Thermo-targeted drug delivery of geldanamycin to hyperthermic tumor margins with diblock elastin-based biopolymers

Journal of Controlled Release

Volumn 155, Issue 2, 2011, Pages 175-183

  Chen, Y ^a   Youn, P ^a   Furgeson, D Y ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

Elastin like polypeptide; Geldanamycin; Heat shock protein 90; Hepatocellular carcinoma; Hyperthermia; Tumor (ablative) margin

Indexed keywords

ELASTIN-LIKE POLYPEPTIDES; GELDANAMYCIN; HEAT SHOCK PROTEIN; HEPATOCELLULAR CARCINOMA; HYPERTHERMIA;

ABLATION; BIOPOLYMERS; CHEMOTHERAPY; DRUG DELIVERY; GLYCOPROTEINS; PH EFFECTS; POLYPEPTIDES; TOXICITY;

TUMORS;

ASPARTIC ACID; BIOPOLYMER; ELASTIN; ELASTIN LIKE POLYPEPTIDE; GELDANAMYCIN; GLUTAMIC ACID; HEAT SHOCK PROTEIN 90; HYDRAZINE; POLYPEPTIDE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; HYDRAZONE DERIVATIVE; PROTEIN KINASE B; PROTEIN P53; RAF PROTEIN;

CANCER CHEMOTHERAPY; CONFERENCE PAPER; CONTROLLED STUDY; COVALENT BOND; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; HEAT SENSITIVITY; HIGH TEMPERATURE; INHIBITION KINETICS; ISOTHERM; LIVER CELL CARCINOMA; MOLECULARLY TARGETED THERAPY; NONHUMAN; PH; PHASE TRANSITION; PRIORITY JOURNAL; TRANSITION TEMPERATURE; TUMOR ABLATION; CHEMOTHERAPY; DRUG TARGETING; IC 50; TOXICITY; TUMOR; UPREGULATION;

ABLATION TECHNIQUES; ANTIBIOTICS, ANTINEOPLASTIC; BENZOQUINONES; CARCINOMA, HEPATOCELLULAR; DRUG CARRIERS; DRUG STABILITY; ELASTIN; HOT TEMPERATURE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; LACTAMS, MACROCYCLIC; LIVER NEOPLASMS; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR STRUCTURE; OLIGONUCLEOTIDES; PARTICLE SIZE; PHASE TRANSITION; SOLUBILITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STREPTOMYCES; SURFACE PROPERTIES; TRANSITION TEMPERATURE;

EID: 80054124189     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.07.040     Document Type: Conference Paper

References (50)

1. H. Sternglanz, and C.E. Bugg Relationship between the mutagenic and base-stacking properties of halogenated uracil derivatives. The crystal structures of 5-chloro- and 5-bromouracil Biochim. Biophys. Acta 378 1975 1 11
2. Y. Matsumura, and H. Maeda A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res. 46 1986 6387 6392 (Pubitemid 17221789)
3. J.R. McDaniel, D.J. Callahan, and A. Chilkoti Drug delivery to solid tumors by elastin-like polypeptides Adv. Drug Deliv. Rev. 62 2010 1456 1467
4. G.L. Bidwell III, A.N. Davis, and D. Raucher Targeting a c-Myc inhibitory polypeptide to specific intracellular compartments using cell penetrating peptides J. Control. Release 135 2009 2 10
5. D.Y. Furgeson, M.R. Dreher, and A. Chilkoti Structural optimization of a "smart" doxorubicin-polypeptide conjugate for thermally targeted delivery to solid tumors J. Control. Release 110 2006 362 369 (Pubitemid 41827490)
6. J.L. Osborne, R. Farmer, and K.A. Woodhouse Self-assembled elastin-like polypeptide particles Acta Biomater. 4 2008 49 57 (Pubitemid 350131557)
7. E.R. Wright, and V.P. Conticello Self-assembly of block copolymers derived from elastin-mimetic polypeptide sequences Adv. Drug Deliv. Rev. 54 2002 1057 1073
8. P.C. Bessa, R. Machado, S. Nurnberger, D. Dopler, A. Banerjee, A.M. Cunha, J.C. Rodriguez-Cabello, H. Redl, M. van Griensven, R.L. Reis, and M. Casal Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs J. Control. Release 142 2010 312 318
9. A. Chilkoti, M.R. Dreher, and D.E. Meyer Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery Adv. Drug Deliv. Rev. 54 2002 1093 1111
10. R.E. Sallach, W. Cui, J. Wen, A. Martinez, V.P. Conticello, and E.L. Chaikof Elastin-mimetic protein polymers capable of physical and chemical crosslinking Biomaterials 30 2009 409 422
11. K.A. Woodhouse, P. Klement, V. Chen, M.B. Gorbet, F.W. Keeley, R. Stahl, J.D. Fromstein, and C.M. Bellingham Investigation of recombinant human elastin polypeptides as non-thrombogenic coatings Biomaterials 25 2004 4543 4553 (Pubitemid 38561141)
12. W.Y. Wu, C. Mee, F. Califano, R. Banki, and D.W. Wood Recombinant protein purification by self-cleaving aggregation tag Nat. Protoc. 1 2006 2257 2262
13. T. Christensen, M. Amiram, S. Dagher, K. Trabbic-Carlson, M.F. Shamji, L.A. Setton, and A. Chilkoti Fusion order controls expression level and activity of elastin-like polypeptide fusion proteins Protein Sci. 18 2009 1377 1387
14. W. Liu, M.R. Dreher, D.Y. Furgeson, K.V. Peixoto, H. Yuan, M.R. Zalutsky, and A. Chilkoti Tumor accumulation, degradation and pharmacokinetics of elastin-like polypeptides in nude mice J. Control. Release 116 2006 170 178 (Pubitemid 44854277)
15. M.R. Dreher, W. Liu, C.R. Michelich, M.W. Dewhirst, and A. Chilkoti Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors Cancer Res. 67 2007 4418 4424 (Pubitemid 46815091)
16. W. Liu, J.A. MacKay, M.R. Dreher, M. Chen, J.R. McDaniel, A.J. Simnick, D.J. Callahan, M.R. Zalutsky, and A. Chilkoti Injectable intratumoral depot of thermally responsive polypeptide-radionuclide conjugates delays tumor progression in a mouse model J. Control. Release 144 2010 2 9
17. R. Lencioni, L. Crocetti, P. De Simone, and F. Filipponi Loco-regional interventional treatment of hepatocellular carcinoma: techniques, outcomes, and future prospects Transpl. Int. 23 2010 698 703
18. I.A. Hashim Clinical biochemistry of hyperthermia Ann. Clin. Biochem. 47 2010 516 523
19. M.N. Rylander, Y. Feng, J. Bass, and K.R. Diller Thermally induced injury and heat-shock protein expression in cells and tissues Ann. N. Y. Acad. Sci. 1066 2005 222 242
20. M. Yano, Z. Naito, S. Tanaka, and G. Asano Expression and roles of heat shock proteins in human breast cancer Jpn. J. Cancer Res. 87 1996 908 915 (Pubitemid 26328915)
21. M. Senju, N. Sueoka, A. Sato, K. Iwanaga, Y. Sakao, S. Tomimitsu, M. Tominaga, K. Irie, S. Hayashi, and E. Sueoka Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines J. Cancer Res. Clin. Oncol. 132 2006 150 158 (Pubitemid 43015775)
22. J. Schwock, N.A. Pham, M.P. Cao, and D.W. Hedley Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo Cancer Chemother. Pharmacol. 61 2008 669 681
23. C.R. Williams, R. Tabios, W.M. Linehan, and L. Neckers Intratumor injection of the Hsp90 inhibitor 17AAG decreases tumor growth and induces apoptosis in a prostate cancer xenograft model J. Urol. 178 2007 1528 1532 (Pubitemid 47376711)
24. Y. Sun, Z. Zang, X. Xu, Z. Zhang, L. Zhong, W. Zan, Y. Zhao, and L. Sun Differential proteomics identification of HSP90 as potential serum biomarker in hepatocellular carcinoma by two-dimensional electrophoresis and mass spectrometry Int. J. Mol. Sci. 11 2010 1423 1433
25. L. Whitesell, and S.L. Lindquist HSP90 and the chaperoning of cancer Nat. Rev. Cancer 5 2005 761 772 (Pubitemid 41400776)
26. B.K. Eustace, T. Sakurai, J.K. Stewart, D. Yimlamai, C. Unger, C. Zehetmeier, B. Lain, C. Torella, S.W. Henning, G. Beste, B.T. Scroggins, L. Neckers, L.L. Ilag, and D.G. Jay Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness Nat. Cell Biol. 6 2004 507 514 (Pubitemid 38786593)
27. J.E. Bohonowych, U. Gopal, and J.S. Isaacs Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls J. Oncol. 2010 2010 412985
28. M.V. Blagosklonny Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs Leukemia 16 2002 455 462 (Pubitemid 34449725)
29. G. Schueller, J. Kettenbach, R. Sedivy, A. Stift, J. Friedl, M. Gnant, and J. Lammer Heat shock protein expression induced by percutaneous radiofrequency ablation of hepatocellular carcinoma in vivo Int. J. Oncol. 24 2004 609 613
30. N.O. Ibrahim, T. Hahn, C. Franke, D.P. Stiehl, R. Wirthner, R.H. Wenger, and D.M. Katschinski Induction of the hypoxia-inducible factor system by low levels of heat shock protein 90 inhibitors Cancer Res. 65 2005 11094 11100 (Pubitemid 41713380)
31. S.M. Roe, C. Prodromou, R. O'Brien, J.E. Ladbury, P.W. Piper, and L.H. Pearl Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin J. Med. Chem. 42 1999 260 266 (Pubitemid 29069861)
32. J.G. Supko, R.L. Hickman, M.R. Grever, and L. Malspeis Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent Cancer Chemother. Pharmacol. 36 1995 305 315
33. E.A. Sausville, J.E. Tomaszewski, and P. Ivy Clinical development of 17-allylamino, 17-demethoxygeldanamycin Curr. Cancer Drug Targets 3 2003 377 383 (Pubitemid 37128324)
34. M.J. Egorin, T.F. Lagattuta, D.R. Hamburger, J.M. Covey, K.D. White, S.M. Musser, and J.L. Eiseman Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats Cancer Chemother. Pharmacol. 49 2002 7 19
35. M.P. Xiong, J.A. Yanez, C.M. Remsberg, Y. Ohgami, G.S. Kwon, N.M. Davies, and M.L. Forrest Formulation of a geldanamycin prodrug in mPEG-b-PCL micelles greatly enhances tolerability and pharmacokinetics in rats J. Control. Release 129 2008 33 40
36. N.N. Rahbari, A. Mehrabi, N.M. Mollberg, S.A. Muller, M. Koch, M.W. Buchler, and J. Weitz Hepatocellular carcinoma: current management and perspectives for the future Ann. Surg. 253 2011 453 469
37. C. Verslype, E. Van Cutsem, M. Dicato, N. Arber, J.D. Berlin, D. Cunningham, A. De Gramont, E. Diaz-Rubio, M. Ducreux, T. Gruenberger, D. Haller, K. Haustermans, P. Hoff, D. Kerr, R. Labianca, M. Moore, B. Nordlinger, A. Ohtsu, P. Rougier, W. Scheithauer, H.J. Schmoll, A. Sobrero, J. Tabernero, and C. van de Velde The management of hepatocellular carcinoma. Current expert opinion and recommendations derived from the 10th World Congress on Gastrointestinal Cancer, Barcelona, 2008 Ann. Oncol. 20 Suppl 7 2009 vii1 vii6
38. Y. Bae, R.A. Buresh, T.P. Williamson, T.H. Chen, and D.Y. Furgeson Intelligent biosynthetic nanobiomaterials for hyperthermic combination chemotherapy and thermal drug targeting of HSP90 inhibitor geldanamycin J. Control. Release 122 2007 16 23 (Pubitemid 47284549)
39. Y. Bae, N. Nishiyama, and K. Kataoka In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments Bioconjug. Chem. 18 2007 1131 1139 (Pubitemid 47122634)
40. D.E. Meyer, and A. Chilkoti Genetically encoded synthesis of protein-based polymers with precisely specified molecular weight and sequence by recursive directional ligation: examples from the elastin-like polypeptide system Biomacromolecules 3 2002 357 367 (Pubitemid 34257157)
41. D.E. Meyer, G.A. Kong, M.W. Dewhirst, M.R. Zalutsky, and A. Chilkoti Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia Cancer Res. 61 2001 1548 1554 (Pubitemid 34292586)
42. C. DeBoer, P.A. Meulman, R.J. Wnuk, and D.H. Peterson Geldanamycin, a new antibiotic J. Antibiot. (Tokyo) 23 1970 442 447
43. D.W. Urry Physical chemistry of biological free energy transduction as demonstrated by elastic protein-based polymers J. Phys. Chem. B 101 1997 11007 11028 (Pubitemid 127627954)
44. D.M. Floss, K. Schallau, S. Rose-John, U. Conrad, and J. Scheller Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application Trends Biotechnol. 28 2010 37 45
45. P. Calvo, J.L. Vila-Jato, and M.J. Alonso Effect of lysozyme on the stability of polyester nanocapsules and nanoparticles: stabilization approaches Biomaterials 18 1997 1305 1310 (Pubitemid 27406136)
46. P.P. Karmali, and D. Simberg Interactions of nanoparticles with plasma proteins: implication on clearance and toxicity of drug delivery systems Expert Opin. Drug Deliv. 8 2011 343 357
47. G.R.L. Cousins, S.-A. Poulsen, and J.K.M. Sanders Dynamic combinatorial libraries of pseudo-peptide hydrazone macrocycles Chem. Commun. 1999 1575 1576 (Pubitemid 29391228)
48. V.A. Polyakov, M.I. Nelen, N. Nazarpack-Kandlousy, A.D. Ryabov, and A.V. Eliseev Imine exchange in O-aryl and O-alkyl oximes as a base reaction for aqueous 'dynamic' combinatorial libraries. A kinetic and thermodynamic study J. Phys. Org. Chem. 12 1999 357 363 (Pubitemid 129663175)
49. G.R. Cousins, R.L. Furlan, Y.F. Ng, J.E. Redman, and J.K. Sanders Identification and Isolation of a Receptor for N-Methyl Alkylammonium Salts: Molecular Amplification in a Pseudo-peptide Dynamic Combinatorial Library This work was supported by the Biotechnology and Biological Sciences Research Council (UK), Engineering and Physical Sciences Research Council (UK), Ethyl Corporation (UK), and Fundacion Antorchas and Consejo Nacional de Investigaciones Cientficas y Tecnicas (Argentina) Angew. Chem. Int. Ed Engl. 40 2001 423 428
50. P. Kovaríková, M. Mokrý, J. Klimes, and K. Vávrová HPLC study on stability of pyridoxal isonicotinoyl hydrazone J. Pharm. Biomed. Anal. 40 2006 105 112 (Pubitemid 43061224)