Chromatin remodeling system, cancer stem-like attractors, and cellular reprogramming

Cellular and Molecular Life Sciences

Volumn 68, Issue 21, 2011, Pages 3557-3571

  Zhang, Yue ^a   Moriguchi, Hisashi ^b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Caenorhabditis elegans; Carcinogenesis; Cell attractors; Cellular reprogramming; Chromatin remodeling system; Drosophila melanogaster

Indexed keywords

ANTINEOPLASTIC AGENT; CELL PROTEIN; HEAT SHOCK PROTEIN 90; HISTONE; NURD PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADVANCED CANCER; ARTICLE; CAENORHABDITIS ELEGANS; CANCER GENETICS; CANCER GROWTH; CANCER INVASION; CANCER PREVENTION; CANCER RESISTANCE; CANCER STEM CELL; CARCINOGENESIS; CARCINOMA; CELL ADHESION; CELL DIFFERENTIATION; CELL DIVISION; CELL FUNCTION; CELL LINEAGE; CELL RENEWAL; CELL TRANSFORMATION; CELL TYPE; CHROMATIN ASSEMBLY AND DISASSEMBLY; DEACETYLATION; DROSOPHILA MELANOGASTER; EMBRYO CELL; EMBRYO DEVELOPMENT; EPIGENETICS; EXTRACELLULAR MATRIX; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GERM LINE; HEMATOPOIETIC STEM CELL; HISTONE ACETYLATION; HUMAN; MELANOMA; MEP 1 GENE; METASTASIS; MOLECULAR CLONING; MOLECULAR DYNAMICS; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOSOME; PLURIPOTENT STEM CELL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; TRANSCRIPTION REGULATION;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA HELICASES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYONIC DEVELOPMENT; HISTONE DEACETYLASES; MI-2 NUCLEOSOME REMODELING AND DEACETYLASE COMPLEX; MICE; MODELS, ANIMAL; NEOPLASTIC STEM CELLS; NUCLEAR REPROGRAMMING; REPRESSOR PROTEINS; RNA INTERFERENCE; TRANSCRIPTION FACTORS;

CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; MAMMALIA;

EID: 80054732323     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0808-1     Document Type: Article

References (90)

1. L Ho GR Crabtree 2010 Chromatin remodeling during development Nature 463 7280 474 484 20110991 10.1038/nature08911 1:CAS:528:DC%2BC3cXht1Sksrs%3D
2. Y Zhang Y Li 2010 The expanding Mi-2/NuRD complexes: a schematic glance Proteomics Insights 3 79 109 1:CAS:528:DC%2BC3MXhsFWht7Y%3D
3. Y Zhang 2011 Biology of Mi-2/NuRD in SLAC (stemness, longevity/ageing and cancer) Gene Regul Syst Biol 5 1 26 10.4137/GRSB.S6510
4. A Janic L Mendizabal S Llamazares D Rossell C Gonzalez 2010 Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila Science 330 6012 1824 1827 21205669 10.1126/science.1195481 1:CAS:528: DC%2BC3cXhsF2jtbvE
5. B Tursun T Patel P Kratsios O Hobert 2011 Direct conversion of C. elegans germ cells into specific neuron types Science 331 6015 304 308 21148348 10.1126/science.1199082 1:CAS:528:DC%2BC3MXmsVCjsQ%3D%3D (Epub 2010 Dec 9)
6. S Kauffman 1969 Homeostasis and differentiation in random genetic control networks Nature 224 177 178 5343519 10.1038/224177a0 1:STN:280: DyaE3c%2FgsFyrtQ%3D%3D
7. CH Waddington 1942 The epigenotype Endeavour 1 18 20
8. S Huang I Ernberg S Kauffman 2009 Cancer attractors: a systems view of tumors from a gene network dynamics and developmental perspective Semin Cell Dev Biol 20 7 869 876 19595782 10.1016/j.semcdb.2009.07.003 1:CAS:528: DC%2BD1MXhtFyntrnE (Epub 2009 Jul 10)
9. S Huang DE Ingber 2007 A non-genetic basis for cancer progression and metastasis: self-organizing attractors in cell regulatory networks Breast Dis 26 27 54 (Pubitemid 46647413)
10. T Graf T Enver 2009 Forcing cells to change lineages Nature 462 7273 587 594 19956253 10.1038/nature08533 1:CAS:528:DC%2BD1MXhsFWjt7nE
11. Dinicola S, D'Anselmi F, Pasqualato A, Proietti S, Lisi E, Cucina A, Bizzarri M (2011) A systems biology approach to cancer: fractals, attractors, and nonlinear dynamics. OMICS (Epub ahead of print)
12. M Bizzarri A Cucina PM Biava S Proietti F D'Anselmi S Dinicola A Pasqualato E Lisi 2011 Embryonic morphogenetic field induces phenotypic reversion in cancer cells Curr Pharm Biotechnol 12 2 243 253 21044001 10.2174/138920111794295701 1:CAS:528:DC%2BC3MXkslSnt7w%3D
13. AY Lai PA Wade 2011 Cancer biology and NuRD: a multifaceted chromatin remodelling complex Nat Rev Cancer 11 8 588 596 10.1038/nrc3091 21734722 10.1038/nrc3091 1:CAS:528:DC%2BC3MXos1Srsro%3D
14. Demicheli R, Coradini D (2010) Gene regulatory networks: a new conceptual framework to analyse breast cancer behaviour. Ann Oncol (Epub ahead of print)
15. Huang S (2011) On the intrinsic inevitability of cancer: from foetal to fatal attraction. Semin Cancer Biol (Epub ahead of print)
16. Y Liu B Clem EK Zuba-Surma S El-Naggar S Telang AB Jenson Y Wang H Shao MZ Ratajczak J Chesney DC Dean 2009 Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype Cell Stem Cell 4 4 336 347 19341623 10.1016/j.stem.2009.02.015 1:CAS:528:DC%2BD1MXltVeqsrg%3D
17. GS Eichler S Huang DE Ingber 2003 Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles Bioinformatics 19 17 2321 2322 14630665 10.1093/bioinformatics/btg307 1:CAS:528:DC%2BD3sXpvVSjur8%3D (Pubitemid 37483992)
18. S Huang G Eichler Y Bar-Yam DE Ingber 2005 Cell fates as high-dimensional attractor states of a complex gene regulatory network Phys Rev Lett 94 12 128701 15903968 10.1103/PhysRevLett.94.128701 (Epub 2005 Apr 1) (Pubitemid 40620583)
19. M Passannante CO Marti C Pfefferli PS Moroni S Kaeser-Pebernard A Puoti P Hunziker C Wicky F Müller 2010 Different Mi-2 complexes for various developmental functions in Caenorhabditis elegans PLoS One 5 10 e13681 21060680 10.1371/journal.pone.0013681
20. T Yoshida I Hazan J Zhang SY Ng T Naito HJ Snippert EJ Heller X Qi LN Lawton CJ Williams K Georgopoulos 2008 The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation Genes Dev 22 9 1174 1189 18451107 10.1101/gad.1642808 1:CAS:528:DC%2BD1cXlslCqsrY%3D (Pubitemid 351656577)
21. J Ramírez J Hagman 2009 The Mi-2/NuRD complex: a critical epigenetic regulator of hematopoietic development, differentiation and cancer Epigenetics 4 8 532 536 19923891 10.4161/epi.4.8.10108
22. KS Ghanta DQ Li J Eswaran R Kumar 2011 Gene profiling of mta1 identifies novel gene targets and functions PLoS One 6 2 e17135 21364872 10.1371/journal.pone.0017135 1:CAS:528:DC%2BC3MXjtVymtrg%3D
23. S Marino R Nusse 2007 Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal PLoS One 2 6 e519 17565372 10.1371/journal.pone.0000519
24. A Blais CJ van Oevelen R Margueron D Acosta-Alvear BD Dynlacht 2007 Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit J Cell Biol 179 7 1399 1412 18166651 10.1083/jcb.200705051 1:CAS:528:DC%2BD1cXktVagsQ%3D%3D
25. Z Jagani D Wiederschain A Loo D He R Mosher P Fordjour J Monahan M Morrissey YM Yao C Lengauer M Warmuth WR Sellers M Dorsch 2010 The Polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells Cancer Res 70 13 5528 5538 20530672 10.1158/0008-5472.CAN-09-4229 1:CAS:528: DC%2BC3cXot1Wks7c%3D (Epub 2010 Jun 8)
26. MH Yang DS Hsu HW Wang HJ Wang HY Lan WH Yang CH Huang SY Kao CH Tzeng SK Tai SY Chang OK Lee KJ Wu 2010 Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition Nat Cell Biol 12 10 982 992 20818389 10.1038/ncb2099 (Epub 2010 Sep 5)
27. T Yuzyuk TH Fakhouri J Kiefer SE Mango 2009 The Polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. elegans embryos Dev Cell 16 5 699 710 19460346 10.1016/j.devcel.2009.03.008 1:CAS:528:DC%2BD1MXps1ymsLo%3D
28. JR Whetstine J Ceron B Ladd P Dufourcq V Reinke Y Shi 2005 Regulation of tissue-specific and extracellular matrix-related genes by a class I histone deacetylase Mol Cell 18 4 483 490 15893731 10.1016/j.molcel.2005.04.006 1:CAS:528:DC%2BD2MXkslejsr8%3D (Pubitemid 40704762)
29. X Wu G Ruvkun 2010 Cancer. Germ cell genes and cancer Science 330 6012 1761 1762 21205660 10.1126/science.1200772 1:CAS:528:DC%2BC3MXhtVSmtb0%3D
30. Maruyama R, Shipitsin M, Choudhury S, Wu Z, Protopopov A, Yao J, Lo PK, Bessarabova M, Ishkin A, Nikolsky Y, Liu XS, Sukumar S, Polyak K (2010) Breast cancer special feature: altered antisense-to-sense transcript ratios in breast cancer. Proc Natl Acad Sci USA (Epub ahead of print)
31. L Poliseno L Salmena J Zhang B Carver WJ Haveman PP Pandolfi 2010 A coding-independent function of gene and pseudogene mRNAs regulates tumour biology Nature 465 7301 1033 1038 20577206 10.1038/nature09144 1:CAS:528:DC%2BC3cXnvFSgtLk%3D
32. M Belfiore LD Mathies P Pugnale G Moulder R Barstead J Kimble A Puoti 2002 The MEP-1 zinc-finger protein acts with MOG DEAH box proteins to control gene expression via the fem-3 3′ untranslated region in Caenorhabditis elegans RNA 8 6 725 739 12088146 10.1017/S1355838202028595 1:CAS:528: DC%2BD38XkvVersbw%3D (Pubitemid 34620450)
33. MM Kirk K Stark SM Miller W Müller BE Taillon H Gruber R Schmitt DL Kirk 1999 RegA, a Volvox gene that plays a central role in germ-soma differentiation, encodes a novel regulatory protein Development 126 4 639 647 9895312 1:CAS:528:DyaK1MXhvFansbY%3D (Pubitemid 29106171)
34. SM Miller 2010 Volvox, Chlamydomonas, and the evolution of multicellularity Nat Edu 3 9 65
35. K Takahashi S Yamanaka 2006 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 4 663 676 16904174 10.1016/j.cell.2006.07.024 1:CAS:528:DC%2BD28Xpt1aktbs%3D (Epub 2006 Aug 10) (Pubitemid 44233629)
36. H Mizuno BT Spike GM Wahl AJ Levine 2010 Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures Proc Natl Acad Sci USA 107 52 22745 22750 21149740 10.1073/pnas.1017001108 1:CAS:528: DC%2BC3MXktlygtQ%3D%3D (Epub 2010 Dec 13)
37. IP Janecka 2007 Cancer control through principles of systems science, complexity, and chaos theory: a model Int J Med Sci 4 3 164 173 17589568 (Pubitemid 46879083)
38. HH Chang M Hemberg M Barahona DE Ingber S Huang 2008 Transcriptome-wide noise controls lineage choice in mammalian progenitor cells Nature 453 7194 544 547 18497826 10.1038/nature06965 1:CAS:528:DC%2BD1cXmt1Ortbs%3D (Pubitemid 351733323)
39. NL Tulloch L Pabon CE Murry 2008 Get with the (re)program: cardiovascular potential of skin-derived induced pluripotent stem cells Circulation 118 5 472 475 18663099 10.1161/CIRCULATIONAHA.108.791442
40. S Huang 2009 Reprogramming cell fates: reconciling rarity with robustness BioEssays 31 5 546 560 10.1002/bies.200800189 19319911 10.1002/bies.200800189 1:CAS:528:DC%2BD1MXmtFelurw%3D
41. NE Vilaboa A Galán A Troyano E de Blas P Aller 2000 Regulation of multidrug resistance 1 (MDR1)/P-glycoprotein gene expression and activity by heat-shock transcription factor 1 (HSF1) J Biol Chem 275 32 24970 24976 10816597 10.1074/jbc.M909136199 1:CAS:528:DC%2BD3cXlsl2jtb8%3D (Pubitemid 30626605)
42. ZP Jiang P Xu GP Wang XL Zhao FP Chen 2010 Hypothesizing that histone deacetylase inhibitors can be used to reverse multiple drug resistance Med Hypotheses 74 1 92 94 19700246 10.1016/j.mehy.2009.07.036 1:CAS:528: DC%2BD1MXhsFSgsr7L (Epub 2009 Aug 22)
43. DQ Matus XY Li S Durbin D Agarwal Q Chi SJ Weiss DR Sherwood 2010 In vivo identification of regulators of cell invasion across basement membranes Sci Signal 3 120 ra35 20442418 10.1126/scisignal.2000654
44. Hochbaum D, Zhang Y, Stuckenholz C, Labhart P, Alexiadis V, Martin R, Knölker H, Fisher AL (2011) DAF-12 regulates a connected network of genes to ensure robust developmental decisions. PLOS Genet 7(7) e1002179 doi: 10.1371/journal.pgen.1002179
45. MB Potts S Cameron 2011 Cell lineage and cell death: Caenorhabditis elegans and cancer research Nat Rev Cancer 11 1 50 58 21150934 10.1038/nrc2984 1:CAS:528:DC%2BC3cXhsV2nsL3E (Epub 2010 Dec 2)
46. SE Prochnik J Umen AM Nedelcu A Hallmann SM Miller I Nishii P Ferris A Kuo T Mitros LK Fritz-Laylin U Hellsten J Chapman O Simakov SA Rensing A Terry J Pangilinan V Kapitonov J Jurka A Salamov H Shapiro J Schmutz J Grimwood E Lindquist S Lucas IV Grigoriev R Schmitt D Kirk DS Rokhsar 2010 Genomic analysis of organismal complexity in the multicellular green alga Volvox carteri Science 329 5988 223 226 20616280 10.1126/science.1188800 1:CAS:528: DC%2BC3cXosVWgu78%3D
47. N Wang JD Tytell DE Ingber 2009 Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus Nat Rev Mol Cell Biol 10 1 75 82 19197334 10.1038/nrm2594 1:CAS:528:DC%2BD1MXptlSl
48. D Huangfu R Maehr W Guo A Eijkelenboom M Snitow AE Chen DA Melton 2008 Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds Nat Biotechnol 26 7 795 797 18568017 10.1038/nbt1418 1:CAS:528:DC%2BD1cXot1entL0%3D (Epub 2008 Jun 22) (Pubitemid 351961456)
49. CJ Williams T Naito PG Arco JR Seavitt SM Cashman B De Souza X Qi P Keables UH Von Andrian K Georgopoulos 2004 The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development Immunity 20 6 719 733 15189737 10.1016/j.immuni.2004.05.005 1:CAS:528:DC%2BD2cXltlKisLc%3D (Pubitemid 38757442)
50. W Niu ZJ Lu M Zhong M Sarov JI Murray CM Brdlik J Janette C Chen P Alves E Preston C Slightha L Jiang AA Hyman SK Kim RH Waterston M Gerstein M Snyder V Reinke 2011 Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans Genome Res 21 2 245 254 21177963 10.1101/gr.114587.110 1:CAS:528:DC%2BC3MXitFSrt7g%3D (Epub 2010 Dec 22)
51. I Ben-Porath MW Thomson VJ Carey R Ge GW Bell A Regev RA Weinberg 2008 An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors Nat Genet 40 5 499 507 18443585 10.1038/ng.127 1:CAS:528:DC%2BD1cXltFylu7o%3D (Pubitemid 351601215)
52. D Hanahan RA Weinberg 2011 Hallmarks of cancer: the next generation Cell 144 5 646 674 21376230 10.1016/j.cell.2011.02.013 1:CAS:528:DC%2BC3MXjsFeqtrk%3D
53. J Liang M Wan Y Zhang P Gu H Xin SY Jung J Qin J Wong AJ Cooney D Liu Zn Songyang 2008 Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells Nat Cell Biol 10 6 731 739 18454139 10.1038/ncb1736 1:CAS:528:DC%2BD1cXmsFyksbY%3D (Epub 2008 May 4) (Pubitemid 351772939)
54. ME Rothenberg MF Clarke M Diehn 2010 The Myc connection: ES cells and cancer Cell 143 2 184 186 20946977 10.1016/j.cell.2010.09.046 1:CAS:528:DC%2BC3cXht12qurjE
55. J Kim AJ Woo J Chu JW Snow Y Fujiwara CG Kim AB Cantor SH Orkin 2010 A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs Cell 143 2 313 324 20946988 10.1016/j.cell.2010.09.010 1:CAS:528:DC%2BC3cXht12qurbM
56. NV Varlakhanova RF Cotterman WN de Vries J Morgan LR Donahue S Murray BB Knowles PS Knoepfler 2010 myc maintains embryonic stem cell pluripotency and self-renewal Differentiation 80 1 9 19 20537458 10.1016/j.diff.2010.05.001 1:CAS:528:DC%2BC3cXpt1CjsL0%3D (Epub 2010 May 27)
57. PB Rahl CY Lin AC Seila RA Flynn S McCuine CB Burge PA Sharp RA Young 2010 c-Myc regulates transcriptional pause release Cell 141 3 432 445 20434984 10.1016/j.cell.2010.03.030 1:CAS:528:DC%2BC3cXlvFygtrY%3D
58. RA Young 2011 Control of the embryonic stem cell state Cell 144 6 940 954 21414485 10.1016/j.cell.2011.01.032 1:CAS:528:DC%2BC3MXjsFCrtrw%3D
59. KN Smith JM Lim L Wells S Dalton 2011 Myc orchestrates a regulatory network required for the establishment and maintenance of pluripotency Cell Cycle 10 4 592 597 21293186 10.4161/cc.10.4.14792 1:CAS:528:DC%2BC3MXkt1Cks78%3D (Epub 2011 Feb 15)
60. G Strübbe C Popp A Schmidt A Pauli L Ringrose C Beisel R Paro 2011 Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners Proc Natl Acad Sci USA 108 14 5572 5577 21415365 10.1073/pnas.1007916108 (Epub 2011 Mar 17)
61. Aichinger E, Villar CB, Di Mambro R, Sabatini S, Köhler C (2011) The CHD3 chromatin remodeler PICKLE and Polycomb group proteins antagonistically regulate meristem activity in the Arabidopsis root. Plant Cell (Epub ahead of print)
62. Gieni RS, Ismail IH, Campbell S, Hendzel MJ (2011) Polycomb group proteins in the DNA damage response-A link between radiation resistance and "stemness". Cell Cycle 10(6) (Epub ahead of print)
63. Y Unhavaithaya TH Shin N Miliaras J Lee T Oyama CC Mello 2002 MEP-1 and a homolog of the NuRD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans Cell 111 991 1002 12507426 10.1016/S0092-8674(02)01202-3 1:CAS:528:DC%2BD3sXis1Kitg%3D%3D (Pubitemid 36044690)
64. TH Shin CC Mello 2003 Chromatin regulation during C. elegans germline development Curr Opin Genet Dev 13 5 455 462 14550409 10.1016/S0959-437X(03) 00109-6 1:CAS:528:DC%2BD3sXnvVOmurc%3D (Pubitemid 37204920)
65. CC Mello BW Draper M Krause H Weintraub JR Priess 1992 The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos Cell 70 1 163 176 1623520 10.1016/0092-8674(92)90542-K 1:CAS:528:DyaK38XltVymsL0%3D
66. UD Akavia O Litvin J Kim F Sanchez-Garcia D Kotliar HC Causton P Pochanard E Mozes LA Garraway D Pe'er 2010 An integrated approach to uncover drivers of cancer Cell 143 6 1005 1017 21129771 10.1016/j.cell.2010.11.013 1:CAS:528:DC%2BC3cXhsFGgsrnP
67. EE Eichler J Flint G Gibson A Kong SM Leal JH Moore JH Nadeau 2010 Missing heritability and strategies for finding the underlying causes of complex disease Nat Rev Genet 11 6 446 450 20479774 10.1038/nrg2809 1:CAS:528:DC%2BC3cXmtFCjt78%3D
68. J Pothof G van Haaften K Thijssen RS Kamath AG Fraser J Ahringer RH Plasterk M Tijsterman 2003 Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi Genes Dev 17 4 443 448 12600937 10.1101/gad.1060703 1:CAS:528:DC%2BD3sXhslCqtbs%3D (Pubitemid 36258758)
69. LN Petrella W Wang CA Spike A Rechtsteiner V Reinke S Strome 2011 synMuv B proteins antagonize germline fate in the intestine and ensure C. elegans survival Development 138 6 1069 1079 21343362 10.1242/dev.059501 1:CAS:528:DC%2BC3MXlt1Oqt7s%3D
70. TC Erren 2099 On the origin of cancer: evolution and a mutation paradox Med Hypotheses 73 1 124 125 10.1016/j.mehy.2009.02.002 (Epub 2009 Mar 6)
71. AH Ludewig C Kober-Eisermann C Weitzel A Bethke K Neubert B Gerisch H Hutter A Antebi 2004 A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging Genes Dev 18 17 2120 2133 15314028 10.1101/gad.312604 1:CAS:528:DC%2BD2cXnsFWksrw%3D (Epub 2004 Aug 16) (Pubitemid 39166629)
72. DF Jarosz S Lindquist 2010 Hsp90 and environmental stress transform the adaptive value of natural genetic variation Science 330 6012 1820 1824 21205668 10.1126/science.1195487 1:CAS:528:DC%2BC3cXhsF2jtbvL
73. M Tariq U Nussbaumer Y Chen C Beisel R Paro 2009 Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression Proc Natl Acad Sci USA 106 4 1157 1162 19144915 10.1073/pnas.0809669106 1:CAS:528: DC%2BD1MXhsFyju7w%3D (Epub 2009 Jan 14)
74. V Specchia L Piacentini P Tritto L Fanti R D'Alessandro G Palumbo S Pimpinelli MP Bozzetti 2010 Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons Nature 463 7281 662 665 20062045 10.1038/nature08739 1:CAS:528:DC%2BC3cXjsVaqsw%3D%3D (Epub 2010 Jan 10)
75. DM Ruden X Lu 2008 Hsp90 affecting chromatin remodeling might explain transgenerational epigenetic inheritance in Drosophila Curr Genomics 9 7 500 508 19506739 10.2174/138920208786241207 1:CAS:528:DC%2BD1cXhtlWiurbP
76. VK Gangaraju H Yin MM Weiner J Wang XA Huang H Lin 2011 Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation Nat Genet 43 2 153 158 21186352 10.1038/ng.743 1:CAS:528:DC%2BC3cXhs1Wis77L (Epub 2010 Dec 26)
77. Sonnenschein C, Soto AM (2011) Why systems biology and cancer? Semin Cancer Biol (Epub ahead of print)
78. Saetzler K, Sonnenschein C, Soto AM (2011) Systems biology beyond networks: generating order from disorder through self-organization. Semin Cancer Biol (Epub ahead of print)
79. Bizzarri M, Giuliani A, Cucina A, D'Anselmi F, Soto AM, Sonnenschein C (2011) Fractal analysis in a systems biology approach to cancer. Semin Cancer Biol (Epub ahead of print)
80. JA Lessard GR Crabtree 2010 Regulatory mechanisms in pluripotency Annu Rev Cell Dev Biol 26 503 532 20624054 10.1146/annurev-cellbio-051809-102012 1:CAS:528:DC%2BC3cXhsFCnurzM
81. AM Soto C Sonnenschein 2011 The tissue organization field theory of cancer: a testable replacement for the somatic mutation theory BioEssays 33 332 340 21503935 10.1002/bies.201100025
82. JT Lee M Herlyn 2006 Embryogenesis meet tumorigenesis Nat Med 12 882 883 16892028 10.1038/nm0806-882 1:CAS:528:DC%2BD28Xnsl2itb4%3D (Pubitemid 44175134)
83. Baverstock K (20011) A comparison of two cell regulatory models entailing high dimensional attractors representing phenotype. Prog Biophys Mol Biol (Epub ahead of print)
84. PH Gunaratane 2009 Embryonic stem cell microRNAs: defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells? Curr Stem Cell Res Ther 4 3 168 177 10.2174/157488809789057400
85. C Furusawa K Kaneko 2000 Complex organization in multicellularity as a necessity in evolution Artif Life 6 4 265 281 11348582 10.1162/ 106454600300103638 1:STN:280:DC%2BD3Mris1ehtQ%3D%3D
86. C Furusawa K Kaneko 2009 Chaotic expression dynamics implies pluripotency: when theory and experiment meet Biol Direct 4 17 19445676 10.1186/1745-6150-4-17
87. SE Hughes K Evason C Xiong K Kornfeld 2007 Genetic and pharmacological factors that influence reproductive aging in nematodes PLoS Genet 3 2 e25 17305431 10.1371/journal.pgen.0030025 (Epub 2006 Dec 28)
88. AV Lichtenstein 2009 Carcinogenesis: evolution of concepts Biochemistry (Mosc) 74 4 353 361 10.1134/S0006297909040014 1:CAS:528:DC%2BD1MXltV2ht7o%3D
89. J Utikal N Maherali W Kulalert K Hochedlinger 2009 Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells J Cell Sci 122 Pt 19 3502 3510 19723802 10.1242/jcs.054783 1:CAS:528:DC%2BD1MXhsVSkurnK (Epub 2009 Sep 1)
90. E Apostolou K Hochedlinger 2011 Stem cells: iPS cells under attack Nature 474 7350 165 166 10.1038/474165a 21654792 10.1038/474165a 1:CAS:528: DC%2BC3MXntFKksLo%3D