Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta

Experimental Eye Research

Volumn 83, Issue 6, 2006, Pages 1459-1471

  Sugita, Sunao ^a   Futagami, Yuri ^a   Smith, Sylvia B ^b   Naggar, Hany ^b   Mochizuki, Manabu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

ciliary body pigment epithelium; immune privilege; retinal pigment epithelium; suppression; T lymphocytes; TGF

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

ANIMAL CELL; ARTICLE; CELL CONTACT; CILIARY BODY EPITHELIUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; BYSTANDER EFFECT; CELL PROLIFERATION; CELLS, CULTURED; CILIARY BODY; COCULTURE TECHNIQUES; DINOPROSTONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; PIGMENT EPITHELIUM OF EYE; RETINA; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 33750482270     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2006.08.005     Document Type: Article

References (32)

1. Caspi R.R., Roberge F.G., and Nussenblatt R.B. Organ-resident, non-lymphoid cells suppress proliferation of autoimmune T-helper lymphocytes. Science 237 (1987) 1029-1032
2. Chancy C.D., Kekuda R., Huang W., Prasad P.D., Kuhnel J.M., Sirotnak F.M., Roon P., Ganapathy V., and Smith S.B. Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium. J. Biol. Chem. 275 (2000) 20676-20684
3. Cousins S.W., McCabe M.M., Danielpour D., and Streilein J.W. Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. Invest. Ophthalmol. Vis. Sci. 32 (1991) 2201-2211
4. Doyen V., Rubio M., Braun D., Nakajima T., Abe J., Saito H., Delespesse G., and Sarfati M. Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation. J. Exp. Med. 198 (2003) 1277-1283
5. Dunn K.C., Aotaki-Keen A.E., Putkey F.R., and Hjelmeland L.M. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp. Eye Res. 62 (1996) 155-169
6. Dunn K.C., Marmorstein A.D., Bonilha V.L., Rodriguez-Boulan E., Giordano F., and Hjelmeland L.M. Use of the ARPE-19 cell line as a model of RPE polarity: basolateral secretion of FGF5. Invest. Ophthalmol. Vis. Sci. 39 (1998) 2744-2749
7. Farrokh-Siar L., Rezai K.A., Semnani R.T., Patel S.C., Ernest J.T., Peterson E.J., Koretzky G.A., and van Seventer G.A. Human fetal retinal pigment epithelial cells induce apoptosis in the T-cell line Jurkat. Invest. Ophthalmol. Vis. Sci. 40 (1999) 1503-1511
8. Holtkamp G.M., Kijlstra A., Peek R., and de Vos A.F. Retinal pigment epithelium-immune system interactions: cytokine production and cytokine-induced changes. Prog. Retin. Eye Res. 20 (2001) 29-48
9. Ishida K., Panjwani N., Cao Z., and Streilein J.W. Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 3. Epithelia cultured from iris, ciliary body, and retina suppress T cell activation by partially non-overlapping mechanisms. Ocul. Immuno. Inflamm. 11 (2003) 91-105
10. Jorgensen A., Wiencke A.K., la Cour M., Kaestel C.G., Madsen H.O., Hamann S., Lui G.M., Scherfig E., Prause J.U., Svejgaard A., Odum N., Nissen M.H., and Ropke C. Human retinal pigment epithelial cell-induced apoptosis in activated T cells. Invest. Ophthalmol. Vis. Sci. 39 (1998) 1590-1599
11. Kawashima H., Prasad S.A., and Gregerson D.S. Corneal endothelial cells inhibit T cell proliferation by blocking IL-2 production. J. Immunol. 153 (1994) 1982-1989
12. Kingsley D.M. The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes. Dev. 8 (1994) 133-146
13. Lawler J. The functions of thrombospondin-1 and-2. Curr. Opin. Cell. Biol. 12 (2000) 634-640
14. Liversidge J., McKay D., Mullen G., and Forrester J.V. Retinal pigment epithelial cells modulate lymphocyte function at the blood-retina barrier by autocrine PGE2 and membrane-bound mechanisms. Cell. Immunol. 149 (1993) 315-330
15. Lowrance J.H., O'Sullivan F.X., Caver T.E., Waegell W., and Gresham H.D. Spontaneous elaboration of transforming growth factor beta suppresses host defense against bacterial infection in autoimmune MRL/lpr mice. J. Exp. Med. 180 (1994) 1693-1703
16. Lucas P.J., Kim S.J., Melby S.J., and Gress R.S. Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor. J. Exp. Med. 191 (2000) 1187-1196
17. Niederkorn J.Y. Immune privilege in the anterior chamber of the eye. Crit. Rev. Immunol. 22 (2002) 13-46
18. Ruscetti F., Varesio L., Ochoa A., and Ortaldo J. Pleiotropic effects of transforming growth factor-beta on cells of the immune system. Ann. NY. Acad. Sci. 23 (1993) 488-500
19. Streilein J.W. Immune privilege as the result of local tissue barriers and immunosuppressive microenvironments. Curr. Opinion. Immunol. 5 (1993) 428-432
20. Streilein J.W. Ocular immune privilege: therapeutic opportunities from an experiment of nature. Nat. Rev. Immunol. 3 (2003) 879-889
21. Streilein J.W., and Stein-Streilein J. Does innate immune privilege exist?. J. Leukoc. Biol. 67 (2000) 479-487
22. +T cells. J. Immunol. 176 (2006) 118-127
23. + iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation. J. Immunol. 172 (2004) 4184-4194
24. Sugita S., and Streilein J.W. Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to CTLA-4. J. Exp. Med. 198 (2003) 161-171
25. +T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens. Invest. Ophthalmol. Vis. Sci. 47 (2006) 2547-2554
26. Takase H., Sugita S., Rhee D.J., Imai Y., Taguchi C., Sugamoto Y., Tagawa Y., Nishihira J., Russell P., and Mochizuki M. The presence of macrophage migration inhibitory factor in human trabecular meshwork and its upregulatory effects on the T helper 1 cytokine. Invest. Ophthalmol. Vis. Sci. 43 (2002) 2691-2696
27. Taylor A.W. Ocular immunosuppressive microenvironment. Chem. Immunol. 73 (1999) 72-89
28. Willermain F., Caspers-Velu L., Baudson N., Dubois C., Hamdane M., Willems F., Velu T., and Bruyns C. Role and expression of CD40 on human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 41 (2000) 3485-3491
29. Yoshida M., Kezuka T., and Streilein J.W. Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 2. Generation of regulatory T cells that suppress bystander T cells via TGF-β. Invest. Ophthalmol. Vis. Sci. 41 (2000) 3862-3870
30. Yoshida M., Takeuchi M., and Streilein J.W. Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 1. Inhibition of T-cell activation in vitro by direct cell-to-cell contact. Invest. Ophthalmol. Vis. Sci. 41 (2000) 811-821
31. Zamiri P., Masli S., Kitaichi N., Taylor A.W., and Streilein J.W. Thrombospondin plays a vital role in the immune privilege of the eye. Invest. Ophthalmol. Vis. Sci. 46 (2005) 908-919
32. Zhumabekov T., Corbella P., Tolaini M., and Kioussis D. Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J. Immunol. Methods 185 (1995) 133-140