Inhibition of TGF-β1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis

Kidney International

Volumn 50, Issue 1, 1996, Pages 148-155

  Akagi, Yoshitaka ^b   Isaka, Yoshitaka ^b   Arai, Makoto ^b   Kaneko, Tetsuya ^b   Takenaka, Masaru ^b   Moriyama, Toshiki ^b   Kaneda, Yasufumi ^b   Ando, Akio ^b   Orita, Yoshimasa ^b   Kamada, Takenobu ^b   Ueda, Naohiko ^b   Imai, Enyu ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; LIPOSOME; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY OX 7; THY ANTIGEN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ALLERGIC GLOMERULONEPHRITIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE REPRESSION; GENE TRANSFER; MALE; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 10144227768     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1996.297     Document Type: Article

References (31)

1. BORDER WA, RUOSLAHTI E: Transforming growth factor-β in disease: The dark side of tissue repair. J Clin Invest 90:1-7, 1992
2. BORDER WA, NOBLE NA: Transforming growth factor β in tissue fibrosis. N Engl J Med 331:1286-1292, 1994
3. WILSON CB: The renal response to immunologic injury, in The Kidney, edited by BRENNER BM, RECTOR FC, Philadelphia, Saunders, 1991, pp 1062-1181
4. STEFFES MW, ØSTERBY R, CHAVERS B, MAUER SM: Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients. Diabetes 38:1077-1081, 1989
5. RISER BL, CORTES P, ZHAO X, BERNSTEIN J, DUMLER F, NARINS RG: Intraglomerular pressure and mesangial stretching stimulate extracellular matrix formation in the rat. J Clin Invest 90:1932-1943, 1992
6. JOHNSON RJ: The glomerular response to injury: Progression or resolution? Kidney Int 45:1769-1782, 1994
7. JOHNSON RJ, FLOEGE J, YOSHIMURA A, IIDA H, COUSER WG, ALPERS CE: The activated mesangial cell: A glomerular "myofibroblast"? J Am Soc Nephrol 2:190-197, 1992
8. ABBOUD HE: Growth factors in glomerulonephritis. Kidney Int 43: 252-267, 1993
9. ROBERTS AB, FLANDERS KC, HEINE UI, JAKOWLEW S, KONDAIAH P, KIM SJ, SPORN MB: Transforming growth factor-β: Multifunctional regulator of differentiation and development. Phil Trans R Soc Lond B 327:145-154, 1990
10. YOSHIOKA K, TAKEMURA T, MURAKAMI K, OKADA M, HINO S, MIYAMOTO H, MAKI S: Transforming growth factor-β protein and mRNA in glomeruli in normal and diseased human kidneys. Lab Invest 68:154-163, 1993
11. YAMAMOTO T, NAKAMURA T, NOBLE NA, RUOSLAHTI E, BORDER WA: Expression of transforming growth factor β is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci USA 90:1814-1818, 1993
12. OKUDA S, LANGUINO LR, RUOSLAHTI E, BORDER WA: Elevated expression of transforming growth factor-β and proteoglycan production in experimental glomerulonephritis. J Clin Invest 86:453-462, 1990
13. ISAKA Y, FUJIWARA Y, UEDA N, KANEDA Y, KAMADA T, IMAI E: Glomerulosclerosis induced by in vivo transfection of transforming growth factor-β or platelet-derived growth factor gene into the rat kidney. J Clin Invest 92:2597-2601, 1993
14. BORDER WA, OKUDA S, LANGUINO LR, SPORN MB, RUOSLAHTI E: Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1. Nature (Lond) 346:371-374, 1990
15. ITOH H, MUKOYAMA M, PRATT RE, GIBBONS GH, DZAU VJ: Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II. J Clin Invest 91:2268-2274, 1993
16. KANEDA Y, IWAI K, UCHIDA T: Increased expression of DNA cointroduced with nuclear protein in adult rat liver. Science (Wash DC) 243:375-378, 1989
17. KATO K, KANEDA Y, SAKURAI M, NAKANISHI M, OKADA Y: Direct injection of Hepatitis B virus DNA into liver induced hepatitis in adult rats. J Biol Chem 266:22071-22074, 1991
18. KITTELBERGER R, DAVIS PF, STEHBENS WE: An improved immunofluorescence technique for the histological examination of blood vessels tissue. Acta Histochem 86:137-142, 1989
19. SHIN S, FUJIWARA Y, WADA A, TAKAMA T, ORITA Y, KAMADA T, TAGAWA K: Angiotensin II-induced increase in inositol 1,4,5-trisphosphate in cultured rat mesangial cells. Biochem Biophys Res Commun 142:70-77, 1987
20. QIAN SW, KONDAIAH P, ROBERTS AB, SPORN MB: cDNA cloning by PCR of rat transforming growth factor β-1. Nucl Acids Res 18:3059, 1990
21. KANEKO T, MORIYAMA T, IMAI E, AKAGI Y, ARAI M, INOUE T, XIA C, NOGUCHI T, KAMADA T, UEDA N: Expression of transmembrane-type protein tyrosine phosphatase mRNA along rat nephron segments. Am J Physiol 268:F1102-F1108, 1995
22. BAGCHUS WM, HOEDERMAEKER J, ROZING J, BAKKER WW: Glomerulonephritis induced by monoclonal anti-Thy 1.1 antibodies. Lab Invest 55:680-687, 1986
23. YAMAMOTO T, NOBLE NA, MILLER DE, BORDER WA: Sustained expression of TGF-β1 underlies development of progressive kidney fibrosis. Kidney Int 45:916-927, 1994
24. RAIJ L, AZAR S, KEANE W: Mesangial immune injury, hypertension and progressive glomerular damage in Dahl rats. Kidney Int 26:137-143, 1984
25. TOMITA N, HIGAKI J, MORISHITA R, KATO K, MIKAMI H, KANEDA Y, OGIHARA T: Direct in vivo gene introduction into rat kidney. Biochem Biophys Res Commun 186:129-134, 1992
26. BORDER WA, NOBLE NA, YAMAMOTO T, HARPER JR, YAMAGUCHI Y, PIERSCHBACHER MD, RUOSLAHTI E: Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease. Nature 360:361-364, 1992
27. WAGNER RW: Gene inhibition using antisense oligodeoxynucleotides. Nature 372:333-335, 1994
28. BURGESS TL, FISHER EF, ROSS SL, BREADY JV, QIAN YX, BAYEWITCH LA, COHEN AM, HERRERA CJ, HU SSF, KRAMER TB, LOTT FD, MARTIN FH, PIERCE GF, SIMONET L, FARRELL CL: The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism. Proc Natl Acad Sci USA 92:4051-4055, 1995
29. STEIN CA, CHENG YC: Antisense oligonucleotides as therapeutic agents - Is the bullet really magical? Science 261:1004-1012, 1993
30. KITAJIMA I, SHINOHARA T, BILAKOVICS J, BROWN DA, XU X, NERENBERG M: Ablation of transplanted HTLV-1 Tax-transformed tumors in mice by antisense inhibition of NF-κB. Science 258:1792-1795, 1992
31. MORISHITA R, GIBBONS GH, ELLISON KE, NAKAJIMA M, VON DER LEYEN H, ZHANG L, KANEDA Y, OGIHARA T, DZAU VJ: Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J Clin Invest 93:1458-1464, 1994