The role of pDC, recipient Treg and donor Treg in HSC engraftment: Mechanisms of facilitation

Chimerism

Volumn 2, Issue 3, 2011, Pages 65-70

  Cardenas, Paul A ^a   Huang, Yiming ^a   Ildstad, Suzanne T ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Facilitating cells; Plasmacytoid dendritic cells; Regulatory T cells; Transplantation tolerance

Indexed keywords

CD8 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ALLOTRANSPLANTATION; ANTIGEN SPECIFICITY; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVITY; CELL EXPANSION; CELL POPULATION; DENDRITIC CELL; DONOR; ENGRAFTMENT; GENETIC DISORDER; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HEMATOLOGIC MALIGNANCY; HLA MATCHING; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IMMUNOSTIMULATION; IN VIVO STUDY; METABOLIC DISORDER; NONHUMAN; PLASMACYTOID DENDRITIC CELL; REGULATORY T LYMPHOCYTE; REVIEW; SICKLE CELL ANEMIA; THALASSEMIA; TISSUE TRANSPLANTATION;

EID: 80054737080     PISSN: 19381956     EISSN: 19381964     Source Type: Journal    
DOI: 10.4161/chim.17588     Document Type: Review

References (44)

1. Ikehara S. The future of stem cell transplantation in autoimmune disease. Clin Rev Allergy Immunol 2010; 38:292-297.
2. Thomson AW, Knolle PA. Antigen-presenting cell function in the tolerogenic liver environment. Nat Rev Immunol 2010; 10:753-766.
3. Herrera OB, Golshayan D, Tibbott R, et al. A novel pathway of alloantigen presentation by dendritic cells. J Immunol 2004; 173:4828-4837.
4. - cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers. Immunity 1999; 11:579-590.
5. Fugier-Vivier I, Rezzoug F, Huang Y, et al. Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment. J Exp Med 2005; 201:373-383; PMCID: PMC2213023.
6. Rezzoug F, Huang Y, Tanner MK, et al. TNFα is critical to facilitation of hematopoietic stem cell engraftment and function. J Immunol 2008; 180:49-57.
7. Matta BM, Castellaneta A, Thomson AW. Tolerogenic plasmacytoid DC. Eur J Immunol 2010; 40:2667-2676.
8. Liu YJ. IPC: Professional Type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 2005; 23:275-306.
9. Olweus J, BitMansour A, Warnke R, et al. Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin. Proc Natl Acad Sci USA 1997; 94:12551-12556.
10. Cella M, Jarrossay D, Facchetti F, et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 1999; 5:919-923.
11. O'Doherty U, Peng M, Gezelter S, et al. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology 1994; 82:487-493.
12. Robinson SP, Patterson S, English N, et al. Human peripheral blood contains two distinct lineages of dendritic cells. Eur J Immunol 1999; 29:2769-2778.
13. Kohrgruber N, Halanek N, Groger M, et al. Survival, maturation and function of CD11c- and CD11c+ peripheral blood dendritic cells are differentially regulated by cytokines. J Immunol 1999; 163:3250-3259.
14. Swiecki M, Colonna M. Accumulation of plasmacytoid DC: Roles in disease pathogenesis and targets for immunotherapy. Eur J Immunol 2010; 40:2094-2098.
15. Powrie F, Maloy KJ. Immunology. Regulating the regulators. Science 2003; 299:1030-1031.
16. Chen W, Frank ME, Jin W, Wahl SM. TGFbeta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity 2001; 14:715-725.
17. Ochando JC, Homma C, Yang Y, et al. Alloantigenpresenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat Immunol 2006; 7:652-662.
18. Puccetti P, Fallarino F. Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism. Blood Cells Mol Dis 2008; 40:101-105.
19. Munn DH, Zhou M, Attwood JT, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998; 281:1191-1193.
20. Mellor AL, Chandler P, Baban B, et al. Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine-2,3-dioxygenase. Int Immunol 2004; 16:1391-1401.
21. Fallarino F, Grohmann U, You S, et al. The combined effects of tryptophan starvation and tryptophan catabolites downregulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol 2006; 176:6752-6761.
22. Grohmann U, Fallarino F, Bianchi R, et al. IL-6 inhibits the tolerogenic function of CD8 alpha+ dendritic cells expressing indoleamine-2,3-dioxygenase. J Immunol 2001; 167:708-714.
23. Grohmann U, Fallarino F, Silla S, et al. CD40 ligation ablates the tolerogenic potential of lymphoid dendritic cells. J Immunol 2001; 166:277-283.
24. Grohmann U, Fallarino F, Puccetti P. Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol 2003; 24:242-248.
25. Cobbold SP, Adams E, Farquhar CA, et al. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci USA 2009; 106:12055-12060.
26. Alexander AM, Crawford M, Bertera S, et al. Indoleamine-2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes 2002; 51:356-365.
27. Swanson KA, Zheng Y, Heidler KM, Mizobuchi T, Wilkes DS. CDllc+ cells modulate pulmonary immune responses by production of indoleamine-2,3-dioxygenase. Am J Respir Cell Mol Biol 2004; 30:311-318.
28. Sakaguchi S, Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T. Regulatory T cells: how do they suppress immune responses? Int Immunol 2009; 21:1105-1111.
29. + natural T regulatory lymphocytes for clinical applications. Clin Exp Immunol 2009; 156:246-253.
30. Apostolou I, Sarukhan A, Klein L, von Boehmer H. Origin of regulatory T cells with known specificity for antigen. Nat Immunol 2002; 3:756-763.
31. von Boehmer H. Dynamics of suppressor T cells: in vivo veritas. J Exp Med 2003; 198:845-849.
32. Wing K, Fehervari Z, Sakaguchi S. Emerging possibilities in the development and function of regulatory T cells. Int Immunol 2006; 18:991-1000.
33. Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 2002; 196:389-399.
34. Taylor PA, Lees CJ, Blazar BR. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 2002; 99:3493-3499.
35. + T cells promote engraftment and tolerance following MHCmismatched hematopoietic cell transplantation. Blood 2005; 105:1828-1836.
36. Gaidot A, Landau DA, Martin GH, et al. Immune reconstitution is preserved in hematopoietic stem cell transplantation coadministered with regulatory T cells for GVHD prevention. Blood 2011; 117:2975-2983.
37. +T cells can expand and comprise a major component of the Treg compartment after experimental HCT. Blood 2009; 113:733-743.
38. + plasmacytoid precursor DC induce antigen-specific regulatory T cells that enhance HSC engraftment in vivo. Blood 2011; 117:2494-2505.
39. + regulatory T cells following hemopoietic stem cell transplantation: role of bone marrow-derived facilitating cells. J Immunol 2007; 179:2153-2162.
40. Kaufman CL, Colson YL, Wren SM, et al. Phenotypic characterization of a novel bone-marrow derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 1994; 84:2436-2446.
41. Grimes HL, Schanie CL, Huang Y, et al. Graft facilitating cells are derived from hematopoietic stem cells and functionally require CD3, but are distinct from T lymphocytes. Exp Hematol 2004; 32:946-954.
42. Huang Y, Rezzoug F, Chilton PM, et al. Matching at the MHC Class I K locus is essential for long-term engraftment of purified hematopoietic stem cells: a role for host NK cells in regulating HSC engraftment. Blood 2004; 104:873-880.
43. Huang Y, Fugier-Vivier I, Miller T, et al. Plasmacytoid precursor dendritic cells from NOD mice exhibit impaired function: are they a component of diabetes pathogenesis? Diabetes 2008; 57:2360-2370;PMCID: PMC2518487.
44. Colson YL, Christopher K, Glickman J, et al. Absence of clinical GVHD and the in vivo induction of regulatory T cells following facilitating cell transplantation. Blood 2004; 104:3829-3835.