Sex-related differences in the expression of mfGSTA2, a novel GST identified in cynomolgus monkey (Macaca fascicularis)

Drug Metabolism and Disposition

Volumn 37, Issue 3, 2009, Pages 453-456

  Uno, Yasuhiro ^a,b   Ohuchi, Tsukasa ^a   Uehara, Shotaro ^b   Kito, Go ^b   Kamataki, Tetsuya ^a   Nagata, Ryoichi ^b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GLUTATHIONE TRANSFERASE;

ADRENAL GLAND; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GENE IDENTIFICATION; HEART; JEJUNUM; KIDNEY; LIVER; MACACA; MALE; MFGSTA2 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SEX DIFFERENCE; TESTIS; TISSUE DISTRIBUTION; UTERUS;

AMINO ACID SEQUENCE; ANIMALS; FEMALE; GENE EXPRESSION; GLUTATHIONE TRANSFERASE; HUMANS; MACACA FASCICULARIS; MALE; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; SEX FACTORS;

MACACA FASCICULARIS;

EID: 61449172086     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.023747     Document Type: Article

References (21)

1. Gandhi M, Aweeka F, Greenblatt RM, and Blaschke TF (2004) Sex differences in pharmacokinetics and pharmacodynamics. Annu Rev Pharmacol Toxicol 44:499-523.
2. Hayes JD, Flanagan JU, and Jowsey IR (2005) Glutathione transferases. Annu Rev Pharmacol Toxicol 45:51-88.
3. Holloway MG, Laz EV, and Waxman DJ (2006) Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4alpha. Mol Endocrinol 20:647-660.
4. Kamataki T, Maeda K, Shimada M, Nagai T, and Kato R (1984) Neonatal testosterone imprinting of hepatic microsomal drug metabolism and a male-specific form of cytochrome P-450 in the rat. J Biochem 96:1939-1942.
5. Kato R, Yamazoe Y, Shimada M, Murayama N, and Kamataki T (1986) Effect of growth hormone and ectopic transplantation of pituitary gland on sex-specific forms of cytochrome P-450 and testosterone and drug oxidations in rat liver. J Biochem 100:895-902.
6. Legraverend C, Mode A, Westin S, Ström A, Eguchi H, Zaphiropoulos PG, and Gustafsson JA (1992) Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion. Mol Endocrinol 6:259-266.
7. Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, and Nebert DW (2004) Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics 14:1-18.
8. Park SH, Liu X, Hennighausen L, Davey HW, and Waxman DJ (1999) Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption. J Biol Chem 274:7421-7430.
9. Schwartz JB (2003) The influence of sex on pharmacokinetics. Clin Pharmacokinet 42:107-121.
10. Sharer JE, Shipley LA, Vandenbranden MR, Binkley SN, and Wrighton SA (1995) Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey. Drug Metab Dispos 23:1231-1241.
11. Sheehan D, Meade G, Foley VM, and Dowd CA (2001) Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem J 360:1-16.
12. Staffas L, Ellis EM, Hayes JD, Lundgren B, Depierre JW, and Mankowitz L (1998) Growth hormone- and testosterone-dependent regulation of glutathione transferase subunit A5 in rat liver. Biochem J 332:763-768.
13. Stevens JC, Shipley LA, Cashman JR, Vandenbranden M, and Wrighton SA (1993) Comparison of human and rhesus monkey in vitro phase I and phase II hepatic drug metabolism activities. Drug Metab Dispos 21:753-760.
14. Swedmark S, Morgenstern R, and Weinander R (1998) The mRNA for GST Pi from FRHK rhesus monkey kidney cells codes for an enzyme with activity towards 1-chloro-2,4-dinitrobenzene in spite of an I68F mutation. Gene 206:99-105.
15. Uno Y, Fujino H, Kito G, Kamataki T, and Nagata R (2006) CYP2C76, a novel CYP in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone. Mol Pharmacol 70:477-486.
16. Uno Y, Kumano T, Kito G, Nagata R, Kamataki T, and Fujino H (2007) CYP2C76-mediated species difference in drug metabolism: a comparison of pitavastatin metabolism between monkeys and humans. Xenobiotica 37:30-43.
17. Uno Y, Suzuki Y, Wakaguri H, Sakamoto Y, Sano H, Osada N, Hashimoto K, Sugano S, and Inoue I (2008) Expressed sequence tags from cynomolgus monkey (Macaca fascicularis) liver: a systematic identification of drug-metabolizing enzymes. FEBS Lett 582:351-358.
18. Wang C, Bammler TK, Guo Y, Kelly EJ, and Eaton DL (2000) Mu-class GSTs are responsible for anatoxin B(1)-8,9-epoxide-conjugating activity in the nonhuman primate Macaca fascicularis liver. Toxicol Sci 56:26-36.
19. Waxman DJ and O'Connor C (2006) Growth hormone regulation of sex-dependent liver gene expression. Mol Endocrinol 20:2613-2629.
20. Weaver RJ, Dickins M, and Burke MD (1999) A comparison of basal and induced hepatic microsomal cytochrome P450 monooxygenase activities in the cynomolgus monkey (Macaca fascicularis) and man. Xenobiotica 29:467-482.
21. Wolbold R, Klein K, Burk O, Nüssler AK, Neuhaus P, Eichelbaum M, Schwab M, and Zanger UM (2003) Sex is a major determinant of CYP3A4 expression in human liver. Hepatology 38:978-988.