Structural optimization of a "smart" doxorubicin-polypeptide conjugate for thermally targeted delivery to solid tumors

Journal of Controlled Release

Volumn 110, Issue 2, 2006, Pages 362-369

  Furgeson, Darin Y ^a   Dreher, Matthew R ^a   Chilkoti, Ashutosh ^a,b  

^a Duke University   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

Doxorubicin; Drug delivery; Elastin like polypeptide; Hydrazone; Thermoresponsive

Indexed keywords

DRUG THERAPY; ENZYME KINETICS; PH EFFECTS; TUMORS;

DOXORUBICIN; DRUG DELIVERY; ELASTIN-LIKE POLYPEPTIDE; HYDRAZONE; THERMORESPONSIVE;

POLYPEPTIDES;

CYSTEINE; DOXORUBICIN; ELASTIN; HYDRAZONE DERIVATIVE; MALEIMIDE; POLYPEPTIDE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL BOND; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; GENETIC ENGINEERING; HYDRODYNAMICS; KINETICS; PH MEASUREMENT; PRIORITY JOURNAL; PURIFICATION; SENSITIVITY ANALYSIS; SOLID TUMOR; STRUCTURE ANALYSIS; SYNTHESIS; TEMPERATURE MEASUREMENT; THERMAL ANALYSIS;

ANTIBIOTICS, ANTINEOPLASTIC; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOXORUBICIN; DRUG DELIVERY SYSTEMS; ELASTIN; ESCHERICHIA COLI; HYDRAZONES; HYDROGEN-ION CONCENTRATION; LIGHT; MALEIMIDES; NEOPLASMS; PEPTIDES; PROTEIN ENGINEERING; SCATTERING, RADIATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 29244462519     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.10.006     Document Type: Article

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