The fur regulon in anaerobically grown Salmonella enterica sv. Typhimurium: Identification of new fur targets

BMC Microbiology

Volumn 11, Issue , 2011, Pages

  Troxell, Bryan ^a,c   Fink, Ryan C ^a,d   Porwollik, Steffen ^b   McClelland, Michael ^b   Hassan, Hosni M ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b Vaccine Research Institute of San Diego   (United States)

^c INDIANA UNIVERSITY   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRIC UPTAKE REGULATOR; HISTONE; IRON SUPEROXIDE DISMUTASE; MANGANESE SUPEROXIDE DISMUTASE; NITRIC OXIDE; THREONINE; BACTERIAL PROTEIN; FERRIC UPTAKE REGULATING PROTEINS, BACTERIAL; IRON; OXYGEN; REPRESSOR PROTEIN;

ANAEROBIC CELL CULTURE; ANAEROBIC GROWTH; ARTICLE; DNA REPAIR; DNA SYNTHESIS; DOWN REGULATION; ENZYME ACTIVATION; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; MICROARRAY ANALYSIS; NONHUMAN; OPERON; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN MOTIF; REGULON; SALMONELLA ENTERICA; SALMONELLA TYPHIMURIUM; UPREGULATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

ESCHERICHIA COLI; SALMONELLA ENTERICA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM;

ANAEROBIOSIS; BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; IRON; OXYGEN; REGULON; REPRESSOR PROTEINS; SALMONELLA TYPHIMURIUM;

EID: 80054719570     PISSN: None     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-11-236     Document Type: Article

References (153)

1. Functional specialization within the Fur family of metalloregulators. Lee JW, Helmann JD, Biometals 2007 20 3-4 485 499 10.1007/s10534-006-9070-7 17216355 (Pubitemid 46776584)
2. Ferric uptake regulation protein acts as a repressor, employing iron (II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli. Bagg A, Neilands JB, Biochemistry 1987 26 17 5471 5477 10.1021/bi00391a039 2823881
3. Siderophores. Neilands JB, Arch Biochem Biophys 1993 302 1 1 3 10.1006/abbi.1993.1172 8470885 (Pubitemid 23212607)
4. Recognition of DNA by Fur: a reinterpretation of the Fur box consensus sequence. Baichoo N, Helmann JD, J Bacteriol 2002 184 21 5826 5832 10.1128/JB.184.21.5826-5832.2002 12374814 (Pubitemid 35168229)
5. Fur-DNA interactions at the bidirectional fepDGC-entS promoter region in Escherichia coli. Lavrrar JL, Christoffersen CA, McIntosh MA, J Mol Biol 2002 322 5 983 995 10.1016/S0022-2836(02)00849-5 12367523 (Pubitemid 35266507)
6. Metal binding characteristics and role of iron oxidation in the ferric uptake regulator from Escherichia coli. Mills SA, Marletta MA, Biochemistry 2005 44 41 13553 13559 10.1021/bi0507579 16216078 (Pubitemid 41443682)
7. Iron specificity of the Fur-dependent regulation of the biosynthesis of the manganese-containing superoxide dismutase in Escherichia coli. Privalle CT, Fridovich I, J Biol Chem 1993 268 7 5178 5181 8444893 (Pubitemid 23081646)
8. X-ray absorption spectroscopy of a new zinc site in the fur protein from Escherichia coli. Jacquamet L, Aberdam D, Adrait A, Hazemann JL, Latour JM, Michaud-Soret I, Biochemistry 1998 37 8 2564 2571 10.1021/bi9721344 9485406 (Pubitemid 28119333)
9. The ferric uptake regulation (Fur) repressor is a zinc metalloprotein. Althaus EW, Outten CE, Olson KE, Cao H, O'Halloran TV, Biochemistry 1999 38 20 6559 6569 10.1021/bi982788s 10350474 (Pubitemid 29242049)
10. The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins. Gaballa A, Antelmann H, Aguilar C, Khakh SK, Song KB, Smaldone GT, Helmann JD, Proc Natl Acad Sci USA 2008 105 33 11927 11932 10.1073/pnas.0711752105 18697947
11. Fur regulon in Gram-negative bacteria. Identification and characterization of new iron-regulated Escherichia coli genes by a fur titration assay. Stojiljkovic I, Baumler AJ, Hantke K, J Mol Biol 1994 236 2 531 545 10.1006/jmbi.1994.1163 8107138 (Pubitemid 24146297)
12. Global iron-dependent gene regulation in Escherichia coli. A new mechanism for iron homeostasis. McHugh JP, Rodriguez-Quinones F, Abdul-Tehrani H, Svistunenko DA, Poole RK, Cooper CE, Andrews SC, J Biol Chem 2003 278 32 29478 29486 10.1074/jbc.M303381200 12746439 (Pubitemid 36962327)
13. Prominent roles of the NorR and Fur regulators in the Escherichia coli transcriptional response to reactive nitrogen species. Mukhopadhyay P, Zheng M, Bedzyk LA, LaRossa RA, Storz G, Proc Natl Acad Sci USA 2004 101 3 745 750 10.1073/pnas.0307741100 14718666 (Pubitemid 38121029)
14. Iron and fur regulation in Vibrio cholerae and the role of fur in virulence. Mey AR, Wyckoff EE, Kanukurthy V, Fisher CR, Payne SM, Infect Immun 2005 73 12 8167 8178 10.1128/IAI.73.12.8167-8178.2005 16299312 (Pubitemid 41740305)
15. Genomic profiling of iron-responsive genes in Salmonella enterica serovar Typhimurium by high-throughput screening of a random promoter library. Bjarnason J, Southward CM, Surette MG, J Bacteriol 2003 185 16 4973 4982 10.1128/JB.185.16.4973-4982.2003 12897017 (Pubitemid 36962305)
16. Fur regulon of Salmonella typhimurium: identification of new iron-regulated genes. Tsolis RM, Baumler AJ, Stojiljkovic I, Heffron F, J Bacteriol 1995 177 16 4628 4637 7642488
17. Effect of Salmonella typhimurium ferric uptake regulator (fur) mutations on iron- and pH-regulated protein synthesis. Foster JW, Hall HK, J Bacteriol 1992 174 13 4317 4323 1624426
18. Role of the Fur regulon in iron transport in Bacillus subtilis. Ollinger J, Song KB, Antelmann H, Hecker M, Helmann JD, J Bacteriol 2006 188 10 3664 3673 10.1128/JB.188.10.3664-3673.2006 16672620 (Pubitemid 43726229)
19. Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon. Baichoo N, Wang T, Ye R, Helmann JD, Mol Microbiol 2002 45 6 1613 1629 10.1046/j.1365-2958.2002.03113.x 12354229 (Pubitemid 35231978)
20. Kinetic analysis of the oxidative conversion of the [4Fe-4S]2+ cluster of FNR to a [2Fe-2S]2+ Cluster. Sutton VR, Mettert EL, Beinert H, Kiley PJ, J Bacteriol 2004 186 23 8018 8025 10.1128/JB.186.23.8018-8025.2004 15547274 (Pubitemid 39552513)
21. FNR is a global regulator of virulence and anaerobic metabolism in Salmonella enterica serovar Typhimurium (ATCC 14028s). Fink RC, Evans MR, Porwollik S, Vazquez-Torres A, Jones-Carson J, Troxell B, Libby SJ, McClelland M, Hassan HM, J Bacteriol 2007 189 6 2262 2273 10.1128/JB.00726-06 17220229 (Pubitemid 46411340)
22. Modulation of Shigella virulence in response to available oxygen in vivo. Marteyn B, West NP, Browning DF, Cole JA, Shaw JG, Palm F, Mounier J, Prevost MC, Sansonetti P, Tang CM, Nature 2010 465 7296 355 358 10.1038/nature08970 20436458
23. Role of FNR and FNR-regulated, sugar fermentation genes in Neisseria meningitidis infection. Bartolini E, Frigimelica E, Giovinazzi S, Galli G, Shaik Y, Genco C, Welsch JA, Granoff DM, Grandi G, Grifantini R, Mol Microbiol 2006 60 4 963 972 10.1111/j.1365-2958.2006.05163.x 16677307
24. Identification of Pseudomonas aeruginosa genes involved in virulence and anaerobic growth. Filiatrault MJ, Picardo KF, Ngai H, Passador L, Iglewski BH, Infect Immun 2006 74 7 4237 4245 10.1128/IAI.02014-05 16790798 (Pubitemid 43993357)
25. Regulatory and structural differences in the Cu, Zn-superoxide dismutases of Salmonella enterica and their significance for virulence. Ammendola S, Pasquali P, Pacello F, Rotilio G, Castor M, Libby SJ, Figueroa-Bossi N, Bossi L, Fang FC, Battistoni A, J Biol Chem 2008 283 20 13688 13699 10.1074/jbc. M710499200 18362154
26. DNA binding and dimerization of the Fe-S-containing FNR protein from Escherichia coli are regulated by oxygen. Lazazzera BA, Beinert H, Khoroshilova N, Kennedy MC, Kiley PJ, J Biol Chem 1996 271 5 2762 2768 10.1074/jbc.271.5.2762 8576252 (Pubitemid 26047894)
27. Differential expression from two iron-responsive promoters in Salmonella enterica serovar Typhimurium reveals the presence of iron in macrophage-phagosomes. Taylor CM, Osman D, Cavet JS, Microb Pathog 2009 46 2 114 118 10.1016/j.micpath.2008.11.001 19049822
28. Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica. Eriksson S, Lucchini S, Thompson A, Rhen M, Hinton JC, Mol Microbiol 2003 47 1 103 118 12492857 (Pubitemid 36051327)
29. Fur negatively regulates hns and is required for the expression of HilA and virulence in Salmonella enterica serovar Typhimurium. Troxell B, Sikes ML, Fink RC, Vazquez-Torres A, Jones-Carson J, Hassan HM, J Bacteriol 2011 193 2 497 505 10.1128/JB.00942-10 21075923
30. New insights into transcriptional regulation by H-NS. Fang FC, Rimsky S, Curr Opin Microbiol 2008 11 2 113 120 10.1016/j.mib.2008.02.011 18387844
31. Selective silencing of foreign DNA with low GC content by the H-NS protein in Salmonella. Navarre WW, Porwollik S, Wang YP, McClelland M, Rosen H, Libby SJ, Fang FC, Science 2006 313 5784 236 238 10.1126/science.1128794 16763111 (Pubitemid 44066257)
32. Expression and mutational analysis of the nucleoid-associated protein H-NS of Salmonella typhimurium. Hinton JC, Santos DS, Seirafi A, Hulton CS, Pavitt GD, Higgins CF, Mol Microbiol 1992 6 16 2327 2337 10.1111/j.1365-2958. 1992.tb01408.x 1406272
33. Coordinate regulation of Salmonella pathogenicity island 1 (SPI1) and SPI4 in Salmonella enterica serovar Typhimurium. Main-Hester KL, Colpitts KM, Thomas GA, Fang FC, Libby SJ, Infect Immun 2008 76 3 1024 1035 10.1128/IAI.01224-07 18160484 (Pubitemid 351428062)
34. Role of nucleoid-associated proteins Hha and H-NS in expression of Salmonella enterica activators HilD, HilC, and RtsA required for cell invasion. Olekhnovich IN, Kadner RJ, J Bacteriol 2007 189 19 6882 6890 10.1128/JB.00905-07 17675384 (Pubitemid 47525432)
35. Crucial roles of both flanking sequences in silencing of the hilA promoter in Salmonella enterica. Olekhnovich IN, Kadner RJ, J Mol Biol 2006 357 2 373 386 10.1016/j.jmb.2006.01.007 16443238 (Pubitemid 43290741)
36. H-NS mediates the silencing of laterally acquired genes in bacteria. Lucchini S, Rowley G, Goldberg MD, Hurd D, Harrison M, Hinton JC, PLoS Pathog 2006 2 8 81 10.1371/journal.ppat.0020081 16933988 (Pubitemid 44299883)
37. A novel mechanism controls anaerobic and catabolite regulation of the Escherichia coli tdc operon. Sawers G, Mol Microbiol 2001 39 5 1285 1298 10.1111/j.1365-2958.2001.02316.x 11251844 (Pubitemid 32225138)
38. Fur activates the expression of Salmonella enterica pathogenicity island 1 by directly interacting with the hilD operator in vivo and in vitro. Teixido L, Carrasco B, Alonso JC, Barbe J, Campoy S, PLoS One 2011 6 5 19711 10.1371/journal.pone.0019711 21573071
39. Fur regulates expression of the Salmonella pathogenicity island 1 type III secretion system through HilD. Ellermeier JR, Slauch JM, J Bacteriol 2008 190 2 476 486 10.1128/JB.00926-07 17993530 (Pubitemid 351360063)
40. Gut inflammation provides a respiratory electron acceptor for Salmonella. Winter SE, Thiennimitr P, Winter MG, Butler BP, Huseby DL, Crawford RW, Russell JM, Bevins CL, Adams LG, Tsolis RM, et al. Nature 2010 467 7314 426 429 10.1038/nature09415 20864996
41. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Datsenko KA, Wanner BL, Proc Natl Acad Sci USA 2000 97 12 6640 6645 10.1073/pnas.120163297 10829079 (Pubitemid 30412767)
42. Probing the ArcA-P modulon of Escherichia coli by whole genome transcriptional analysis and sequence recognition profiling. Liu X, De Wulf P, J Biol Chem 2004 279 13 12588 12597 14711822 (Pubitemid 38445830)
43. Analysis of the ArcA regulon in anaerobically grown Salmonella enterica sv. Typhimurium. Evans MR, Fink RC, Vazquez-Torres A, Porwollik S, Jones-Carson J, McClelland M, Hassan HM, BMC Microbiol 2011 11 58 10.1186/1471-2180-11-58 21418628
44. The Delta uvrB mutations in the Ames strains of Salmonella span 15 to 119 genes. Porwollik S, Wong RM, Sims SH, Schaaper RM, DeMarini DM, McClelland M, Mutat Res 2001 483 1-2 1 11 10.1016/S0027-5107(01)00239-1 11600126 (Pubitemid 33000059)
45. Identifying DNA and protein patterns with statistically significant alignments of multiple sequences. Hertz GZ, Stormo GD, Bioinformatics 1999 15 7-8 563 577 10487864 (Pubitemid 29462105)
46. Construction of targeted single copy lac fusions using lambda Red and FLP-mediated site-specific recombination in bacteria. Ellermeier CD, Janakiraman A, Slauch JM, Gene 2002 290 1-2 153 161 10.1016/S0378-1119(02)00551-6 12062810 (Pubitemid 34615918)
47. Experiments in molecular genetics. Miller JH, Cold Spring Harbor Laboratory 1972
48. AN OUTLINE OF ENZYME INDUCTION. Monod J, Recueil Des Travaux Chimiques Des Pays-Bas-Journal of the Royal Netherlands Chemical Society 1958 77 7 569 585
49. Physiology of the bacterial cell: a molecular approach. Neidhardt FC, Ingraham JL, Schaechter M, Sunderland, Mass.: Sinauer Associates 1990 331
50. Promoter strength properties of the complete sigma E regulon of Escherichia coli and Salmonella enterica. Mutalik VK, Nonaka G, Ades SE, Rhodius VA, Gross CA, J Bacteriol 2009 191 23 7279 7287 10.1128/JB.01047-09 19783623
51. ppGpp and DksA likely regulate the activity of the extracytoplasmic stress factor sigmaE in Escherichia coli by both direct and indirect mechanisms. Costanzo A, Nicoloff H, Barchinger SE, Banta AB, Gourse RL, Ades SE, Mol Microbiol 2008 67 3 619 632 10.1111/j.1365-2958.2007.06072.x 18086212
52. Growth phase-dependent regulation of the extracytoplasmic stress factor, sigmaE, by guanosine 3',5'-bispyrophosphate (ppGpp). Costanzo A, Ades SE, J Bacteriol 2006 188 13 4627 4634 10.1128/JB.01981-05 16788171 (Pubitemid 43956060)
53. Regulatory roles of Fnr, Fur, and Arc in expression of manganese-containing superoxide dismutase in Escherichia coli. Hassan HM, Sun HC, Proc Natl Acad Sci USA 1992 89 8 3217 3221 10.1073/pnas.89.8.3217 1565612
54. Protein measurement with the Folin phenol reagent. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ, J Biol Chem 1951 193 1 265 275 14907713
55. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Beauchamp C, Fridovich I, Anal Biochem 1971 44 1 276 287 10.1016/0003-2697(71)90370-8 4943714
56. Fumarate reductase of Escherichia coli. Lemire BD, Weiner JH, Methods Enzymol 1986 126 377 386 3078445
57. Oxidation of tartaric acid in presence of iron. Fenton H, J Chem Soc, Trans 1894 65 65 899 911
58. IroN, a novel outer membrane siderophore receptor characteristic of Salmonella enterica. Baumler AJ, Norris TL, Lasco T, Voigt W, Reissbrodt R, Rabsch W, Heffron F, J Bacteriol 1998 180 6 1446 1453 9515912 (Pubitemid 28125728)
59. Identification of a new iron regulated locus of Salmonella typhi. Baumler AJ, Tsolis RM, vanderVelden AWM, Stojiljkovic I, Anic S, Heffron F, Gene 1996 183 1-2 207 213 10.1016/S0378-1119(96)00560-4 8996108 (Pubitemid 27007512)
60. Identification of cutC and cutF (nlpE) genes involved in copper tolerance in Escherichia coli. Gupta SD, Lee BT, Camakaris J, Wu HC, J Bacteriol 1995 177 15 4207 4215 7635807
61. Transcriptional regulation of sitABCD of Salmonella enterica serovar typhimurium by MntR and Fur. Ikeda JS, Janakiraman A, Kehres DG, Maguire ME, Slauch JM, J Bacteriol 2005 187 3 912 922 10.1128/JB.187.3.912-922.2005 15659669 (Pubitemid 40189765)
62. The putative iron transport system SitABCD encoded on SPI1 is required for full virulence of Salmonella typhimurium. Janakiraman A, Slauch JM, Mol Microbiol 2000 35 5 1146 1155 10.1046/j.1365-2958.2000.01783.x 10712695 (Pubitemid 30137783)
63. RstA-promoted expression of the ferrous iron transporter FeoB under iron-replete conditions enhances Fur activity in Salmonella enterica. Jeon J, Kim H, Yun J, Ryu S, Groisman EA, Shin D, J Bacteriol 2008 190 22 7326 7334 10.1128/JB.00903-08 18790861
64. Contribution of TonB- and Feo-mediated iron uptake to growth of Salmonella typhimurium in the mouse. Tsolis RM, Baumler AJ, Heffron F, Stojiljkovic I, Infect Immun 1996 64 11 4549 4556 8890205 (Pubitemid 26357057)
65. SitABCD is the alkaline Mn(2+) transporter of Salmonella enterica serovar Typhimurium. Kehres DG, Janakiraman A, Slauch JM, Maguire ME, J Bacteriol 2002 184 12 3159 3166 10.1128/JB.184.12.3159-3166.2002 12029031 (Pubitemid 34568924)
66. Selection of Bacterial Virulence Genes That Are Specifically Induced in Host Tissues. Mahan MJ, Slauch JM, Mekalanos JJ, Science 1993 259 5095 686 688 10.1126/science.8430319 8430319 (Pubitemid 23066292)
67. Antibiotic-Based Selection for Bacterial Genes That Are Specifically Induced during Infection of a Host. Mahan MJ, Tobias JW, Slauch JM, Hanna PC, Collier RJ, Mekalanos JJ, Proc Natl Acad Sci USA 1995 92 3 669 673 10.1073/pnas.92.3.669 7846034
68. Interplay between three global regulatory proteins mediates oxygen regulation of the Escherichia coli cytochrome-d oxidase (cydAB) operon. Govantes F, Orjalo AV, Gunsalus RP, Mol Microbiol 2000 38 5 1061 1073 11123679 (Pubitemid 32009680)
69. Hemin uptake system of Yersinia enterocolitica: similarities with other TonB-dependent systems in gram-negative bacteria. Stojiljkovic I, Hantke K, EMBO J 1992 11 12 4359 4367 1425573
70. Escherichia coli possesses two homologous anaerobic C4-dicarboxylate membrane transporters (DcuA and DcuB) distinct from the aerobic dicarboxylate transport system (Dct). Six S, Andrews SC, Unden G, Guest JR, J Bacteriol 1994 176 21 6470 6478 7961398 (Pubitemid 24338058)
71. Ethanolamine utilization in Salmonella typhimurium. Roof DM, Roth JR, J Bacteriol 1988 170 9 3855 3863 3045078
72. Escherichia coli K-12 mutation that inactivates biodegradative threonine dehydratase by transposon Tn5 insertion. Goss TJ, Datta P, J Bacteriol 1984 158 3 826 831 6327641 (Pubitemid 14088596)
73. Molecular characterization of the tdc operon of Escherichia coli K-12. Goss TJ, Schweizer HP, Datta P, J Bacteriol 1988 170 11 5352 5359 3053659
74. Functional analysis of the tdcABC promoter of Escherichia coli: roles of TdcA and TdcR. Hagewood BT, Ganduri YL, Datta P, J Bacteriol 1994 176 20 6214 6220 7928991 (Pubitemid 24313800)
75. TdcA, a transcriptional activator of the tdcABC operon of Escherichia coli, is a member of the LysR family of proteins. Ganduri YL, Sadda SR, Datta MW, Jambukeswaran RK, Datta P, Mol Gen Genet 1993 240 3 395 402 8413189 (Pubitemid 23285954)
76. Molecular analysis of the Salmonella typhimurium tdc operon regulation. Kim MJ, Lim S, Ryu S, J Microbiol Biotechnol 2008 18 6 1024 1032 18600042
77. A mutation in tdcA attenuates the virulence of Salmonella enterica serovar Typhimurium. Lim S, Kim M, Choi J, Ryu S, Mol Cells 2010 29 5 509 517 10.1007/s10059-010-0063-6 20396961
78. A tdcA mutation reduces the invasive ability of Salmonella enterica serovar typhimurium. Kim M, Lim S, Kim D, Choy HE, Ryu S, Mol Cells 2009 28 4 389 395 10.1007/s10059-009-0133-9 19812899
79. The role of ferritins in the physiology of Salmonella enterica sv. Typhimurium: a unique role for ferritin B in iron-sulphur cluster repair and virulence. Velayudhan J, Castor M, Richardson A, Main-Hester KL, Fang FC, Mol Microbiol 2007 63 5 1495 1507 10.1111/j.1365-2958.2007.05600.x 17302823
80. Two global regulators repress the anaerobic expression of MnSOD in Escherichia coli:Fur (ferric uptake regulation) and Arc (aerobic respiration control). Tardat B, Touati D, Mol Microbiol 1991 5 2 455 465 10.1111/j.1365-2958.1991.tb02129.x 2041478 (Pubitemid 21896066)
81. Interaction of six global transcription regulators in expression of manganese superoxide dismutase in Escherichia coli K-12. Compan I, Touati D, J Bacteriol 1993 175 6 1687 1696 8449876 (Pubitemid 23084131)
82. soxR, a locus governing a superoxide response regulon in Escherichia coli K-12. Tsaneva IR, Weiss B, J Bacteriol 1990 172 8 4197 4205 1695893 (Pubitemid 20236706)
83. Fur-mediated transcriptional and post-transcriptional regulation of FeSOD expression in Escherichia coli. Dubrac S, Touati D, Microbiology 2002 148 Pt 1 147 156 11782507 (Pubitemid 34083193)
84. Fur positive regulation of iron superoxide dismutase in Escherichia coli: functional analysis of the sodB promoter. Dubrac S, Touati D, J Bacteriol 2000 182 13 3802 3808 10.1128/JB.182.13.3802-3808.2000 10850997 (Pubitemid 30413033)
85. Control of Escherichia coli superoxide dismutase (sodA and sodB) genes by the ferric uptake regulation (fur) locus. Niederhoffer EC, Naranjo CM, Bradley KL, Fee JA, J Bacteriol 1990 172 4 1930 1938 2180912 (Pubitemid 20112014)
86. Identification of SoxS-regulated genes in Salmonella enterica serovar typhimurium. Pomposiello PJ, Demple B, J Bacteriol 2000 182 1 23 29 10.1128/JB.182.1.23-29.2000 10613858 (Pubitemid 30004553)
87. A hybrid superoxide dismutase containing both functional iron and manganese. Clare DA, Blum J, Fridovich I, J Biol Chem 1984 259 9 5932 5936 6371011 (Pubitemid 14142738)
88. A small RNA regulates the expression of genes involved in iron metabolism in Escherichia coli. Masse E, Gottesman S, Proc Natl Acad Sci USA 2002 99 7 4620 4625 10.1073/pnas.032066599 11917098 (Pubitemid 34286034)
89. Interaction of the RNA chaperone Hfq with mRNAs: direct and indirect roles of Hfq in iron metabolism of Escherichia coli. Vecerek B, Moll I, Afonyushkin T, Kaberdin V, Blasi U, Mol Microbiol 2003 50 3 897 909 10.1046/j.1365-2958.2003.03727.x 14617150 (Pubitemid 37372252)
90. Reprogramming of anaerobic metabolism by the FnrS small RNA. Durand S, Storz G, Mol Microbiol 2010 75 5 1215 1231 10.1111/j.1365-2958.2010.07044.x 20070527
91. Translational regulation of gene expression by an anaerobically induced small non-coding RNA in Escherichia coli. Boysen A, Moller-Jensen J, Kallipolitis B, Valentin-Hansen P, Overgaard M, J Biol Chem 2010 285 14 10690 10702 10.1074/jbc.M109.089755 20075074
92. Enzymatic defenses against the toxicity of oxygen and of streptonigrin in Escherichia coli. Hassan HM, Fridovich I, J Bacteriol 1977 129 3 1574 1583 321433 (Pubitemid 8065052)
93. Lethal oxidative damage and mutagenesis are generated by iron in delta fur mutants of Escherichia coli: protective role of superoxide dismutase. Touati D, Jacques M, Tardat B, Bouchard L, Despied S, J Bacteriol 1995 177 9 2305 2314 7730258
94. Universal chemical assay for the detection and determination of siderophores. Schwyn B, Neilands JB, Anal Biochem 1987 160 1 47 56 10.1016/0003-2697(87)90612-9 2952030 (Pubitemid 17020596)
95. Nitric oxide, nitrite, and Fnr regulation of hmp (flavohemoglobin) gene expression in Escherichia coli K-12. Poole RK, Anjum MF, Membrillo-Hernandez J, Kim SO, Hughes MN, Stewart V, J Bacteriol 1996 178 18 5487 5492 8808940 (Pubitemid 26304384)
96. Nitric oxide formation by Escherichia coli. Dependence on nitrite reductase, the NO-sensing regulator Fnr, and flavohemoglobin Hmp. Corker H, Poole RK, J Biol Chem 2003 278 34 31584 31592 10.1074/jbc.M303282200 12783887 (Pubitemid 37048336)
97. Maintenance of nitric oxide and redox homeostasis by the Salmonella flavohemoglobin hmp. Bang IS, Liu L, Vazquez-Torres A, Crouch ML, Stamler JS, Fang FC, J Biol Chem 2006 281 38 28039 28047 10.1074/jbc.M605174200 16873371 (Pubitemid 44414517)
98. Multiple regulators of the Flavohaemoglobin (hmp) gene of Salmonella enterica serovar Typhimurium include RamA, a transcriptional regulator conferring the multidrug resistance phenotype. Hernandez-Urzua E, Zamorano-Sanchez DS, Ponce-Coria J, Morett E, Grogan S, Poole RK, Membrillo-Hernandez J, Arch Microbiol 2007 187 1 67 77 17024490 (Pubitemid 46025498)
99. NsrR targets in the Escherichia coli genome: new insights into DNA sequence requirements for binding and a role for NsrR in the regulation of motility. Partridge JD, Bodenmiller DM, Humphrys MS, Spiro S, Mol Microbiol 2009 73 4 680 694 10.1111/j.1365-2958.2009.06799.x 19656291
100. The gonococcal fur regulon: identification of additional genes involved in major catabolic, recombination, and secretory pathways. Sebastian S, Agarwal S, Murphy JR, Genco CA, J Bacteriol 2002 184 14 3965 3974 10.1128/JB.184.14. 3965-3974.2002 12081969 (Pubitemid 34705455)
101. Expression of the iron-activated nspA and secY genes in Neisseria meningitidis group B by Fur-dependent and -independent mechanisms. Shaik YB, Grogan S, Davey M, Sebastian S, Goswami S, Szmigielski B, Genco CA, J Bacteriol 2007 189 2 663 669 10.1128/JB.01638-06 17085550 (Pubitemid 46106400)
102. Functional analysis of the Streptomyces coelicolor NrdR ATP-cone domain: role in nucleotide binding, oligomerization, and DNA interactions. Grinberg I, Shteinberg T, Hassan AQ, Aharonowitz Y, Borovok I, Cohen G, J Bacteriol 2009 191 4 1169 1179 10.1128/JB.01145-08 19047342
103. NrdR controls differential expression of the Escherichia coli ribonucleotide reductase genes. Torrents E, Grinberg I, Gorovitz-Harris B, Lundstrom H, Borovok I, Aharonowitz Y, Sjoberg BM, Cohen G, J Bacteriol 2007 189 14 5012 5021 10.1128/JB.00440-07 17496099 (Pubitemid 47076046)
104. Streptomyces spp. contain class Ia and class II ribonucleotide reductases: expression analysis of the genes in vegetative growth. Borovok I, Kreisberg-Zakarin R, Yanko M, Schreiber R, Myslovati M, Aslund F, Holmgren A, Cohen G, Aharonowitz Y, Microbiology 2002 148 Pt 2 391 404 11832503 (Pubitemid 34162782)
105. Ribonucleotide reductases of Salmonella typhimurium: transcriptional regulation and differential role in pathogenesis. Panosa A, Roca I, Gibert I, PLoS One 2010 5 6 11328 10.1371/journal.pone.0011328 20593029
106. The interaction of mitochondrial iron with manganese superoxide dismutase. Naranuntarat A, Jensen LT, Pazicni S, Penner-Hahn JE, Culotta VC, J Biol Chem 2009 284 34 22633 22640 10.1074/jbc.M109.026773 19561359
107. Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis. Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel ED, Winge DR, McClain DA, Mol Med 2008 14 3-4 98 108 18317567 (Pubitemid 351481840)
108. Transition of Escherichia coli from aerobic to micro-aerobic conditions involves fast and slow reacting regulatory components. Partridge JD, Sanguinetti G, Dibden DP, Roberts RE, Poole RK, Green J, J Biol Chem 2007 282 15 11230 11237 10.1074/jbc.M700728200 17307737 (Pubitemid 47100741)
109. Increased bending rigidity of single DNA molecules by H-NS, a temperature and osmolarity sensor. Amit R, Oppenheim AB, Stavans J, Biophys J 2003 84 4 2467 2473 10.1016/S0006-3495(03)75051-6 12668454 (Pubitemid 36373568)
110. DNA bridging: a property shared among H-NS-like proteins. Dame RT, Luijsterburg MS, Krin E, Bertin PN, Wagner R, Wuite GJ, J Bacteriol 2005 187 5 1845 1848 10.1128/JB.187.5.1845-1848.2005 15716456 (Pubitemid 40289386)
111. H-NS: a universal regulator for a dynamic genome. Dorman CJ, Nat Rev Microbiol 2004 2 5 391 400 10.1038/nrmicro883 15100692 (Pubitemid 39490118)
112. Transcriptional silencing and thermoregulation of gene expression in Escherichia coli. Goransson M, Sonden B, Nilsson P, Dagberg B, Forsman K, Emanuelsson K, Uhlin BE, Nature 1990 344 6267 682 685 10.1038/344682a0 1691451 (Pubitemid 20108373)
113. In vivo supercoiling of plasmid and chromosomal DNA in an Escherichia coli hns mutant. Mojica FJ, Higgins CF, J Bacteriol 1997 179 11 3528 3533 9171396 (Pubitemid 27232989)
114. The Escherichia coli nucleoid protein H-NS functions directly as a transcriptional repressor. Ueguchi C, Mizuno T, EMBO J 1993 12 3 1039 1046 8458322 (Pubitemid 23095853)
115. Regulation of the Salmonella typhimurium flavohemoglobin gene. A new pathway for bacterial gene expression in response to nitric oxide. Crawford MJ, Goldberg DE, J Biol Chem 1998 273 51 34028 34032 10.1074/jbc.273.51.34028 9852058 (Pubitemid 29008870)
116. Regulation of the Salmonella typhimurium flavohemoglobin gene. A NEW PATHWAY FOR BACTERIAL GENE EXPRESSION IN RESPONSE TO NITRIC OXIDE. Crawford MJ, Goldberg DE, J Biol Chem 2006 281 6 3752
117. NsrR: a key regulator circumventing Salmonella enterica serovar Typhimurium oxidative and nitrosative stress in vitro and in IFN-gamma-stimulated J774.2 macrophages. Gilberthorpe NJ, Lee ME, Stevanin TM, Read RC, Poole RK, Microbiology 2007 153 Pt 6 1756 1771 17526833 (Pubitemid 46952506)
118. Identification of Listeria monocytogenes genes contributing to intracellular replication by expression profiling and mutant screening. Joseph B, Przybilla K, Stuhler C, Schauer K, Slaghuis J, Fuchs TM, Goebel W, J Bacteriol 2006 188 2 556 568 10.1128/JB.188.2.556-568.2006 16385046 (Pubitemid 43100544)
119. Ethanolamine utilization in Salmonella typhimurium: nucleotide sequence, protein expression, and mutational analysis of the cchA cchB eutE eutJ eutG eutH gene cluster. Stojiljkovic I, Baumler AJ, Heffron F, J Bacteriol 1995 177 5 1357 1366 7868611
120. In vivo cycling of the Escherichia coli transcription factor FNR between active and inactive states. Dibden DP, Green J, Microbiology 2005 151 Pt 12 4063 4070 16339951 (Pubitemid 41829986)
121. Regulation of Escherichia coli fumarate reductase (frdABCD) operon expression by respiratory electron acceptors and the fnr gene product. Jones HM, Gunsalus RP, J Bacteriol 1987 169 7 3340 3349 3298218 (Pubitemid 17106364)
122. Mutations in fnr that alter anaerobic regulation of electron transport-associated genes in Escherichia coli. Melville SB, Gunsalus RP, J Biol Chem 1990 265 31 18733 18736 2229038
123. Microbial dimethylsulfoxide and trimethylamine-N-oxide respiration. McCrindle SL, Kappler U, McEwan AG, Adv Microb Physiol 2005 50 147 198 16221580 (Pubitemid 41428407)
124. Transcriptional and maturational effects of manganese and iron on the biosynthesis of manganese-superoxide dismutase in Escherichia coli. Privalle CT, Fridovich I, J Biol Chem 1992 267 13 9140 9145 1577750
125. Repression of SPI2 transcription by nitric oxide-producing, IFNgamma-activated macrophages promotes maturation of Salmonella phagosomes. McCollister BD, Bourret TJ, Gill R, Jones-Carson J, Vazquez-Torres A, J Exp Med 2005 202 5 625 635 10.1084/jem.20050246 16129704 (Pubitemid 41248414)
126. Acid-sensitive mutants of Salmonella typhimurium identified through a dinitrophenol lethal screening strategy. Foster JW, Bearson B, J Bacteriol 1994 176 9 2596 2602 8169207 (Pubitemid 24139038)
127. Transcriptional mapping and nucleotide sequence of the Escherichia coli fepA-fes enterobactin region. Identification of a unique iron-regulated bidirectional promoter. Pettis GS, Brickman TJ, McIntosh MA, J Biol Chem 1988 263 35 18857 18863 2974033 (Pubitemid 19016344)
128. Promoter and operator determinants for Fur-mediated iron regulation in the bidirectional fepA-fes control region of the Escherichia coli enterobactin gene system. Hunt MD, Pettis GS, McIntosh MA, J Bacteriol 1994 176 13 3944 3955 8021177 (Pubitemid 24191278)
129. Coordinated repression in vitro of the divergent fepA-fes promoters of Escherichia coli by the iron uptake regulation (Fur) protein. Escolar L, Perez-Martin J, de Lorenzo V, J Bacteriol 1998 180 9 2579 2582 9573216 (Pubitemid 28217378)
130. Regulation of divergent transcription from the iron-responsive fepB-entC promoter-operator regions in Escherichia coli. Brickman TJ, Ozenberger BA, McIntosh MA, J Mol Biol 1990 212 4 669 682 10.1016/0022-2836(90)90229-F 2139473 (Pubitemid 20150499)
131. The Rcs phosphorelay system is specific to enteric pathogens/commensals and activates ydeI, a gene important for persistent Salmonella infection of mice. Erickson KD, Detweiler CS, Mol Microbiol 2006 62 3 883 894 10.1111/j.1365-2958.2006.05420.x 17010160 (Pubitemid 44571609)
132. Repression of tonB transcription during anaerobic growth requires Fur binding at the promoter and a second factor binding upstream. Young GM, Postle K, Mol Microbiol 1994 11 5 943 954 10.1111/j.1365-2958.1994.tb00373.x 8022270 (Pubitemid 24199662)
133. Mechanism for iron-regulated transcription of the Escherichia coli cir gene: metal-dependent binding of fur protein to the promoters. Griggs DW, Konisky J, J Bacteriol 1989 171 2 1048 1054 2644221
134. Contribution of the Shigella flexneri Sit, Iuc, and Feo iron acquisition systems to iron acquisition in vitro and in cultured cells. Runyen-Janecky LJ, Reeves SA, Gonzales EG, Payne SM, Infect Immun 2003 71 4 1919 1928 10.1128/IAI.71.4.1919-1928.2003 12654809 (Pubitemid 36368724)
135. The Sinorhizobium meliloti fur gene regulates, with dependence on Mn(II), transcription of the sitABCD operon, encoding a metal-type transporter. Chao TC, Becker A, Buhrmester J, Puhler A, Weidner S, J Bacteriol 2004 186 11 3609 3620 10.1128/JB.186.11.3609-3620.2004 15150249 (Pubitemid 38661559)
136. Agrobacterium tumefaciens fur has important physiological roles in iron and manganese homeostasis, the oxidative stress response, and full virulence. Kitphati W, Ngok-Ngam P, Suwanmaneerat S, Sukchawalit R, Mongkolsuk S, Appl Environ Microbiol 2007 73 15 4760 4768 10.1128/AEM.00531-07 17545320 (Pubitemid 47237223)
137. Fur is involved in manganese-dependent regulation of mntA (sitA) expression in Sinorhizobium meliloti. Platero R, Peixoto L, O'Brian MR, Fabiano E, Appl Environ Microbiol 2004 70 7 4349 4355 10.1128/AEM.70.7.4349-4355.2004 15240318 (Pubitemid 38976515)
138. Role and regulation of the Shigella flexneri sit and MntH systems. Runyen-Janecky L, Dazenski E, Hawkins S, Warner L, Infect Immun 2006 74 8 4666
139. Characterization of the ferrous iron uptake system of Escherichia coli. Kammler M, Schon C, Hantke K, J Bacteriol 1993 175 19 6212 6219 8407793 (Pubitemid 23292435)
140. Contribution of the FeoB transporter to Streptococcus suis virulence. Aranda J, Cortes P, Garrido ME, Fittipaldi N, Llagostera M, Gottschalk M, Barbe J, Int Microbiol 2009 12 2 137 143 19784934
141. Anaerobic regulation of Shigella flexneri virulence: ArcA regulates Fur and iron acquisition genes. Boulette ML, Payne SM, J Bacteriol 2007 189 19 6957 6967 10.1128/JB.00621-07 17660284 (Pubitemid 47525440)
142. The iscS gene deficiency affects the expression of pyrimidine metabolism genes. Mihara H, Hidese R, Yamane M, Kurihara T, Esaki N, Biochem Biophys Res Commun 2008 372 3 407 411 10.1016/j.bbrc.2008.05.019 18482579
143. Regulation of sod genes in Escherichia coli: relevance to superoxide dismutase function. Fee JA, Mol Microbiol 1991 5 11 2599 2610 10.1111/j.1365-2958.1991.tb01968.x 1779751 (Pubitemid 21895992)
144. Novel effect of aromatic compounds on the iron-dependent expression of the Escherichia coli K12 manganese superoxide dismutase (sodA) gene. Niederhoffer EC, Fee JA, Biol Met 1990 3 3-4 237 241 10.1007/BF01140586 2127370
145. The effects of fur on the transcriptional and post-transcriptional regulation of MnSOD gene (sodA) in Escherichia coli. Schrum LW, Hassan HM, Arch Biochem Biophys 1994 309 2 288 292 10.1006/abbi.1994.1115 8135540 (Pubitemid 24172654)
146. Iron and oxygen regulation of Escherichia coli MnSOD expression: competition between the global regulators Fur and ArcA for binding to DNA. Tardat B, Touati D, Mol Microbiol 1993 9 1 53 63 10.1111/j.1365-2958.1993. tb01668.x 8412671 (Pubitemid 23217737)
147. Ferric uptake regulator (Fur) mutants of Pseudomonas aeruginosa demonstrate defective siderophore-mediated iron uptake, altered aerobic growth, and decreased superoxide dismutase and catalase activities. Hassett DJ, Sokol PA, Howell ML, Ma JF, Schweizer HT, Ochsner U, Vasil ML, J Bacteriol 1996 178 14 3996 4003 8763923 (Pubitemid 26240876)
148. An operon containingfumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa fur mutants produce elevated alginate levels. Hassett DJ, Howell ML, Ochsner UA, Vasil ML, Johnson Z, Dean GE, J Bacteriol 1997 179 5 1452 1459 9045799 (Pubitemid 27100428)
149. Hierarchical control of anaerobic gene expression in Escherichia coli K-12: the nitrate-responsive NarX-NarL regulatory system represses synthesis of the fumarate-responsive DcuS-DcuR regulatory system. Goh EB, Bledsoe PJ, Chen LL, Gyaneshwar P, Stewart V, Igo MM, J Bacteriol 2005 187 14 4890 4899 10.1128/JB.187.14.4890-4899.2005 15995204 (Pubitemid 40962206)
150. Microarray analysis of gene regulation by oxygen, nitrate, nitrite, FNR, NarL and NarP during anaerobic growth of Escherichia coli: new insights into microbial physiology. Overton TW, Griffiths L, Patel MD, Hobman JL, Penn CW, Cole JA, Constantinidou C, Biochem Soc Trans 2006 34 Pt 1 104 107 16417494 (Pubitemid 43235545)
151. Transcriptional regulation and organization of the dcuA and dcuB genes, encoding homologous anaerobic C4-dicarboxylate transporters in Escherichia coli. Golby P, Kelly DJ, Guest JR, Andrews SC, J Bacteriol 1998 180 24 6586 6596 9852003
152. Molecular characterization of the ferric-uptake regulator, fur, from Staphylococcus aureus. Xiong A, Singh VK, Cabrera G, Jayaswal RK, Microbiology 2000 146 Pt 3 659 668 10746769 (Pubitemid 30157661)
153. FhuF, an iron-regulated protein of Escherichia coli with a new type of [2Fe-2S] center. Muller K, Matzanke BF, Schunemann V, Trautwein AX, Hantke K, Eur J Biochem 1998 258 3 1001 1008 10.1046/j.1432-1327.1998.2581001.x 9990318 (Pubitemid 29013538)