Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 1, 2000, Pages 127-131

  Avichezer, Dody ^a   Silver, Phyllis B ^a   Chan, Chi Chao ^a   Wiggert, Barbara ^a   Caspi, Rachel R ^a  

^a NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; EPITOPE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; HAPLOTYPE; HISTOPATHOLOGY; IMMUNIZATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; UVEORETINITIS;

ADOPTIVE TRANSFER; AMINO ACID SEQUENCE; ANIMALS; AUTOIMMUNE DISEASES; CATTLE; CYTOKINES; EPITOPES; EYE PROTEINS; H-2 ANTIGENS; HAPLOTYPES; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNIZATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; RETINITIS; RETINOL-BINDING PROTEINS; T-LYMPHOCYTES; UVEITIS;

EID: 0033989076     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Gery I, Mochizuki M, Nussenblatt RB. Retinal specific antigens and immunopathogenic processes they provoke. In: Osborne NN, Chader GJ, eds. Progress in Retinal Research. Vol. 5. New York, NY: Pergamon Press; 1986:75-109.
2. Caspi R, Nussenblatt R. Natural and therapeutic control of ocular autoimmunity-rodent and man. In: Coutinho A, Kazatchkine M, eds. Autoimmunity: Physiology and Disease. New York, NY: Wiley-Liss; 1994:377-405.
3. Faure JP. Autoimmunity and the retina. Curr Top Eye Res. 1980; 2:215-302.
4. Borst DE, Redmond TM, Elser JE, et al. Interphotoreceptor retinoid-binding protein: gene characterization, protein repeat structure, and its evolution. J Biol Chem. 1989;264:1115-1123.
5. Pepperberg DR, Okajima TL, Wiggert B, Ripps H, Crouch RK, Chader GJ. Interphotoreceptor retinoid-binding protein (IRBP): molecular biology and physiological role in the visual cycle of rhodopsin. Mol Neurobiol. 1993;7:61-85.
6. Caspi RR, Grubbs BG, Chan CC, Chader GJ, Wiggert B. Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model: concomitant regulation by MHC and non-MHC genes. J Immunol. 1992;148:2384-2389.
7. Silver PB, Rizzo LV,Chan CC, Donoso LA, Wiggert B, Caspi RR. Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype. Invest Ophthalmol Vis Sci. 1995;36:946-954.
8. Namba K, Ogasawara K, Kitaichi N, et al. Identification of a peptide inducing experimental autoimmune uveoretinitis (EAU) in H-2Ak-carrying mice. Clin Exp Immunol. 1998;111:442-449.
9. Chan CC, Caspi RR, Ni M, et al. Pathology of experimental autoimmune uveoretinitis in mice. J Autoimmun. 1990;3:247-255.
10. Rizzo LV, Miller-Rivero NE, Chan CC, Wiggert B, Nussenblatt RB, Caspi RR. Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity. J Clin Invest. 1994; 94:1668-1672.
11. Snedecor GW, Cochran WG. Statistical Methods. 6th edition. Ames, IA: Iowa State University Press; 1967:246-247.
12. Fong SL, Cook RG, Alvarez RA, Liou GI, Landers RA, Bridges CD. N-terminal sequence homologies in interstitial retinol-binding proteins from 10 vertebrate species. FEBS Lett. 1986;205:309-312.
13. Redmond TM, Wiggert B, Robey FA, Chader GJ. Interspecies conservation of structure of interphotoreceptor retinoid-binding protein. Invest Ophthalmol Vis Sci. 1986;240:19-26.
14. Caspi RR. Th1 and Th2 lymphocytes in experimental autoimmune uveoretinitis. In: Advances in Ocular Immunology (Proceedings of the 6th International Symposium on the Immunology and Immunopathology of the Eye, held in Bethesda, Maryland, 1994). New York: Elsevier Science; 1994:55-58.
15. Liblau RS, Singer SM, McDevitt HO. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today. 1995;16:34-38.
16. Cua DJ, Hinton DR, Stohlman SA. Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resisiant mice: Th2-mediated suppression of autoimmune disease. J Immunol. 1995;155:1052-4059.