Insight into the binding of the wild type and mutated alginate lyase (AlyVI) with its substrate: A computational and experimental study

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1814, Issue 12, 2011, Pages 1739-1747

  Hamza, Adel ^b   Piao, Yu Lan ^c   Kim, Mi Sun ^a   Choi, Cheol Hee ^c   Zhan, Chang Guo ^b   Cho, Hoon ^a  

^a Chosun University   (South Korea)

^b University of Kentucky   (United States)

^c Chosun University College of Medicine   (South Korea)

Author keywords

Alginate lyase; AlyVI; Docking; Homology modeling; MD simulations; Site directed mutagenesis

Indexed keywords

ALGINATE LYASE; ARGININE; ASPARAGINE; HISTIDINE; LYASE; LYSINE; MUTANT PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DECOMPOSITION; ENERGY; ENZYME INACTIVATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; MOLECULAR DOCKING; MOLECULAR INTERACTION; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SIMULATION; SITE DIRECTED MUTAGENESIS; SPHINGOMONAS; STRUCTURE ACTIVITY RELATION; VIBRIO; WILD TYPE;

AMINO ACID SEQUENCE; CHEMISTRY TECHNIQUES, ANALYTICAL; COMPUTATIONAL BIOLOGY; HEXURONIC ACIDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; POLYSACCHARIDE-LYASES; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; SEQUENCE HOMOLOGY; SUBSTRATE SPECIFICITY; VALIDATION STUDIES AS TOPIC; VIBRIO ALGINOLYTICUS;

BACTERIA (MICROORGANISMS); SPHINGOMONAS SP.; VIBRIO SP.;

EID: 80054767731     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2011.08.018     Document Type: Article

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