Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia

Cancer Research

Volumn 61, Issue 4, 2001, Pages 1548-1554

  Meyer, Dan E ^a   Kong, Garheng A ^a   Dewhirst, Mark W ^a   Zalutsky, Michael R ^a   Chilkoti, Ashutosh ^a  

^a Duke University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELASTIN; ELASTIN LIKE POLYPEPTIDE; POLYPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG SYNTHESIS; GENETIC ENGINEERING; HUMAN; HUMAN CELL; HYPERTHERMIC THERAPY; MOUSE; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; SOLID TUMOR;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DRUG STABILITY; ELASTIN; FEMALE; GLIOMA; HUMANS; HYPERTHERMIA, INDUCED; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, FLUORESCENCE; MICROSCOPY, VIDEO; MOLECULAR SEQUENCE DATA; OVARIAN NEOPLASMS; PEPTIDES; PROTEIN ENGINEERING; TEMPERATURE; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035866357     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Drug-polymer conjugates: Potential for improved chemotherapy
2. Polymeric micelles: A new generation of colloidal drug carriers
3. Polymer-coated long-circulating microparticulate pharmaceuticals
4. Liposomal drug formulations: Rationale for development and what we can expect in the future
5. Drug delivery and targeting
6. A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanisms of tumoritropic accumulation of protein and the antitumor agent SMANCS
7. Hyperthermic treatment of malignant diseases: Current status and a view toward the future
8. Rationale and clinical status of local hyperthermia, radiation, and chemotherapy in locally advanced malignancies
9. Hyperthermia combined with chemotherapy: Biological rationale, clinical application, and treatment results
10. Free energy transduction in polypeptides and proteins based on inverse temperature transitions
11. Physical chemistry of biological free energy transduction as demonstrated by elastic protein-based polymers
12. Temperature of polypeptide inverse temperature transition depends on mean residue hydrophobicity
13. Purification of recombinant proteins by fusion with thermally responsive polypeptides
14. Product purification by reversible phase transition following Escherichia coli expression of genes encoding up to 251 repeats of the clastomeric pentapeptide GVGVP
15. Copper staining: A five-minute protein stain for sodium dodecyl sulfate-polyacrylamide gels
16. A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine
17. Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature
18. Increased microvascular permeability contributes to preferential accumulation of stealth liposomes in tumor tissue
19. Measurement of material extravasation in microvascular networks using fluorescence videomicroscopy
20. A uniform thermal field in a hyperthermia chamber for microvascular studies
21. Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model
22. Thermal dosimetry
23. Phase-structure transitions of the elastin polypentapeptide-water system within the framework of composition temperature studies
24. Microsphere and dilution techniques for the determination of blood flows and volumes in conscious mice
25. Gross composition and plasma and extracellular water volumes of tissues of a reference mouse
26. Hyperthermia liposomes
27. "Smart" polymers and what they could do in biotechnology and medicine
28. Phase-transition polymers for drug delivery
29. Monoclonal antibodies in drug targeting
30. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
31. Polymerizable Fab' antibody fragments for targeting of anticancer drugs