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Volumn 11, Issue 1, 2011, Pages 50-58

Cell lineage and cell death: Caenorhabditis elegans and cancer research

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS PROTEIN; EGG LAYING DEFECTIVE 1; HOMEODOMAIN PROTEIN; ONCOPROTEIN; PROTEIN BCL 2; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 78650602309     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2984     Document Type: Review
Times cited : (21)

References (129)
  • 1
    • 0028200532 scopus 로고
    • Genetic control of programmed cell death in Drosophila
    • White, K. et al. Genetic control of programmed cell death in Drosophila. Science 264, 677-683 (1994).
    • (1994) Science , vol.264 , pp. 677-683
    • White, K.1
  • 2
    • 0022497852 scopus 로고
    • Genetic control of programmed cell death in the nematode C. elegans
    • Ellis, H. M. & Horvitz, H. R. Genetic control of programmed cell death in the nematode C. elegans. Cell 44, 817-829 (1986).
    • (1986) Cell , vol.44 , pp. 817-829
    • Ellis, H.M.1    Horvitz, H.R.2
  • 3
    • 0031038137 scopus 로고    scopus 로고
    • Bax suppresses tumorigenesis and stimulates apoptosis in vivo
    • Yin, C, Knudson, C. M., Korsmeyer, S. J. & Van Dyke, T. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385, 637-640 (1997).
    • (1997) Nature , vol.385 , pp. 637-640
    • Yin, C.1    Knudson, C.M.2    Korsmeyer, S.J.3    Van Dyke, T.4
  • 4
    • 0017618537 scopus 로고
    • Post-embryonic cell lineages of the nematode Caenorhabditis elegans
    • Sulston, J. E. & Horvitz, H. R. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol. 56, 110-156 (1977).
    • (1977) Dev Biol. , vol.56 , pp. 110-156
    • Sulston, J.E.1    Horvitz, H.R.2
  • 5
    • 0020858899 scopus 로고
    • The embryonic cell lineage of the nematode Caenorhabditis elegans
    • Sulston, J. E., Schierenberg, E., White, J. G. & Thomson, J. N. The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol. 100, 64-119 (1983).
    • (1983) Dev. Biol. , vol.100 , pp. 64-119
    • Sulston, J.E.1    Schierenberg, E.2    White, J.G.3    Thomson, J.N.4
  • 6
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J. F., Wyllie, A. H. & Currie, A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257 (1972).
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 7
    • 78650865771 scopus 로고    scopus 로고
    • Somatic sex determination
    • [online]
    • Zarkower, D. Somatic sex determination. WormBook [online], http://www.wormbook.org/chapters/www-somaticsexdeterm/somaticsexdeterm.html (2007).
    • (2007) WormBook
    • Zarkower, D.1
  • 8
    • 0036336510 scopus 로고    scopus 로고
    • PAG-3, a Zn-finger transcription factor, determines neuroblast fate in C. elegans
    • Cameron, S., Clark, S. G., McDermott, J. B., Aamodt, E. & Horvitz, H. R. PAG-3, a Zn-finger transcription factor, determines neuroblast fate in C. elegans. Development 129, 1763-1774 (2002).
    • (2002) Development , vol.129 , pp. 1763-1774
    • Cameron, S.1    Clark, S.G.2    McDermott, J.B.3    Aamodt, E.4    Horvitz, H.R.5
  • 9
    • 0030922707 scopus 로고    scopus 로고
    • The C. elegans gene pag-3 is homologous to the zinc finger proto-oncogene gfi-1
    • Jia, Y., Xie, G., McDermott, J. B. & Aamodt, E. The C. elegans gene pag-3 is homologous to the zinc finger proto-oncogene gfi-1. Development 124, 2063-2073 (1997).
    • (1997) Development , vol.124 , pp. 2063-2073
    • Jia, Y.1    Xie, G.2    McDermott, J.B.3    Aamodt, E.4
  • 10
    • 7244231429 scopus 로고    scopus 로고
    • Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
    • Hock, H. et al. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature 431, 1002-1007 (2004).
    • (2004) Nature , vol.431 , pp. 1002-1007
    • Hock, H.1
  • 11
    • 0037244284 scopus 로고    scopus 로고
    • Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation
    • Hock, H. et al. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity 18, 109-120 (2003).
    • (2003) Immunity , vol.18 , pp. 109-120
    • Hock, H.1
  • 12
    • 0036467868 scopus 로고    scopus 로고
    • The zinc-finger proto-oncogene Gfi-1 b is essential for development of the erythroid and megakaryocytic lineages
    • Saleque, S., Cameron, S. & Orkin, S. H. The zinc-finger proto-oncogene Gfi-1 b is essential for development of the erythroid and megakaryocytic lineages. Genes Dev 16, 301-306 (2002).
    • (2002) Genes Dev , vol.16 , pp. 301-306
    • Saleque, S.1    Cameron, S.2    Orkin, S.H.3
  • 13
    • 35848948403 scopus 로고    scopus 로고
    • Imaging hematopoietic precursor division in real time
    • Wu, M. et al. Imaging hematopoietic precursor division in real time. Cell Stem Cell 1, 541-554 (2007).
    • (2007) Cell Stem Cell , vol.1 , pp. 541-554
    • Wu, M.1
  • 14
    • 0027525104 scopus 로고
    • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
    • DOI 10.1016/0092-8674(93)90485-9
    • Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M. & Horvitz, H. R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 (3-converting enzyme. Cell 75, 641-652 (1993). (Pubitemid 23346363)
    • (1993) Cell , vol.75 , Issue.4 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3    Ellis, H.M.4    Horvitz, H.R.5
  • 15
    • 0025255636 scopus 로고
    • The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death
    • Yuan, J. Y & Horvitz, H. R. The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Dev. Biol. 138, 33-41 (1990).
    • (1990) Dev. Biol. , vol.138 , pp. 33-41
    • Yuan, J.Y.1    Horvitz, H.R.2
  • 16
    • 0026582702 scopus 로고
    • Caenorhabditis elegans gene ced-9 protects cells from programmed cell death
    • Hengartner, M. O., Ellis, R. E. & Horvitz, H. R. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356, 494-499 (1992).
    • (1992) Nature , vol.356 , pp. 494-499
    • Hengartner, M.O.1    Ellis, R.E.2    Horvitz, H.R.3
  • 17
    • 0028288277 scopus 로고
    • C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
    • Hengartner, M. O. & Horvitz, H. R. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76, 665-676 (1994).
    • (1994) Cell , vol.76 , pp. 665-676
    • Hengartner, M.O.1    Horvitz, H.R.2
  • 18
    • 0033529717 scopus 로고    scopus 로고
    • The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene
    • Conradt, B. & Horvitz, H. R. The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene. Cell 98, 317-327 (1999).
    • (1999) Cell , vol.98 , pp. 317-327
    • Conradt, B.1    Horvitz, H.R.2
  • 19
    • 0032524885 scopus 로고    scopus 로고
    • The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
    • Conradt, B. & Horvitz, H. R. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93, 519-529 (1998).
    • (1998) Cell , vol.93 , pp. 519-529
    • Conradt, B.1    Horvitz, H.R.2
  • 20
    • 0042469295 scopus 로고    scopus 로고
    • Worms, life, and death (Nobel lecture)
    • Horvitz, H. R. Worms, life, and death (Nobel lecture). Chembiochem 4, 697-711 (2003).
    • (2003) Chembiochem , vol.4 , pp. 697-711
    • Horvitz, H.R.1
  • 21
    • 0027050145 scopus 로고
    • Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2
    • Vaux, D. L, Weissman, I. L. & Kim, S. K. Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2. Science 258, 1955-1957 (1992).
    • (1992) Science , vol.258 , pp. 1955-1957
    • Vaux, D.L.1    Weissman, I.L.2    Kim, S.K.3
  • 22
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux, D. L, Cory, S. & Adams, J. M. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335, 440-442 (1988).
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 23
    • 0037439151 scopus 로고    scopus 로고
    • Proapoptotic BID is required for myeloid homeostasis and tumor suppression
    • Zinkel, S. S. et al. Proapoptotic BID is required for myeloid homeostasis and tumor suppression. Genes Dev. 17, 229-239 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 229-239
    • Zinkel, S.S.1
  • 24
    • 0042424706 scopus 로고    scopus 로고
    • Bad-deficient mice develop diffuse large B cell lymphoma
    • Ranger, A. M. et al. Bad-deficient mice develop diffuse large B cell lymphoma. Proc. Natl Acad. Sci. USA 100, 9324-9329 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 9324-9329
    • Ranger, A.M.1
  • 25
    • 26844485563 scopus 로고    scopus 로고
    • Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
    • Yan, N. et al. Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature 437, 831-837 (2005).
    • (2005) Nature , vol.437 , pp. 831-837
    • Yan, N.1
  • 26
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou, H., Henzel, W. J., Liu, X., Lutschg, A. & Wang, X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413 (1997).
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 27
    • 0033596980 scopus 로고    scopus 로고
    • An APAF-1. cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
    • Zou, H., Li, Y., Liu, X. & Wang, X. An APAF-1. cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 274, 11549-11556 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 11549-11556
    • Zou, H.1    Li, Y.2    Liu, X.3    Wang, X.4
  • 28
    • 45449083640 scopus 로고    scopus 로고
    • Living with death: The evolution of the mitochondrial pathway of apoptosis in animals
    • Oberst, A., Bender, C. & Green, D. R. Living with death: the evolution of the mitochondrial pathway of apoptosis in animals. Cell Death Differ. 15, 1139-1146 (2008).
    • (2008) Cell Death Differ. , vol.15 , pp. 1139-1146
    • Oberst, A.1    Bender, C.2    Green, D.R.3
  • 29
    • 68149157524 scopus 로고    scopus 로고
    • Inhibitor of apoptosis proteins in Drosophila: Gatekeepers of death
    • Orme, M. & Meier, P. Inhibitor of apoptosis proteins in Drosophila: gatekeepers of death. Apoptosis 14, 950-960 (2009).
    • (2009) Apoptosis , vol.14 , pp. 950-960
    • Orme, M.1    Meier, P.2
  • 30
    • 0035937420 scopus 로고    scopus 로고
    • Cell death inhibition: Keeping caspases in check
    • Goyal, L. Cell death inhibition: keeping caspases in check. Cell 104, 805-808 (2001).
    • (2001) Cell , vol.104 , pp. 805-808
    • Goyal, L.1
  • 31
    • 34248180046 scopus 로고    scopus 로고
    • Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene
    • Maurer, C. W., Chiorazzi, M. & Shaham, S. Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene. Development 134, 1357-1368 (2007).
    • (2007) Development , vol.134 , pp. 1357-1368
    • Maurer, C.W.1    Chiorazzi, M.2    Shaham, S.3
  • 32
    • 33751533482 scopus 로고    scopus 로고
    • Pax2/5/8 proteins promote cell survival in C. elegans
    • Park, D., Jia, H., Rajakumar, V. & Chamberlin, H. M. Pax2/5/8 proteins promote cell survival in C. elegans. Development 133, 4193-4202 (2006).
    • (2006) Development , vol.133 , pp. 4193-4202
    • Park, D.1    Jia, H.2    Rajakumar, V.3    Chamberlin, H.M.4
  • 33
    • 77954658825 scopus 로고    scopus 로고
    • Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons
    • Nehme, R. et al. Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons. Cell Death Differ. 17, 1266-1276 (2010).
    • (2010) Cell Death Differ. , vol.17 , pp. 1266-1276
    • Nehme, R.1
  • 34
    • 0025752461 scopus 로고
    • Two C. elegans genes control the programmed deaths of specific cells in the pharynx
    • Ellis, R. E. & Horvitz, H. R. Two C. elegans genes control the programmed deaths of specific cells in the pharynx. Development 11 2, 591-603 (1991).
    • (1991) Development , vol.112 , pp. 591-603
    • Ellis, R.E.1    Horvitz, H.R.2
  • 35
    • 0029761433 scopus 로고    scopus 로고
    • Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
    • Metzstein, M. M., Hengartner, M. O., Tsung, N., Ellis, R. E. & Horvitz, H. R. Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2. Nature 382, 545-547 (1996).
    • (1996) Nature , vol.382 , pp. 545-547
    • Metzstein, M.M.1    Hengartner, M.O.2    Tsung, N.3    Ellis, R.E.4    Horvitz, H.R.5
  • 36
    • 0033197540 scopus 로고    scopus 로고
    • The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein
    • Metzstein, M. M. & Horvitz, H. R. The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein. Mol. Cell 4, 309-319 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 309-319
    • Metzstein, M.M.1    Horvitz, H.R.2
  • 37
    • 0041827179 scopus 로고    scopus 로고
    • The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins
    • Thellmann, M., Hatzold, J. & Conradt, B. The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins. Development 130, 4057-4071 (2003).
    • (2003) Development , vol.130 , pp. 4057-4071
    • Thellmann, M.1    Hatzold, J.2    Conradt, B.3
  • 38
    • 0029759926 scopus 로고    scopus 로고
    • Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor
    • Inaba, T. et al. Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. Nature 382, 541-544 (1996).
    • (1996) Nature , vol.382 , pp. 541-544
    • Inaba, T.1
  • 39
    • 0026744416 scopus 로고
    • Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia
    • Inaba, T. et al. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science 257, 531-534 (1992).
    • (1992) Science , vol.257 , pp. 531-534
    • Inaba, T.1
  • 40
    • 0026069091 scopus 로고
    • The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias
    • Hunger, S. P. et al. The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. Blood 77, 687-693 (1991).
    • (1991) Blood , vol.77 , pp. 687-693
    • Hunger, S.P.1
  • 41
    • 0033916759 scopus 로고    scopus 로고
    • Human Slug is a repressor that localizes to sites of active transcription
    • Hemavathy, K., Guru, S. C., Harris, J., Chen, J. D. & Ip, Y. T. Human Slug is a repressor that localizes to sites of active transcription. Mol. Cell. Biol. 20, 5087-5095 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5087-5095
    • Hemavathy, K.1    Guru, S.C.2    Harris, J.3    Chen, J.D.4    Ip, Y.T.5
  • 42
    • 0033197879 scopus 로고    scopus 로고
    • SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein
    • Inukai, T. et al. SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol. Cell 4, 343-352 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 343-352
    • Inukai, T.1
  • 43
    • 27744547091 scopus 로고    scopus 로고
    • Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
    • Wu, W. S. et al. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123, 641-653 (2005).
    • (2005) Cell , vol.123 , pp. 641-653
    • Wu, W.S.1
  • 44
    • 43249115184 scopus 로고    scopus 로고
    • Control of apoptosis by asymmetric cell division
    • Hatzold, J. & Conradt, B. Control of apoptosis by asymmetric cell division. PLoS Biol. 6, e84 (2008).
    • (2008) PLoS Biol. , vol.6
    • Hatzold, J.1    Conradt, B.2
  • 45
    • 33846460770 scopus 로고    scopus 로고
    • Spindle regulation in neural precursors of flies and mammals
    • Buchman, J. J. & Tsai, L. H. Spindle regulation in neural precursors of flies and mammals. Nature Rev. Neurosci. 8, 89-100 (2007).
    • (2007) Nature Rev. Neurosci. , vol.8 , pp. 89-100
    • Buchman, J.J.1    Tsai, L.H.2
  • 46
    • 72549092813 scopus 로고    scopus 로고
    • Dividing cellular asymmetry: Asymmetric cell division and its implications for stem cells and cancer
    • Neumuller, R. A. & Knoblich, J. A. Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. Genes Dev. 23, 2675-2699 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 2675-2699
    • Neumuller, R.A.1    Knoblich, J.A.2
  • 47
    • 38449094845 scopus 로고    scopus 로고
    • Sex determination in the germ line
    • [online]
    • Ellis, R. & Schedl, T. Sex determination in the germ line. WormBook [online], http://www.wormbook.org/ chapters/www-sexgermline/sexgermline.html (2007).
    • (2007) WormBook
    • Ellis, R.1    Schedl, T.2
  • 48
    • 0017399078 scopus 로고
    • Mutations causing transformation of sexual phenotype in the nematode Caenorhabditis elegans
    • Hodgkin, J. A. & Brenner, S. Mutations causing transformation of sexual phenotype in the nematode Caenorhabditis elegans. Genetics 86, 275-287 (1977).
    • (1977) Genetics , vol.86 , pp. 275-287
    • Hodgkin, J.A.1    Brenner, S.2
  • 49
    • 36849006499 scopus 로고    scopus 로고
    • Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho
    • Peden, E., Kimberly, E., Gengyo-Ando, K., Mitani, S. & Xue, D. Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho. Genes Dev. 21, 3195-3207 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 3195-3207
    • Peden, E.1    Kimberly, E.2    Gengyo-Ando, K.3    Mitani, S.4    Xue, D.5
  • 50
    • 35548973782 scopus 로고    scopus 로고
    • The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9
    • Schwartz, H. T. & Horvitz, H. R. The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9. Genes Dev. 21, 3181-3194 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 3181-3194
    • Schwartz, H.T.1    Horvitz, H.R.2
  • 51
    • 0026714692 scopus 로고
    • A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system
    • Collum, R. G. et al. A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system. Nucleic Acids Res. 20, 4919-4925 (1992).
    • (1992) Nucleic Acids Res. , vol.20 , pp. 4919-4925
    • Collum, R.G.1
  • 52
    • 0344063368 scopus 로고    scopus 로고
    • Oct-3/4 is a dose-dependent oncogenic fate determinant
    • Gidekel, S., Pizov, G., Bergman, Y. & Pikarsky, E. Oct-3/4 is a dose-dependent oncogenic fate determinant. Cancer Cell 4, 361-370 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 361-370
    • Gidekel, S.1    Pizov, G.2    Bergman, Y.3    Pikarsky, E.4
  • 54
    • 0028806819 scopus 로고
    • The POU domain transcription factor Brn-2: Elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression
    • Eisen, T., Easty, D. J., Bennett, D. C. & Goding, C. R. The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression. Oncogene 11, 2157-2164 (1995).
    • (1995) Oncogene , vol.11 , pp. 2157-2164
    • Eisen, T.1    Easty, D.J.2    Bennett, D.C.3    Goding, C.R.4
  • 55
    • 44349149820 scopus 로고    scopus 로고
    • Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knockdown analysis
    • Shin, S. H. et al. Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knockdown analysis. Exp. Mol. Med. 40, 229-236 (2008).
    • (2008) Exp. Mol. Med. , vol.40 , pp. 229-236
    • Shin, S.H.1
  • 56
    • 34547128888 scopus 로고    scopus 로고
    • 'Marx'of Groucho on development and disease
    • Buscarlet, M. & Stifani, S. The 'Marx' of Groucho on development and disease. Trends Cell Biol. 17, 353-361 (2007).
    • (2007) Trends Cell Biol. , vol.17 , pp. 353-361
    • Buscarlet, M.1    The, S.S.2
  • 57
    • 53249137796 scopus 로고    scopus 로고
    • Potential roles for the PIM1 kinase in human cancer - A molecular and therapeutic appraisal
    • Shah, N. et al. Potential roles for the PIM1 kinase in human cancer - a molecular and therapeutic appraisal. Eur. J. Cancer 44, 2144-2151 (2008).
    • (2008) Eur. J. Cancer , vol.44 , pp. 2144-2151
    • Shah, N.1
  • 58
    • 0026720835 scopus 로고
    • Molecular analysis of the C. elegans sex-determining gene tra-1: A gene encoding two zinc finger proteins
    • Zarkower, D. & Hodgkin, J. Molecular analysis of the C. elegans sex-determining gene tra-1: a gene encoding two zinc finger proteins. Cell 70, 237-249 (1992).
    • (1992) Cell , vol.70 , pp. 237-249
    • Zarkower, D.1    Hodgkin, J.2
  • 59
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement for hedgehog signalling in cancer
    • Yauch, R. L. et al. A paracrine requirement for hedgehog signalling in cancer. Nature 455, 406-410 (2008).
    • (2008) Nature , vol.455 , pp. 406-410
    • Yauch, R.L.1
  • 60
    • 34547683699 scopus 로고    scopus 로고
    • Essential role of stromally induced hedgehog signaling in B-cell malignancies
    • Dierks, C. et al. Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nature Med. 13, 944-951 (2007).
    • (2007) Nature Med. , vol.13 , pp. 944-951
    • Dierks, C.1
  • 61
    • 7444247429 scopus 로고    scopus 로고
    • Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2
    • Regl, G. et al. Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Cancer Res. 64, 7724-7731 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 7724-7731
    • Regl, G.1
  • 62
    • 0346463039 scopus 로고    scopus 로고
    • Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1
    • Bigelow, R. L. et al. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J. Biol. Chem. 279, 1197-1205 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 1197-1205
    • Bigelow, R.L.1
  • 63
    • 77957251870 scopus 로고    scopus 로고
    • Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans
    • Hirose, T., Galvin, B. D. & Horvitz, H. R. Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 107, 15479-15484 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 15479-15484
    • Hirose, T.1    Galvin, B.D.2    Horvitz, H.R.3
  • 65
    • 0027220590 scopus 로고
    • Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39
    • Clark, S. G., Chisholm, A. D. & Horvitz, H. R. Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39. Cell 74, 43-55 (1993).
    • (1993) Cell , vol.74 , pp. 43-55
    • Clark, S.G.1    Chisholm, A.D.2    Horvitz, H.R.3
  • 66
    • 0027275190 scopus 로고
    • Multiple HOM-C gene interactions specify cell fates in the nematode central nervous system
    • Salser, S. J., Loer, C. M. & Kenyon, C. Multiple HOM-C gene interactions specify cell fates in the nematode central nervous system. Genes Dev. 7, 1714-1724 (1993).
    • (1993) Genes Dev. , vol.7 , pp. 1714-1724
    • Salser, S.J.1    Loer, C.M.2    Kenyon, C.3
  • 67
    • 0022761114 scopus 로고
    • A gene involved in the development of the posterior body region of C. elegans
    • Kenyon, C. A gene involved in the development of the posterior body region of C. elegans. Cell 46, 477-487 (1986).
    • (1986) Cell , vol.46 , pp. 477-487
    • Kenyon, C.1
  • 68
    • 0033106156 scopus 로고    scopus 로고
    • Patterning of Caenorhabditis elegans posterior structures by the Abdominal-B homolog, egl-5
    • Ferreira, H. B., Zhang, Y., Zhao, C. & Emmons, S. W. Patterning of Caenorhabditis elegans posterior structures by the Abdominal-B homolog, egl-5. Dev. Biol. 207, 215-228 (1999).
    • (1999) Dev. Biol. , vol.207 , pp. 215-228
    • Ferreira, H.B.1    Zhang, Y.2    Zhao, C.3    Emmons, S.W.4
  • 69
    • 0025910601 scopus 로고
    • Control of cell fate in the tail region of C. elegans by the gene egl-5
    • Chisholm, A. Control of cell fate in the tail region of C. elegans by the gene egl-5. Development 111, 921-932 (1991).
    • (1991) Development , vol.111 , pp. 921-932
    • Chisholm, A.1
  • 70
    • 0032963910 scopus 로고    scopus 로고
    • Anterior organization of the Caenorhabditis elegans embryo by the labial-like Hox gene ceh-13
    • Brunschwig, K. et al. Anterior organization of the Caenorhabditis elegans embryo by the labial-like Hox gene ceh-13. Development 126, 1537-1546 (1999).
    • (1999) Development , vol.126 , pp. 1537-1546
    • Brunschwig, K.1
  • 71
    • 0345016265 scopus 로고    scopus 로고
    • Hox gene evolution in nematodes: Novelty conserved
    • DOI 10.1016/j.gde.2003.10.009
    • Aboobaker, A. & Blaxter, M. Hox gene evolution in nematodes: novelty conserved. Curr. Opin. Genet. Dev. 13, 593-598 (2003). (Pubitemid 37456877)
    • (2003) Current Opinion in Genetics and Development , vol.13 , Issue.6 , pp. 593-598
    • Aboobaker, A.1    Blaxter, M.2
  • 72
    • 0027966927 scopus 로고
    • The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein
    • Chan, S. K., Jaffe, L., Capovilla, M., Botas, J. & Mann, R. S. The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell 78, 603-615 (1994).
    • (1994) Cell , vol.78 , pp. 603-615
    • Chan, S.K.1    Jaffe, L.2    Capovilla, M.3    Botas, J.4    Mann, R.S.5
  • 73
    • 0034529493 scopus 로고    scopus 로고
    • Overlapping roles of two Hox genes and the exd ortholog ceh-20 in diversification of the C. elegans postembryonic mesoderm
    • Liu, J. & Fire, A. Overlapping roles of two Hox genes and the exd ortholog ceh-20 in diversification of the C. elegans postembryonic mesoderm. Development 127, 5179-5190 (2000).
    • (2000) Development , vol.127 , pp. 5179-5190
    • Liu, J.1    Fire, A.2
  • 74
    • 33645094394 scopus 로고    scopus 로고
    • Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1
    • Liu, H., Strauss, T. J., Potts, M. B. & Cameron, S. Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1. Development 133, 641-650 (2006).
    • (2006) Development , vol.133 , pp. 641-650
    • Liu, H.1    Strauss, T.J.2    Potts, M.B.3    Cameron, S.4
  • 75
    • 17244373421 scopus 로고    scopus 로고
    • The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development
    • Yang, L., Sym, M. & Kenyon, C. The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development. Development 132, 1413-1428 (2005).
    • (2005) Development , vol.132 , pp. 1413-1428
    • Yang, L.1    Sym, M.2    Kenyon, C.3
  • 76
    • 0037083388 scopus 로고    scopus 로고
    • Conserved regulation of the Caenorhabditis elegans labial/Hox1 gene ceh-13
    • Streit, A. et al. Conserved regulation of the Caenorhabditis elegans labial/Hox1 gene ceh-13. Dev. Biol. 242, 96-108 (2002).
    • (2002) Dev. Biol. , vol.242 , pp. 96-108
    • Streit, A.1
  • 77
    • 0036826906 scopus 로고    scopus 로고
    • Roles of the Homothorax/Meis/ Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis
    • Van Auken, K. et al. Roles of the Homothorax/Meis/ Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis. Development 129, 5255-5268 (2002).
    • (2002) Development , vol.129 , pp. 5255-5268
    • Van Auken, K.1
  • 78
    • 33644976371 scopus 로고    scopus 로고
    • Hox cofactors in vertebrate development
    • Moens, C. B. & Selleri, L. Hox cofactors in vertebrate development. Dev. Biol. 291, 193-206 (2006).
    • (2006) Dev. Biol. , vol.291 , pp. 193-206
    • Moens, C.B.1    Selleri, L.2
  • 79
    • 67349124418 scopus 로고    scopus 로고
    • Trithorax, Hox, and TALE-class homeodomain proteins ensure cell survival through repression of the BH3-only gene egl-1
    • Potts, M. B., Wang, D. P. & Cameron, S. Trithorax, Hox, and TALE-class homeodomain proteins ensure cell survival through repression of the BH3-only gene egl-1. Dev. Biol. 329, 374-385 (2009).
    • (2009) Dev. Biol. , vol.329 , pp. 374-385
    • Potts, M.B.1    Wang, D.P.2    Cameron, S.3
  • 80
    • 0037162712 scopus 로고    scopus 로고
    • The Drosophila Hox gene deformed sculpts head morphology via direct regulation of the apoptosis activator reaper
    • Lohmann, I., McGinnis, N., Bodmer, M. & McGinnis, W. The Drosophila Hox gene deformed sculpts head morphology via direct regulation of the apoptosis activator reaper. Cell 110, 457-466 (2002).
    • (2002) Cell , vol.110 , pp. 457-466
    • Lohmann, I.1    McGinnis, N.2    Bodmer, M.3    McGinnis, W.4
  • 81
    • 58149238200 scopus 로고    scopus 로고
    • Antagonistic roles for Ultrabithorax and Antennapedia in regulating segment-specific apoptosis of differentiated motoneurons in the Drosophila embryonic central nervous system
    • Rogulja-Ortmann, A., Renner, S. & Technau, G. M. Antagonistic roles for Ultrabithorax and Antennapedia in regulating segment-specific apoptosis of differentiated motoneurons in the Drosophila embryonic central nervous system. Development 135, 3435-3445 (2008).
    • (2008) Development , vol.135 , pp. 3435-3445
    • Rogulja-Ortmann, A.1    Renner, S.2    Technau, G.M.3
  • 82
    • 64049095814 scopus 로고    scopus 로고
    • HOXA9 is required for survival in human MLL-rearranged acute leukemias
    • Faber, J. et al. HOXA9 is required for survival in human MLL-rearranged acute leukemias. Blood 11 3, 2375-2385 (2008).
    • (2008) Blood , vol.113 , pp. 2375-2385
    • Faber, J.1
  • 84
    • 0029998350 scopus 로고    scopus 로고
    • Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma
    • Busslinger, M., Klix, N., Pfeffer, P., Graninger, P. G. & Kozmik, Z. Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma. Proc. Natl Acad. Sci. USA 93, 6129-6134 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 6129-6134
    • Busslinger, M.1    Klix, N.2    Pfeffer, P.3    Graninger, P.G.4    Kozmik, Z.5
  • 85
    • 0028867940 scopus 로고
    • Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma
    • Davis, R. J. et al. Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma. Hum. Mol. Genet. 4, 2355-2362 (1995).
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 2355-2362
    • Davis, R.J.1
  • 86
    • 0028239775 scopus 로고
    • Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes
    • Epstein, J., Cai, J., Glaser, T., Jepeal, L. & Maas, R. Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J. Biol. Chem. 269, 8355-8361 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 8355-8361
    • Epstein, J.1    Cai, J.2    Glaser, T.3    Jepeal, L.4    Maas, R.5
  • 87
    • 0028881603 scopus 로고
    • The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3
    • Fredericks, W. J. et al. The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. Mol. Cell. Biol. 15, 1522-1535 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1522-1535
    • Fredericks, W.J.1
  • 88
    • 0027366917 scopus 로고
    • Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma
    • Shapiro, D. N., Sublett, J. E., Li, B., Downing, J. R. & Naeve, C. W. Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. Cancer Res. 53, 5108-5112 (1993).
    • (1993) Cancer Res. , vol.53 , pp. 5108-5112
    • Shapiro, D.N.1    Sublett, J.E.2    Li, B.3    Downing, J.R.4    Naeve, C.W.5
  • 89
    • 0344255673 scopus 로고    scopus 로고
    • Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival
    • Muratovska, A., Zhou, C., He, S., Goodyer, P. & Eccles, M. R. Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival. Oncogene 22, 7989-7997 (2003).
    • (2003) Oncogene , vol.22 , pp. 7989-7997
    • Muratovska, A.1    Zhou, C.2    He, S.3    Goodyer, P.4    Eccles, M.R.5
  • 90
    • 0034622048 scopus 로고    scopus 로고
    • Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR
    • Margue, C. M., Bernasconi, M., Barr, F. G. & Schafer, B. W. Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR. Oncogene 19, 2921-2929 (2000).
    • (2000) Oncogene , vol.19 , pp. 2921-2929
    • Margue, C.M.1    Bernasconi, M.2    Barr, F.G.3    Schafer, B.W.4
  • 91
    • 0033026027 scopus 로고    scopus 로고
    • Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline
    • Gumienny, T. L., Lambie, E., Hartwieg, E., Horvitz, H. R. & Hengartner, M. O. Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline. Development 126, 1011-1022 (1999).
    • (1999) Development , vol.126 , pp. 1011-1022
    • Gumienny, T.L.1    Lambie, E.2    Hartwieg, E.3    Horvitz, H.R.4    Hengartner, M.O.5
  • 92
    • 36148979346 scopus 로고    scopus 로고
    • C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions
    • Schertel, C. & Conradt, B. C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. Development 134, 3691-3701 (2007).
    • (2007) Development , vol.134 , pp. 3691-3701
    • Schertel, C.1    Conradt, B.2
  • 93
    • 1642514804 scopus 로고    scopus 로고
    • Death and more: DNA damage response pathways in the nematode C. elegans
    • Stergiou, L. & Hengartner, M. O. Death and more: DNA damage response pathways in the nematode C. elegans. Cell Death Differ. 11, 21-28 (2004).
    • (2004) Cell Death Differ. , vol.11 , pp. 21-28
    • Stergiou, L.1    Hengartner, M.O.2
  • 94
    • 77953184918 scopus 로고    scopus 로고
    • HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase
    • Sendoel, A., Kohler, I., Fellmann, C., Lowe, S. W. & Hengartner, M. O. HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature 465, 577-583 (2010).
    • (2010) Nature , vol.465 , pp. 577-583
    • Sendoel, A.1    Kohler, I.2    Fellmann, C.3    Lowe, S.W.4    Hengartner, M.O.5
  • 95
    • 34249074239 scopus 로고    scopus 로고
    • DPL-1 D P, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans
    • Reddien, P. W., Andersen, E. C., Huang, M. C. & Horvitz, H. R. DPL-1 D P, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans. Genetics 175, 1719-1733 (2007).
    • (2007) Genetics , vol.175 , pp. 1719-1733
    • Reddien, P.W.1    Andersen, E.C.2    Huang, M.C.3    Horvitz, H.R.4
  • 96
    • 18744373853 scopus 로고    scopus 로고
    • MLL targets SET domain methyltransferase activity to Hox gene promoters
    • Milne, T. A. et al. MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol. Cell 10, 1107-1117 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 1107-1117
    • Milne, T.A.1
  • 97
    • 0032717039 scopus 로고    scopus 로고
    • The role of chromosome translocations in leukemogenesis
    • Rowley, J. D. The role of chromosome translocations in leukemogenesis. Semin. Hematol. 36, 59-72 (1999).
    • (1999) Semin. Hematol. , vol.36 , pp. 59-72
    • Rowley, J.D.1
  • 98
    • 0036014973 scopus 로고    scopus 로고
    • The role of MLL in hematopoiesis and leukemia
    • Ernst, P., Wang, J. & Korsmeyer, S. J. The role of MLL in hematopoiesis and leukemia. Curr. Opin. Hematol. 9, 282-287 (2002).
    • (2002) Curr. Opin. Hematol. , vol.9 , pp. 282-287
    • Ernst, P.1    Wang, J.2    Korsmeyer, S.J.3
  • 99
    • 35548934558 scopus 로고    scopus 로고
    • MLL translocations, histone modifications and leukaemia stem-cell development
    • Krivtsov, A. V. & Armstrong, S. A. MLL translocations, histone modifications and leukaemia stem-cell development. Nature Rev. Cancer 7, 823-833 (2007).
    • (2007) Nature Rev. Cancer , vol.7 , pp. 823-833
    • Krivtsov, A.V.1    Armstrong, S.A.2
  • 100
    • 18544375333 scopus 로고    scopus 로고
    • MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
    • Armstrong, S. A. et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nature Genet. 30, 41-47 (2002).
    • (2002) Nature Genet. , vol.30 , pp. 41-47
    • Armstrong, S.A.1
  • 101
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial
    • The Medical Research Council Adult and Children's Leukaemia Working Parties
    • Grimwade, D. et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 92, 2322-2333 (1998).
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1
  • 102
    • 34147135183 scopus 로고    scopus 로고
    • Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): Analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
    • Moorman, A. V. et al. Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial. Blood 109, 3189-3197 (2007).
    • (2007) Blood , vol.109 , pp. 3189-3197
    • Moorman, A.V.1
  • 103
    • 0034235115 scopus 로고    scopus 로고
    • Biological and therapeutic aspects of infant leukemia
    • Biondi, A., Cimino, G., Pieters, R. & Pui, C. H. Biological and therapeutic aspects of infant leukemia. Blood 96, 24-33 (2000).
    • (2000) Blood , vol.96 , pp. 24-33
    • Biondi, A.1    Cimino, G.2    Pieters, R.3    Pui, C.H.4
  • 105
    • 20944444880 scopus 로고    scopus 로고
    • A comprehensive genetic classification of adult acute lymphoblastic leukemia (ALL): Analysis of the GIMEMA 0496 protocol
    • Mancini, M. et al. A comprehensive genetic classification of adult acute lymphoblastic leukemia (ALL): analysis of the GIMEMA 0496 protocol. Blood 105, 3434-3441 (2005).
    • (2005) Blood , vol.105 , pp. 3434-3441
    • Mancini, M.1
  • 106
    • 33745605199 scopus 로고    scopus 로고
    • Analysis of HSC activity and compensatory Hox gene expression profile in Hoxb cluster mutant fetal liver cells
    • Bijl, J. et al. Analysis of HSC activity and compensatory Hox gene expression profile in Hoxb cluster mutant fetal liver cells. Blood 108, 116-122 (2006).
    • (2006) Blood , vol.108 , pp. 116-122
    • Bijl, J.1
  • 107
    • 0030942488 scopus 로고    scopus 로고
    • Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis
    • Lawrence, H. J. et al. Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Blood 89, 1922-1930 (1997).
    • (1997) Blood , vol.89 , pp. 1922-1930
    • Lawrence, H.J.1
  • 108
    • 33847069599 scopus 로고    scopus 로고
    • Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrow
    • Ko, K. H. et al. Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrow. Exp. Hematol. 35, 465-475 (2007).
    • (2007) Exp. Hematol. , vol.35 , pp. 465-475
    • Ko, K.H.1
  • 109
    • 34548180591 scopus 로고    scopus 로고
    • Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic defects
    • Magnusson, M., Brun, A. C., Lawrence, H. J. & Karlsson, S. Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic defects. Exp. Hematol. 35, 1421-1428 (2007).
    • (2007) Exp. Hematol. , vol.35 , pp. 1421-1428
    • Magnusson, M.1    Brun, A.C.2    Lawrence, H.J.3    Karlsson, S.4
  • 110
    • 2542467750 scopus 로고    scopus 로고
    • Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells
    • Brun, A. C. et al. Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. Blood 103, 4126-4133 (2004).
    • (2004) Blood , vol.103 , pp. 4126-4133
    • Brun, A.C.1
  • 111
    • 33746498580 scopus 로고    scopus 로고
    • Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
    • Krivtsov, A. V. et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 442, 818-822 (2006).
    • (2006) Nature , vol.442 , pp. 818-822
    • Krivtsov, A.V.1
  • 112
    • 35948964020 scopus 로고    scopus 로고
    • Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential
    • Wong, P., Iwasaki, M., Somervaille, T. C., So, C. W. & Cleary, M. L. Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev. 21, 2762-2774 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 2762-2774
    • Wong, P.1    Iwasaki, M.2    Somervaille, T.C.3    So, C.W.4    Cleary, M.L.5
  • 113
    • 33749440584 scopus 로고    scopus 로고
    • Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
    • Somervaille, T. C. & Cleary, M. L. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 10, 257-268 (2006).
    • (2006) Cancer Cell , vol.10 , pp. 257-268
    • Somervaille, T.C.1    Cleary, M.L.2
  • 114
    • 1442356858 scopus 로고    scopus 로고
    • Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia
    • Kumar, A. R. et al. Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia. Blood 103, 1823-1828 (2004).
    • (2004) Blood , vol.103 , pp. 1823-1828
    • Kumar, A.R.1
  • 115
    • 0041370095 scopus 로고    scopus 로고
    • Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
    • Ayton, P. M. & Cleary, M. L. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev. 17, 2298-2307 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 2298-2307
    • Ayton, P.M.1    Cleary, M.L.2
  • 116
    • 0034598793 scopus 로고    scopus 로고
    • HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis
    • Schnabel, C. A., Jacobs, Y. & Cleary, M. L. HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis. Oncogene 19, 608-616 (2000).
    • (2000) Oncogene , vol.19 , pp. 608-616
    • Schnabel, C.A.1    Jacobs, Y.2    Cleary, M.L.3
  • 117
    • 0026761786 scopus 로고
    • Hlf a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia
    • Hunger, S. P., Ohyashiki, K., Toyama, K. & Cleary, M. L. Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. Genes Dev. 6, 1608-1620 (1992).
    • (1992) Genes Dev. , vol.6 , pp. 1608-1620
    • Hunger, S.P.1    Ohyashiki, K.2    Toyama, K.3    Cleary, M.L.4
  • 118
    • 0035839880 scopus 로고    scopus 로고
    • E2A-HLF usurps control of evolutionarily conserved survival pathways
    • Seidel, M. G. & Look, A. T. E2A-HLF usurps control of evolutionarily conserved survival pathways. Oncogene 20, 5718-5725 (2001).
    • (2001) Oncogene , vol.20 , pp. 5718-5725
    • Seidel, M.G.1    Look, A.T.2
  • 119
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • Beachy, P. A., Karhadkar, S. S. & Berman, D. M. Tissue repair and stem cell renewal in carcinogenesis. Nature 432, 324-331 (2004).
    • (2004) Nature , vol.432 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 120
    • 52149110383 scopus 로고    scopus 로고
    • Cancer: Hedgehog's other great trick
    • Curran, T. & Ng, J. M. Cancer: Hedgehog's other great trick. Nature 455, 293-294 (2008).
    • (2008) Nature , vol.455 , pp. 293-294
    • Curran, T.1    Ng, J.M.2
  • 121
    • 33846582947 scopus 로고    scopus 로고
    • The role of HOX genes in malignant myeloid disease
    • Eklund, E. A. The role of HOX genes in malignant myeloid disease. Curr. Opin. Hematol. 14, 85-89 (2007).
    • (2007) Curr. Opin. Hematol. , vol.14 , pp. 85-89
    • Eklund, E.A.1
  • 122
    • 36248937213 scopus 로고    scopus 로고
    • Unraveling the crucial roles of Meis1 in leukemogenesis and normal hematopoiesis
    • Argiropoulos, B., Yung, E. & Humphries, R. K. Unraveling the crucial roles of Meis1 in leukemogenesis and normal hematopoiesis. Genes Dev. 21, 2845-2849 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 2845-2849
    • Argiropoulos, B.1    Yung, E.2    Humphries, R.K.3
  • 123
    • 18744366334 scopus 로고    scopus 로고
    • Hox regulation of normal and leukemic hematopoietic stem cells
    • Abramovich, C. & Humphries, R. K. Hox regulation of normal and leukemic hematopoietic stem cells. Curr. Opin. Hematol. 12, 210-216 (2005).
    • (2005) Curr. Opin. Hematol. , vol.12 , pp. 210-216
    • Abramovich, C.1    Humphries, R.K.2
  • 124
    • 13644265950 scopus 로고    scopus 로고
    • The pathophysiology of HOX genes and their role in cancer
    • Grier, D. G. et al. The pathophysiology of HOX genes and their role in cancer. J. Pathol. 205, 154-171 (2005).
    • (2005) J. Pathol. , vol.205 , pp. 154-171
    • Grier, D.G.1
  • 125
    • 33847309514 scopus 로고    scopus 로고
    • Fusions involving PAX and FOX genes in the molecular pathogenesis of alveolar rhabdomyosarcoma: Recent advances
    • Mercado, G. E. & Barr, F. G. Fusions involving PAX and FOX genes in the molecular pathogenesis of alveolar rhabdomyosarcoma: recent advances. Curr. Mol. Med. 7, 47-61 (2007).
    • (2007) Curr. Mol. Med. , vol.7 , pp. 47-61
    • Mercado, G.E.1    Barr, F.G.2
  • 126
    • 67649880329 scopus 로고    scopus 로고
    • Cdx genes, inflammation and the pathogenesis of Barrett's metaplasia
    • Colleypriest, B. J., Palmer, R. M., Ward, S. G. & Tosh, D. Cdx genes, inflammation and the pathogenesis of Barrett's metaplasia. Trends Mol. Med. 15, 313-322 (2009).
    • (2009) Trends Mol. Med. , vol.15 , pp. 313-322
    • Colleypriest, B.J.1    Palmer, R.M.2    Ward, S.G.3    Tosh, D.4
  • 127
    • 33750951686 scopus 로고    scopus 로고
    • Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model
    • Bansal, D. et al. Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Proc. Natl Acad. Sci. USA 103, 16924-16929 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 16924-16929
    • Bansal, D.1
  • 128
    • 16244388032 scopus 로고    scopus 로고
    • The role of Cdx proteins in intestinal development and cancer
    • Guo, R. J., Suh, E. R. & Lynch, J. P. The role of Cdx proteins in intestinal development and cancer. Cancer Biol. Ther. 3, 593-601 (2004).
    • (2004) Cancer Biol. Ther. , vol.3 , pp. 593-601
    • Guo, R.J.1    Suh, E.R.2    Lynch, J.P.3
  • 129
    • 0042337002 scopus 로고    scopus 로고
    • Genetic and cellular basis for acetylcholine inhibition of Caenorhabditis elegans egg-laying behavior
    • Bany, I. A., Dong, M. Q. & Koelle, M. R. Genetic and cellular basis for acetylcholine inhibition of Caenorhabditis elegans egg-laying behavior. J. Neurosci. 23, 8060-8069 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 8060-8069
    • Bany, I.A.1    Dong, M.Q.2    Koelle, M.R.3


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