Application of physiology-based pharmacokinetic and pharmacodynamic modeling to individualized target-controlled propofol infusions

Advances in Therapy

Volumn 23, Issue 1, 2006, Pages 143-158

  Edginton, Andrea N ^a   Schmitt, Walter ^a   Willmann, Stefan ^a  

^a BAYER AG   (Germany)

Author keywords

Compartmental models; PBPK models; Pharmacodynamics; Pharmacokinetics; Physiology based pharmacokinetic models; Propofol; Target controlled infusion device

Indexed keywords

PROPOFOL;

ADULT; ARTICLE; BODY WEIGHT; BRAIN TISSUE; CHILD; COMPARTMENT MODEL; CONSCIOUSNESS; DEVICE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG INFUSION; DRUG PROTEIN BINDING; DRUG SOLUBILITY; FEMALE; GROUPS BY AGE; HUMAN; LIPOPHILICITY; MALE; OBESITY; PHARMACODYNAMICS; PHYSIOLOGY; PREGNANCY; SIMULATION; TARGET CONTROLLED INFUSION; UNCONSCIOUSNESS;

ADULT; AGE FACTORS; ANESTHETICS, INTRAVENOUS; BODY HEIGHT; BODY WEIGHT; CHILD; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; OBESITY; PREGNANCY; PROPOFOL; REPRODUCIBILITY OF RESULTS; SEX FACTORS; TISSUE DISTRIBUTION;

EID: 33646123064     PISSN: 0741238X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02850355     Document Type: Article

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