Alginate lyase promotes diffusion of aminoglycosides through the extracellular polysaccharide of mucoid Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 4, 1998, Pages 974-977

  Hatch, Richard A ^a   Schiller, Neal L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINIC ACID; AMINOGLYCOSIDE ANTIBIOTIC AGENT; LYASE;

ANTIBIOTIC RESISTANCE; DRUG DIFFUSION; DRUG EFFICACY; DRUG FORMULATION; DRUG MIXTURE; DRUG PENETRATION; ENZYME ACTIVITY; NONHUMAN; NOTE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

EID: 0031956869     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.4.974     Document Type: Note

References (42)

1. Allison, D. G., and M. J. Matthews. 1992. Effect of polysaccharide interactions on antibiotic susceptibility of Pseudomonas aeruginosa. J. Appl. Bacteriol. 73:484-488.
2. Bayer, A. S., S. Park, M. C. Ramos, C. C. Nast, F. Eftekhar, and N. L. Schiller. 1992. Effects of alginase on the natural history and antibiotic therapy of experimental endocarditis caused by mucoid Pseudomonas aeruginosa. Infect. Immun. 60:3979-3985.
3. Bayer, A. S., D. P. Speert, S. Park, J. Tu, M. Witt, C. C. Nast, and D. C. Norman. 1991. Functional role of mucoid exopolysaccharide (alginate) in antibiotic-induced and polymorphonuclear leukocyte-mediated killing of Pseudomonas aeruginosa. Infect. Immun. 59:302-308.
4. Boyd, A., M. Ghosh, T. B. May, D. Shinabarger, R. Keogh, and A. M. Chakrabarty. 1993. Sequence of the algL gene of Pseudomonas aeruginosa and purification of its alginate lyase product. Gene 131:1-8.
5. Caswell, R. C., P. Gacesa, K. E. Lutrell, and A. J. Weightman. 1989. Molecular cloning and heterologous expression of a Klebsiella pneumoniae gene encoding alginate lyase. Gene 75:127-134.
6. Costerton, J. W., K.-J. Cheng, G. G. Geesey, T. J. Ladd, J. C. Nickel, M. Dasgupta, and T. J. Marrie. 1987. Bacterial biofilms in nature and disease. Annu. Rev. Microbiol. 41:435-464.
7. Cross, A., J. R. Allen, J. Burke, G. Ducel, A. Harris, J. John, D. Johnson, M. Lew, B. MacMillan, R. Skalova, R. Wenzel, and J. Tenney. 1983. Nosocomial infections due to Pseudomonas aeruginosa: review of recent trends. Rev. Infect. Dis. 5(Suppl.):S837-S845.
8. Doig, P., N. R. Smith, T. Todd, and R. T. Irvin. 1987. Characterization of the binding of Pseudomonas aeruginosa alginate to epithelial cells. Infect. Immun. 55:864-873.
9. Dunne, W. M., Jr., and F. L. A. Buckmire. 1985. Partial purification and characterization of a polymannuronic acid depolymerase produced by a mucoid strain of Pseudomonas aeruginosa isolated from a patient with cystic fibrosis. Appl. Environ. Microbiol. 50:562-567.
10. Eftekhar, F., and N. L. Schiller. 1994. Partial purification and characterization of a mannuronan-specific alginate lyase from Pseudomonas aeruginosa. Curr. Microbiol. 29:37-42.
11. Eftekhar, F., and D. P. Speert. 1988. Alginase treatment of mucoid Pseudomonas aeruginosa enhances phagocytosis by human monocyte-derived macrophages. Infect. Immun. 56:2788-2793.
12. Franklin, M. J., and D. E. Ohman. 1993. Identification of algF in the alginate biosynthetic gene cluster of Pseudomonas aeruginosa which is required for alginate acetylation. J. Bacteriol. 175:5057-5065.
13. Gacesa, P., and N. J. Russell. 1990. The structure and properties of alginate, p. 29-49. In P. Gacesa and N. J. Russell (ed.), Pseudomonas infection and alginates: biochemistry, genetics and pathology. Chapman and Hall, London, England.
14. George, R. H. 1987. Pseudomonas infection in cystic fibrosis. Arch. Dis. Child. 62:438-439.
15. Gilbert, P., and M. R. W. Brown. 1995. Mechanisms of the protection of bacterial biofilms from antimicrobial agents, p. 118-130. In H. M. Lappin-Scott and J. W. Costerton (ed.), Microbial biofilms. Cambridge University Press, Cambridge, Great Britain.
16. Gordon, C. A., N. A. Hodges, and C. Marriott. 1991. Use of slime dispersants to promote antibiotic penetration through the extracellular polysaccharide of mucoid Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 35:1258-1260.
17. Govan, J. R. W., and V. Deretic. 1996. Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol. Rev. 60:539-574.
18. Govan, J. R. W., and J. A. M. Fyfe. 1978. Mucoid Pseudomonas aeruginosa and cystic fibrosis: resistance of the mucoid form to carbenicillin, flucloxacillin, and tobramycin and the isolation of mucoid variants in vitro. J. Antimicrob. Chemother. 4:233-240.
19. Hansen, J. B., R. S. Doubet, and J. Ram. 1984. Alginase enzyme production by Bacillus circulans. Appl. Environ. Microbiol. 47:704-709.
20. Kumon, H., K. Tomachika, T. Matunaga, M. Ogawa, and H. Ohmori. 1994. A sandwich cup method for the penetration assay of antimicrobial agents through Pseudomonas exopolysaccharides. Microbiol. Immunol. 38:615-619.
21. Linker, A., and L. R. Evans. 1984. Isolation and characterization of an alginase from mucoid strains of Pseudomonas aeruginosa. J. Bacteriol. 159: 58-64.
22. May, T. B., D. Shinabarger, R. Maharaj, J. Kato, L. Chu, J. D. DeVault, S. Roychoudhury, N. A. Zielinsky, A. Berry, R. K. Rothmel, T. K. Misra, and A. M. Chakrabarty. 1991. Alginatc synthesis by Pseudomonus aeruginosa: a key pathogenic factor in chronic pulmonary infections of cystic fibrosis patients. Clin. Microbiol. Rev. 4:191-196.
23. Meluleni, G. J., M. Grout, D. J. Evans, and G. B. Pier. 1995. Mucoid Pseudomonas aeruginosa growing in a biofilm in vitro are killed by opsonic antibodies to the mucoid exopolysaccharide capsule but not by antibodies produced during chronic lung infection in cystic fibrosis patients. J. Immunol. 155:2029-2038.
24. Nguyen, L. K., and N. L. Schiller. 1989. Identification of a slime exopolysaccharide depolymerase in mucoid strains of Pseudomonas aeruginosa. Curr. Microbiol. 18:323-329.
25. Nichols, W. W., S. M. Dorrington, M. P. E. Slack, and H. L. Walmsley. 1988. Inhibition of tobramycin diffusion by binding to alginate. Antimicrob. Agents Chemother. 32:518-523.
26. Nichols, W. W., M. J. Evans, M. P. E. Slack, and H. L. Walmsley. 1989. The penetration of antibiotics into aggregates of mucoid and non-mucoid Pseudomonas aeruginosa. J. Gen. Microbiol. 135:1291-1303.
27. Ohman, D. E., and A. M. Chakrabarty. 1981. Genetic mapping of chromosomal determinants for the production of the exopolysaccharide alginate in a Pseudomonas aeruginosa cystic fibrosis isolate. Infect. Immun. 33:142-148.
28. Ohman, D. E., and A. M. Chakrabarty. 1982. Utilization of human respiratory secretions by mucoid Pseudomonas aeruginosa of cystic fibrosis origin. Infect. Immun. 37:662-669.
29. Pedersen, S. S. 1992. Lung infection with alginate-producing, mucoid Pseudomonas aeruginosa in cystic fibrosis. APMIS 100(Suppl. 28):1-79.
30. Pier, G. B. 1985. Pulmonary disease associated with Pseudomonas aeruginosa in cystic fibrosis: current status of the host-bacterium interaction. J. Infect. Dis. 151:575-580.
31. Ramphal, R., C. Guay, and G. B. Pier. 1987. Pseudomonas aeruginosa adhesins for tracheobronchial mucin. Infect. Immun. 55:600-603.
32. Romeo, T., and J. F. Preston III. 1986. Depolymerization of alginate by an extracellular alginate lyase from a marine bacterium: substrate specificity and accumulation of reaction products. Biochemistry 25:8391-8396.
33. Schiller, N. L., and R. A. Hatch. 1983. The serum sensitivity, colonial morphology, serogroup specificity, and outer membrane protein of Pseudomonas aeruginosa strains isolated from several clinical sites. Diagn. Microbiol. Infect. Dis. 1:143-157.
34. Schiller, N. L., S. R. Monday, C. M. Boyd, N. T. Keen, and D. E. Ohman. 1993. Characterization of the Pseudomonas aeruginosa alginate lyase gene (algL): cloning, sequencing and expression in Escherichia coli. J. Bacteriol. 175:4780-4789.
35. Sferra, T. J., and F. S. Collins. 1993. The molecular biology of cystic fibrosis. Annu. Rev. Med. 44:133-144.
36. Sutherland, I. W., and G. A. Keen. 1981. Alginases from Beneckea pelagia and Pseudomonas species. J. Appl. Biochem. 3:48-57.
37. Thomassen, M. J., C. A. Demko, B. Boxerbaum, R. C. Stern, and P. J. Kuchenbrod. 1979. Multiple isolates of Pseudomonas aeruginosa with differing antimicrobial susceptibility patterns from patients with cystic fibrosis. J. Infect. Dis. 140:873-880.
38. Thomassen, M. J., C. A. Demko, and C. F. Doershuk. 1987. Cystic fibrosis: a review of pulmonary infections and interventions. Pediatr. Pulmonol. 3:334-351.
39. Von Riesen, L. V. 1980. Digestion of algin by Pseudomonas mallophilia and Pseudomonas putida. Appl. Environ. Microbiol. 39:92-96.
40. Warner, J. O. 1992. Immunology of cystic fibrosis. Br. Med. Bull. 48:893-911.
41. Welsh, M. J., L.-C. Tsui, T. F. Boat, and A. L. Beaudet. 1995. Cystic fibrosis, p. 3799-3876. In C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, (ed.), The metabolic basis of inherited disease. McGraw-Hill, Inc., New York, N.Y.
42. Wood, R. E., T. F. Boat, and C. F. Doershuk. 1976. Cystic fibrosis: state of the art. Am. Rev. Respir. Dis. 113:833-878.