Ligand binding and thermostability of different allosteric states of the insulin zinc-hexamer

Biochemistry

Volumn 45, Issue 12, 2006, Pages 4014-4024

  Huus, Kasper ^a   Havelund, Svend ^b   Olsen, Helle B ^b   Sigurskjold, Bent W ^c   Van De Weert, Marco ^a   Frokjaer, Sven ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; PHENOLS; THERMODYNAMIC STABILITY; ZINC;

ANIONIC LIGAND; INSULIN HEXAMER; PHENOLIC LIGANDS;

INSULIN;

4 AMINOBENZOIC ACID; 4 HYDROXY 3 NITROBENZOATE; ANION; CHLORIDE; HEXAMER; INSULIN ZINC SUSPENSION; LIGAND; META CRESOL; NITROBENZOIC ACID DERIVATIVE; PHENOL; POLYMER; RESORCINOL; THIOCYANATE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; DIFFERENTIAL SCANNING CALORIMETRY; DISSOCIATION CONSTANT; EVALUATION; INSULIN BINDING; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; REACTION ANALYSIS; STRUCTURE ANALYSIS; THERMOSTABILITY; TRANSITION TEMPERATURE;

ALLOSTERIC REGULATION; BIOPOLYMERS; CALORIMETRY, DIFFERENTIAL SCANNING; HUMANS; INSULIN; LIGANDS; PHENOLS; SPECTROPHOTOMETRY, ULTRAVIOLET; ZINC;

EID: 33645459665     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0524520     Document Type: Article

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