Effect of estradiol on gene expression profile in cynomolgus macaque liver: Implications for drug-metabolizing enzymes

Drug Metabolism and Disposition

Volumn 39, Issue 11, 2011, Pages 2003-2007

  Uno, Yasuhiro ^a,b   Kito, Go ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLIZING ENZYME; ESTRADIOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYP3A8 GENE; CYP4F12 GENE; DOWN REGULATION; FEMALE; GENE EXPRESSION PROFILING; GSTM5 GENE; LIVER; MACACA; MICROARRAY ANALYSIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; DOWN-REGULATION; ESTRADIOL; ESTROGENS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUTATHIONE TRANSFERASE; HUMANS; LIVER; MACACA; MACACA FASCICULARIS; METABOLIC DETOXICATION, DRUG; MICROARRAY ANALYSIS; OVARIECTOMY; UP-REGULATION;

MACACA; PRIMATES; RODENTIA;

EID: 80054753296     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.041004     Document Type: Article

References (36)

1. Anakk S, Ku CY, Vore M, and Strobel HW (2003) Insights into gender bias: rat cytochrome P450 3A9. J Pharmacol Exp Ther 305:703-709. (Pubitemid 36459190)
2. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al. (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium.Nat Genet 25:25-29. (Pubitemid 30257031)
3. Boverhof DR, Fertuck KC, Burgoon LD, Eckel JE, Gennings C, and Zacharewski TR (2004) Temporal- and dose-dependent hepatic gene expression changes in immature ovariectomized mice following exposure to ethynyl estradiol. Carcinogenesis 25:1277-1291. (Pubitemid 38968056)
4. Cáceres M, Lachuer J, Zapala MA, Redmond JC, Kudo L, Geschwind DH, Lockhart DJ, Preuss TM, and Barlow C (2003) Elevated gene expression levels distinguish human from non-human primate brains. Proc Natl Acad Sci USA 100:13030-13035. (Pubitemid 37340020)
5. Cheung C, Yu AM, Chen CS, Krausz KW, Byrd LG, Feigenbaum L, Edwards RJ, Waxman DJ, and Gonzalez FJ (2006) Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. J Pharmacol Exp Ther 316:1328-1334. (Pubitemid 43345309)
6. Dhir RN, Dworakowski W, Thangavel C, and Shapiro BH (2006) Sexually dimorphic regulation of hepatic isoforms of human cytochrome P450 by growth hormone. J Pharmacol Exp Ther 316:87-94. (Pubitemid 41832584)
7. Diel P (2002) Tissue-specific estrogenic response and molecular mechanisms. Toxicol Lett 127:217-224.
8. Gao H, Bryzgalova G, Hedman E, Khan A, Efendic S, Gustafsson JA, and Dahlman-Wright K (2006) Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3. Mol Endocrinol 20:1287-1299. (Pubitemid 43801232)
9. Hayes JD, Flanagan JU, and Jowsey IR (2005) Glutathione transferases. Annu Rev Pharmacol Toxicol 45:51-88. (Pubitemid 40261798)
10. Higashi E, Fukami T, Itoh M, Kyo S, Inoue M, Yokoi T, and Nakajima M (2007) Human CYP2A6 is induced by estrogen via estrogen receptor. Drug Metab Dispos 35:1935-1941. (Pubitemid 47481589)
11. Hodge LS and Tracy TS (2007) Alterations in drug disposition during pregnancy: implications for drug therapy. Expert Opin Drug Metab Toxicol 3:557-571. (Pubitemid 351324964)
12. Hoffman SM and Hu S (2007) Dynamic evolution of the CYP2ABFGST gene cluster in primates. Mutat Res 616:133-138. (Pubitemid 46198861)
13. Hunt CM, Westerkam WR, and Stave GM (1992) Effect of age and gender on the activity of human hepatic CYP3A. Biochem Pharmacol 44:275-283.
14. Iwasaki K, Murayama N, Koizumi R, Uno Y, and Yamazaki H (2010) Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans. Drug Metab Pharmacokinet 25:388-391.
15. Jaffe CA, Turgeon DK, Lown K, Demott-Friberg R, and Watkins PB (2002) Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans. Am J Physiol Endocrinol Metab 283:E1008-E1015. (Pubitemid 35216960)
16. Kalsotra A, Anakk S, Boehme CL, and Strobel HW (2002) Sexual dimorphism and tissue specificity in the expression of CYP4F forms in Sprague Dawley rats. Drug Metab Dispos 30:1022-1028.
17. Kim S, Dinchuk JE, Anthony MN, Orcutt T, Zoeckler ME, Sauer MB, Mosure KW, Vuppugalla R, Grace JE Jr, Simmermacher J, et al. (2010) Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction. Drug Metab Dispos 38:16-24.
18. Leung KC, Johannsson G, Leong GM, and Ho KK (2004) Estrogen regulation of growth hormone action. Endocr Rev 25:693-721. (Pubitemid 39366048)
19. Liddle C, Goodwin BJ, George J, Tapner M, and Farrell GC (1998) Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes. J Clin Endocrinol Metab 83:2411-2416. (Pubitemid 28503039)
20. Marvanová M, Ménager J, Bezard E, Bontrop RE, Pradier L, and Wong G (2003) Microarray analysis of nonhuman primates: validation of experimental models in neurological disorders. FASEB J 17:929-931.
21. Qiu H, Taudien S, Herlyn H, Schmitz J, Zhou Y, Chen G, Roberto R, Rocchi M, Platzer M, and Wojnowski L (2008) CYP3 phylogenomics: evidence for positive selection of CYP3A4 and CYP3A7. Pharmacogenet Genomics 18:53-66. (Pubitemid 351161648)
22. Robb VA, Pepe GJ, and Albrecht ED (2004) Acute temporal regulation of placental vascular endothelial growth/permeability factor expression in baboons by estrogen. Biol Reprod 71:1694-1698. (Pubitemid 39403267)
23. Rosenthal MD, Albrecht ED, and Pepe GJ (2004) Estrogen modulates developmentally regulated gene expression in the fetal baboon liver. Endocrine 23:219-228. (Pubitemid 39140236)
24. Sakuma T, Endo Y, Mashino M, Kuroiwa M, Ohara A, Jarukamjorn K, and Nemoto N (2002) Regulation of the expression of two female-predominant CYP3A mRNAs (CYP3A41 and CYP3A44) in mouse liver by sex and growth hormones. Arch Biochem Biophys 404:234-242. (Pubitemid 34913554)
25. Schmidt R, Baumann F, Hanschmann H, Geissler F, and Preiss R (2001) Gender difference in ifosfamide metabolism by human liver microsomes. Eur J Drug Metab Pharmacokinet 26:193-200. (Pubitemid 32988561)
26. Singhal R, Shankar K, Badger TM, and Ronis MJ (2009) Hepatic gene expression following consumption of soy protein isolate in female Sprague-Dawley rats differs from that produced by 17β-estradiol treatment. J Endocrinol 202:141-152.
27. Thummel KE and Wilkinson GR (1998) In vitro and in vivo drug interactions involving human CYP3A. Annu Rev Pharmacol Toxicol 38:389-430. (Pubitemid 28231501)
28. Uno Y, Fujino H, Kito G, Kamataki T, and Nagata R (2006) CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone. Mol Pharmacol 70:477-486. (Pubitemid 44092308)
29. Uno Y, Iwasaki K, Yamazaki H, and Nelson DR (2011) Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function. Drug Metab Rev 43:346-361.
30. Uno Y, Matsuno K, Nakamura C, Utoh M, and Yamazaki H (2009a) Cloning, expression, and characterization of CYP3A43 cDNA in cynomolgus macaque (Macaca fascicularis). Drug Metab Lett 3:228-233.
31. Uno Y, Matsushita A, Osada N, Uehara S, Kohara S, Nagata R, Fukuzaki K, Utoh M, Murayama N, and Yamazaki H (2010) Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques. Drug Metab Dispos 38:209-214.
32. Uno Y, Ohuchi T, Uehara S, Kito G, Kamataki T, and Nagata R (2009b) Sex-related differences in the expression of mfGSTA2, a novel GST identified in cynomolgus monkey (Macaca fascicularis). Drug Metab Dispos 37:453-456.
33. Walker SJ, Wang Y, Grant KA, Chan F, and Hellmann GM (2006) Long versus short oligonucleotide microarrays for the study of gene expression in nonhuman primates. J Neurosci Methods 152:179-189. (Pubitemid 43343489)
34. Waxman DJ and O'Connor C (2006) Growth hormone regulation of sex-dependent liver gene expression. Mol Endocrinol 20:2613-2629. (Pubitemid 44833525)
35. Williams ET, Leyk M, Wrighton SA, Davies PJ, Loose DS, Shipley GL, and Strobel HW (2004) Estrogen regulation of the cytochrome P450 3A subfamily in humans. J Pharmacol Exp Ther 311:728-735. (Pubitemid 39391561)
36. Wolbold R, Klein K, Burk O, Nüssler AK, Neuhaus P, Eichelbaum M, Schwab M, and Zanger UM (2003) Sex is a major determinant of CYP3A4 expression in human liver. Hepatology 38:978-988. (Pubitemid 37221681)