
Roscovitine, olomoucine, purvalanol: Inducers of apoptosis in maturing cerebellar granule neurons
-
Monaco EA III, Beaman-Hall CM, Mathur A, Vallano ML (2004) Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons. Biochem. Pharmacol. 67, 1947 1964.
-
(2004)
Biochem. Pharmacol.
, vol.67
, pp. 1947-1964
-
-
Iii A., M.E.1
Beaman-Hall, C.M.2
Mathur, A.3
Vallano, M.L.4
-
19
-
-
3142724031
-
Toll-like receptor signaling
-
Akira S, Takeda K (2004) Toll-like receptor signaling. Nat. Rev. Immunol. 4, 499 511.
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
21
-
-
0037309925
-
Pathogenesis of sepsis: New concepts and implications for future treatment
-
Bochud PY, Calandra T (2003) Pathogenesis of sepsis: new concepts and implications for future treatment. BMJ 326, 262 266.
-
(2003)
BMJ
, vol.326
, pp. 262-266
-
-
Bochud, P.Y.1
Calandra, T.2
-
22
-
-
3142779901
-
Therapeutics targeting the innate immune system
-
Ulevitch RJ (2004) Therapeutics targeting the innate immune system. Nat. Rev. Immunol. 4, 512 520.
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 512-520
-
-
Ulevitch, R.J.1
-
23
-
-
25844459154
-
NF-κB: Linking inflammation and immunity to cancer development and progression
-
Karin M, Greten FR (2005) NF-κB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5, 749 759.
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
24
-
-
23344446570
-
Intestinal macrophages: Unique effector cells of the innate immune system
-
Smith PD, Ochsenbauer-Jambor C, Smythies LE (2005) Intestinal macrophages: unique effector cells of the innate immune system. Immunol. Rev. 206, 149 159.
-
(2005)
Immunol. Rev.
, vol.206
, pp. 149-159
-
-
Smith, P.D.1
Ochsenbauer-Jambor, C.2
Smythies, L.E.3
-
26
-
-
0035104119
-
LPS induction of gene expression in human monocytes
-
Guha M, Mackman N (2001) LPS induction of gene expression in human monocytes. Cell Signal 13, 85 94.
-
(2001)
Cell Signal
, vol.13
, pp. 85-94
-
-
Guha, M.1
MacKman, N.2
-
27
-
-
0042809629
-
Identification of a nuclear factor kappa B-dependent gene network
-
Tian B, Brasier AR (2003) Identification of a nuclear factor kappa B-dependent gene network. Recent Prog. Horm. Res. 58, 95 130.
-
(2003)
Recent Prog. Horm. Res.
, vol.58
, pp. 95-130
-
-
Tian, B.1
Brasier, A.R.2
-
28
-
-
0037080483
-
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints
-
Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD (2002) E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev. 16, 245 256.
-
(2002)
Genes Dev.
, vol.16
, pp. 245-256
-
-
Ren, B.1
Cam, H.2
Takahashi, Y.3
Volkert, T.4
Terragni, J.5
Young, R.A.6
Dynlacht, B.D.7
-
29
-
-
27144510937
-
Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation
-
Ying L, Marino J, Hussain SP, Khan MA, You S, Hofseth AB, Trivers GE, Dixon DA, Harris CC, Hofseth LJ (2005) Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation. Cancer Res. 65, 9132 9136.
-
(2005)
Cancer Res.
, vol.65
, pp. 9132-9136
-
-
Ying, L.1
Marino, J.2
Hussain, S.P.3
Khan, M.A.4
You, S.5
Hofseth, A.B.6
Trivers, G.E.7
Dixon, D.A.8
Harris, C.C.9
Hofseth, L.J.10
-
30
-
-
38849166053
-
Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target
-
Peer D, Park EJ, Morishita Y, Carman CV, Shimaoka M (2008) Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science 319, 627 630.
-
(2008)
Science
, vol.319
, pp. 627-630
-
-
Peer, D.1
Park, E.J.2
Morishita, Y.3
Carman, C.V.4
Shimaoka, M.5
-
31
-
-
34547838179
-
Genome-wide mapping of RELA (p65) binding identifies E2F1 as a transcriptional activator recruited by NF-κB upon TLR4 activation
-
Lim C-A, Yao F, Wong j J-Y, George J, Xu Han Chiu KP (2007) Genome-wide mapping of RELA (p65) binding identifies E2F1 as a transcriptional activator recruited by NF-κB upon TLR4 activation. Mol. Cell 27, 622 635.
-
(2007)
Mol. Cell
, vol.27
, pp. 622-635
-
-
Lim, C.-A.1
Yao, F.2
Wong, J.J.-Y.3
George, J.4
Xu Han Chiu, K.P.5
-
32
-
-
0030709410
-
Interaction between cell cycle regulator, E2F-1, and NF-κB mediates repression of HIV-1 gene transcription
-
Kundu M, Guermah M, Roeder RG, Amini S, Khalili K (1997) Interaction between cell cycle regulator, E2F-1, and NF-κB mediates repression of HIV-1 gene transcription. J. Biol. Chem. 272, 29468 29474.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 29468-29474
-
-
Kundu, M.1
Guermah, M.2
Roeder, R.G.3
Amini, S.4
Khalili, K.5
-
33
-
-
0036279279
-
E2F1 and c-Myc potentiate apoptosis through inhibition of NF-κB activity that facilitates MnSOD-mediated ROS elimination
-
Tanaka H, Matsumura I, Ezoe S, Satoh Y, Sakamaki T, Albanese C, Machii T, Testell RG, Kanakura Y (2002) E2F1 and c-Myc potentiate apoptosis through inhibition of NF-κB activity that facilitates MnSOD-mediated ROS elimination. Mol. Cell 9, 1017 1029.
-
(2002)
Mol. Cell
, vol.9
, pp. 1017-1029
-
-
Tanaka, H.1
Matsumura, I.2
Ezoe, S.3
Satoh, Y.4
Sakamaki, T.5
Albanese, C.6
MacHii, T.7
Testell, R.G.8
Kanakura, Y.9
-
34
-
-
33749462602
-
Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine
-
Tian DS, Yu ZY, Xie MJ, Bu BT, Witte OW, Wang W (2006) Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine. J. Neurosci. Res. 85, 1053 1063.
-
(2006)
J. Neurosci. Res.
, vol.85
, pp. 1053-1063
-
-
Tian, D.S.1
Yu, Z.Y.2
Xie, M.J.3
Bu, B.T.4
Witte, O.W.5
Wang, W.6
-
35
-
-
33846590145
-
Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats
-
Tian DS, Xie MJ, Yu ZY, Zhang Q, Wang YH, Chen B, Chen C, Wang W (2007) Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. Brain Res. 1135, 177 185.
-
(2007)
Brain Res.
, vol.1135
, pp. 177-185
-
-
Tian, D.S.1
Xie, M.J.2
Yu, Z.Y.3
Zhang, Q.4
Wang, Y.H.5
Chen, B.6
Chen, C.7
Wang, W.8
-
36
-
-
33847749886
-
Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo
-
Zhu Z, Zhang Q, Yu Z, Zhang L, Tian D, Zhu S, Bu B, Xie M, Wang W (2007) Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo. Glia 55, 546 558.
-
(2007)
Glia
, vol.55
, pp. 546-558
-
-
Zhu, Z.1
Zhang, Q.2
Yu, Z.3
Zhang, L.4
Tian, D.5
Zhu, S.6
Bu, B.7
Xie, M.8
Wang, W.9
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