Myc orchestrates a regulatory network required for the establishment and maintenance of pluripotency

Cell Cycle

Volumn 10, Issue 4, 2011, Pages 592-597

  Smith, Keriayn N ^a,b,c   Lim, Jae Min ^a,b   Wells, Lance ^a,b   Dalton, Stephen ^a,b  

^a UNIVERSITY OF GEORGIA   (United States)

^b University of North Carolina ^*  (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Myc; Pluripotency; Proteomics; Reprogramming; Self renewal

Indexed keywords

MICRORNA; MYC PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 6; UNTRANSLATED RNA;

CELL CYCLE; EPIGENETICS; GENE ACTIVATION; GENE REPRESSION; NONHUMAN; PLURIPOTENT STEM CELL; PROTEIN FUNCTION; REVIEW;

EID: 79951893490     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.4.14792     Document Type: Review

References (54)

1. Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 1981; 78:7634-8. (Pubitemid 12186197)
2. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282:1145-7. (Pubitemid 28516247)
3. Rossant J, Tam PPL. Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development 2009; 136:701.
4. Evans M, Kaufman M. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292:154-6. (Pubitemid 11050741)
5. Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R, et al. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 2005; 123:917-29. (Pubitemid 41721036)
6. Niwa H, Miyazaki J, Smith AG. Quantitative expression of oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 2000; 24:372-6. (Pubitemid 30187435)
7. Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, et al. Functional expression cloning of nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003; 113:643-55. (Pubitemid 36694189)
8. Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, et al. The homeoprotein nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 2003; 113:631-42. (Pubitemid 36694188)
9. Masui S, Nakatake Y, Toyooka Y, Shimosato D, Yagi R, Takahashi K, et al. Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol 2007.
10. Williams RL, Hilton DJ, Pease S, Willson TA, Stewart CL, Gearing DP, et al. Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 1988; 336:684-7. (Pubitemid 19007951)
11. Smith AG, Heath JK, Donaldson DD, Wong GG, Moreau J, Stahl M, et al. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 1988; 336:688-90. (Pubitemid 19007952)
12. Cartwright P, McLean C, Sheppard A, Rivett D, Jones K, Dalton S. LIF/STAT3 controls ES cell self-renewal and pluripotency by a myc-dependent mechanism. Development 2005; 132:885-96. (Pubitemid 40484924)
13. Davis AC, Wims M, Spotts GD, Hann SR, Bradley A. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev 1993; 7:671-82. (Pubitemid 23125266)
14. Charron J, Malynn BA, Fisher P, Stewart V, Jeannotte L, Goff SP, et al. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev 1992; 6:2248-57. (Pubitemid 23037391)
15. Smith K, Dalton S. Myc transcription factors: Key regulators behind establishment and maintenance of pluripotency. Regen Med 2010; 5:947-59.
16. Meyer N, Penn LZ. Reflecting on 25 years with MYC. Nat Rev Cancer 2008; 8:976-90.
17. Kuttler F, Mai S. c-myc, genomic instability and disease. Genome Dyn 2006; 1:171-90.
18. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126:663-76. (Pubitemid 44233629)
19. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131:861-72. (Pubitemid 350138099)
20. Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008; 133:1106-17. (Pubitemid 351787745)
21. Kim J, Chu J, Shen X, Wang J, Orkin SH. An extended transcriptional network for pluripotency of embryonic stem cells. Cell 2008; 132:1049-61. (Pubitemid 351381745)
22. Sridharan R, Tchieu J, Mason MJ, Yachechko R, Kuoy E, Horvath S, et al. Role of the murine reprogramming factors in the induction of pluripotency. Cell 2009; 136:364-77.
23. Kidder BL, Yang J, Palmer S. Stat3 and c-myc genome-wide promoter occupancy in embryonic stem cells. PLoS One 2008; 3:3932.
24. Lin CH, Lin CW, Tanaka H, Fero ML, Eisenman RN. Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-myc. PLoS One 2009; 4:7839.
25. Smith KN, Singh AM, Dalton S. Myc represses primitive endoderm differentiation in pluripotent stem cells. Cell Stem Cell 2010; 7:343-54.
26. Cole MD, Henriksson M. 25 years of the c-myc oncogene. Semin Cancer Biol 2006; 16:241. (Pubitemid 44311042)
27. Varlakhanova NV, Cotterman RF, deVries WN, Morgan J, Donahue LR, Murray S, et al. Myc maintains embryonic stem cell pluripotency and self-renewal. Differentiation 2010; 80:9-19.
28. Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006; 125:315-26.
29. Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, Giannoukos G, et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007; 448:553-60. (Pubitemid 47206934)
30. Ralston A, Rossant J. Genetic regulation of stem cell origins in the mouse embryo. Clin Genet 2005; 68:106-12. (Pubitemid 40990621)
31. Hough SR, Clements I, Welch PJ, Wiederholt KA. Differentiation of mouse embryonic stem cells after RNA interference-mediated silencing of Oct4 and Nanog. Stem Cells 2006; 24:1467-75. (Pubitemid 44464663)
32. Singh AM, Hamazaki T, Hankowski KE, Terada N. A heterogeneous expression pattern for nanog in embryonic stem cells. Stem Cells 2007; 25:2534.
33. Mendell JT. miRiad roles for the miR-17-92 cluster in development and disease. Cell 2008; 133:217-22.
34. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. c-myc-regulated microRNAs modulate E2F1 expression. Nature 2005; 435:839-43. (Pubitemid 40839736)
35. Fontana L, Fiori ME, Albini S, Cifaldi L, Giovinazzi S, Forloni M, et al. Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM. PLoS One 2008; 3:2236.
36. Wang Q, Li YC, Wang J, Kong J, Qi Y, Quigg RJ, et al. miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/ p130. Proc Nat Acad Sci USA 2008; 105:2889-94. (Pubitemid 351723639)
37. Singh AM, Dalton S. The cell cycle and myc intersect with mechanisms that regulate pluripotency and reprogramming. Cell Stem Cell 2009; 5:141-9.
38. Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009; 460:1132-5.
39. Hanna J, Saha K, Pando B, Van Zon J, Lengner CJ, Creyghton MP, et al. Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 2009; 462:595-601.
40. Baudino TA, McKay C, Pendeville-Samain H, Nilsson JA, Maclean KH, White EL, et al. c-myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev 2002; 16:2530-43.
41. Koch HB, Zhang R, Verdoodt B, Bailey A, Zhang CD, 3rd, Menssen A, et al. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Cell Cycle 2007; 6:205-17. (Pubitemid 46232502)
42. Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, et al. A myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 2010; 143:313-24.
43. Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, et al. The p400 complex is an essential E1A transformation target. Cell 2001; 106:297-307. (Pubitemid 32772614)
44. Shen X, Mizuguchi G, Hamiche A, Wu C. A chromatin remodeling complex involved in transcription and DNA processing. Nature 2000; 406:541-4. (Pubitemid 30625741)
45. Fazzio TG, Huff JT, Panning B. An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Cell 2008; 134:162-74. (Pubitemid 351905738)
46. Xue Y, Wong J, Moreno GT, Young MK, Côté J, Wang W. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell 1998; 2:851-61. (Pubitemid 128378992)
47. Kaji K, Caballero IM, MacLeod R, Nichols J, Wilson VA, Hendrich B. The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Nat Cell Biol 2006; 8:285-92. (Pubitemid 43336071)
48. Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004; 119:941-53. (Pubitemid 40037608)
49. Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y. Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell 2005; 19:857-64. (Pubitemid 41316679)
50. Agrawal P, Yu K, Salomon AR, Sedivy JM. Proteomic profiling of Myc-associated proteins Cell Cycle 2010; 9:4908-21.
51. Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung SY, et al. Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol 2008; 10:731-9. (Pubitemid 351772939)
52. Wang J, Hevi S, Kurash JK, Lei H, Gay F, Bajko J, et al. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet 2008; 41:125-9.
53. Oliveros JC. VENN. An interactive tool for comparing lists with Venn Diagrams 2007. bioinfogp.cnb. csic.es/tools/venny/index.html.
54. Lim JM, Sherling D, Teo CF, Hausman DB, Lin D, Wells L. Defining the regulated secreted proteome of rodent adipocytes upon the induction of insulin resistance. J Proteome Res 2008; 7:1251-63.